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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-75 Sentence denotes Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes.
T2 76-233 Sentence denotes Phagocyte recognition, uptake, and nonphlogistic degradation of neutrophils and other leukocytes undergoing apoptosis promote the resolution of inflammation.
T3 234-341 Sentence denotes This study assessed the effects of anti-inflammatory glucocorticoids on this leukocyte clearance mechanism.
T4 342-620 Sentence denotes Pretreatment of "semimature" 5-day human monocyte-derived macrophages (M phi) for 24 h with methylprednisolone, dexamethasone, and hydrocortisone, but not the nonglucocorticoid steroids aldosterone, estradiol, and progesterone, potentiated phagocytosis of apoptotic neutrophils.
T5 621-869 Sentence denotes These effects were specific in that the potentiated phagocytosis of apoptotic neutrophils was completely blocked by the glucocorticoid receptor antagonist RU38486, and glucocorticoids did not promote 5-day M phi ingestion of opsonized erythrocytes.
T6 870-1194 Sentence denotes Similar glucocorticoid-mediated potentiation was observed with 5-day M phi uptake of alternative apoptotic "targets" (eosinophils and Jurkat T cells) and in uptake of apoptotic neutrophils by alternative phagocytes (human glomerular mesangial cells and murine M phi elicited into the peritoneum or derived from bone marrow).
T7 1195-1377 Sentence denotes Importantly, methylprednisolone-mediated enhancement of the uptake of apoptotic neutrophils did not trigger the release of the chemokines IL-8 and monocyte chemoattractant protein-1.
T8 1378-1649 Sentence denotes Furthermore, longer-term potentiation by methylprednisolone was observed in maturing human monocyte-derived M phi, with greater increases in 5-day M phi uptake of apoptotic cells being observed the earlier glucocorticoids were added during monocyte maturation into M phi.
T9 1650-1905 Sentence denotes We conclude that potentiation of nonphlogistic clearance of apoptotic leukocytes by phagocytes is a hitherto unrecognized property of glucocorticoids that has potential implications for therapies aimed at promoting the resolution of inflammatory diseases.
T1 0-75 Sentence denotes Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes.
T2 76-233 Sentence denotes Phagocyte recognition, uptake, and nonphlogistic degradation of neutrophils and other leukocytes undergoing apoptosis promote the resolution of inflammation.
T3 234-341 Sentence denotes This study assessed the effects of anti-inflammatory glucocorticoids on this leukocyte clearance mechanism.
T4 342-620 Sentence denotes Pretreatment of "semimature" 5-day human monocyte-derived macrophages (M phi) for 24 h with methylprednisolone, dexamethasone, and hydrocortisone, but not the nonglucocorticoid steroids aldosterone, estradiol, and progesterone, potentiated phagocytosis of apoptotic neutrophils.
T5 621-869 Sentence denotes These effects were specific in that the potentiated phagocytosis of apoptotic neutrophils was completely blocked by the glucocorticoid receptor antagonist RU38486, and glucocorticoids did not promote 5-day M phi ingestion of opsonized erythrocytes.
T6 870-1194 Sentence denotes Similar glucocorticoid-mediated potentiation was observed with 5-day M phi uptake of alternative apoptotic "targets" (eosinophils and Jurkat T cells) and in uptake of apoptotic neutrophils by alternative phagocytes (human glomerular mesangial cells and murine M phi elicited into the peritoneum or derived from bone marrow).
T7 1195-1377 Sentence denotes Importantly, methylprednisolone-mediated enhancement of the uptake of apoptotic neutrophils did not trigger the release of the chemokines IL-8 and monocyte chemoattractant protein-1.
T8 1378-1649 Sentence denotes Furthermore, longer-term potentiation by methylprednisolone was observed in maturing human monocyte-derived M phi, with greater increases in 5-day M phi uptake of apoptotic cells being observed the earlier glucocorticoids were added during monocyte maturation into M phi.
