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PubMed:10089211 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
10089211_0 903-916 ProteinMutation denotes Gly170 to Ser rs3745635
10089211_1 939-952 ProteinMutation denotes Ile356 to Lys rs3894326
10089211_2 1455-1467 ProteinMutation denotes Leu20 to Arg rs28362459

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1417-1422 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-51 Sentence denotes Molecular behavior of mutant Lewis enzymes in vivo.
TextSentencer_T2 52-266 Sentence denotes The expression of type-1 Lewis antigens on erythrocytes and in digestive organs is determined by a Lewis type alpha(1,3/1, 4)-fucosyltransferase (Lewis enzyme) encoded by the Fuc-TIII gene ( FUT3 gene; Lewis gene).
TextSentencer_T3 267-520 Sentence denotes We have classified the Lewis alleles in the Japanese population into four types, the wild-type allele ( Le ) and three mutated alleles, i.e., le1, which has missense mutations T59G and G508A, le2, which has T59G and T1067A, and le3, which has only T59G.
TextSentencer_T4 521-1214 Sentence denotes Here we carried out an extensive study on the biological properties of the three mutant Lewis enzymes, the le1, le2, and le3 enzymes, using native tissues and obtained the following results. (1) In in vivo and in vitro experiments, the le1 and le2 enzymes were found to be susceptible to protease digestion probably because the one missense mutation in the catalytic domains, i.e., Gly170 to Ser in the le1 enzyme and Ile356 to Lys in the le2 enzyme, makes the three-dimensional structures of the enzymesunstable, while the le3 and wild-type Lewis enzymes wereresistant to protease digestion. (2) The le1 and le2 enzymes cannot synthesize type 1 Lewis antigens on either glycolipids or mucins.
TextSentencer_T5 1215-1431 Sentence denotes The le3 enzyme cannot synthesize Lewis-active glycolipids, which result in the Lewis antigen-negative phenotype of erythrocytes, while it can synthesize Lewis antigens on mucins in normal and cancerous colon tissues.
TextSentencer_T6 1432-1820 Sentence denotes The missense mutation, Leu20 to Arg, in the transmembrane domain reduces retention of the le3 enzyme in the Golgi membrane resulting in an apparent reduction of enzyme activity as revealed by the lack of Lewis antigen synthesis. (3) The Lewis gene dosage actually has effects in vivo on the amount of the Lewis enzyme, its activity, and finally the amounts of Lewis carbohydrate antigens.
TextSentencer_T7 1821-2010 Sentence denotes This is the first article that clearly demonstrates the gene dosage effects on the amount of the glycosyltransferase protein, its activity, and the amounts of carbohydrate products in vivo.
T1 0-51 Sentence denotes Molecular behavior of mutant Lewis enzymes in vivo.
T2 52-266 Sentence denotes The expression of type-1 Lewis antigens on erythrocytes and in digestive organs is determined by a Lewis type alpha(1,3/1, 4)-fucosyltransferase (Lewis enzyme) encoded by the Fuc-TIII gene ( FUT3 gene; Lewis gene).
T3 267-520 Sentence denotes We have classified the Lewis alleles in the Japanese population into four types, the wild-type allele ( Le ) and three mutated alleles, i.e., le1, which has missense mutations T59G and G508A, le2, which has T59G and T1067A, and le3, which has only T59G.
T4 521-1214 Sentence denotes Here we carried out an extensive study on the biological properties of the three mutant Lewis enzymes, the le1, le2, and le3 enzymes, using native tissues and obtained the following results. (1) In in vivo and in vitro experiments, the le1 and le2 enzymes were found to be susceptible to protease digestion probably because the one missense mutation in the catalytic domains, i.e., Gly170 to Ser in the le1 enzyme and Ile356 to Lys in the le2 enzyme, makes the three-dimensional structures of the enzymesunstable, while the le3 and wild-type Lewis enzymes wereresistant to protease digestion. (2) The le1 and le2 enzymes cannot synthesize type 1 Lewis antigens on either glycolipids or mucins.
T5 1215-1431 Sentence denotes The le3 enzyme cannot synthesize Lewis-active glycolipids, which result in the Lewis antigen-negative phenotype of erythrocytes, while it can synthesize Lewis antigens on mucins in normal and cancerous colon tissues.
T6 1432-1820 Sentence denotes The missense mutation, Leu20 to Arg, in the transmembrane domain reduces retention of the le3 enzyme in the Golgi membrane resulting in an apparent reduction of enzyme activity as revealed by the lack of Lewis antigen synthesis. (3) The Lewis gene dosage actually has effects in vivo on the amount of the Lewis enzyme, its activity, and finally the amounts of Lewis carbohydrate antigens.
T7 1821-2010 Sentence denotes This is the first article that clearly demonstrates the gene dosage effects on the amount of the glycosyltransferase protein, its activity, and the amounts of carbohydrate products in vivo.
T1 0-51 Sentence denotes Molecular behavior of mutant Lewis enzymes in vivo.
T2 52-266 Sentence denotes The expression of type-1 Lewis antigens on erythrocytes and in digestive organs is determined by a Lewis type alpha(1,3/1, 4)-fucosyltransferase (Lewis enzyme) encoded by the Fuc-TIII gene ( FUT3 gene; Lewis gene).
T3 267-520 Sentence denotes We have classified the Lewis alleles in the Japanese population into four types, the wild-type allele ( Le ) and three mutated alleles, i.e., le1, which has missense mutations T59G and G508A, le2, which has T59G and T1067A, and le3, which has only T59G.
T4 521-1214 Sentence denotes Here we carried out an extensive study on the biological properties of the three mutant Lewis enzymes, the le1, le2, and le3 enzymes, using native tissues and obtained the following results. (1) In in vivo and in vitro experiments, the le1 and le2 enzymes were found to be susceptible to protease digestion probably because the one missense mutation in the catalytic domains, i.e., Gly170 to Ser in the le1 enzyme and Ile356 to Lys in the le2 enzyme, makes the three-dimensional structures of the enzymesunstable, while the le3 and wild-type Lewis enzymes wereresistant to protease digestion. (2) The le1 and le2 enzymes cannot synthesize type 1 Lewis antigens on either glycolipids or mucins.
T5 1215-1431 Sentence denotes The le3 enzyme cannot synthesize Lewis-active glycolipids, which result in the Lewis antigen-negative phenotype of erythrocytes, while it can synthesize Lewis antigens on mucins in normal and cancerous colon tissues.
T6 1432-1820 Sentence denotes The missense mutation, Leu20 to Arg, in the transmembrane domain reduces retention of the le3 enzyme in the Golgi membrane resulting in an apparent reduction of enzyme activity as revealed by the lack of Lewis antigen synthesis. (3) The Lewis gene dosage actually has effects in vivo on the amount of the Lewis enzyme, its activity, and finally the amounts of Lewis carbohydrate antigens.
T7 1821-2010 Sentence denotes This is the first article that clearly demonstrates the gene dosage effects on the amount of the glycosyltransferase protein, its activity, and the amounts of carbohydrate products in vivo.

