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PubMed:10087993 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 18-46 DNA denotes upstream regulatory elements
T2 74-102 DNA denotes adult beta-like globin genes
T3 187-199 DNA denotes cis-elements
T4 243-271 DNA denotes adult beta-like globin genes
T5 273-278 DNA denotes delta
T6 283-287 DNA denotes beta
T7 384-394 cell_line denotes K562 cells
T8 399-424 cell_line denotes erythroleukemia cell line
T9 469-482 DNA denotes DNA sequences
T10 492-526 DNA denotes delta and beta 5' flanking regions
T11 556-569 DNA denotes -500 to +50bp
T12 571-587 DNA denotes promoter regions
T13 610-634 DNA denotes beta 5' flanking regions
T14 664-678 DNA denotes -250 to +50 bp
T15 684-715 DNA denotes chimeric promoter constructions
T16 745-767 DNA denotes delta or beta fragment
T17 779-810 DNA denotes proximal beta or delta sequence
T18 815-841 DNA denotes CAT reporter constructions
T19 866-869 protein denotes CAT
T20 900-920 DNA denotes beta globin promoter
T21 957-971 DNA denotes delta promoter
T22 991-1011 DNA denotes beta globin promoter
T23 1090-1106 DNA denotes upstream portion
T24 1114-1128 DNA denotes delta promoter
T25 1186-1215 DNA denotes upstream beta globin sequence
T26 1268-1282 DNA denotes delta promoter
T27 1398-1431 DNA denotes beta globin gene upstream element
T28 1450-1466 DNA denotes upstream portion
T29 1474-1488 DNA denotes delta promoter
T30 1506-1526 DNA denotes beta globin promoter
T31 1590-1618 DNA denotes truncated beta gene promoter
T32 1649-1681 DNA denotes positive transcriptional element
T33 1692-1731 DNA denotes upstream delta globin regulatory region
T34 1784-1814 protein denotes repressor proteins BP1 and BP2
T35 1822-1838 DNA denotes upstream portion
T36 1846-1878 DNA denotes beta globin gene flanking region
T37 1928-1935 protein denotes DNase I
T38 1956-1984 DNA denotes upstream delta-globin region
T39 1994-2013 DNA denotes protected sequences
T40 2031-2054 DNA denotes consensus binding sites
T41 2059-2065 protein denotes GATA-1
T42 2070-2073 protein denotes BP2
T43 2119-2143 DNA denotes upstream promoter region
T44 2151-2173 DNA denotes adult beta globin gene

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 90-96 protein denotes globin
T2 259-265 protein denotes globin
T3 815-818 protein denotes CAT
T4 866-869 protein denotes CAT
T5 991-1002 protein denotes beta globin
T6 1195-1206 protein denotes beta globin
T7 1398-1409 protein denotes beta globin
T8 1506-1517 protein denotes beta globin
T9 1701-1713 protein denotes delta globin
T10 1803-1806 protein denotes BP1
T11 1811-1814 protein denotes BP2
T12 1846-1857 protein denotes beta globin
T13 1928-1935 protein denotes DNase I
T14 1965-1977 protein denotes delta-globin
T15 2059-2065 protein denotes GATA-1
T16 2070-2073 protein denotes BP2
T17 2157-2168 protein denotes beta globin

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 18-46 NP denotes upstream regulatory elements
C2 47-51 NP denotes that
C3 187-332 NP denotes cis-elements responsible for the down regulation of the adult beta-like globin genes (delta and beta) in immature, or primitive erythroid tissues
C4 345-350 NP denotes their
C5 384-394 NP denotes K562 cells
C6 396-458 NP denotes an erythroleukemia cell line with an embryonic-fetal phenotype
C7 684-715 NP denotes chimeric promoter constructions
C8 717-722 NP denotes which
C9 896-920 NP denotes the beta globin promoter
C10 953-971 NP denotes the delta promoter
C11 987-1011 NP denotes the beta globin promoter
C12 1042-1059 NP denotes promoter activity
C14 1110-1128 NP denotes the delta promoter
C13 1086-1128 NP denotes the upstream portion of the delta promoter
C16 1470-1488 NP denotes the delta promoter
C15 1446-1488 NP denotes the upstream portion of the delta promoter
C17 1909-1926 NP denotes promoter activity
C18 2147-2173 NP denotes the adult beta globin gene
C19 2188-2191 NP denotes its
C20 2263-2266 NP denotes its
R1 C2 C1 coref-relat that,upstream regulatory elements
R2 C4 C3 coref-pron their,"cis-elements responsible for the down regulation of the adult beta-like globin genes (delta and beta) in immature, or primitive erythroid tissues"
R3 C6 C5 coref-appos an erythroleukemia cell line with an embryonic-fetal phenotype,K562 cells
R4 C8 C7 coref-relat which,chimeric promoter constructions
R5 C11 C9 coref-ident the beta globin promoter,the beta globin promoter
R6 C14 C10 coref-ident the delta promoter,the delta promoter
R7 C16 C14 coref-ident the delta promoter,the delta promoter
R8 C15 C13 coref-ident the upstream portion of the delta promoter,the upstream portion of the delta promoter
R9 C17 C12 coref-ident promoter activity,promoter activity
R10 C19 C18 coref-pron its,the adult beta globin gene
R11 C20 C18 coref-pron its,the adult beta globin gene

