> top > docs > PubMed:10082473 > annotations

PubMed:10082473 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 175-196 protein denotes nuclear factor-kappaB
T2 231-266 protein denotes endothelial cell adhesion molecules
T3 529-585 cell_line denotes human umbilical vein endothelial cell (HUVEC) monolayers
T4 918-928 cell_type denotes neutrophil
T5 941-947 cell_line denotes HUVECs
T6 1066-1076 cell_type denotes neutrophil
T7 1282-1292 cell_type denotes neutrophil
T8 1373-1406 protein denotes Intercellular adhesion molecule-1
T9 1411-1452 protein denotes P-selectin-specific monoclonal antibodies
T10 1478-1488 cell_type denotes neutrophil
T11 1529-1564 protein denotes anti-E-selectin monoclonal antibody
T12 1706-1727 protein denotes nuclear factor-kappaB
T13 1731-1750 protein denotes activator protein-1
T14 1897-1930 protein denotes intercellular adhesion molecule-1
T15 1932-1942 protein denotes P-selectin
T16 1948-1958 protein denotes E-selectin
T17 1962-1968 cell_line denotes HUVECs
T18 2003-2013 cell_type denotes neutrophil
T19 2192-2227 protein denotes endothelial cell adhesion molecules
T20 2254-2264 cell_type denotes neutrophil

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 175-196 NP denotes nuclear factor-kappaB
C2 324-358 NP denotes endothelial cell glutathione (GSH)
C3 362-389 NP denotes oxidized glutathione (GSSG)
C4 436-459 NP denotes the molecular mechanism
C5 460-464 NP denotes that
C6 674-684 NP denotes GSH levels
C7 712-716 NP denotes GSSG
C8 720-723 NP denotes GSH
C9 941-947 NP denotes HUVECs
C10 980-1026 NP denotes 15 minutes (phase 1) and 240 minutes (phase 2)
C12 1089-1100 NP denotes both phases
C11 1066-1100 NP denotes neutrophil adhesion in both phases
C13 1102-1107 NP denotes which
C14 1129-1132 NP denotes GSH
C15 1222-1232 NP denotes GSH levels
C16 1246-1264 NP denotes the GSSG/GSH ratio
C17 1333-1347 NP denotes GSSG/GSH ratio
C18 1361-1371 NP denotes GSH levels
C19 1505-1516 NP denotes both phases
C20 1661-1690 NP denotes competing ds-oligonucleotides
C21 1691-1695 NP denotes that
C22 1706-1727 NP denotes nuclear factor-kappaB
C23 1798-1818 NP denotes the phase 2 response
C24 1820-1825 NP denotes which
C25 1962-1968 NP denotes HUVECs
C26 2106-2227 NP denotes transcription-independent and transcription-dependent surface expression of different endothelial cell adhesion molecules
C27 2229-2234 NP denotes which
R1 C5 C4 coref-relat that,the molecular mechanism
R2 C7 C3 coref-ident GSSG,oxidized glutathione (GSSG)
R3 C8 C2 coref-ident GSH,endothelial cell glutathione (GSH)
R4 C12 C10 coref-ident both phases,15 minutes (phase 1) and 240 minutes (phase 2)
R5 C13 C11 coref-relat which,neutrophil adhesion in both phases
R6 C14 C8 coref-ident GSH,GSH
R7 C15 C6 coref-ident GSH levels,GSH levels
R8 C17 C16 coref-ident GSSG/GSH ratio,the GSSG/GSH ratio
R9 C18 C15 coref-ident GSH levels,GSH levels
R10 C19 C12 coref-ident both phases,both phases
R11 C21 C20 coref-relat that,competing ds-oligonucleotides
R12 C22 C1 coref-ident nuclear factor-kappaB,nuclear factor-kappaB
R13 C24 C23 coref-relat which,the phase 2 response
R14 C25 C9 coref-ident HUVECs,HUVECs
R15 C27 C26 coref-relat which,transcription-independent and transcription-dependent surface expression of different endothelial cell adhesion molecules

