> top > docs > PubMed:10085150 > annotations

PubMed:10085150 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells.
T2 116-235 Sentence denotes HFE is the protein product of the gene mutated in the autosomal recessive disease hereditary hemochromatosis (Feder, J.
T3 236-290 Sentence denotes N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D.
T4 291-334 Sentence denotes A., Basava, A., Dormishian, F., Domingo, R.
T5 335-348 Sentence denotes J., Ellis, M.
T6 349-375 Sentence denotes C., Fullan, A., Hinton, L.
T7 376-389 Sentence denotes M., Jones, N.
T8 390-404 Sentence denotes L., Kimmel, B.
T9 405-420 Sentence denotes E., Kronmal, G.
T10 421-443 Sentence denotes S., Lauer, P., Lee, V.
T11 444-456 Sentence denotes K., Loeb, D.
T12 457-469 Sentence denotes B., Mapa, F.
T13 470-499 Sentence denotes A., McClelland, E., Meyer, N.
T14 500-515 Sentence denotes C., Mintier, G.
T15 516-568 Sentence denotes A., Moeller, N., Moore, T., Morikang, E., Prasss, C.
T16 569-598 Sentence denotes E., Quintana, L., Starnes, S.
T17 599-616 Sentence denotes M., Schatzman, R.
T18 617-631 Sentence denotes C., Brunke, K.
T19 632-646 Sentence denotes J., Drayna, D.
T20 647-660 Sentence denotes T., Risch, N.
T21 661-674 Sentence denotes J., Bacon, B.
T22 675-692 Sentence denotes R., and Wolff, R.
T23 693-707 Sentence denotes R. (1996) Nat.
T24 708-714 Sentence denotes Genet.
T25 715-728 Sentence denotes 13, 399-408).
T26 729-889 Sentence denotes At the cell surface, HFE complexes with transferrin receptor (TfR), increasing the dissociation constant of transferrin (Tf) for its receptor 10-fold (Gross, C.
T27 890-916 Sentence denotes N., Irrinki, A., Feder, J.
T28 917-933 Sentence denotes N., and Enns, C.
T29 934-946 Sentence denotes A. (1998) J.
T30 947-952 Sentence denotes Biol.
T31 953-958 Sentence denotes Chem.
T32 959-986 Sentence denotes 273, 22068-22074; Feder, J.
T33 987-1000 Sentence denotes N., Penny, D.
T34 1001-1025 Sentence denotes M., Irrinki, A., Lee, V.
T35 1026-1040 Sentence denotes K., Lebron, J.
T36 1041-1098 Sentence denotes A., Watson, N. , Tsuchihashi, Z., Sigal, E., Bjorkman, P.
T37 1099-1120 Sentence denotes J., and Schatzman, R.
T38 1121-1136 Sentence denotes C. (1998) Proc.
T39 1137-1142 Sentence denotes Natl.
T40 1143-1148 Sentence denotes Acad.
T41 1149-1153 Sentence denotes Sci.
T42 1154-1175 Sentence denotes U S A 95, 1472-1477).
T43 1176-1297 Sentence denotes HFE does not remain at the cell surface, but traffics with TfR to Tf-positive internal compartments (Gross et al., 1998).
T44 1298-1520 Sentence denotes Using a HeLa cell line in which the expression of HFE is controlled by tetracycline, we show that the expression of HFE reduces 55Fe uptake from Tf by 33% but does not affect the endocytic or exocytic rates of TfR cycling.
T45 1521-1621 Sentence denotes Therefore, HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments.
T46 1622-1744 Sentence denotes HFE specifically reduces iron uptake from Tf, as non-Tf-mediated iron uptake from Fe-nitrilotriacetic acid is not altered.
T47 1745-1914 Sentence denotes These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf-mediated pathway of iron uptake.
T48 1915-2146 Sentence denotes These results also have implications for the understanding of cellular iron homeostasis in organs such as the liver, pancreas, heart, and spleen that are iron loaded in hereditary hemochromatotic individuals lacking functional HFE.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 2025-2030 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 2032-2040 http://purl.obolibrary.org/obo/MAT_0000075 denotes pancreas
T3 2042-2047 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T4 2053-2059 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10085150-1#0#3#gene3077 116-119 gene3077 denotes HFE
10085150-1#74#108#diseaseC0392514 190-224 diseaseC0392514 denotes disease hereditary hemochromatosis
0#3#gene307774#108#diseaseC0392514 10085150-1#0#3#gene3077 10085150-1#74#108#diseaseC0392514 associated_with HFE,disease hereditary hemochromatosis