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 95-107 FMAID:62845 denotes erythrocytes
_T23 1798-1810 FMAID:197276 denotes carbohydrate
_T2 95-107 FMAID:167137 denotes erythrocytes
_T3 125-131 FMAID:67498 denotes organs
_T4 125-131 FMAID:166081 denotes organs
_T5 236-240 FMAID:198663 denotes gene
_T6 248-252 FMAID:198663 denotes gene
_T7 260-264 FMAID:198663 denotes gene
_T8 668-675 FMAID:256050 denotes tissues
_T9 1192-1203 FMAID:196773 denotes glycolipids
_T10 1192-1203 FMAID:82780 denotes glycolipids
_T11 1261-1272 FMAID:82780 denotes glycolipids
_T12 1261-1272 FMAID:196773 denotes glycolipids
_T13 1327-1342 FMAID:263005 denotes of erythrocytes
_T14 1327-1342 FMAID:263004 denotes of erythrocytes
_T15 1330-1342 FMAID:62845 denotes erythrocytes
_T16 1330-1342 FMAID:167137 denotes erythrocytes
_T17 1417-1422 FMAID:14543 denotes colon
_T18 1417-1422 FMAID:104231 denotes colon
_T19 1423-1430 FMAID:256050 denotes tissues
_T20 1540-1554 FMAID:199154 denotes Golgi membrane
_T21 1675-1679 FMAID:198663 denotes gene
_T22 1798-1810 FMAID:82737 denotes carbohydrate
_T24 1877-1881 FMAID:198663 denotes gene
_T25 1938-1945 FMAID:165447 denotes protein
_T26 1938-1945 FMAID:67257 denotes protein
_T27 1980-1992 FMAID:197276 denotes carbohydrate
_T28 1980-1992 FMAID:82737 denotes carbohydrate