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-88 Sentence denotes Molecular mechanisms of neutrophil-endothelial cell adhesion induced by redox imbalance.
S2 89-267 Sentence denotes Previous studies have implicated a role for intracellular thiols in the activation of nuclear factor-kappaB and transcriptional regulation of endothelial cell adhesion molecules.
S3 268-515 Sentence denotes This study was designed to determine whether changes in endothelial cell glutathione (GSH) or oxidized glutathione (GSSG) can alter neutrophil adhesivity and to define the molecular mechanism that underlies this GSSG/GSH-induced adhesion response.
S4 516-746 Sentence denotes Treatment of human umbilical vein endothelial cell (HUVEC) monolayers for 6 hours with 0.2 mmol/L diamide and 1 mmol/L buthionine sulfoximine (BSO) decreased GSH levels and increased the ratio of GSSG to GSH without cell toxicity.
S5 747-823 Sentence denotes These redox changes are similar to those observed with anoxia/reoxygenation.
S6 824-1027 Sentence denotes Diamide plus BSO-induced thiol/disulfide imbalance was associated with a biphasic increase in neutrophil adhesion to HUVECs with peak responses observed at 15 minutes (phase 1) and 240 minutes (phase 2).
S7 1028-1159 Sentence denotes N-Acetylcysteine treatment attenuated neutrophil adhesion in both phases, which indicated a role for GSH in the adhesion responses.
S8 1160-1372 Sentence denotes Interestingly, phase 1 adhesion was inversely correlated with GSH levels but not with the GSSG/GSH ratio, whereas phase 2 neutrophil adhesion was positively correlated with GSSG/GSH ratio but not with GSH levels.
S9 1373-1602 Sentence denotes Intercellular adhesion molecule-1 and P-selectin-specific monoclonal antibodies attenuated the increased neutrophil adhesion during both phases, whereas an anti-E-selectin monoclonal antibody also attenuated the phase 2 response.
S10 1603-1874 Sentence denotes Pretreatment with actinomycin D and cycloheximide or with competing ds-oligonucleotides that contained nuclear factor-kappaB or activator protein-1 cognate DNA sequences significantly attenuated the phase 2 response, which implicated a role for de novo protein synthesis.
S11 1875-2033 Sentence denotes Surface expression of intercellular adhesion molecule-1, P-selectin, and E-selectin on HUVECs correlated with the phase 1 and 2 neutrophil adhesion responses.
S12 2034-2295 Sentence denotes This study demonstrates that changes in endothelial cell GSSG/GSH cause transcription-independent and transcription-dependent surface expression of different endothelial cell adhesion molecules, which leads to a 2-phase neutrophil-endothelial adhesion response.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 other_name denotes Molecular mechanisms
T2 24-60 other_name denotes neutrophil-endothelial cell adhesion
T3 72-87 other_name denotes redox imbalance
T4 133-153 other_organic_compound denotes intracellular thiols
T5 175-196 protein_complex denotes nuclear factor-kappaB
T6 201-227 other_name denotes transcriptional regulation
T7 231-266 protein_family_or_group denotes endothelial cell adhesion molecules
T8 324-340 peptide denotes endothelial cell
T9 341-352 peptide denotes glutathione
T10 354-357 peptide denotes GSH
T11 362-370 peptide denotes oxidized
T12 371-382 peptide denotes glutathione
T13 384-388 peptide denotes GSSG
T14 400-421 other_name denotes neutrophil adhesivity
T15 440-459 other_name denotes molecular mechanism
T16 480-484 peptide denotes GSSG
T17 485-488 peptide denotes GSH
T18 529-566 cell_line denotes human umbilical vein endothelial cell
T19 568-573 cell_line denotes HUVEC
T20 635-657 other_organic_compound denotes buthionine sulfoximine
T21 659-662 other_organic_compound denotes BSO
T22 674-677 peptide denotes GSH
T23 712-716 peptide denotes GSSG
T24 720-723 peptide denotes GSH
T25 732-745 other_name denotes cell toxicity
T26 802-822 other_name denotes anoxia/reoxygenation
T27 837-840 other_organic_compound denotes BSO
T28 849-874 other_name denotes thiol/disulfide imbalance
T29 918-928 cell_type denotes neutrophil
T30 941-947 cell_line denotes HUVECs
T31 1028-1044 amino_acid_monomer denotes N-Acetylcysteine
T32 1066-1076 cell_type denotes neutrophil
T33 1129-1132 peptide denotes GSH
T34 1140-1158 other_name denotes adhesion responses
T35 1175-1191 other_name denotes phase 1 adhesion
T36 1222-1225 peptide denotes GSH
T37 1250-1254 peptide denotes GSSG
T38 1255-1258 peptide denotes GSH
T39 1282-1292 cell_type denotes neutrophil
T40 1333-1337 peptide denotes GSSG
T41 1337-1341 peptide denotes /GSH
T42 1361-1364 peptide denotes GSH
T43 1373-1406 protein_family_or_group denotes Intercellular adhesion molecule-1
T44 1411-1452 protein_family_or_group denotes P-selectin-specific monoclonal antibodies
T45 1478-1488 cell_type denotes neutrophil
T46 1529-1544 protein_family_or_group denotes anti-E-selectin
T47 1545-1564 protein_family_or_group denotes monoclonal antibody
T48 1621-1634 other_organic_compound denotes actinomycin D
T49 1639-1652 other_organic_compound denotes cycloheximide
T50 1671-1690 polynucleotide denotes ds-oligonucleotides
T51 1706-1727 protein_complex denotes nuclear factor-kappaB
T52 1731-1750 protein_molecule denotes activator protein-1
T53 1802-1818 other_name denotes phase 2 response
T54 1848-1873 other_name denotes de novo protein synthesis
T55 1897-1930 protein_molecule denotes intercellular adhesion molecule-1
T56 1932-1942 protein_molecule denotes P-selectin
T57 1948-1958 protein_molecule denotes E-selectin
T58 1962-1968 cell_line denotes HUVECs
T59 2003-2013 cell_type denotes neutrophil
T60 2074-2090 peptide denotes endothelial cell
T61 2091-2095 peptide denotes GSSG
T62 2095-2099 peptide denotes /GSH
T63 2136-2178 other_name denotes transcription-dependent surface expression
T64 2192-2227 protein_family_or_group denotes endothelial cell adhesion molecules
T65 2246-2253 other_name denotes 2-phase
T66 2254-2264 cell_type denotes neutrophil