PubMed:10087185 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	10-20	protein	denotes	proteasome
T2	45-52	cell_type	denotes	T cells
T3	113-121	protein	denotes	NFkappaB
T4	199-209	protein	denotes	proteasome
T5	238-257	protein	denotes	cytosolic inhibitor
T6	258-270	protein	denotes	IkappaBalpha
T7	302-314	protein	denotes	IkappaBalpha
T8	318-349	cell_type	denotes	TNF-alpha-treated T lymphocytes
T9	425-437	protein	denotes	IkappaBalpha
T10	441-448	cell_type	denotes	T cells
T11	539-551	protein	denotes	IkappaBalpha
T12	637-647	protein	denotes	proteasome
T13	666-673	cell_type	denotes	T cells
T14	816-826	protein	denotes	proteasome
T15	874-886	protein	denotes	IkappaBalpha
T16	927-939	protein	denotes	IkappaBalpha
T17	983-991	protein	denotes	NFkappaB
T18	1010-1014	protein	denotes	IL-2
T19	1038-1057	cell_line	denotes	TNF-treated T cells
T20	1088-1098	protein	denotes	proteasome

Id	Subject	Object	Predicate	Lexical cue
C2	58-69	NP	denotes	the elderly
C1	45-69	NP	denotes	T cells from the elderly
C3	100-121	NP	denotes	Induction of NFkappaB
C4	234-270	NP	denotes	the cytosolic inhibitor IkappaBalpha
C5	302-314	NP	denotes	IkappaBalpha
C6	318-379	NP	denotes	TNF-alpha-treated T lymphocytes from young and elderly donors
C7	425-437	NP	denotes	IkappaBalpha
C9	454-465	NP	denotes	the elderly
C8	441-465	NP	denotes	T cells from the elderly
C10	539-551	NP	denotes	IkappaBalpha
C11	660-673	NP	denotes	these T cells
C13	890-901	NP	denotes	the elderly
C12	847-901	NP	denotes	a failure to fully degrade IkappaBalpha in the elderly
C15	927-939	NP	denotes	IkappaBalpha
C14	903-939	NP	denotes	This failure to degrade IkappaBalpha
C16	983-1001	NP	denotes	NFkappaB induction
C17	1065-1070	NP	denotes	aging
C18	1138-1156	NP	denotes	immune dysfunction
C19	1157-1161	NP	denotes	that
C20	1174-1179	NP	denotes	aging
R1	C5	C4	coref-ident	IkappaBalpha,the cytosolic inhibitor IkappaBalpha
R2	C7	C5	coref-ident	IkappaBalpha,IkappaBalpha
R3	C9	C2	coref-ident	the elderly,the elderly
R4	C8	C1	coref-ident	T cells from the elderly,T cells from the elderly
R5	C10	C7	coref-ident	IkappaBalpha,IkappaBalpha
R6	C11	C6	coref-ident	these T cells,TNF-alpha-treated T lymphocytes from young and elderly donors
R7	C13	C9	coref-ident	the elderly,the elderly
R8	C15	C10	coref-ident	IkappaBalpha,IkappaBalpha
R9	C14	C12	coref-ident	This failure to degrade IkappaBalpha,a failure to fully degrade IkappaBalpha in the elderly
R10	C16	C3	coref-ident	NFkappaB induction,Induction of NFkappaB
R11	C19	C18	coref-relat	that,immune dysfunction
R12	C20	C17	coref-ident	aging,aging

Id	Subject	Object	Predicate	Lexical cue
S1	0-99	Sentence	denotes	Decreased proteasome-mediated degradation in T cells from the elderly: A role in immune senescence.
S2	100-271	Sentence	denotes	Induction of NFkappaB is a highly regulated process requiring phosphorylation, ubiquitination, and proteasome-mediated degradation of the cytosolic inhibitor IkappaBalpha.
S3	272-466	Sentence	denotes	Analyses of the regulation of IkappaBalpha in TNF-alpha-treated T lymphocytes from young and elderly donors revealed severely compromised degradation of IkappaBalpha in T cells from the elderly.
S4	467-612	Sentence	denotes	Examination of activation-induced phosphorylation and ubiquitination of IkappaBalpha did not demonstrate any significant age-related alterations.
S5	613-775	Sentence	denotes	However, examination of proteasome activity in these T cells using fluorogenic peptide assays revealed a significant age-related decline in chymotryptic activity.
S6	776-902	Sentence	denotes	These results suggest that a decline in proteasome activity results in a failure to fully degrade IkappaBalpha in the elderly.
S7	903-1071	Sentence	denotes	This failure to degrade IkappaBalpha may underlie both the observed decrease in NFkappaB induction and the IL-2 receptor expression in TNF-treated T cells during aging.
S8	1072-1180	Sentence	denotes	Thus, decreased proteasome-mediated degradation may be central to immune dysfunction that accompanies aging.

Id	Subject	Object	Predicate	Lexical cue
T1	10-20	protein_complex	denotes	proteasome
T2	45-52	cell_type	denotes	T cells
T3	62-69	multi_cell	denotes	elderly
T4	81-98	other_name	denotes	immune senescence
T5	113-121	protein_molecule	denotes	NFkappaB
T6	162-177	other_name	denotes	phosphorylation
T7	179-193	other_name	denotes	ubiquitination
T8	199-209	protein_complex	denotes	proteasome
T9	238-257	protein_family_or_group	denotes	cytosolic inhibitor
T10	258-270	protein_molecule	denotes	IkappaBalpha
T11	302-314	protein_molecule	denotes	IkappaBalpha
T12	318-327	protein_molecule	denotes	TNF-alpha
T13	425-437	protein_molecule	denotes	IkappaBalpha
T14	441-448	cell_type	denotes	T cells
T15	458-465	multi_cell	denotes	elderly
T16	482-516	other_name	denotes	activation-induced phosphorylation
T17	539-551	protein_molecule	denotes	IkappaBalpha
T18	588-611	other_name	denotes	age-related alterations
T19	637-647	protein_complex	denotes	proteasome
T20	666-673	cell_type	denotes	T cells
T21	680-699	peptide	denotes	fluorogenic peptide
T22	753-774	other_name	denotes	chymotryptic activity
T23	816-826	protein_complex	denotes	proteasome
T24	874-886	protein_molecule	denotes	IkappaBalpha
T25	894-901	multi_cell	denotes	elderly
T26	927-939	protein_molecule	denotes	IkappaBalpha
T27	983-991	protein_molecule	denotes	NFkappaB
T28	1010-1014	protein_molecule	denotes	IL-2
T29	1038-1049	cell_line	denotes	TNF-treated
T30	1050-1057	cell_type	denotes	T cells
T31	1088-1098	protein_complex	denotes	proteasome
T32	1138-1156	other_name	denotes	immune dysfunction