NCBIDiseaseCorpus

Id Subject Object Predicate Lexical cue
T1 4-30 Modifier:D006432 denotes hereditary hemochromatosis
T2 170-197 DiseaseClass:D030342 denotes autosomal recessive disease
T3 198-224 SpecificDisease:D006432 denotes hereditary hemochromatosis
T4 2084-2110 Modifier:D006432 denotes hereditary hemochromatotic

DisGeNET

Id Subject Object Predicate Lexical cue
T0 116-119 gene:3077 denotes HFE
T1 190-224 disease:C0392514 denotes disease hereditary hemochromatosis
T2 116-119 gene:3077 denotes HFE
T3 190-224 disease:C0019247 denotes disease hereditary hemochromatosis
R1 T0 T1 associated_with HFE,disease hereditary hemochromatosis
R2 T2 T3 associated_with HFE,disease hereditary hemochromatosis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 170-189 HP_0000007 denotes autosomal recessive

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 2025-2030 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 2032-2040 Body_part denotes pancreas http://purl.obolibrary.org/obo/MAT_0000075
T3 2042-2047 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T4 2053-2059 Body_part denotes spleen http://purl.obolibrary.org/obo/MAT_0000085

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 4-30 Disease denotes hereditary hemochromatosis http://purl.obolibrary.org/obo/MONDO_0006507
T2 170-197 Disease denotes autosomal recessive disease http://purl.obolibrary.org/obo/MONDO_0006025
T3 198-224 Disease denotes hereditary hemochromatosis http://purl.obolibrary.org/obo/MONDO_0006507
T4 2032-2040 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040

testtesttest

Id Subject Object Predicate Lexical cue
T1 4-30 Modifier:D006432 denotes hereditary hemochromatosis
T2 170-197 DiseaseClass:D030342 denotes autosomal recessive disease
T3 198-224 SpecificDisease:D006432 denotes hereditary hemochromatosis
T4 2084-2110 Modifier:D006432 denotes hereditary hemochromatotic

NCBI-Disease-Train

Id Subject Object Predicate Lexical cue database_id
T62 4-30 Modifier denotes hereditary hemochromatosis D006432
T63 170-197 DiseaseClass denotes autosomal recessive disease D030342
T64 198-224 SpecificDisease denotes hereditary hemochromatosis D006432
T65 2084-2110 Modifier denotes hereditary hemochromatotic D006432

NCBI-Disease-Corpus-All

Id Subject Object Predicate Lexical cue database_id
T62 4-30 Modifier denotes hereditary hemochromatosis D006432
T63 170-197 DiseaseClass denotes autosomal recessive disease D030342
T64 198-224 SpecificDisease denotes hereditary hemochromatosis D006432
T65 2084-2110 Modifier denotes hereditary hemochromatotic D006432

NCBI-Disease-Corpus-2stage-All

Id Subject Object Predicate Lexical cue
T1 15-30 Modifier denotes hemochromatosis
T2 198-224 DiseaseClass denotes hereditary hemochromatosis
T3 2084-2110 SpecificDisease denotes hereditary hemochromatotic

NCBI-Disease-Corpus-rezarta-All

Id Subject Object Predicate Lexical cue
T1 15-30 Modifier denotes hemochromatosis
T2 198-224 DiseaseClass denotes hereditary hemochromatosis
T3 2084-2110 DiseaseClass denotes hereditary hemochromatotic

NCBI-Disease-Corpus-4oGuideline-All

Id Subject Object Predicate Lexical cue
T1 15-30 SpecificDisease denotes hemochromatosis
T2 198-224 SpecificDisease denotes hereditary hemochromatosis
T3 2084-2110 SpecificDisease denotes hereditary hemochromatotic

NCBI-Disease-Corpus-Simple-All

Id Subject Object Predicate Lexical cue
T1 15-30 SpecificDisease denotes hemochromatosis
T2 198-224 SpecificDisease denotes hereditary hemochromatosis
T3 2084-2094 Modifier denotes hereditary
T4 2095-2110 SpecificDisease denotes hemochromatotic

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 573-581 OrganismTaxon denotes Quintana 417473

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 2025-2030 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T2 2032-2040 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264|http://purl.obolibrary.org/obo/UBERON_3011040
T4 2042-2047 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T8 2053-2059 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106