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PubMed:10092091 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-9 protein denotes NF-kappaB
T2 67-80 cell_type denotes T lymphocytes
T3 205-225 protein denotes transcription factor
T4 226-235 protein denotes NF-kappaB
T5 312-315 protein denotes TNF
T6 334-343 protein denotes NF-kappaB
T7 374-377 protein denotes Fas
T8 378-383 protein denotes APO-1
T9 384-388 protein denotes CD95
T10 424-441 cell_type denotes peripheral T cell
T11 465-477 cell_line denotes Jurkat cells
T12 487-505 protein denotes NF-kappaB subunits
T13 506-509 protein denotes p50
T14 514-517 protein denotes p65
T15 597-606 protein denotes NF-kappaB
T16 675-684 protein denotes NF-kappaB
T17 696-703 protein denotes IkappaB
T18 792-801 protein denotes NF-kappaB
T19 855-871 cell_line denotes T cell hybridoma
T20 949-952 protein denotes p50
T21 957-960 protein denotes p65
T22 1074-1077 protein denotes Fas
T23 1096-1111 cell_type denotes primary T cells
T24 1138-1159 cell_line denotes cycling T cell blasts
T25 1198-1223 protein denotes dominant IkappaB molecule
T26 1315-1334 protein denotes NF-kappaB complexes
T27 1373-1376 protein denotes TNF
T28 1409-1418 protein denotes NF-kappaB
T29 1425-1448 protein denotes neutralizing antibodies
T30 1573-1582 protein denotes NF-kappaB
T31 1600-1603 protein denotes Fas

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-81 Sentence denotes NF-kappaB regulates Fas/APO-1/CD95- and TCR- mediated apoptosis of T lymphocytes.
S2 82-200 Sentence denotes The maintenance of lymphocyte homeostasis by apoptosis is a critical regulatory mechanism in the normal immune system.
S3 201-315 Sentence denotes The transcription factor NF-kappaB has been shown to play a role in protecting cells against death mediated by TNF
S4 316-448 Sentence denotes We show here that NF-kappaB also has a role in regulating Fas/APO-1/CD95-mediated death, a major pathway of peripheral T cell death.
S5 449-568 Sentence denotes Transfection of Jurkat cells with the NF-kappaB subunits p50 and p65 confers resistance against Fas-mediated apoptosis.
S6 569-764 Sentence denotes Reciprocally, inhibition of NF-kappaB activation by a soluble peptide inhibitor or a dominant form of the NF-kappaB inhibitor, IkappaB, makes the cells more susceptible to Fas-mediated apoptosis.
S7 765-915 Sentence denotes Furthermore, inhibition of NF-kappaB activation by a soluble peptide inhibitor rendered a T cell hybridoma more susceptible to TCR-mediated apoptosis.
S8 916-1022 Sentence denotes Correspondingly, transfection of p50 and p65 provided considerable protection from TCR-mediated apoptosis.
S9 1023-1112 Sentence denotes These observations were corroborated by studies on Fas-mediated death in primary T cells.
S10 1113-1350 Sentence denotes Concanavalin A-activated cycling T cell blasts from mice that are transgenic for the dominant IkappaB molecule have increased sensitivity to Fas-mediated apoptosis, associated with a down-regulation of NF-kappaB complexes in the nucleus.
S11 1351-1515 Sentence denotes In addition, blocking TNF, itself a positive regulator of NF-kappaB, with neutralizing antibodies renders the cells more susceptible to anti-Fas-mediated apoptosis.
S12 1516-1698 Sentence denotes In summary, our results provide compelling evidence that NF-kappaB protects against Fas-mediated death and is likely to be an important regulator of T cell homeostasis and tolerance.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-9 NP denotes NF-kappaB
C2 201-235 NP denotes The transcription factor NF-kappaB
C3 312-315 NP denotes TNF
C4 334-343 NP denotes NF-kappaB
C5 374-403 NP denotes Fas/APO-1/CD95-mediated death
C6 405-447 NP denotes a major pathway of peripheral T cell death
C7 465-477 NP denotes Jurkat cells
C8 483-517 NP denotes the NF-kappaB subunits p50 and p65
C9 545-567 NP denotes Fas-mediated apoptosis
C10 597-617 NP denotes NF-kappaB activation
C11 621-648 NP denotes a soluble peptide inhibitor
C12 652-694 NP denotes a dominant form of the NF-kappaB inhibitor
C13 696-703 NP denotes IkappaB
C14 711-720 NP denotes the cells
C15 741-763 NP denotes Fas-mediated apoptosis
C16 792-812 NP denotes NF-kappaB activation
C17 816-843 NP denotes a soluble peptide inhibitor