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-140 Sentence denotes Identification of upstream regulatory elements that repress expression of adult beta-like globin genes in a primitive erythroid environment.
S2 141-333 Sentence denotes Our investigations have focused on localizing cis-elements responsible for the down regulation of the adult beta-like globin genes (delta and beta) in immature, or primitive erythroid tissues.
S3 334-459 Sentence denotes We studied their activity after transfection into K562 cells, an erythroleukemia cell line with an embryonic-fetal phenotype.
S4 460-811 Sentence denotes Analyzed DNA sequences included delta and beta 5' flanking regions extending from approximately -500 to +50bp (promoter regions), truncated delta and beta 5' flanking regions extending from approximately -250 to +50 bp, and chimeric promoter constructions, which consisted of a distal delta or beta fragment fused to a proximal beta or delta sequence.
S5 812-972 Sentence denotes In CAT reporter constructions no appreciable level of CAT activity was supported by the beta globin promoter, and only low level activity by the delta promoter.
S6 973-1060 Sentence denotes Truncation of the beta globin promoter led to a 2-3 fold increase in promoter activity.
S7 1061-1169 Sentence denotes In contrast, deletion of the upstream portion of the delta promoter led to a 10 fold decrease in expression.
S8 1170-1435 Sentence denotes Coupling of the upstream beta globin sequence from approximately -500 to -250 bp to the truncated delta promoter fragment led to complete extinction of transcription activity, consistent with a negative regulatory effect of the beta globin gene upstream element(s).
S9 1436-1732 Sentence denotes Fusion of the upstream portion of the delta promoter to the truncated beta globin promoter yielded a modest increase in promoter strength relative to the truncated beta gene promoter, indicating the presence of a positive transcriptional element(s) in the upstream delta globin regulatory region.
S10 1733-1927 Sentence denotes Site-directed mutagenesis of binding sites for the repressor proteins BP1 and BP2 in the upstream portion of the beta globin gene flanking region led to a 4-6 fold increase in promoter activity.
S11 1928-2074 Sentence denotes DNase I footprinting of the upstream delta-globin region revealed protected sequences corresponding to consensus binding sites for GATA-1 and BP2.
S12 2075-2295 Sentence denotes These results confirm that sequences in the upstream promoter region of the adult beta globin gene contribute to its factor-mediated suppression early in development and then may modulate its expression at a later stage.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-46 DNA_family_or_group denotes upstream regulatory elements
T2 74-102 DNA_family_or_group denotes adult beta-like globin genes
T3 108-139 other_name denotes primitive erythroid environment
T4 187-199 DNA_family_or_group denotes cis-elements
T5 243-271 DNA_family_or_group denotes adult beta-like globin genes
T6 273-278 DNA_domain_or_region denotes delta
T7 283-287 DNA_domain_or_region denotes beta
T8 384-394 cell_line denotes K562 cells
T9 399-424 cell_line denotes erythroleukemia cell line
T10 433-458 other_name denotes embryonic-fetal phenotype
T11 469-482 DNA_domain_or_region denotes DNA sequences
T12 556-569 DNA_domain_or_region denotes -500 to +50bp
T13 571-587 DNA_domain_or_region denotes promoter regions
T14 610-634 DNA_domain_or_region denotes beta 5' flanking regions
T15 664-678 DNA_domain_or_region denotes -250 to +50 bp
T16 684-715 DNA_family_or_group denotes chimeric promoter constructions
T17 815-841 DNA_family_or_group denotes CAT reporter constructions
T18 866-869 protein_molecule denotes CAT
T19 900-920 DNA_domain_or_region denotes beta globin promoter
T20 957-971 DNA_domain_or_region denotes delta promoter
T21 991-1011 DNA_domain_or_region denotes beta globin promoter
T22 1042-1059 other_name denotes promoter activity
T23 1090-1106 DNA_domain_or_region denotes upstream portion
T24 1114-1128 DNA_domain_or_region denotes delta promoter
T25 1186-1215 DNA_domain_or_region denotes upstream beta globin sequence
T26 1268-1282 DNA_domain_or_region denotes delta promoter
T27 1398-1431 DNA_domain_or_region denotes beta globin gene upstream element
T28 1450-1466 DNA_domain_or_region denotes upstream portion
T29 1474-1488 DNA_domain_or_region denotes delta promoter
T30 1506-1526 DNA_domain_or_region denotes beta globin promoter
T31 1590-1618 DNA_domain_or_region denotes truncated beta gene promoter
T32 1649-1681 DNA_family_or_group denotes positive transcriptional element
T33 1692-1731 DNA_domain_or_region denotes upstream delta globin regulatory region
T34 1733-1758 other_name denotes Site-directed mutagenesis
T35 1822-1838 DNA_domain_or_region denotes upstream portion
T36 1846-1878 DNA_domain_or_region denotes beta globin gene flanking region
T37 1909-1926 other_name denotes promoter activity
T38 1928-1935 protein_molecule denotes DNase I
T39 1956-1984 DNA_domain_or_region denotes upstream delta-globin region
T40 1994-2013 DNA_domain_or_region denotes protected sequences
T41 2031-2054 DNA_domain_or_region denotes consensus binding sites
T42 2059-2065 protein_molecule denotes GATA-1
T43 2070-2073 protein_molecule denotes BP2
T44 2119-2143 DNA_domain_or_region denotes upstream promoter region
T45 2151-2173 DNA_domain_or_region denotes adult beta globin gene
T46 2192-2219 other_name denotes factor-mediated suppression