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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 61-70 cell_type denotes platelets
T2 326-359 protein denotes regulatory and catalytic subunits
T3 363-392 protein denotes cAMP-dependent protein kinase
T4 394-410 protein denotes protein kinase A
T5 437-441 protein denotes Rap1
T6 446-455 cell_type denotes platelets
T7 564-573 cell_type denotes Platelets
T8 720-749 protein denotes cAMP-dependent protein kinase
T9 754-758 protein denotes Rap1
T10 881-898 protein denotes catalytic subunit
T11 902-931 protein denotes cAMP-dependent protein kinase
T12 1219-1238 protein denotes regulatory subunits
T13 1263-1292 protein denotes cAMP-dependent protein kinase
T14 1316-1320 protein denotes Rap1
T15 1456-1460 protein denotes Rap1
T16 1469-1486 protein denotes catalytic subunit
T17 1490-1519 protein denotes cAMP-dependent protein kinase
T18 1539-1548 cell_type denotes platelets

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 17-57 NP denotes cyclic adenosine monophosphate signaling
C2 100-116 NP denotes bipolar disorder
C4 267-283 NP denotes bipolar disorder
C3 253-283 NP denotes patients with bipolar disorder
C6 363-411 NP denotes cAMP-dependent protein kinase (protein kinase A)
C8 421-424 NP denotes its
C7 416-435 NP denotes 1 of its substrates
C9 437-441 NP denotes Rap1
C5 363-441 NP denotes cAMP-dependent protein kinase (protein kinase A) and 1 of its substrates, Rap1
C12 516-532 NP denotes bipolar disorder
C11 461-532 NP denotes untreated euthymic, manic, and depressed patients with bipolar disorder
C13 537-553 NP denotes healthy subjects
C10 461-553 NP denotes untreated euthymic, manic, and depressed patients with bipolar disorder and healthy subjects
C16 622-638 NP denotes bipolar disorder
C15 594-680 NP denotes 112 drug-free patients with bipolar disorder (52 euthymic, 29 depressed, and 31 manic)
C17 685-704 NP denotes 62 healthy subjects
C14 594-704 NP denotes 112 drug-free patients with bipolar disorder (52 euthymic, 29 depressed, and 31 manic) and 62 healthy subjects
C19 720-749 NP denotes cAMP-dependent protein kinase
C20 754-758 NP denotes Rap1
C18 720-758 NP denotes cAMP-dependent protein kinase and Rap1
C22 902-931 NP denotes cAMP-dependent protein kinase
C21 877-931 NP denotes the catalytic subunit of cAMP-dependent protein kinase
C23 1049-1065 NP denotes bipolar disorder
C24 1113-1129 NP denotes bipolar disorder
C25 1134-1150 NP denotes healthy subjects
C26 1263-1292 NP denotes cAMP-dependent protein kinase
C27 1316-1320 NP denotes Rap1
C28 1358-1407 NP denotes untreated euthymic, depressed, and manic patients
C29 1416-1431 NP denotes healthy persons
C30 1456-1460 NP denotes Rap1
C32 1490-1519 NP denotes cAMP-dependent protein kinase
C31 1465-1519 NP denotes the catalytic subunit of cAMP-dependent protein kinase
C33 1552-1568 NP denotes bipolar patients
C34 1643-1657 NP denotes cAMP signaling
C35 1681-1697 NP denotes bipolar disorder
R1 C4 C2 coref-ident bipolar disorder,bipolar disorder
R2 C8 C6 coref-pron its,cAMP-dependent protein kinase (protein kinase A)
R3 C9 C7 coref-appos Rap1,1 of its substrates
R4 C12 C4 coref-ident bipolar disorder,bipolar disorder
R5 C16 C12 coref-ident bipolar disorder,bipolar disorder
R6 C15 C11 coref-ident "112 drug-free patients with bipolar disorder (52 euthymic, 29 depressed, and 31 manic)","untreated euthymic, manic, and depressed patients with bipolar disorder"
R7 C17 C13 coref-ident 62 healthy subjects,healthy subjects
R8 C14 C10 coref-ident "112 drug-free patients with bipolar disorder (52 euthymic, 29 depressed, and 31 manic) and 62 healthy subjects","untreated euthymic, manic, and depressed patients with bipolar disorder and healthy subjects"
R9 C19 C6 coref-ident cAMP-dependent protein kinase,cAMP-dependent protein kinase (protein kinase A)
R10 C20 C7 coref-ident Rap1,1 of its substrates
R11 C18 C5 coref-ident cAMP-dependent protein kinase and Rap1,"cAMP-dependent protein kinase (protein kinase A) and 1 of its substrates, Rap1"
R12 C22 C19 coref-ident cAMP-dependent protein kinase,cAMP-dependent protein kinase
R13 C23 C16 coref-ident bipolar disorder,bipolar disorder
R14 C24 C23 coref-ident bipolar disorder,bipolar disorder
R15 C25 C17 coref-ident healthy subjects,62 healthy subjects
R16 C26 C22 coref-ident cAMP-dependent protein kinase,cAMP-dependent protein kinase
R17 C27 C20 coref-ident Rap1,Rap1
R18 C28 C15 coref-ident "untreated euthymic, depressed, and manic patients","112 drug-free patients with bipolar disorder (52 euthymic, 29 depressed, and 31 manic)"
R19 C29 C25 coref-ident healthy persons,healthy subjects
R20 C30 C27 coref-ident Rap1,Rap1
R21 C32 C26 coref-ident cAMP-dependent protein kinase,cAMP-dependent protein kinase
R22 C31 C21 coref-ident the catalytic subunit of cAMP-dependent protein kinase,the catalytic subunit of cAMP-dependent protein kinase
R23 C33 C3 coref-ident bipolar patients,patients with bipolar disorder
R24 C34 C1 coref-ident cAMP signaling,cyclic adenosine monophosphate signaling
R25 C35 C24 coref-ident bipolar disorder,bipolar disorder

