PubMed:10087181
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-16 | protein | denotes | Interferon-alpha |
| T2 | 30-40 | protein | denotes | STATs1, -3 |
| T3 | 89-92 | protein | denotes | Lck |
| T4 | 104-128 | protein | denotes | mitogen-activated kinase |
| T5 | 132-139 | cell_type | denotes | T cells |
| T6 | 148-159 | protein | denotes | interferons |
| T7 | 161-165 | protein | denotes | IFNs |
| T8 | 183-192 | protein | denotes | cytokines |
| T9 | 288-297 | protein | denotes | cytokines |
| T10 | 427-430 | protein | denotes | JAK |
| T11 | 430-435 | protein | denotes | -STAT |
| T12 | 501-518 | protein | denotes | Src-family kinase |
| T13 | 519-522 | protein | denotes | Lck |
| T14 | 526-529 | protein | denotes | JAK |
| T15 | 529-534 | protein | denotes | -STAT |
| T16 | 604-607 | protein | denotes | Lck |
| T17 | 611-620 | protein | denotes | IFN-alpha |
| T18 | 661-684 | cell_line | denotes | Lck-defective cell line |
| T19 | 698-704 | cell_line | denotes | Jurkat |
| T20 | 711-719 | cell_line | denotes | JCam/Lck |
| T21 | 721-731 | cell_line | denotes | JCam cells |
| T22 | 737-740 | protein | denotes | Lck |
| T23 | 774-783 | protein | denotes | IFN-alpha |
| T24 | 795-799 | protein | denotes | MAPK |
| T25 | 839-842 | protein | denotes | Lck |
| T26 | 857-870 | protein | denotes | STATs1 and -3 |
| T27 | 946-949 | protein | denotes | Lck |
| T28 | 964-987 | cell_line | denotes | IFN-alpha-treated cells |
| T29 | 1027-1036 | protein | denotes | IFN-alpha |
| T30 | 1122-1125 | protein | denotes | Lck |
| T31 | 1137-1141 | protein | denotes | MAPK |
| T32 | 1156-1165 | protein | denotes | IFN-alpha |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 141-166 | NP | denotes | Type I interferons (IFNs) |
| C2 | 183-192 | NP | denotes | cytokines |
| C3 | 193-197 | NP | denotes | that |
| C4 | 259-272 | NP | denotes | the processes |
| C5 | 276-281 | NP | denotes | which |
| C6 | 282-297 | NP | denotes | these cytokines |
| C7 | 427-445 | NP | denotes | JAK-STAT signaling |
| C8 | 497-522 | NP | denotes | the Src-family kinase Lck |
| C9 | 526-544 | NP | denotes | JAK-STAT signaling |
| C10 | 604-607 | NP | denotes | Lck |
| C11 | 640-750 | NP | denotes | the Jurkat, JCam (an Lck-defective cell line derived from Jurkat), and JCam/Lck (JCam cells with Lck restored) |
| C12 | 774-783 | NP | denotes | IFN-alpha |
| C13 | 839-842 | NP | denotes | Lck |
| C14 | 1027-1036 | NP | denotes | IFN-alpha |
| C15 | 1075-1095 | NP | denotes | all three cell lines |
| C16 | 1122-1125 | NP | denotes | Lck |
| R1 | C3 | C2 | coref-relat | that,cytokines |
| R2 | C5 | C4 | coref-relat | which,the processes |
| R3 | C6 | C1 | coref-ident | these cytokines,Type I interferons (IFNs) |
| R4 | C9 | C7 | coref-ident | JAK-STAT signaling,JAK-STAT signaling |
| R5 | C10 | C8 | coref-ident | Lck,the Src-family kinase Lck |
| R6 | C13 | C10 | coref-ident | Lck,Lck |
| R7 | C14 | C12 | coref-ident | IFN-alpha,IFN-alpha |
| R8 | C15 | C11 | coref-ident | all three cell lines,"the Jurkat, JCam (an Lck-defective cell line derived from Jurkat), and JCam/Lck (JCam cells with Lck restored)" |
| R9 | C16 | C13 | coref-ident | Lck,Lck |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-140 | Sentence | denotes | Interferon-alpha induction of STATs1, -3 DNA binding and growth arrest is independent of Lck and active mitogen-activated kinase in T cells. |
| S2 | 141-243 | Sentence | denotes | Type I interferons (IFNs) are a family of cytokines that have antiviral and antiproliferative effects. |
