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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 27-33 protein denotes 4E-BP1
T2 38-44 protein denotes 4E-BP2
T3 95-113 cell_type denotes human myeloid cell
T4 344-362 cell_type denotes human myeloid cell
T5 389-427 cell_line denotes HL-60 promyelocytic leukemia cell line
T6 436-463 cell_line denotes U-937 monoblastic cell line
T7 747-753 protein denotes 4E-BP1
T8 758-764 protein denotes 4E-BP2
T9 779-784 cell_line denotes HL-60
T10 789-794 cell_line denotes U-937
T11 821-842 cell_type denotes monocytes/macrophages
T12 846-855 protein denotes IFN-gamma
T13 923-929 protein denotes 4E-BP1
T14 952-958 protein denotes 4E-BP1
T15 982-993 cell_line denotes U-937 cells
T16 1029-1050 cell_type denotes monocytes/macrophages
T17 1125-1136 cell_line denotes HL-60 cells
T18 1239-1245 protein denotes 4E-BP1
T19 1314-1320 protein denotes 4E-BP2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-130 Sentence denotes Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation.
S2 131-212 Sentence denotes Human myeloid differentiation is accompanied by a decrease in cell proliferation.
S3 213-464 Sentence denotes Because the translation rate is an important determinant of cell proliferation, we have investigated translation initiation during human myeloid cell differentiation using the HL-60 promyelocytic leukemia cell line and the U-937 monoblastic cell line.
S4 465-629 Sentence denotes A decrease in the translation rate is observed when the cells are induced to differentiate along the monocytic/macrophage pathway or along the granulocytic pathway.
S5 630-765 Sentence denotes The inhibition in protein synthesis correlates with specific regulation of two repressors of translation initiation, 4E-BP1 and 4E-BP2.
S6 766-930 Sentence denotes Induction of HL-60 and U-937 cell differentiation into monocytes/macrophages by IFN-gamma or PMA results in a dephosphorylation and consequent activation of 4E-BP1.
S7 931-1098 Sentence denotes Dephosphorylation of 4E-BP1 was also observed when U-937 cells were induced to differentiate into monocytes/macrophages following treatment with retinoic acid or DMSO.
S8 1099-1328 Sentence denotes In contrast, treatment of HL-60 cells with retinoic acid or DMSO, which results in a granulocytic differentiation of these cells, decreases 4E-BP1 amount without affecting its phosphorylation and strongly increases 4E-BP2 amount.
S9 1329-1546 Sentence denotes Taken together, these data provide evidence for differential regulation of the translational machinery during human myeloid differentiation, specific to the monocytic/macrophage pathway or to the granulocytic pathway.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 27-33 NP denotes 4E-BP1
C1 27-44 NP denotes 4E-BP1 and 4E-BP2
C3 46-86 NP denotes two repressors of translation initiation
C4 95-129 NP denotes human myeloid cell differentiation
C5 131-160 NP denotes Human myeloid differentiation
C6 193-211 NP denotes cell proliferation
C7 221-241 NP denotes the translation rate
C8 273-291 NP denotes cell proliferation
C9 344-378 NP denotes human myeloid cell differentiation
C10 479-499 NP denotes the translation rate
C11 562-594 NP denotes the monocytic/macrophage pathway
C12 604-628 NP denotes the granulocytic pathway
C13 705-745 NP denotes two repressors of translation initiation
C15 747-753 NP denotes 4E-BP1
C14 747-764 NP denotes 4E-BP1 and 4E-BP2
C16 821-842 NP denotes monocytes/macrophages
C17 923-929 NP denotes 4E-BP1
C18 952-958 NP denotes 4E-BP1
C19 1029-1050 NP denotes monocytes/macrophages
C20 1076-1097 NP denotes retinoic acid or DMSO
C22 1125-1136 NP denotes HL-60 cells
C23 1142-1163 NP denotes retinoic acid or DMSO