uniprot-human

Id Subject Object Predicate Lexical cue
T1 175-196 http://www.uniprot.org/uniprot/P22083 denotes 4)-fucosyltransferase
T2 243-247 http://www.uniprot.org/uniprot/P21217 denotes FUT3
T3 809-817 http://www.uniprot.org/uniprot/P63128 denotes protease
T4 1094-1102 http://www.uniprot.org/uniprot/P63128 denotes protease
T5 809-817 http://www.uniprot.org/uniprot/P10265 denotes protease
T6 1094-1102 http://www.uniprot.org/uniprot/P10265 denotes protease
T7 809-817 http://www.uniprot.org/uniprot/P63119 denotes protease
T8 1094-1102 http://www.uniprot.org/uniprot/P63119 denotes protease
T9 809-817 http://www.uniprot.org/uniprot/P63120 denotes protease
T10 1094-1102 http://www.uniprot.org/uniprot/P63120 denotes protease
T11 809-817 http://www.uniprot.org/uniprot/P63121 denotes protease
T12 1094-1102 http://www.uniprot.org/uniprot/P63121 denotes protease
T13 809-817 http://www.uniprot.org/uniprot/P63122 denotes protease
T14 1094-1102 http://www.uniprot.org/uniprot/P63122 denotes protease
T15 809-817 http://www.uniprot.org/uniprot/P63123 denotes protease
T16 1094-1102 http://www.uniprot.org/uniprot/P63123 denotes protease
T17 809-817 http://www.uniprot.org/uniprot/P63124 denotes protease
T18 1094-1102 http://www.uniprot.org/uniprot/P63124 denotes protease
T19 809-817 http://www.uniprot.org/uniprot/P63125 denotes protease
T20 1094-1102 http://www.uniprot.org/uniprot/P63125 denotes protease
T21 809-817 http://www.uniprot.org/uniprot/P63127 denotes protease
T22 1094-1102 http://www.uniprot.org/uniprot/P63127 denotes protease
T23 809-817 http://www.uniprot.org/uniprot/P63129 denotes protease
T24 1094-1102 http://www.uniprot.org/uniprot/P63129 denotes protease
T25 809-817 http://www.uniprot.org/uniprot/P63131 denotes protease
T26 1094-1102 http://www.uniprot.org/uniprot/P63131 denotes protease
T27 809-817 http://www.uniprot.org/uniprot/Q9Y6I0 denotes protease
T28 1094-1102 http://www.uniprot.org/uniprot/Q9Y6I0 denotes protease

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 175-196 http://www.uniprot.org/uniprot/Q11127 denotes 4)-fucosyltransferase

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 10-18 http://purl.bioontology.org/ontology/STY/T053 denotes behavior
T2 668-675 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T3 1407-1416 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancerous
T4 1423-1430 http://purl.bioontology.org/ontology/STY/T024 denotes tissues

