PubMed:10092783
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-4 | protein | denotes | IL-2 |
| T2 | 82-92 | protein | denotes | NF-kappa B |
| T3 | 158-162 | protein | denotes | IL-2 |
| T4 | 218-231 | cell_type | denotes | T lymphocytes |
| T5 | 269-273 | protein | denotes | IL-2 |
| T6 | 342-362 | cell_type | denotes | Ag-activated T cells |
| T7 | 428-438 | protein | denotes | NF-kappa B |
| T8 | 446-466 | protein | denotes | activating protein-1 |
| T9 | 468-472 | protein | denotes | AP-1 |
| T10 | 590-611 | protein | denotes | transcription factors |
| T11 | 683-687 | protein | denotes | IL-2 |
| T12 | 689-710 | cell_type | denotes | primary human T cells |
| T13 | 837-841 | protein | denotes | IL-2 |
| T14 | 858-867 | protein | denotes | I kappa B |
| T15 | 889-899 | protein | denotes | NF-kappa B |
| T16 | 914-935 | cell_type | denotes | primary human T cells |
| T17 | 952-956 | protein | denotes | IL-2 |
| T18 | 1019-1023 | protein | denotes | IL-2 |
| T19 | 1042-1045 | protein | denotes | JNK |
| T20 | 1060-1064 | protein | denotes | AP-1 |
| T21 | 1097-1153 | DNA | denotes | o-tetradecanoylphorbol 13-acetate (TPA) response element |
| T22 | 1178-1191 | protein | denotes | growth factor |
| T23 | 1222-1227 | protein | denotes | STAT3 |
| T24 | 1232-1237 | protein | denotes | STAT5 |
| T25 | 1320-1330 | protein | denotes | NF-kappa B |
| T26 | 1335-1339 | protein | denotes | AP-1 |
| T27 | 1367-1371 | protein | denotes | IL-2 |
| T28 | 1429-1450 | cell_type | denotes | primary human T cells |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-153 | Sentence | denotes | IL-2-mediated cell cycle progression and inhibition of apoptosis does not require NF-kappa B or activating protein-1 activation in primary human T cells. |
| S2 | 154-268 | Sentence | denotes | The IL-2 growth hormone is the major growth factor of activated T lymphocytes during a developing immune response. |
| S3 | 269-390 | Sentence | denotes | IL-2 is required not only for cell cycle progression but also to protect Ag-activated T cells from programmed cell death. |
| S4 | 391-544 | Sentence | denotes | In several cell types, activation of NF-kappa B and/or activating protein-1 (AP-1) has been demonstrated to be extremely important in blocking apoptosis. |
| S5 | 545-792 | Sentence | denotes | To determine whether either or both of these transcription factors are involved in cell survival or cell cycle progression in response to IL-2, primary human T cells responsive to the growth factor were analyzed for NF-kappa B and AP-1 activation. |
| S6 | 793-1007 | Sentence | denotes | The current study clearly demonstrates that IL-2 does not induce I kappa B alpha degradation or NF-kappa B activation in primary human T cells that respond to IL-2 by entering the cell cycle and avoiding apoptosis. |
| S7 | 1008-1154 | Sentence | denotes | Similarly, IL-2 neither activates JNK nor increases AP-1 binding activity to a consensus o-tetradecanoylphorbol 13-acetate (TPA) response element. |
| S8 | 1155-1290 | Sentence | denotes | On the other hand, the growth factor does induce the activation of STAT3 and STAT5 in these cells, as has been previously demonstrated. |
| S9 | 1291-1451 | Sentence | denotes | These data show that neither NF-kappa B nor AP-1 activation is required for IL-2-mediated survival or cell cycle progression in activated primary human T cells. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 55-64 | NP | denotes | apoptosis |
| C2 | 269-273 | NP | denotes | IL-2 |
| C3 | 299-321 | NP | denotes | cell cycle progression |
| C4 | 428-473 | NP | denotes | NF-kappa B and/or activating protein-1 (AP-1) |
| C5 | 534-543 | NP | denotes | apoptosis |
