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PubMed:10090931 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 54-116 cell_line denotes retinoic acid-resistant acute promyelocytic leukemia cell line
T2 118-122 cell_line denotes UF-1
T3 154-168 protein denotes p21(WAF1/CIP1)
T4 173-182 protein denotes p27(KIP1)
T5 388-397 cell_type denotes APL cells
T6 485-508 protein denotes transcriptional factors
T7 510-522 protein denotes RA receptors
T8 524-528 protein denotes RARs
T9 534-554 protein denotes retinoid X receptors
T10 556-560 protein denotes RXRs
T11 563-567 protein denotes RXRs
T12 588-636 protein denotes 1, 25-dihydroxyvitamin D3 [1,25(OH)2D3] receptor
T13 638-641 protein denotes VDR
T14 701-740 protein denotes cyclin-dependent kinase (cdk) inhibitor
T15 741-755 protein denotes p21(WAF1/CIP1)
T16 762-791 DNA denotes vitamin D3-responsive element
T17 793-797 DNA denotes VDRE
T18 806-814 DNA denotes promoter
T19 859-873 protein denotes p21(WAF1/CIP1)
T20 914-941 cell_line denotes myeloid leukemic cell lines
T21 980-993 cell_line denotes APL cell line
T22 995-999 cell_line denotes UF-1
T23 1091-1101 cell_line denotes UF-1 cells
T24 1154-1166 cell_type denotes granulocytes
T25 1426-1440 protein denotes p21(WAF1/CIP1)
T26 1445-1459 RNA denotes p27(KIP1) mRNA
T27 1533-1566 RNA denotes p21(WAF1/CIP1) and p27(KIP1) mRNA
T28 1640-1654 protein denotes p21(WAF1/CIP1)
T29 1659-1668 protein denotes p27(KIP1)
T30 1820-1834 protein denotes p21(WAF1/CIP1)
T31 1939-1948 protein denotes p27(KIP1)
T32 1996-2006 cell_line denotes UF-1 cells
T33 2094-2103 protein denotes p27(KIP1)
T34 2205-2214 protein denotes p27(KIP1)
T35 2251-2264 protein denotes CD11b antigen
T36 2268-2290 cell_type denotes myeloid leukemic cells
T37 2338-2348 cell_line denotes UF-1 cells
T38 2395-2409 protein denotes p21(WAF1/CIP1)
T39 2414-2423 protein denotes p27(KIP1)
T40 2558-2572 protein denotes cdk inhibitors
T41 2666-2676 cell_line denotes UF-1 cells
T42 2691-2703 cell_type denotes granulocytes

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10090931-0#163#167#gene1026 163-167 gene1026 denotes CIP1
10090931-0#163#167#gene56996 163-167 gene56996 denotes CIP1
10090931-0#177#181#gene1027 177-181 gene1027 denotes KIP1
10090931-0#177#181#gene10519 177-181 gene10519 denotes KIP1
10090931-0#158#162#gene1026 158-162 gene1026 denotes WAF1
10090931-0#78#106#diseaseC0023487 78-106 diseaseC0023487 denotes acute promyelocytic leukemia
163#167#gene102678#106#diseaseC0023487 10090931-0#163#167#gene1026 10090931-0#78#106#diseaseC0023487 associated_with CIP1,acute promyelocytic leukemia
163#167#gene5699678#106#diseaseC0023487 10090931-0#163#167#gene56996 10090931-0#78#106#diseaseC0023487 associated_with CIP1,acute promyelocytic leukemia
177#181#gene102778#106#diseaseC0023487 10090931-0#177#181#gene1027 10090931-0#78#106#diseaseC0023487 associated_with KIP1,acute promyelocytic leukemia
177#181#gene1051978#106#diseaseC0023487 10090931-0#177#181#gene10519 10090931-0#78#106#diseaseC0023487 associated_with KIP1,acute promyelocytic leukemia
158#162#gene102678#106#diseaseC0023487 10090931-0#158#162#gene1026 10090931-0#78#106#diseaseC0023487 associated_with WAF1,acute promyelocytic leukemia

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-24 NP denotes 1,25-Dihydroxyvitamin D3
C2 154-168 NP denotes p21(WAF1/CIP1)
C3 184-213 NP denotes Retinoic acid (RA) resistance
C4 239-287 NP denotes patients with acute promyelocytic leukemia (APL)