C18 892-914 NP denotes TCR-mediated apoptosis
C19 949-960 NP denotes p50 and p65
C20 999-1021 NP denotes TCR-mediated apoptosis
C21 1096-1111 NP denotes primary T cells
C22 1165-1169 NP denotes mice
C23 1170-1174 NP denotes that
C24 1254-1276 NP denotes Fas-mediated apoptosis
C25 1373-1376 NP denotes TNF
C27 1378-1384 NP denotes itself
C28 1409-1418 NP denotes NF-kappaB
C26 1378-1418 NP denotes itself a positive regulator of NF-kappaB
C29 1457-1466 NP denotes the cells
C30 1548-1567 NP denotes compelling evidence
C31 1568-1572 NP denotes that
C32 1573-1582 NP denotes NF-kappaB
R1 C2 C1 coref-ident The transcription factor NF-kappaB,NF-kappaB
R2 C4 C2 coref-ident NF-kappaB,The transcription factor NF-kappaB
R3 C6 C5 coref-appos a major pathway of peripheral T cell death,Fas/APO-1/CD95-mediated death
R4 C13 C12 coref-appos IkappaB,a dominant form of the NF-kappaB inhibitor
R5 C14 C7 coref-ident the cells,Jurkat cells
R6 C15 C9 coref-ident Fas-mediated apoptosis,Fas-mediated apoptosis
R7 C16 C10 coref-ident NF-kappaB activation,NF-kappaB activation
R8 C17 C11 coref-ident a soluble peptide inhibitor,a soluble peptide inhibitor
R9 C19 C8 coref-ident p50 and p65,the NF-kappaB subunits p50 and p65
R10 C20 C18 coref-ident TCR-mediated apoptosis,TCR-mediated apoptosis
R11 C23 C22 coref-relat that,mice
R12 C24 C15 coref-ident Fas-mediated apoptosis,Fas-mediated apoptosis
R13 C25 C3 coref-ident TNF,TNF
R14 C27 C25 coref-pron itself,TNF
R15 C28 C4 coref-ident NF-kappaB,NF-kappaB
R16 C26 C25 coref-appos itself a positive regulator of NF-kappaB,TNF
R17 C29 C21 coref-ident the cells,primary T cells
R18 C31 C30 coref-relat that,compelling evidence
R19 C32 C28 coref-ident NF-kappaB,NF-kappaB

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-9 protein_complex denotes NF-kappaB
T2 67-80 cell_type denotes T lymphocytes
T3 101-123 other_name denotes lymphocyte homeostasis
T4 127-136 other_name denotes apoptosis
T5 142-171 other_name denotes critical regulatory mechanism
T6 179-199 body_part denotes normal immune system
T7 205-225 protein_family_or_group denotes transcription factor
T8 226-235 protein_complex denotes NF-kappaB
T9 312-315 protein_family_or_group denotes TNF
T10 334-343 protein_complex denotes NF-kappaB
T11 374-377 protein_molecule denotes Fas
T12 378-383 protein_molecule denotes APO-1
T13 384-388 protein_molecule denotes CD95
T14 424-441 cell_type denotes peripheral T cell
T15 465-477 cell_line denotes Jurkat cells
T16 487-505 protein_subunit denotes NF-kappaB subunits
T17 506-509 protein_subunit denotes p50
T18 514-517 protein_subunit denotes p65
T19 545-557 other_name denotes Fas-mediated
T20 558-567 other_name denotes apoptosis
T21 597-606 protein_complex denotes NF-kappaB
T22 623-638 peptide denotes soluble peptide
T23 675-684 protein_complex denotes NF-kappaB
T24 696-703 protein_molecule denotes IkappaB
T25 741-753 other_name denotes Fas-mediated
T26 754-763 other_name denotes apoptosis
T27 792-801 protein_complex denotes NF-kappaB
T28 855-871 cell_line denotes T cell hybridoma
T29 892-904 other_name denotes TCR-mediated
T30 905-914 other_name denotes apoptosis
T31 949-952 protein_subunit denotes p50
T32 957-960 protein_subunit denotes p65
T33 1012-1021 other_name denotes apoptosis
T34 1074-1077 protein_molecule denotes Fas
T35 1096-1111 cell_type denotes primary T cells
T36 1113-1127 other_organic_compound denotes Concanavalin A
T37 1138-1159 cell_line denotes cycling T cell blasts
T38 1165-1169 multi_cell denotes mice
T39 1198-1206 protein_molecule denotes dominant
T40 1207-1214 protein_molecule denotes IkappaB
T41 1254-1266 other_name denotes Fas-mediated
T42 1267-1276 other_name denotes apoptosis
T43 1296-1311 other_name denotes down-regulation
T44 1315-1324 protein_complex denotes NF-kappaB
T45 1373-1376 protein_family_or_group denotes TNF
T46 1409-1418 protein_complex denotes NF-kappaB
T47 1425-1448 protein_family_or_group denotes neutralizing antibodies
T48 1487-1504 other_name denotes anti-Fas-mediated
T49 1505-1514 other_name denotes apoptosis
T50 1573-1582 protein_complex denotes NF-kappaB
T51 1600-1603 protein_molecule denotes Fas
T52 1665-1683 other_name denotes T cell homeostasis
T53 1688-1697 other_name denotes tolerance