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PubMed:10080908 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 235-256 protein denotes transcription factors
T2 257-261 protein denotes PU.1
T3 266-276 protein denotes C/EBPalpha
T4 333-343 cell_type denotes stem cells
T5 347-356 cell_type denotes monocytes
T6 389-393 protein denotes PU.1
T7 420-473 protein denotes macrophage colony-stimulating factor (M-CSF) receptor
T8 497-506 cell_type denotes monocytes
T9 516-526 protein denotes C/EBPalpha
T10 559-613 protein denotes granulocyte colony-stimulating factor (G-CSF) receptor
T11 634-646 cell_type denotes granulocytes
T12 690-702 protein denotes oncoproteins
T13 711-719 protein denotes AML1/ETO
T14 721-733 protein denotes PML/RARalpha
T15 738-751 protein denotes activated Ras
T16 821-829 protein denotes AML1/ETO
T17 846-866 protein denotes transcription factor
T18 867-877 protein denotes C/EBPalpha
T19 887-897 protein denotes C/EBPalpha
T20 972-980 protein denotes AML1/ETO
T21 1009-1029 protein denotes transcription factor
T22 1030-1034 protein denotes AML1
T23 1066-1089 DNA denotes M-CSF receptor promoter
T24 1114-1141 protein denotes PML/RARalpha fusion protein
T25 1194-1249 protein denotes nuclear corepressor (N-CoR) histone deacetylase complex
T26 1289-1296 protein denotes histone
T27 1326-1335 DNA denotes chromatin
T28 1464-1476 protein denotes oncoproteins
T29 1523-1544 protein denotes transcription factors

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 91-119 NP denotes Acute myeloid leukemia (AML)
C2 171-174 NP denotes AML
C3 206-229 NP denotes myeloid differentiation
C4 347-356 NP denotes monocytes
C5 497-506 NP denotes monocytes
C6 516-526 NP denotes C/EBPalpha
C7 651-654 NP denotes AML
C10 711-719 NP denotes AML1/ETO
C11 721-733 NP denotes PML/RARalpha
C9 690-751 NP denotes oncoproteins such as AML1/ETO, PML/RARalpha, or activated Ras
C12 753-758 NP denotes which
C8 690-813 NP denotes oncoproteins such as AML1/ETO, PML/RARalpha, or activated Ras, which can deregulate genes important for normal myelopoiesis
C13 821-829 NP denotes AML1/ETO
C14 842-877 NP denotes the transcription factor C/EBPalpha
C15 972-980 NP denotes AML1/ETO
C16 1110-1141 NP denotes the PML/RARalpha fusion protein
C17 1149-1260 NP denotes transcriptional repression by recruiting the nuclear corepressor (N-CoR) histone deacetylase complex to the DNA
C18 1262-1267 NP denotes which
C19 1432-1455 NP denotes myeloid differentiation
C20 1464-1476 NP denotes oncoproteins
C21 1489-1492 NP denotes AML
C22 1523-1544 NP denotes transcription factors
C23 1545-1549 NP denotes that
R1 C2 C1 coref-ident AML,Acute myeloid leukemia (AML)
R2 C5 C4 coref-ident monocytes,monocytes
R3 C7 C2 coref-ident AML,AML
R4 C12 C9 coref-relat which,"oncoproteins such as AML1/ETO, PML/RARalpha, or activated Ras"
R5 C13 C10 coref-ident AML1/ETO,AML1/ETO
R6 C14 C6 coref-ident the transcription factor C/EBPalpha,C/EBPalpha
R7 C15 C13 coref-ident AML1/ETO,AML1/ETO
R8 C16 C11 coref-ident the PML/RARalpha fusion protein,PML/RARalpha
R9 C18 C17 coref-relat which,transcriptional repression by recruiting the nuclear corepressor (N-CoR) histone deacetylase complex to the DNA
R10 C19 C3 coref-ident myeloid differentiation,myeloid differentiation
R11 C20 C8 coref-ident oncoproteins,"oncoproteins such as AML1/ETO, PML/RARalpha, or activated Ras, which can deregulate genes important for normal myelopoiesis"
R12 C21 C7 coref-ident AML,AML
R13 C23 C22 coref-relat that,transcription factors