| S3 | 244-388 | Sentence | denotes | Data regarding the processes by which these cytokines transduce signals from the cell membrane to the nucleus are becoming increasingly complex. |
| S4 | 389-446 | Sentence | denotes | The most characterized pathway is via JAK-STAT signaling. |
| S5 | 447-545 | Sentence | denotes | Previous studies established a potential role for the Src-family kinase Lck in JAK-STAT signaling. |
| S6 | 546-751 | Sentence | denotes | Therefore, this study was designed to analyze the role of Lck in IFN-alpha signaling by using the Jurkat, JCam (an Lck-defective cell line derived from Jurkat), and JCam/Lck (JCam cells with Lck restored). |
| S7 | 752-843 | Sentence | denotes | The results show that IFN-alpha can induce MAPK activity, but only in cells containing Lck. |
| S8 | 844-988 | Sentence | denotes | Furthermore, STATs1 and -3 are effectively phosphorylated and activated to bind DNA in the absence of Lck expression in IFN-alpha-treated cells. |
| S9 | 989-1096 | Sentence | denotes | Finally, the results demonstrate that IFN-alpha exerts an antiproliferative effect in all three cell lines. |
| S10 | 1097-1239 | Sentence | denotes | These data indicate that Lck and active MAPK do not affect IFN-alpha-induced growth arrest or induction of STAT1s1 and -3 DNA binding ability. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-16 | protein_molecule | denotes | Interferon-alpha |
| T2 | 89-92 | protein_molecule | denotes | Lck |
| T3 | 104-128 | protein_molecule | denotes | mitogen-activated kinase |
| T4 | 132-139 | cell_type | denotes | T cells |
| T5 | 148-159 | protein_family_or_group | denotes | interferons |
| T6 | 161-165 | protein_family_or_group | denotes | IFNs |
| T7 | 183-192 | protein_family_or_group | denotes | cytokines |
| T8 | 288-297 | protein_family_or_group | denotes | cytokines |
| T9 | 325-338 | cell_component | denotes | cell membrane |
| T10 | 346-353 | cell_component | denotes | nucleus |
| T11 | 427-430 | protein_family_or_group | denotes | JAK |
| T12 | 430-435 | protein_family_or_group | denotes | -STAT |
| T13 | 501-518 | protein_family_or_group | denotes | Src-family kinase |
| T14 | 519-522 | protein_molecule | denotes | Lck |
| T15 | 526-529 | protein_family_or_group | denotes | JAK |
| T16 | 529-534 | protein_family_or_group | denotes | -STAT |
| T17 | 604-607 | protein_molecule | denotes | Lck |
| T18 | 611-620 | protein_molecule | denotes | IFN-alpha |
| T19 | 661-664 | protein_molecule | denotes | Lck |
| T20 | 698-704 | cell_line | denotes | Jurkat |
| T21 | 711-716 | cell_line | denotes | JCam/ |
| T22 | 716-719 | protein_molecule | denotes | Lck |
| T23 | 721-731 | cell_line | denotes | JCam cells |
| T24 | 737-740 | protein_molecule | denotes | Lck |
| T25 | 774-783 | protein_molecule | denotes | IFN-alpha |
| T26 | 795-799 | protein_family_or_group | denotes | MAPK |
| T27 | 839-842 | protein_molecule | denotes | Lck |
| T28 | 946-949 | protein_molecule | denotes | Lck |
| T29 | 964-973 | protein_molecule | denotes | IFN-alpha |
| T30 | 1027-1036 | protein_molecule | denotes | IFN-alpha |
| T31 | 1047-1071 | other_name | denotes | antiproliferative effect |
| T32 | 1122-1125 | protein_molecule | denotes | Lck |
| T33 | 1137-1141 | protein_family_or_group | denotes | MAPK |
| T34 | 1156-1165 | protein_molecule | denotes | IFN-alpha |
| T35 | 1204-1238 | other_name | denotes | STAT1s1 and -3 DNA binding ability |