C5 288-291 NP denotes who
C6 306-318 NP denotes all-trans RA
C7 371-384 NP denotes RA resistance
C8 441-443 NP denotes RA
C9 460-508 NP denotes two distinct families of transcriptional factors
C11 534-561 NP denotes retinoid X receptors (RXRs)
C10 510-561 NP denotes RA receptors (RARs) and retinoid X receptors (RXRs)
C12 563-567 NP denotes RXRs
C13 653-658 NP denotes their
C14 697-755 NP denotes The cyclin-dependent kinase (cdk) inhibitor p21(WAF1/CIP1)
C15 802-805 NP denotes its
C16 820-831 NP denotes 1,25(OH)2D3
C17 859-873 NP denotes p21(WAF1/CIP1)
C18 1018-1031 NP denotes RA resistance
C19 1033-1044 NP denotes 1,25(OH)2D3
C20 1091-1101 NP denotes UF-1 cells
C21 1135-1146 NP denotes these cells
C22 1219-1231 NP denotes all-trans RA
C23 1298-1300 NP denotes RA
C24 1426-1471 NP denotes p21(WAF1/CIP1) and p27(KIP1) mRNA and protein
C25 1485-1496 NP denotes these cells
C26 1498-1520 NP denotes Northern blot analysis
C27 1533-1578 NP denotes p21(WAF1/CIP1) and p27(KIP1) mRNA and protein
C28 1592-1603 NP denotes these cells
C29 1605-1627 NP denotes Northern blot analysis
C30 1721-1732 NP denotes 1,25(OH)2D3
C31 1996-2006 NP denotes UF-1 cells
C32 2042-2054 NP denotes 1, 25(OH)2D3
C33 2059-2061 NP denotes RA
C34 2162-2180 NP denotes 1, 25(OH)2D3 alone
C35 2305-2313 NP denotes RA alone
C36 2338-2349 NP denotes UF-1 cells;
C37 2359-2361 NP denotes it
C38 2514-2525 NP denotes 1,25(OH)2D3
C39 2534-2572 NP denotes increased expression of cdk inhibitors
C40 2574-2579 NP denotes which
R1 C5 C4 coref-relat who,patients with acute promyelocytic leukemia (APL)
R2 C7 C3 coref-ident RA resistance,Retinoic acid (RA) resistance
R3 C10 C9 coref-appos RA receptors (RARs) and retinoid X receptors (RXRs),two distinct families of transcriptional factors
R4 C12 C11 coref-ident RXRs,retinoid X receptors (RXRs)
R5 C13 C12 coref-pron their,RXRs
R6 C14 C2 coref-ident The cyclin-dependent kinase (cdk) inhibitor p21(WAF1/CIP1),p21(WAF1/CIP1)
R7 C15 C14 coref-pron its,The cyclin-dependent kinase (cdk) inhibitor p21(WAF1/CIP1)
R8 C16 C1 coref-ident "1,25(OH)2D3","1,25-Dihydroxyvitamin D3"
R9 C17 C14 coref-ident p21(WAF1/CIP1),The cyclin-dependent kinase (cdk) inhibitor p21(WAF1/CIP1)
R10 C18 C7 coref-ident RA resistance,RA resistance
R11 C19 C16 coref-ident "1,25(OH)2D3","1,25(OH)2D3"
R12 C21 C20 coref-ident these cells,UF-1 cells
R13 C22 C6 coref-ident all-trans RA,all-trans RA
R14 C23 C8 coref-ident RA,RA
R15 C25 C21 coref-ident these cells,these cells
R16 C27 C24 coref-ident p21(WAF1/CIP1) and p27(KIP1) mRNA and protein,p21(WAF1/CIP1) and p27(KIP1) mRNA and protein
R17 C28 C25 coref-ident these cells,these cells
R18 C29 C26 coref-ident Northern blot analysis,Northern blot analysis
R19 C30 C19 coref-ident "1,25(OH)2D3","1,25(OH)2D3"
R20 C31 C28 coref-ident UF-1 cells,these cells
R21 C32 C30 coref-ident "1, 25(OH)2D3","1,25(OH)2D3"
R22 C33 C23 coref-ident RA,RA
R23 C34 C32 coref-ident "1, 25(OH)2D3 alone","1, 25(OH)2D3"
R24 C35 C33 coref-ident RA alone,RA
R25 C36 C31 coref-ident UF-1 cells;,UF-1 cells
R26 C37 C35 coref-pron it,RA alone
R27 C38 C34 coref-ident "1,25(OH)2D3","1, 25(OH)2D3 alone"
R28 C40 C39 coref-relat which,increased expression of cdk inhibitors

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-183 Sentence denotes 1,25-Dihydroxyvitamin D3 induces differentiation of a retinoic acid-resistant acute promyelocytic leukemia cell line (UF-1) associated with expression of p21(WAF1/CIP1) and p27(KIP1).