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-90 Sentence denotes Analysis of the modulation of transcriptional activity in myelopoiesis and leukemogenesis.
S2 91-170 Sentence denotes Acute myeloid leukemia (AML) is still associated with a mortality of 60 to 80%.
S3 171-230 Sentence denotes AML is characterized by a block in myeloid differentiation.
S4 231-373 Sentence denotes The transcription factors PU.1 and C/EBPalpha are responsible for normal myeloid differentiation from stem cells to monocytes or granulocytes.
S5 374-647 Sentence denotes In particular, PU.1 induces expression of the macrophage colony-stimulating factor (M-CSF) receptor and the development of monocytes, whereas C/EBPalpha increases the expression of the granulocyte colony-stimulating factor (G-CSF) receptor and leads to mature granulocytes.
S6 648-814 Sentence denotes In AML, chromosomal aberrations result in oncoproteins such as AML1/ETO, PML/RARalpha, or activated Ras, which can deregulate genes important for normal myelopoiesis.
S7 815-962 Sentence denotes Thus, AML1/ETO can bind to the transcription factor C/EBPalpha, inhibit C/EBPalpha-dependent transcription, and block granulocytic differentiation.
S8 963-1090 Sentence denotes However, AML1/ETO can also synergize with the transcription factor AML1 to enhance the activity of the M-CSF receptor promoter.
S9 1091-1349 Sentence denotes On the other hand, the PML/RARalpha fusion protein causes transcriptional repression by recruiting the nuclear corepressor (N-CoR) histone deacetylase complex to the DNA, which results in decreased histone acetylation and a repressive chromatin organization.
S10 1350-1593 Sentence denotes Here we describe methods to investigate whether and how signaling agonists induce myeloid differentiation and how oncoproteins might cause AML by modulating the activity of transcription factors that are pivotal for normal myeloid development.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 30-54 other_name denotes transcriptional activity
T2 58-70 other_name denotes myelopoiesis
T3 75-89 other_name denotes leukemogenesis
T4 91-113 other_name denotes Acute myeloid leukemia
T5 115-118 other_name denotes AML
T6 171-174 other_name denotes AML
T7 206-229 other_name denotes myeloid differentiation
T8 235-256 protein_family_or_group denotes transcription factors
T9 257-261 protein_molecule denotes PU.1
T10 266-276 protein_molecule denotes C/EBPalpha
T11 304-327 other_name denotes myeloid differentiation
T12 333-343 cell_type denotes stem cells
T13 347-356 cell_type denotes monocytes
T14 389-393 protein_molecule denotes PU.1
T15 420-473 protein_molecule denotes macrophage colony-stimulating factor (M-CSF) receptor
T16 497-506 cell_type denotes monocytes
T17 516-526 protein_molecule denotes C/EBPalpha
T18 559-613 protein_molecule denotes granulocyte colony-stimulating factor (G-CSF) receptor
T19 634-646 cell_type denotes granulocytes
T20 651-654 other_name denotes AML
T21 656-679 other_name denotes chromosomal aberrations
T22 690-702 protein_family_or_group denotes oncoproteins
T23 711-719 protein_molecule denotes AML1/ETO
T24 721-733 protein_molecule denotes PML/RARalpha
T25 738-751 protein_molecule denotes activated Ras
T26 801-813 other_name denotes myelopoiesis
T27 821-829 protein_molecule denotes AML1/ETO
T28 846-866 protein_family_or_group denotes transcription factor
T29 867-877 protein_molecule denotes C/EBPalpha
T30 887-897 protein_molecule denotes C/EBPalpha
T31 972-980 protein_molecule denotes AML1/ETO
T32 1009-1029 protein_family_or_group denotes transcription factor
T33 1030-1034 protein_molecule denotes AML1
T34 1066-1089 DNA_domain_or_region denotes M-CSF receptor promoter
T35 1114-1126 protein_molecule denotes PML/RARalpha
T36 1149-1175 other_name denotes transcriptional repression
T37 1194-1249 protein_complex denotes nuclear corepressor (N-CoR) histone deacetylase complex
T38 1289-1296 protein_family_or_group denotes histone
T39 1326-1335 DNA_family_or_group denotes chromatin
T40 1406-1424 other_name denotes signaling agonists
T41 1432-1455 other_name denotes myeloid differentiation
T42 1464-1476 protein_family_or_group denotes oncoproteins
T43 1489-1492 other_name denotes AML
T44 1523-1544 protein_family_or_group denotes transcription factors
T45 1566-1592 other_name denotes normal myeloid development

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 91-113 HP_0004808 denotes Acute myeloid leukemia
T2 97-113 HP_0012324 denotes myeloid leukemia
T3 105-113 HP_0001909 denotes leukemia