PubMed:10092801 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	9-24	cell_type	denotes	fetal thymocyte
T2	87-97	protein	denotes	NF-kappa B
T3	324-334	protein	denotes	NF-kappa B
T4	345-360	protein	denotes	I kappa B alpha
T5	362-375	protein	denotes	mut-I kappa B
T6	428-438	protein	denotes	NF-kappa B
T7	489-505	cell_type	denotes	Fetal thymocytes
T8	542-555	protein	denotes	mut-I kappa B
T9	597-601	protein	denotes	CD44
T10	609-612	protein	denotes	CD4
T11	613-616	protein	denotes	CD8
T12	868-882	protein	denotes	TCR beta-chain
T13	963-976	protein	denotes	mut-I kappa B
T14	1064-1074	protein	denotes	NF-kappa B
T15	1144-1154	cell_type	denotes	thymocytes

Id	Subject	Object	Predicate	Lexical cue
S1	0-109	Sentence	denotes	Impaired fetal thymocyte development after efficient adenovirus-mediated inhibition of NF-kappa B activation.
S2	110-231	Sentence	denotes	We introduce a new experimental system combining adenovirus-mediated gene transfer and fetal thymic organ culture (FTOC).
S3	232-488	Sentence	denotes	This system allowed us to efficiently express in developing thymocytes a mutant form of the NF-kappa B inhibitor I kappa B alpha (mut-I kappa B) and to study the maturation defects occurring when NF-kappa B activation is inhibited during fetal development.
S4	489-744	Sentence	denotes	Fetal thymocytes infected with adenovirus containing mut-I kappa B were found to develop normally until the CD44-CD25+, CD4-CD8- double-negative stage, while production of more mature double-positive and single-positive populations was strongly decreased.
S5	745-883	Sentence	denotes	Proliferation, as measured by the percentage of cells in cycle appeared normal, as did rearrangement and expression of the TCR beta-chain.
S6	884-1020	Sentence	denotes	However, apoptosis was much higher in FTOC infected with adenovirus containing mut-I kappa B than in FTOC infected with a control virus.
S7	1021-1196	Sentence	denotes	Taken together, these results suggest that NF-kappa B plays a crucial role in ensuring the differentiation and survival of thymocytes in the early stages of their development.

Id	Subject	Object	Predicate	Lexical cue
C1	87-108	NP	denotes	NF-kappa B activation
C2	123-230	NP	denotes	a new experimental system combining adenovirus-mediated gene transfer and fetal thymic organ culture (FTOC)
C3	232-243	NP	denotes	This system
C4	303-376	NP	denotes	a mutant form of the NF-kappa B inhibitor I kappa B alpha (mut-I kappa B)
C5	428-449	NP	denotes	NF-kappa B activation
C7	542-555	NP	denotes	mut-I kappa B
C6	520-555	NP	denotes	adenovirus containing mut-I kappa B
C9	963-976	NP	denotes	mut-I kappa B
C8	941-976	NP	denotes	adenovirus containing mut-I kappa B
C10	1144-1154	NP	denotes	thymocytes
C11	1178-1183	NP	denotes	their
R1	C3	C2	coref-ident	This system,a new experimental system combining adenovirus-mediated gene transfer and fetal thymic organ culture (FTOC)
R2	C5	C1	coref-ident	NF-kappa B activation,NF-kappa B activation
R3	C7	C4	coref-ident	mut-I kappa B,a mutant form of the NF-kappa B inhibitor I kappa B alpha (mut-I kappa B)
R4	C9	C7	coref-ident	mut-I kappa B,mut-I kappa B
R5	C8	C6	coref-ident	adenovirus containing mut-I kappa B,adenovirus containing mut-I kappa B
R6	C11	C10	coref-pron	their,thymocytes

Id	Subject	Object	Predicate	Lexical cue
T1	9-24	cell_type	denotes	fetal thymocyte
T2	53-63	virus	denotes	adenovirus
T3	87-97	protein_molecule	denotes	NF-kappa B
T4	129-148	other_name	denotes	experimental system
T5	159-169	virus	denotes	adenovirus
T6	197-223	other_artificial_source	denotes	fetal thymic organ culture
T7	225-229	other_artificial_source	denotes	FTOC
T8	324-334	protein_complex	denotes	NF-kappa B
T9	345-360	protein_molecule	denotes	I kappa B alpha
T10	362-375	protein_molecule	denotes	mut-I kappa B
T11	428-438	protein_complex	denotes	NF-kappa B
T12	489-505	cell_type	denotes	Fetal thymocytes
T13	520-530	virus	denotes	adenovirus
T14	542-555	protein_molecule	denotes	mut-I kappa B
T15	597-601	protein_molecule	denotes	CD44
T16	609-612	protein_molecule	denotes	CD4
T17	613-616	protein_molecule	denotes	CD8
T18	666-688	other_name	denotes	mature double-positive
T19	693-720	other_name	denotes	single-positive populations
T20	868-882	protein_subunit	denotes	TCR beta-chain
T21	922-926	other_artificial_source	denotes	FTOC
T22	941-951	virus	denotes	adenovirus
T23	963-976	protein_molecule	denotes	mut-I kappa B
T24	985-989	other_artificial_source	denotes	FTOC
T25	1006-1019	virus	denotes	control virus
T26	1064-1074	protein_complex	denotes	NF-kappa B
T27	1144-1154	cell_type	denotes	thymocytes