GO-BP

Id Subject Object Predicate Lexical cue
T1 10-18 http://purl.obolibrary.org/obo/GO_0007610 denotes behavior
T2 115-124 http://purl.obolibrary.org/obo/GO_0007586 denotes digestive
T3 818-827 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T4 1103-1112 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T5 949-952 http://purl.obolibrary.org/obo/GO_0050065 denotes Lys
T6 1505-1514 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T7 1593-1608 http://purl.obolibrary.org/obo/GO_0003824 denotes enzyme activity
T8 1650-1659 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

GO-CC

Id Subject Object Predicate Lexical cue
T1 913-916 http://purl.obolibrary.org/obo/GO_0005790 denotes Ser
T2 1476-1489 http://purl.obolibrary.org/obo/GO_0016021 denotes transmembrane
T3 1476-1489 http://purl.obolibrary.org/obo/GO_0044214 denotes transmembrane
T4 1540-1545 http://purl.obolibrary.org/obo/GO_0005794 denotes Golgi
T5 1540-1554 http://purl.obolibrary.org/obo/GO_0000139 denotes Golgi membrane
T6 1546-1554 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 125-131 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organs
T2 544-553 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
T3 668-675 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T4 1423-1430 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T5 1417-1422 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 83-91 http://edamontology.org/topic_2830 denotes antigens
T2 386-393 http://edamontology.org/topic_0199 denotes mutated
T3 433-442 http://edamontology.org/topic_0199 denotes mutations
T4 554-559 http://edamontology.org/topic_3678 denotes study
T5 828-836 http://edamontology.org/topic_2269 denotes probably
T6 862-870 http://edamontology.org/topic_0199 denotes mutation
T7 1173-1181 http://edamontology.org/topic_2830 denotes antigens
T8 1300-1307 http://edamontology.org/topic_2830 denotes antigen
T9 1317-1326 http://edamontology.org/topic_0625 denotes phenotype
T10 1374-1382 http://edamontology.org/topic_2830 denotes antigens
T11 1407-1416 http://edamontology.org/topic_2640 denotes cancerous
T12 1445-1453 http://edamontology.org/topic_0199 denotes mutation
T13 1642-1649 http://edamontology.org/topic_2830 denotes antigen
T14 1798-1810 http://edamontology.org/topic_0152 denotes carbohydrate
T15 1811-1819 http://edamontology.org/topic_2830 denotes antigens
T16 1938-1945 http://edamontology.org/topic_0078 denotes protein
T17 1980-1992 http://edamontology.org/topic_0152 denotes carbohydrate

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 341-346 http://edamontology.org/data_2100 denotes types
T2 1000-1010 http://edamontology.org/data_0883 denotes structures
T3 1317-1326 http://edamontology.org/data_3275 denotes phenotype
T4 1396-1402 http://edamontology.org/operation_3435 denotes normal
T5 1839-1846 http://edamontology.org/data_0971 denotes article
T6 1860-1872 http://edamontology.org/operation_2246 denotes demonstrates
T7 1938-1945 http://edamontology.org/format_1208 denotes protein
T8 1938-1945 http://edamontology.org/data_1467 denotes protein