T9 1650-1905 Sentence denotes We conclude that potentiation of nonphlogistic clearance of apoptotic leukocytes by phagocytes is a hitherto unrecognized property of glucocorticoids that has potential implications for therapies aimed at promoting the resolution of inflammatory diseases.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 54-74 cell_type denotes apoptotic leukocytes
T2 140-151 cell_type denotes neutrophils
T3 162-172 cell_type denotes leukocytes
T4 377-411 cell_type denotes human monocyte-derived macrophages
T5 598-619 cell_type denotes apoptotic neutrophils
T6 689-710 cell_type denotes apoptotic neutrophils
T7 741-764 protein denotes glucocorticoid receptor
T8 846-868 cell_type denotes opsonized erythrocytes
T9 988-999 cell_type denotes eosinophils
T10 1004-1018 cell_line denotes Jurkat T cells
T11 1037-1058 cell_type denotes apoptotic neutrophils
T12 1074-1084 cell_type denotes phagocytes
T13 1086-1118 cell_type denotes human glomerular mesangial cells
T14 1123-1135 cell_line denotes murine M phi
T15 1265-1286 cell_type denotes apoptotic neutrophils
T16 1322-1332 protein denotes chemokines
T17 1333-1337 protein denotes IL-8
T18 1342-1376 protein denotes monocyte chemoattractant protein-1
T19 1454-1491 cell_line denotes maturing human monocyte-derived M phi
T20 1525-1530 cell_line denotes M phi
T21 1541-1556 cell_type denotes apoptotic cells
T22 1643-1648 cell_line denotes M phi
T23 1710-1730 cell_type denotes apoptotic leukocytes
T24 1734-1744 cell_type denotes phagocytes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-75 Sentence denotes Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes.
S2 76-233 Sentence denotes Phagocyte recognition, uptake, and nonphlogistic degradation of neutrophils and other leukocytes undergoing apoptosis promote the resolution of inflammation.
S3 234-341 Sentence denotes This study assessed the effects of anti-inflammatory glucocorticoids on this leukocyte clearance mechanism.
S4 342-620 Sentence denotes Pretreatment of "semimature" 5-day human monocyte-derived macrophages (M phi) for 24 h with methylprednisolone, dexamethasone, and hydrocortisone, but not the nonglucocorticoid steroids aldosterone, estradiol, and progesterone, potentiated phagocytosis of apoptotic neutrophils.
S5 621-869 Sentence denotes These effects were specific in that the potentiated phagocytosis of apoptotic neutrophils was completely blocked by the glucocorticoid receptor antagonist RU38486, and glucocorticoids did not promote 5-day M phi ingestion of opsonized erythrocytes.
S6 870-1194 Sentence denotes Similar glucocorticoid-mediated potentiation was observed with 5-day M phi uptake of alternative apoptotic "targets" (eosinophils and Jurkat T cells) and in uptake of apoptotic neutrophils by alternative phagocytes (human glomerular mesangial cells and murine M phi elicited into the peritoneum or derived from bone marrow).
S7 1195-1377 Sentence denotes Importantly, methylprednisolone-mediated enhancement of the uptake of apoptotic neutrophils did not trigger the release of the chemokines IL-8 and monocyte chemoattractant protein-1.
S8 1378-1649 Sentence denotes Furthermore, longer-term potentiation by methylprednisolone was observed in maturing human monocyte-derived M phi, with greater increases in 5-day M phi uptake of apoptotic cells being observed the earlier glucocorticoids were added during monocyte maturation into M phi.
