| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-96 |
Sentence |
denotes |
Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome. |
| TextSentencer_T2 |
97-329 |
Sentence |
denotes |
We studied the circadian rhythm of serum melatonin levels in two patients with classical Rett syndrome having severe sleep disorders; serum melatonin levels were measured before and during melatonin treatment using radioimmunoassay. |
| TextSentencer_T3 |
330-406 |
Sentence |
denotes |
Patient 1 had a free-running rhythm of sleep-wake cycle from 3 years of age. |
| TextSentencer_T4 |
407-542 |
Sentence |
denotes |
At the age of 4 years, the peak time of melatonin was delayed 6 h compared to normal control and the peak value was at the lower limit. |
| TextSentencer_T5 |
543-647 |
Sentence |
denotes |
Patient 2 had a fragmented sleep pattern accompanied by night screaming from 1 year and 6 months of age. |
| TextSentencer_T6 |
648-762 |
Sentence |
denotes |
At the age of 10 years, the peak time of melatonin secretion was normal but the peak value was at the lower limit. |
| TextSentencer_T7 |
763-828 |
Sentence |
denotes |
These patients were given 5 mg melatonin orally prior to bedtime. |
| TextSentencer_T8 |
829-905 |
Sentence |
denotes |
Exogenous melatonin dramatically improved the sleep-wake cycle in patient 1. |
| TextSentencer_T9 |
906-1016 |
Sentence |
denotes |
In patient 2, exogenous melatonin showed a hypnotic effect but early morning awakenings occurred occasionally. |
| TextSentencer_T10 |
1017-1155 |
Sentence |
denotes |
When melatonin treatment was stopped, the sleep disorders recurred and re-administration of 3 mg melatonin was effective in both patients. |
| TextSentencer_T11 |
1156-1223 |
Sentence |
denotes |
The effect was maintained over 2 years without any adverse effects. |
| TextSentencer_T12 |
1224-1351 |
Sentence |
denotes |
These findings suggests that sleep disorders in patients with Rett syndrome may relate with an impaired secretion of melatonin. |
| T1 |
0-96 |
Sentence |
denotes |
Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome. |
| T2 |
97-329 |
Sentence |
denotes |
We studied the circadian rhythm of serum melatonin levels in two patients with classical Rett syndrome having severe sleep disorders; serum melatonin levels were measured before and during melatonin treatment using radioimmunoassay. |
| T3 |
330-406 |
Sentence |
denotes |
Patient 1 had a free-running rhythm of sleep-wake cycle from 3 years of age. |
| T4 |
407-542 |
Sentence |
denotes |
At the age of 4 years, the peak time of melatonin was delayed 6 h compared to normal control and the peak value was at the lower limit. |
| T5 |
543-647 |
Sentence |
denotes |
Patient 2 had a fragmented sleep pattern accompanied by night screaming from 1 year and 6 months of age. |
| T6 |
648-762 |
Sentence |
denotes |
At the age of 10 years, the peak time of melatonin secretion was normal but the peak value was at the lower limit. |
| T7 |
763-828 |
Sentence |
denotes |
These patients were given 5 mg melatonin orally prior to bedtime. |
| T8 |
829-905 |
Sentence |
denotes |
Exogenous melatonin dramatically improved the sleep-wake cycle in patient 1. |
| T9 |
906-1016 |
Sentence |
denotes |
In patient 2, exogenous melatonin showed a hypnotic effect but early morning awakenings occurred occasionally. |
| T10 |
1017-1155 |
Sentence |
denotes |
When melatonin treatment was stopped, the sleep disorders recurred and re-administration of 3 mg melatonin was effective in both patients. |
| T11 |
1156-1223 |
Sentence |
denotes |
The effect was maintained over 2 years without any adverse effects. |
| T12 |
1224-1351 |
Sentence |
denotes |
These findings suggests that sleep disorders in patients with Rett syndrome may relate with an impaired secretion of melatonin. |