C21 1112-1163 NP denotes treatment of HL-60 cells with retinoic acid or DMSO
C24 1165-1170 NP denotes which
C25 1216-1227 NP denotes these cells
C26 1271-1274 NP denotes its
C27 1439-1468 NP denotes human myeloid differentiation
C28 1482-1514 NP denotes the monocytic/macrophage pathway
C29 1521-1545 NP denotes the granulocytic pathway
R1 C3 C1 coref-appos two repressors of translation initiation,4E-BP1 and 4E-BP2
R2 C5 C4 coref-ident Human myeloid differentiation,human myeloid cell differentiation
R3 C8 C6 coref-ident cell proliferation,cell proliferation
R4 C9 C5 coref-ident human myeloid cell differentiation,Human myeloid differentiation
R5 C10 C7 coref-ident the translation rate,the translation rate
R6 C13 C1 coref-ident two repressors of translation initiation,4E-BP1 and 4E-BP2
R7 C15 C2 coref-ident 4E-BP1,4E-BP1
R8 C14 C13 coref-appos 4E-BP1 and 4E-BP2,two repressors of translation initiation
R9 C17 C15 coref-ident 4E-BP1,4E-BP1
R10 C18 C17 coref-ident 4E-BP1,4E-BP1
R11 C19 C16 coref-ident monocytes/macrophages,monocytes/macrophages
R12 C23 C20 coref-ident retinoic acid or DMSO,retinoic acid or DMSO
R13 C24 C21 coref-relat which,treatment of HL-60 cells with retinoic acid or DMSO
R14 C25 C22 coref-ident these cells,HL-60 cells
R15 C26 C18 coref-pron its,4E-BP1
R16 C27 C9 coref-ident human myeloid differentiation,human myeloid cell differentiation
R17 C28 C11 coref-ident the monocytic/macrophage pathway,the monocytic/macrophage pathway
R18 C29 C12 coref-ident the granulocytic pathway,the granulocytic pathway

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 27-33 protein_molecule denotes 4E-BP1
T2 38-44 protein_molecule denotes 4E-BP2
T3 64-86 other_name denotes translation initiation
T4 95-113 cell_type denotes human myeloid cell
T5 131-160 other_name denotes Human myeloid differentiation
T6 193-211 other_name denotes cell proliferation
T7 273-291 other_name denotes cell proliferation
T8 314-336 other_name denotes translation initiation
T9 344-362 cell_type denotes human myeloid cell
T10 389-427 cell_line denotes HL-60 promyelocytic leukemia cell line
T11 436-463 cell_line denotes U-937 monoblastic cell line
T12 566-594 other_name denotes monocytic/macrophage pathway
T13 608-628 other_name denotes granulocytic pathway
T14 648-665 other_name denotes protein synthesis
T15 723-745 other_name denotes translation initiation
T16 747-753 protein_molecule denotes 4E-BP1
T17 758-764 protein_molecule denotes 4E-BP2
T18 779-784 cell_line denotes HL-60
T19 789-794 cell_line denotes U-937
T20 795-815 other_name denotes cell differentiation
T21 821-830 cell_type denotes monocytes
T22 846-855 protein_molecule denotes IFN-gamma
T23 859-862 other_organic_compound denotes PMA
T24 876-893 other_name denotes dephosphorylation
T25 923-929 protein_molecule denotes 4E-BP1
T26 952-958 protein_molecule denotes 4E-BP1
T27 982-993 cell_line denotes U-937 cells
T28 1029-1038 cell_type denotes monocytes
T29 1076-1089 other_organic_compound denotes retinoic acid
T30 1093-1097 other_organic_compound denotes DMSO
T31 1125-1136 cell_line denotes HL-60 cells
T32 1142-1155 other_organic_compound denotes retinoic acid
T33 1159-1163 other_organic_compound denotes DMSO
T34 1184-1212 other_name denotes granulocytic differentiation
T35 1239-1245 protein_molecule denotes 4E-BP1
T36 1275-1290 other_name denotes phosphorylation
T37 1314-1320 protein_molecule denotes 4E-BP2
T38 1377-1400 other_name denotes differential regulation
T39 1439-1468 other_name denotes human myeloid differentiation
T40 1486-1514 other_name denotes monocytic/macrophage pathway
T41 1525-1545 other_name denotes granulocytic pathway

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 409-417 HP_0001909 denotes leukemia