PubMed:10085243
Annnotations
ggdb-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 10-15 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| T2 | 417-422 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| T3 | 567-572 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| T4 | 940-945 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| T5 | 1075-1080 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| T6 | 1113-1118 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-163 | Sentence | denotes | Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis. |
| T2 | 164-269 | Sentence | denotes | Glycosylphosphatidylinositol (GPI) is used as a membrane anchor by many eukaryotic cell-surface proteins. |
| T3 | 270-382 | Sentence | denotes | The second step of GPI biosynthesis is de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). |
| T4 | 383-532 | Sentence | denotes | We have previously cloned the rat PIG-L gene by expression cloning that complemented a mutant Chinese hamster ovary cell line defective in this step. |
| T5 | 533-683 | Sentence | denotes | Here we show that recombinant rat PIG-L protein purified from Escherichia coli as a complex with GroEL has GlcNAc-PI de-N-acetylase activity in vitro. |
| T6 | 684-805 | Sentence | denotes | The activity was not enhanced by GTP, which is known to enhance the de-N-acetylase activity of mammalian cell microsomes. |
| T7 | 806-946 | Sentence | denotes | As with other de-N-acetylases that act on the GlcNAc moiety, metal ions, in particular Mn2+ and Ni2+, enhanced the enzyme activity of PIG-L. |
| T8 | 947-1081 | Sentence | denotes | The Saccharomyces cerevisiae YMR281W open reading frame encodes a protein (termed Gpi12p) with 24% amino acid identity with rat PIG-L. |
| T9 | 1082-1254 | Sentence | denotes | On transfection into mammalian PIG-L-deficient cells, this gene, GPI12, restored the cell-surface expression of GPI-anchored proteins and GlcNAc-PI de-N-acetylase activity. |
| T10 | 1255-1316 | Sentence | denotes | The disruption of the gene caused lethality in S. cerevisiae. |
| T11 | 1317-1477 | Sentence | denotes | These results indicate that GlcNAc-PI de-N-acetylase is conserved between mammals and yeasts and that the de-N-acetylation step is also indispensable in yeasts. |
GGDB-2020
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 10-15 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| T2 | 417-422 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| T3 | 567-572 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| T4 | 940-945 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| T5 | 1075-1080 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| T6 | 1113-1118 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
glycogenes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoGenes20190927-B_T1 | 10-15 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| PD-GlycoGenes20190927-B_T2 | 417-422 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| PD-GlycoGenes20190927-B_T3 | 567-572 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| PD-GlycoGenes20190927-B_T4 | 636-639 | https://acgg.asia/db/ggdb/info/gg135 | denotes | has |
| PD-GlycoGenes20190927-B_T5 | 940-945 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| PD-GlycoGenes20190927-B_T6 | 1075-1080 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
| PD-GlycoGenes20190927-B_T7 | 1113-1118 | https://acgg.asia/db/ggdb/info/gg219 | denotes | PIG-L |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 371-377 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T2 | 640-646 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T3 | 852-858 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T4 | 1220-1226 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T5 | 1345-1351 | chem:24139 | denotes | GlcNAc |