PubMed:10077156 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	44-54	cell_type	denotes	neutrophil
T2	171-181	cell_type	denotes	neutrophil
T3	340-367	protein	denotes	tumor necrosis factor-alpha
T4	416-439	protein	denotes	glucocorticoid receptor
T5	552-566	protein	denotes	beta2 integrin
T6	574-584	cell_type	denotes	neutrophil
T7	628-638	cell_type	denotes	neutrophil
T8	693-703	cell_type	denotes	neutrophil
T9	859-869	cell_type	denotes	neutrophil
T10	974-988	protein	denotes	beta2 integrin
T11	996-1006	cell_type	denotes	neutrophil

Id	Subject	Object	Predicate	Lexical cue
C1	38-85	NP	denotes	human neutrophil-mediated tumor cell cytostasis
C2	171-212	NP	denotes	neutrophil-mediated tumor cell cytostasis
C3	247-266	NP	denotes	a synthetic hormone
C4	268-287	NP	denotes	dexamethasone (Dex)
C5	383-386	NP	denotes	Dex
C6	414-450	NP	denotes	a glucocorticoid receptor antagonist
C7	452-459	NP	denotes	RU38486
C9	522-525	NP	denotes	Dex
C10	552-566	NP	denotes	beta2 integrin
C11	570-592	NP	denotes	the neutrophil surface
C8	511-592	NP	denotes	effects of Dex on the binding avidity of beta2 integrin on the neutrophil surface
C12	601-606	NP	denotes	these
C13	662-665	NP	denotes	Dex
C14	720-727	NP	denotes	RU38486
C15	859-900	NP	denotes	neutrophil-mediated tumor cell cytostasis
C16	974-988	NP	denotes	beta2 integrin
C17	992-1014	NP	denotes	the neutrophil surface
R1	C2	C1	coref-ident	neutrophil-mediated tumor cell cytostasis,human neutrophil-mediated tumor cell cytostasis
R2	C4	C3	coref-appos	dexamethasone (Dex),a synthetic hormone
R3	C5	C3	coref-ident	Dex,a synthetic hormone
R4	C7	C6	coref-appos	RU38486,a glucocorticoid receptor antagonist
R5	C9	C5	coref-ident	Dex,Dex
R6	C12	C8	coref-pron	these,effects of Dex on the binding avidity of beta2 integrin on the neutrophil surface
R7	C13	C9	coref-ident	Dex,Dex
R8	C14	C6	coref-ident	RU38486,a glucocorticoid receptor antagonist
R9	C15	C2	coref-ident	neutrophil-mediated tumor cell cytostasis,neutrophil-mediated tumor cell cytostasis
R10	C16	C10	coref-ident	beta2 integrin,beta2 integrin
R11	C17	C11	coref-ident	the neutrophil surface,the neutrophil surface

Id	Subject	Object	Predicate	Lexical cue
S1	0-86	Sentence	denotes	Glucocorticoid hormone suppression of human neutrophil-mediated tumor cell cytostasis.
S2	87-368	Sentence	denotes	In the present study, we have investigated the effect of glucocorticoid hormones on neutrophil-mediated tumor cell cytostasis and found that hydrocortisone and a synthetic hormone, dexamethasone (Dex), inhibited cytostasis in the presence or absence of tumor necrosis factor-alpha.
S3	369-460	Sentence	denotes	The effect of Dex was completely reversed by a glucocorticoid receptor antagonist, RU38486.
S4	461-661	Sentence	denotes	To clarify the underlying mechanisms, we examined effects of Dex on the binding avidity of beta2 integrin on the neutrophil surface and how these might in turn affect neutrophil-to-tumor cell binding.
S5	662-779	Sentence	denotes	Dex was found to inhibit these neutrophil properties, and RU38486 completely suppressed both forms of Dex inhibition.
S6	780-1015	Sentence	denotes	Taken together, our findings suggest that glucocorticoid hormone inhibition of neutrophil-mediated tumor cell cytostasis is at least partially due to a lowering of the ligand binding avidity of beta2 integrin on the neutrophil surface.

Id	Subject	Object	Predicate	Lexical cue
T1	0-34	other_name	denotes	Glucocorticoid hormone suppression
T2	38-43	other_name	denotes	human
T3	44-54	cell_type	denotes	neutrophil
T4	144-167	lipid	denotes	glucocorticoid hormones
T5	171-181	cell_type	denotes	neutrophil
T6	228-242	lipid	denotes	hydrocortisone
T7	249-266	lipid	denotes	synthetic hormone
T8	268-281	lipid	denotes	dexamethasone
T9	283-286	lipid	denotes	Dex
T10	340-367	protein_molecule	denotes	tumor necrosis factor-alpha
T11	383-386	lipid	denotes	Dex
T12	416-439	protein_family_or_group	denotes	glucocorticoid receptor
T13	452-459	other_organic_compound	denotes	RU38486
T14	476-497	other_name	denotes	underlying mechanisms
T15	522-525	lipid	denotes	Dex
T16	552-566	protein_molecule	denotes	beta2 integrin
T17	574-584	cell_type	denotes	neutrophil
T18	616-627	other_name	denotes	turn affect
T19	628-638	cell_type	denotes	neutrophil
T20	662-665	lipid	denotes	Dex
T21	693-703	cell_type	denotes	neutrophil
T22	720-727	other_organic_compound	denotes	RU38486
T23	764-767	lipid	denotes	Dex
T24	822-855	other_name	denotes	glucocorticoid hormone inhibition
T25	859-869	cell_type	denotes	neutrophil
T26	948-970	other_name	denotes	ligand binding avidity
T27	974-988	protein_molecule	denotes	beta2 integrin
T28	996-1006	cell_type	denotes	neutrophil

Id	Subject	Object	Predicate	Lexical cue
T1	191-196	HP_0002664	denotes	tumor
T2	340-345	HP_0002664	denotes	tumor
T3	642-647	HP_0002664	denotes	tumor
T4	879-884	HP_0002664	denotes	tumor