> top > docs > PubMed:10089907 > annotations

PubMed:10089907 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 61-97 protein denotes 17 beta-hydroxysteroid dehydrogenase
T2 259-283 cell_type denotes myeloid progenitor cells
T3 320-337 protein denotes hormone receptors
T4 761-771 cell_line denotes HL60 cells
T5 793-817 cell_type denotes myeloid progenitor cells
T6 885-889 cell_line denotes HL60
T7 894-906 cell_type denotes normal cells
T8 1136-1160 cell_type denotes myeloid progenitor cells
T9 1171-1175 RNA denotes mRNA
T10 1210-1246 protein denotes 17 beta-hydroxysteroid dehydrogenase
T11 1308-1318 cell_line denotes HL60 cells
T12 1424-1435 cell_type denotes neutrophils
T13 1439-1448 cell_type denotes monocytes
T14 1521-1545 cell_type denotes myeloid progenitor cells
T15 1614-1624 cell_line denotes HL60 cells
T16 1635-1659 cell_type denotes myeloid progenitor cells
T17 1961-1983 cell_type denotes leukemic myeloid cells

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-7 NP denotes Estrone
C2 61-97 NP denotes 17 beta-hydroxysteroid dehydrogenase
C4 142-179 NP denotes 1 alpha, 25-dihydroxy vitamin D3 (D3)
C5 181-204 NP denotes all-trans retinoic acid
C3 125-229 NP denotes Hormones such as 1 alpha, 25-dihydroxy vitamin D3 (D3), all-trans retinoic acid, and 9-cis retinoic acid
C6 288-293 NP denotes their
C7 311-337 NP denotes specific hormone receptors
C8 376-388 NP denotes these agents
C9 433-448 NP denotes their receptors
C11 554-556 NP denotes D3
C10 554-570 NP denotes D3 and retinoids
C12 574-586 NP denotes myelopoiesis
C13 761-771 NP denotes HL60 cells
C14 928-940 NP denotes estrone (E1)
C15 946-960 NP denotes estradiol (E2)
C16 1019-1021 NP denotes E2
C17 1027-1029 NP denotes E1
C18 1210-1246 NP denotes 17 beta-hydroxysteroid dehydrogenase
C19 1262-1264 NP denotes E2
C20 1268-1270 NP denotes E1
C21 1308-1318 NP denotes HL60 cells
C22 1344-1367 NP denotes all-trans retinoic acid
C23 1371-1373 NP denotes D3
C24 1377-1382 NP denotes doses
C25 1383-1387 NP denotes that
C26 1395-1400 NP denotes their
C27 1514-1545 NP denotes normal myeloid progenitor cells
C28 1597-1599 NP denotes E1
C29 1605-1607 NP denotes E2
C31 1614-1624 NP denotes HL60 cells
C32 1628-1659 NP denotes normal myeloid progenitor cells
C30 1614-1659 NP denotes HL60 cells or normal myeloid progenitor cells
C33 1689-1693 NP denotes they
C34 1759-1761 NP denotes D3
C35 1831-1843 NP denotes myelopoiesis
C36 1931-1939 NP denotes steroids
C37 1995-2000 NP denotes their
C39 2019-2021 NP denotes D3
C38 2019-2035 NP denotes D3 and retinoids
R1 C6 C3 coref-pron their,"Hormones such as 1 alpha, 25-dihydroxy vitamin D3 (D3), all-trans retinoic acid, and 9-cis retinoic acid"
R2 C8 C3 coref-ident these agents,"Hormones such as 1 alpha, 25-dihydroxy vitamin D3 (D3), all-trans retinoic acid, and 9-cis retinoic acid"
R3 C9 C7 coref-ident their receptors,specific hormone receptors
R4 C11 C4 coref-ident D3,"1 alpha, 25-dihydroxy vitamin D3 (D3)"
R5 C10 C8 coref-ident D3 and retinoids,these agents
R6 C14 C1 coref-ident estrone (E1),Estrone
R7 C16 C15 coref-ident E2,estradiol (E2)
R8 C17 C14 coref-ident E1,estrone (E1)
R9 C18 C2 coref-ident 17 beta-hydroxysteroid dehydrogenase,17 beta-hydroxysteroid dehydrogenase
R10 C19 C16 coref-ident E2,E2
R11 C20 C17 coref-ident E1,E1
R12 C21 C13 coref-ident HL60 cells,HL60 cells
R13 C22 C5 coref-ident all-trans retinoic acid,all-trans retinoic acid
R14 C23 C11 coref-ident D3,D3
R15 C25 C24 coref-relat that,doses
R16 C26 C21 coref-pron their,HL60 cells
R17 C28 C20 coref-ident E1,E1
R18 C29 C19 coref-ident E2,E2
R19 C31 C21 coref-ident HL60 cells,HL60 cells
R20 C32 C27 coref-ident normal myeloid progenitor cells,normal myeloid progenitor cells
R21 C33 C30 coref-pron they,HL60 cells or normal myeloid progenitor cells
R22 C34 C23 coref-ident D3,D3
R23 C35 C12 coref-ident myelopoiesis,myelopoiesis
R24 C37 C36 coref-pron their,steroids
R25 C39 C34 coref-ident D3,D3
R26 C38 C10 coref-ident D3 and retinoids,D3 and retinoids