S2 184-319 Sentence denotes Retinoic acid (RA) resistance is a serious problem for patients with acute promyelocytic leukemia (APL) who are receiving all-trans RA.
S3 320-416 Sentence denotes However, the mechanisms and strategies to overcome RA resistance by APL cells are still unclear.
S4 417-562 Sentence denotes The biologic effects of RA are mediated by two distinct families of transcriptional factors: RA receptors (RARs) and retinoid X receptors (RXRs).
S5 563-696 Sentence denotes RXRs heterodimerize with 1, 25-dihydroxyvitamin D3 [1,25(OH)2D3] receptor (VDR), enabling their efficient transcriptional activation.
S6 697-942 Sentence denotes The cyclin-dependent kinase (cdk) inhibitor p21(WAF1/CIP1) has a vitamin D3-responsive element (VDRE) in its promoter, and 1,25(OH)2D3 enhances the expression of p21(WAF1/CIP1) and induces differentiation of selected myeloid leukemic cell lines.
S7 943-1032 Sentence denotes We have recently established a novel APL cell line (UF-1) with features of RA resistance.
S8 1033-1167 Sentence denotes 1,25(OH)2D3 can induce growth inhibition and G1 arrest of UF-1 cells, resulting in differentiation of these cells toward granulocytes.
S9 1168-1232 Sentence denotes This 1, 25(OH)2D3-induced G1 arrest is enhanced by all-trans RA.
S10 1233-1379 Sentence denotes Also, 1, 25(OH)2D3 (10(-10) to 10(-7) mol/L) in combination with RA markedly inhibits cellular proliferation in a dose- and time-dependent manner.
S11 1380-1497 Sentence denotes Associated with these findings, the levels of p21(WAF1/CIP1) and p27(KIP1) mRNA and protein increased in these cells.
S12 1498-1604 Sentence denotes Northern blot analysis showed that p21(WAF1/CIP1) and p27(KIP1) mRNA and protein increased in these cells.
S13 1605-1782 Sentence denotes Northern blot analysis showed that p21(WAF1/CIP1) and p27(KIP1) transcripts were induced after 6 hours' exposure to 1,25(OH)2D3 and then decreased to basal levels over 48 hours.
S14 1783-2007 Sentence denotes Western blot experiments showed that p21(WAF1/CIP1) protein levels increased and became detectable after 12 hours of 1,25(OH)2D3 treatment and induction of p27(KIP1) protein was much more gradual and sustained in UF-1 cells.
S15 2008-2181 Sentence denotes Interestingly, the combination of 1, 25(OH)2D3 and RA markedly enhanced the levels of p27(KIP1) transcript and protein as compared with levels induced by 1, 25(OH)2D3 alone.
S16 2182-2291 Sentence denotes In addition, exogenous p27(KIP1) expression can enhance the level of CD11b antigen in myeloid leukemic cells.
S17 2292-2480 Sentence denotes In contrast, RA alone can induce G1 arrest of UF-1 cells; however, it did not result in an increase of p21(WAF1/CIP1) and p27(KIP1) transcript and protein expression in RA-resistant cells.
S18 2481-2704 Sentence denotes Taken together, we conclude that 1,25(OH)2D3 induces increased expression of cdk inhibitors, which mediates a G1 arrest, and this may be associated with differentiation of RA-resistant UF-1 cells toward mature granulocytes.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-24 lipid denotes 1,25-Dihydroxyvitamin D3
T2 54-67 other_organic_compound denotes retinoic acid
T3 118-122 cell_line denotes UF-1
T4 154-168 protein_molecule denotes p21(WAF1/CIP1)
T5 173-182 protein_molecule denotes p27(KIP1)
T6 184-197 other_organic_compound denotes Retinoic acid
T7 239-247 multi_cell denotes patients
T8 253-281 other_name denotes acute promyelocytic leukemia
T9 283-286 other_name denotes APL
T10 306-318 other_organic_compound denotes all-trans RA
T11 371-373 other_organic_compound denotes RA
T12 388-391 other_name denotes APL
T13 441-443 other_organic_compound denotes RA
T14 485-508 protein_family_or_group denotes transcriptional factors
T15 510-512 other_organic_compound denotes RA
T16 524-528 protein_family_or_group denotes RARs