| C6 | 566-611 | NP | denotes | either or both of these transcription factors |
| C7 | 645-667 | NP | denotes | cell cycle progression |
| C8 | 683-687 | NP | denotes | IL-2 |
| C9 | 725-742 | NP | denotes | the growth factor |
| C10 | 837-841 | NP | denotes | IL-2 |
| C12 | 914-935 | NP | denotes | primary human T cells |
| C13 | 936-940 | NP | denotes | that |
| C14 | 952-956 | NP | denotes | IL-2 |
| C11 | 914-956 | NP | denotes | primary human T cells that respond to IL-2 |
| C15 | 997-1006 | NP | denotes | apoptosis |
| C16 | 1019-1023 | NP | denotes | IL-2 |
| C17 | 1174-1191 | NP | denotes | the growth factor |
| C18 | 1241-1252 | NP | denotes | these cells |
| R1 | C5 | C1 | coref-ident | apoptosis,apoptosis |
| R2 | C6 | C4 | coref-ident | either or both of these transcription factors,NF-kappa B and/or activating protein-1 (AP-1) |
| R3 | C7 | C3 | coref-ident | cell cycle progression,cell cycle progression |
| R4 | C8 | C2 | coref-ident | IL-2,IL-2 |
| R5 | C10 | C8 | coref-ident | IL-2,IL-2 |
| R6 | C13 | C12 | coref-relat | that,primary human T cells |
| R7 | C14 | C10 | coref-ident | IL-2,IL-2 |
| R8 | C15 | C5 | coref-ident | apoptosis,apoptosis |
| R9 | C16 | C14 | coref-ident | IL-2,IL-2 |
| R10 | C17 | C9 | coref-ident | the growth factor,the growth factor |
| R11 | C18 | C11 | coref-ident | these cells,primary human T cells that respond to IL-2 |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-4 | protein_molecule | denotes | IL-2 |
| T2 | 55-64 | other_name | denotes | apoptosis |
| T3 | 82-92 | protein_complex | denotes | NF-kappa B |
| T4 | 158-162 | protein_molecule | denotes | IL-2 |
| T5 | 218-231 | cell_type | denotes | T lymphocytes |
| T6 | 241-267 | other_name | denotes | developing immune response |
| T7 | 269-273 | protein_molecule | denotes | IL-2 |
| T8 | 342-362 | cell_type | denotes | Ag-activated T cells |
| T9 | 368-389 | other_name | denotes | programmed cell death |
| T10 | 428-438 | protein_complex | denotes | NF-kappa B |
| T11 | 446-466 | protein_molecule | denotes | activating protein-1 |
| T12 | 468-472 | protein_molecule | denotes | AP-1 |
| T13 | 534-543 | other_name | denotes | apoptosis |
| T14 | 590-611 | protein_family_or_group | denotes | transcription factors |
| T15 | 628-641 | other_name | denotes | cell survival |
| T16 | 645-667 | other_name | denotes | cell cycle progression |
| T17 | 683-687 | protein_molecule | denotes | IL-2 |
| T18 | 689-710 | cell_type | denotes | primary human T cells |
| T19 | 837-841 | protein_molecule | denotes | IL-2 |
| T20 | 858-867 | protein_molecule | denotes | I kappa B |
| T21 | 889-899 | protein_complex | denotes | NF-kappa B |
| T22 | 914-935 | cell_type | denotes | primary human T cells |
| T23 | 952-956 | protein_molecule | denotes | IL-2 |
| T24 | 997-1006 | other_name | denotes | apoptosis |
| T25 | 1019-1023 | protein_molecule | denotes | IL-2 |
| T26 | 1042-1045 | protein_family_or_group | denotes | JNK |
| T27 | 1060-1064 | protein_molecule | denotes | AP-1 |
| T28 | 1097-1130 | other_organic_compound | denotes | o-tetradecanoylphorbol 13-acetate |
| T29 | 1132-1135 | other_organic_compound | denotes | TPA |
| T30 | 1178-1191 | protein_family_or_group | denotes | growth factor |
| T31 | 1222-1227 | protein_molecule | denotes | STAT3 |
| T32 | 1232-1237 | protein_family_or_group | denotes | STAT5 |
| T33 | 1266-1289 | other_name | denotes | previously demonstrated |
| T34 | 1320-1330 | protein_complex | denotes | NF-kappa B |
| T35 | 1335-1339 | protein_molecule | denotes | AP-1 |
| T36 | 1367-1371 | protein_molecule | denotes | IL-2 |
| T37 | 1393-1415 | other_name | denotes | cell cycle progression |
| T38 | 1429-1450 | cell_type | denotes | primary human T cells |