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-124 Sentence denotes Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis.
S2 125-338 Sentence denotes Hormones such as 1 alpha, 25-dihydroxy vitamin D3 (D3), all-trans retinoic acid, and 9-cis retinoic acid stimulate differentiation of myeloid progenitor cells via their interaction with specific hormone receptors.
S3 339-493 Sentence denotes However, the sensitivity of cells to these agents is not merely governed by the expression of their receptors and the availability of ligand to bind them.
S4 494-665 Sentence denotes Recent studies from our group suggested that the actions of D3 and retinoids on myelopoiesis also are influenced by endogenous mechanisms involving other steroid hormones.
S5 666-818 Sentence denotes In this study we examined the influence of local estrogen metabolism on the differentiation of HL60 cells and normal primitive myeloid progenitor cells.
S6 819-961 Sentence denotes Quantitative thin-layer chromatography (TLC) analyses showed that HL60 and normal cells are able to generate estrone (E1) from estradiol (E2).
S7 962-1030 Sentence denotes Neither cell population generated significant amounts of E2 from E1.
S8 1031-1247 Sentence denotes Reverse transcriptase polymerase chain reaction and Northern analyses confirmed that normal and leukemic myeloid progenitor cells expressed mRNA for the type I and IV isoforms of 17 beta-hydroxysteroid dehydrogenase.
S9 1248-1463 Sentence denotes Conversion of E2 to E1 was upregulated within 24 hours when HL60 cells were treated with either all-trans retinoic acid or D3 at doses that induce their differentiation toward neutrophils or monocytes, respectively.
S10 1464-1608 Sentence denotes Similarly, D3-induced monocyte differentiation of normal myeloid progenitor cells was associated with increased capacity to generate E1 from E2.
S11 1609-1762 Sentence denotes When HL60 cells or normal myeloid progenitor cells were exposed to exogenous E1 they became more sensitive to the differentiation-inducing effects of D3.
S12 1763-1869 Sentence denotes Data presented provide further evidence for the local modulation of myelopoiesis by intracrine mechanisms.
S13 1870-2036 Sentence denotes In particular, our findings suggest that local metabolism of steroids by normal as well as leukemic myeloid cells influences their responsiveness to D3 and retinoids.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-7 lipid denotes Estrone
T2 20-48 other_name denotes myeloid cell differentiation
T3 61-97 protein_molecule denotes 17 beta-hydroxysteroid dehydrogenase
T4 142-174 lipid denotes 1 alpha, 25-dihydroxy vitamin D3
T5 176-178 lipid denotes D3
T6 181-190 other_organic_compound denotes all-trans
T7 191-204 other_organic_compound denotes retinoic acid
T8 210-215 other_organic_compound denotes 9-cis
T9 216-229 other_organic_compound denotes retinoic acid
T10 259-283 cell_type denotes myeloid progenitor cells
T11 320-337 protein_family_or_group denotes hormone receptors
T12 554-556 lipid denotes D3
T13 561-570 other_organic_compound denotes retinoids
T14 574-586 other_name denotes myelopoiesis
T15 648-664 lipid denotes steroid hormones
T16 761-771 cell_line denotes HL60 cells
T17 793-817 cell_type denotes myeloid progenitor cells
T18 832-859 other_name denotes thin-layer chromatography (
T19 859-862 other_name denotes TLC
T20 885-889 cell_line denotes HL60
T21 894-906 cell_type denotes normal cells
T22 928-935 lipid denotes estrone
T23 937-939 lipid denotes E1
T24 946-955 lipid denotes estradiol
T25 957-959 lipid denotes E2
T26 1019-1021 lipid denotes E2
T27 1027-1029 lipid denotes E1
T28 1031-1078 other_name denotes Reverse transcriptase polymerase chain reaction
T29 1083-1100 other_name denotes Northern analyses
T30 1136-1160 cell_type denotes myeloid progenitor cells
T31 1171-1175 RNA_family_or_group denotes mRNA
T32 1210-1246 protein_molecule denotes 17 beta-hydroxysteroid dehydrogenase
T33 1262-1264 lipid denotes E2
T34 1268-1270 lipid denotes E1
T35 1308-1318 cell_line denotes HL60 cells
T36 1344-1353 other_organic_compound denotes all-trans
T37 1354-1367 other_organic_compound denotes retinoic acid
T38 1371-1373 lipid denotes D3
T39 1424-1435 cell_type denotes neutrophils
T40 1439-1448 cell_type denotes monocytes
T41 1475-1477 lipid denotes D3
T42 1521-1545 cell_type denotes myeloid progenitor cells
T43 1597-1599 lipid denotes E1
T44 1605-1607 lipid denotes E2
T45 1614-1624 cell_line denotes HL60 cells
T46 1635-1659 cell_type denotes myeloid progenitor cells
T47 1686-1688 lipid denotes E1
T48 1723-1755 other_name denotes differentiation-inducing effects
T49 1759-1761 lipid denotes D3
T50 1831-1843 other_name denotes myelopoiesis
T51 1847-1868 other_name denotes intracrine mechanisms
T52 1961-1983 cell_type denotes leukemic myeloid cells
T53 2019-2021 lipid denotes D3
T54 2026-2035 other_organic_compound denotes retinoids