T17 534-554 protein_family_or_group denotes retinoid X receptors
T18 556-560 protein_family_or_group denotes RXRs
T19 563-567 protein_family_or_group denotes RXRs
T20 588-613 lipid denotes 1, 25-dihydroxyvitamin D3
T21 615-626 lipid denotes 1,25(OH)2D3
T22 638-641 protein_family_or_group denotes VDR
T23 669-695 other_name denotes transcriptional activation
T24 701-724 protein_family_or_group denotes cyclin-dependent kinase
T25 726-729 protein_family_or_group denotes cdk
T26 741-755 protein_molecule denotes p21(WAF1/CIP1)
T27 762-791 DNA_domain_or_region denotes vitamin D3-responsive element
T28 793-797 DNA_domain_or_region denotes VDRE
T29 806-814 DNA_domain_or_region denotes promoter
T30 820-831 lipid denotes 1,25(OH)2D3
T31 859-873 protein_molecule denotes p21(WAF1/CIP1)
T32 914-941 cell_line denotes myeloid leukemic cell lines
T33 980-983 other_name denotes APL
T34 995-999 cell_line denotes UF-1
T35 1018-1020 other_organic_compound denotes RA
T36 1033-1044 lipid denotes 1,25(OH)2D3
T37 1078-1087 other_name denotes G1 arrest
T38 1091-1101 cell_line denotes UF-1 cells
T39 1154-1166 cell_type denotes granulocytes
T40 1173-1185 lipid denotes 1, 25(OH)2D3
T41 1194-1203 other_name denotes G1 arrest
T42 1229-1231 other_organic_compound denotes RA
T43 1239-1251 lipid denotes 1, 25(OH)2D3
T44 1298-1300 other_organic_compound denotes RA
T45 1319-1341 other_name denotes cellular proliferation
T46 1426-1440 protein_molecule denotes p21(WAF1/CIP1)
T47 1445-1454 protein_molecule denotes p27(KIP1)
T48 1605-1627 other_name denotes Northern blot analysis
T49 1640-1654 protein_molecule denotes p21(WAF1/CIP1)
T50 1659-1668 protein_molecule denotes p27(KIP1)
T51 1721-1732 lipid denotes 1,25(OH)2D3
T52 1783-1807 other_name denotes Western blot experiments
T53 1820-1834 protein_molecule denotes p21(WAF1/CIP1)
T54 1900-1911 lipid denotes 1,25(OH)2D3
T55 1939-1948 protein_molecule denotes p27(KIP1)
T56 1996-2006 cell_line denotes UF-1 cells
T57 2042-2054 lipid denotes 1, 25(OH)2D3
T58 2059-2061 other_organic_compound denotes RA
T59 2094-2103 protein_molecule denotes p27(KIP1)
T60 2162-2174 lipid denotes 1, 25(OH)2D3
T61 2205-2214 protein_molecule denotes p27(KIP1)
T62 2251-2264 protein_molecule denotes CD11b antigen
T63 2268-2290 cell_type denotes myeloid leukemic cells
T64 2305-2307 other_organic_compound denotes RA
T65 2325-2334 other_name denotes G1 arrest
T66 2338-2348 cell_line denotes UF-1 cells
T67 2395-2409 protein_molecule denotes p21(WAF1/CIP1)
T68 2414-2423 protein_molecule denotes p27(KIP1)
T69 2461-2463 other_organic_compound denotes RA
T70 2514-2525 lipid denotes 1,25(OH)2D3
T71 2558-2561 protein_family_or_group denotes cdk
T72 2591-2600 other_name denotes G1 arrest
T73 2653-2655 other_organic_compound denotes RA
T74 2666-2676 cell_line denotes UF-1 cells
T75 2691-2703 cell_type denotes granulocytes

DisGeNET

Id Subject Object Predicate Lexical cue
T0 158-162 gene:1026 denotes WAF1
T1 78-106 disease:C0023487 denotes acute promyelocytic leukemia
T2 163-167 gene:1026 denotes CIP1
T3 78-106 disease:C0023487 denotes acute promyelocytic leukemia
T4 163-167 gene:56996 denotes CIP1
T5 78-106 disease:C0023487 denotes acute promyelocytic leukemia
T6 177-181 gene:1027 denotes KIP1
T7 78-106 disease:C0023487 denotes acute promyelocytic leukemia
T8 177-181 gene:10519 denotes KIP1
T9 78-106 disease:C0023487 denotes acute promyelocytic leukemia
R1 T0 T1 associated_with WAF1,acute promyelocytic leukemia
R2 T2 T3 associated_with CIP1,acute promyelocytic leukemia
R3 T4 T5 associated_with CIP1,acute promyelocytic leukemia
R4 T6 T7 associated_with KIP1,acute promyelocytic leukemia
R5 T8 T9 associated_with KIP1,acute promyelocytic leukemia

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 253-281 HP_0004836 denotes acute promyelocytic leukemia
T2 273-281 HP_0001909 denotes leukemia