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PubMed:10085159 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes The Cdc6 protein is ubiquitinated in vivo for proteolysis in Saccharomyces cerevisiae.
T2 87-273 Sentence denotes The Saccharomyces cerevisiae Cdc6 protein is necessary for the formation of pre-replicative complexes that are required for firing DNA replication at origins at the beginning of S phase.
T3 274-327 Sentence denotes Cdc6p protein levels oscillate during the cell cycle.
T4 328-542 Sentence denotes In a normal cell cycle the presence of this protein is restricted to G1, partly because the CDC6 gene is transcribed only during G1 and partly because the Cdc6p protein is rapidly degraded at late G1/early S phase.
T5 543-732 Sentence denotes We report here that the Cdc6p protein is degraded in a Cdc4-dependent manner, suggesting that phosphorylated Cdc6 is specifically recognized by the ubiquitin-mediated proteolysis machinery.
T6 733-833 Sentence denotes Indeed, we have found that Cdc6 is ubiquitinated in vivo and degraded by a Cdc4-dependent mechanism.
T7 834-1042 Sentence denotes Our data, together with previous observations regarding Cdc6 stability, suggest that under physiological conditions budding yeast cells degrade ubiquitinated Cdc6 every cell cycle at the beginning of S phase.

bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 4-8 Gene_or_gene_product denotes Cdc6
T2 116-120 Gene_or_gene_product denotes Cdc6
T3 163-188 Complex denotes pre-replicative complexes
T4 274-279 Gene_or_gene_product denotes Cdc6p
T5 420-424 Gene_or_gene_product denotes CDC6
T6 483-488 Gene_or_gene_product denotes Cdc6p
T7 567-572 Gene_or_gene_product denotes Cdc6p
T8 598-602 Gene_or_gene_product denotes Cdc4
T9 652-656 Gene_or_gene_product denotes Cdc6
T10 691-700 Gene_or_gene_product denotes ubiquitin
T11 760-764 Gene_or_gene_product denotes Cdc6
T12 808-812 Gene_or_gene_product denotes Cdc4
T13 890-894 Gene_or_gene_product denotes Cdc6
T14 992-996 Gene_or_gene_product denotes Cdc6

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 61-85 OrganismTaxon denotes Saccharomyces cerevisiae 4932
T2 91-115 OrganismTaxon denotes Saccharomyces cerevisiae 4932

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 316-326 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T2 340-350 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T3 1003-1013 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098