S9 1650-1905 Sentence denotes We conclude that potentiation of nonphlogistic clearance of apoptotic leukocytes by phagocytes is a hitherto unrecognized property of glucocorticoids that has potential implications for therapies aimed at promoting the resolution of inflammatory diseases.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-15 NP denotes Glucocorticoids
C2 54-74 NP denotes apoptotic leukocytes
C3 434-452 NP denotes methylprednisolone
C4 598-619 NP denotes apoptotic neutrophils
C5 689-710 NP denotes apoptotic neutrophils
C6 789-804 NP denotes glucocorticoids
C7 1037-1058 NP denotes apoptotic neutrophils
C8 1265-1286 NP denotes apoptotic neutrophils
C9 1419-1437 NP denotes methylprednisolone
C10 1710-1730 NP denotes apoptotic leukocytes
C12 1784-1799 NP denotes glucocorticoids
C11 1748-1799 NP denotes a hitherto unrecognized property of glucocorticoids
C13 1800-1804 NP denotes that
R1 C5 C4 coref-ident apoptotic neutrophils,apoptotic neutrophils
R2 C6 C1 coref-ident glucocorticoids,Glucocorticoids
R3 C7 C5 coref-ident apoptotic neutrophils,apoptotic neutrophils
R4 C8 C7 coref-ident apoptotic neutrophils,apoptotic neutrophils
R5 C9 C3 coref-ident methylprednisolone,methylprednisolone
R6 C10 C2 coref-ident apoptotic leukocytes,apoptotic leukocytes
R7 C12 C6 coref-ident glucocorticoids,glucocorticoids
R8 C13 C11 coref-relat that,a hitherto unrecognized property of glucocorticoids

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-15 lipid denotes Glucocorticoids
T2 24-50 other_name denotes nonphlogistic phagocytosis
T3 54-74 cell_type denotes apoptotic leukocytes
T4 76-97 other_name denotes Phagocyte recognition
T5 111-136 other_name denotes nonphlogistic degradation
T6 140-151 cell_type denotes neutrophils
T7 162-172 cell_type denotes leukocytes
T8 184-193 other_name denotes apoptosis
T9 220-232 other_name denotes inflammation
T10 269-302 lipid denotes anti-inflammatory glucocorticoids
T11 311-340 other_name denotes leukocyte clearance mechanism
T12 377-411 cell_type denotes human monocyte-derived macrophages
T13 434-452 lipid denotes methylprednisolone
T14 454-467 lipid denotes dexamethasone
T15 473-487 lipid denotes hydrocortisone
T16 501-527 lipid denotes nonglucocorticoid steroids
T17 528-539 lipid denotes aldosterone
T18 541-550 lipid denotes estradiol
T19 556-568 lipid denotes progesterone
T20 582-594 other_name denotes phagocytosis
T21 598-619 cell_type denotes apoptotic neutrophils
T22 673-685 other_name denotes phagocytosis
T23 689-710 cell_type denotes apoptotic neutrophils
T24 741-764 protein_family_or_group denotes glucocorticoid receptor
T25 776-783 other_organic_compound denotes RU38486
T26 789-804 lipid denotes glucocorticoids
T27 846-868 cell_type denotes opsonized erythrocytes
T28 878-914 other_name denotes glucocorticoid-mediated potentiation
T29 955-976 other_name denotes alternative apoptotic
T30 988-999 cell_type denotes eosinophils
T31 1004-1018 cell_line denotes Jurkat T cells
T32 1037-1058 cell_type denotes apoptotic neutrophils
T33 1074-1084 cell_type denotes phagocytes
T34 1086-1118 cell_type denotes human glomerular mesangial cells
T35 1123-1135 cell_line denotes murine M phi
T36 1154-1164 tissue denotes peritoneum
T37 1181-1192 tissue denotes bone marrow
T38 1208-1226 lipid denotes methylprednisolone
T39 1265-1286 cell_type denotes apoptotic neutrophils
T40 1322-1332 protein_family_or_group denotes chemokines
T41 1333-1337 protein_molecule denotes IL-8
T42 1342-1376 protein_molecule denotes monocyte chemoattractant protein-1
T43 1419-1437 lipid denotes methylprednisolone
T44 1454-1491 cell_line denotes maturing human monocyte-derived M phi
T45 1525-1530 cell_line denotes M phi
T46 1541-1556 cell_type denotes apoptotic cells
T47 1584-1599 lipid denotes glucocorticoids
T48 1618-1637 other_name denotes monocyte maturation
T49 1643-1648 cell_line denotes M phi
T50 1710-1730 cell_type denotes apoptotic leukocytes
T51 1734-1744 cell_type denotes phagocytes
T52 1784-1799 lipid denotes glucocorticoids
T53 1883-1904 other_name denotes inflammatory diseases

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 856-868 HP_0001901 denotes erythrocytes