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-117 Sentence denotes Abnormalities of cyclic adenosine monophosphate signaling in platelets from untreated patients with bipolar disorder.
S2 118-284 Sentence denotes BACKGROUND: Abnormalities in the cyclic adenosine monophosphate (cAMP)-dependent phosphorylation system have been recently reported in patients with bipolar disorder.
S3 285-554 Sentence denotes We evaluated the immunoreactivity of the regulatory and catalytic subunits of cAMP-dependent protein kinase (protein kinase A) and 1 of its substrates, Rap1, in platelets from untreated euthymic, manic, and depressed patients with bipolar disorder and healthy subjects.
S4 555-705 Sentence denotes METHODS: Platelets were collected from 112 drug-free patients with bipolar disorder (52 euthymic, 29 depressed, and 31 manic) and 62 healthy subjects.
S5 706-845 Sentence denotes The levels of cAMP-dependent protein kinase and Rap1 were assessed by Western blot analysis, immunostaining, and computer-assisted imaging.
S6 846-1151 Sentence denotes RESULTS: The immunolabeling of the catalytic subunit of cAMP-dependent protein kinase was significantly different among groups (P<.001), with higher values in untreated depressed and manic patients with bipolar disorder compared with untreated euthymic patients with bipolar disorder and healthy subjects.
S7 1152-1293 Sentence denotes No significant differences were found in the immunolabeling of the regulatory subunits (type I and type II) of cAMP-dependent protein kinase.
S8 1294-1432 Sentence denotes The immunolabeling of Rap1 was significantly higher (P<.001) in untreated euthymic, depressed, and manic patients than in healthy persons.
S9 1433-1569 Sentence denotes CONCLUSIONS: Levels of Rap1 and the catalytic subunit of cAMP-dependent protein kinase are altered in the platelets of bipolar patients.
S10 1570-1698 Sentence denotes These findings may provide clues toward understanding the involvement of cAMP signaling in the pathogenesis of bipolar disorder.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 17-47 nucleotide denotes cyclic adenosine monophosphate
T2 61-70 cell_type denotes platelets
T3 100-116 other_name denotes bipolar disorder
T4 151-181 nucleotide denotes cyclic adenosine monophosphate
T5 267-283 other_name denotes bipolar disorder
T6 302-318 other_name denotes immunoreactivity
T7 363-392 protein_family_or_group denotes cAMP-dependent protein kinase
T8 394-410 protein_molecule denotes protein kinase A
T9 437-441 protein_molecule denotes Rap1
T10 446-455 cell_type denotes platelets
T11 516-532 other_name denotes bipolar disorder
T12 537-553 multi_cell denotes healthy subjects
T13 564-573 cell_type denotes Platelets
T14 598-616 other_name denotes drug-free patients
T15 622-638 other_name denotes bipolar disorder
T16 688-704 multi_cell denotes healthy subjects
T17 720-749 protein_family_or_group denotes cAMP-dependent protein kinase
T18 754-758 protein_molecule denotes Rap1
T19 819-844 other_name denotes computer-assisted imaging
T20 881-898 protein_subunit denotes catalytic subunit
T21 902-931 protein_family_or_group denotes cAMP-dependent protein kinase
T22 1029-1043 multi_cell denotes manic patients
T23 1049-1065 other_name denotes bipolar disorder
T24 1080-1107 multi_cell denotes untreated euthymic patients
T25 1113-1129 other_name denotes bipolar disorder
T26 1134-1150 multi_cell denotes healthy subjects
T27 1219-1238 protein_subunit denotes regulatory subunits
T28 1263-1292 protein_family_or_group denotes cAMP-dependent protein kinase
T29 1316-1320 protein_molecule denotes Rap1
T30 1416-1431 multi_cell denotes healthy persons
T31 1456-1460 protein_molecule denotes Rap1
T32 1469-1486 protein_subunit denotes catalytic subunit
T33 1490-1519 protein_family_or_group denotes cAMP-dependent protein kinase
T34 1539-1548 cell_type denotes platelets
T35 1552-1568 multi_cell denotes bipolar patients
T36 1643-1647 nucleotide denotes cAMP
T37 1681-1697 other_name denotes bipolar disorder

PubmedHPO

Id Subject Object Predicate Lexical cue
T4 516-532 HP_0007302 denotes bipolar disorder
T3 492-501 HP_0000716 denotes depressed
T2 481-486 HP_0100754 denotes manic
T1 267-283 HP_0007302 denotes bipolar disorder