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1417-1422 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 29-34 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T2 77-82 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T3 151-156 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T4 198-203 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T5 254-259 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T6 290-295 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T7 609-614 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T8 1063-1068 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T9 1167-1172 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T10 1248-1253 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T11 1294-1299 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T12 1368-1373 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T13 1636-1641 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T14 1669-1674 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T15 1737-1742 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T16 1792-1797 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 668-675 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 1423-1430 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T3 125-131 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organs
PD-UBERON-AE-B_T4 544-553 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
PD-UBERON-AE-B_T5 1417-1422 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 227-230 "http://rdf.glycoinfo.org/glycan/G49112ZN" denotes Fuc
GlycanIUPAC_T2 227-230 "http://rdf.glycoinfo.org/glycan/G50059AJ" denotes Fuc
GlycanIUPAC_T3 227-230 "http://rdf.glycoinfo.org/glycan/G76218YK" denotes Fuc
GlycanIUPAC_T4 227-230 "http://rdf.glycoinfo.org/glycan/G50102KR" denotes Fuc
GlycanIUPAC_T5 227-230 "http://rdf.glycoinfo.org/glycan/G10717VS" denotes Fuc
GlycanIUPAC_T6 227-230 "http://rdf.glycoinfo.org/glycan/G60524RK" denotes Fuc
GlycanIUPAC_T7 227-230 "http://rdf.glycoinfo.org/glycan/G84407TT" denotes Fuc
GlycanIUPAC_T8 227-230 "http://rdf.glycoinfo.org/glycan/G64717JT" denotes Fuc
GlycanIUPAC_T9 227-230 "http://rdf.glycoinfo.org/glycan/G45003TT" denotes Fuc
GlycanIUPAC_T10 227-230 "http://rdf.glycoinfo.org/glycan/G73923FP" denotes Fuc
GlycanIUPAC_T11 227-230 "http://rdf.glycoinfo.org/glycan/G78231MB" denotes Fuc
GlycanIUPAC_T12 227-230 "http://rdf.glycoinfo.org/glycan/G80487UG" denotes Fuc
GlycanIUPAC_T13 227-230 "http://rdf.glycoinfo.org/glycan/G29758MI" denotes Fuc
GlycanIUPAC_T14 227-230 "http://rdf.glycoinfo.org/glycan/G02671KD" denotes Fuc
GlycanIUPAC_T15 227-230 "http://rdf.glycoinfo.org/glycan/G57926TZ" denotes Fuc
GlycanIUPAC_T16 227-230 "http://rdf.glycoinfo.org/glycan/G41718FD" denotes Fuc
GlycanIUPAC_T17 227-230 "http://rdf.glycoinfo.org/glycan/G99840FL" denotes Fuc
GlycanIUPAC_T18 227-230 "http://rdf.glycoinfo.org/glycan/G64321UX" denotes Fuc
GlycanIUPAC_T19 227-230 "http://rdf.glycoinfo.org/glycan/G11231EG" denotes Fuc
GlycanIUPAC_T20 227-230 "http://rdf.glycoinfo.org/glycan/G62741TN" denotes Fuc
GlycanIUPAC_T21 227-230 "http://rdf.glycoinfo.org/glycan/G51576ZQ" denotes Fuc
GlycanIUPAC_T22 227-230 "http://rdf.glycoinfo.org/glycan/G66056LD" denotes Fuc
GlycanIUPAC_T23 227-230 "http://rdf.glycoinfo.org/glycan/G02768BF" denotes Fuc
GlycanIUPAC_T24 227-230 "http://rdf.glycoinfo.org/glycan/G26168RO" denotes Fuc
GlycanIUPAC_T25 227-230 "http://rdf.glycoinfo.org/glycan/G42890HL" denotes Fuc
GlycanIUPAC_T26 227-230 "http://rdf.glycoinfo.org/glycan/G17533VU" denotes Fuc
GlycanIUPAC_T27 227-230 "http://rdf.glycoinfo.org/glycan/G34306RG" denotes Fuc
GlycanIUPAC_T28 227-230 "http://rdf.glycoinfo.org/glycan/G88735KU" denotes Fuc
GlycanIUPAC_T29 227-230 "http://rdf.glycoinfo.org/glycan/G82605UA" denotes Fuc

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 95-107 HP_0001901 denotes erythrocytes
T2 1330-1342 HP_0001901 denotes erythrocytes
T3 1407-1416 HP_0002664 denotes cancerous
T4 1407-1422 HP_0003003 denotes cancerous colon
T5 1407-1422 HP_0100273 denotes cancerous colon

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1407-1422 Disease denotes cancerous colon http://purl.obolibrary.org/obo/MONDO_0021063

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1417-1422 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 95-107 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T2 115-131 Body_part denotes digestive organs http://purl.obolibrary.org/obo/UBERON_0013765
T3 1330-1342 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T4 1417-1422 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T5 1476-1489 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T6 1540-1554 Body_part denotes Golgi membrane http://purl.obolibrary.org/obo/GO_0000139

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 95-107 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232
T2 1330-1342 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232