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PubMed:10075738 JSONTXT

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Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1204-1215 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063

sentences

Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate.
T2 89-306 Sentence denotes Androgen receptor (AR) is a hormone-activated transcriptional factor that can bind to androgen response elements and that regulates the transcription of target genes via a mechanism that presumably involves cofactors.
T3 307-398 Sentence denotes We report here the cloning of a novel AR coactivator ARA55 using a yeast two-hybrid system.
T4 399-561 Sentence denotes ARA55 consists of 444 amino acids with the predicted molecular mass of 55 kDa and its sequence shows very high homology to mouse hic5, a TGF-beta1-inducible gene.
T5 562-695 Sentence denotes Yeast and mammalian two-hybrid systems and co-immunoprecipitation assays all prove ARA55 can bind to AR in a ligand-dependent manner.
T6 696-952 Sentence denotes Transient transfection assay in prostate cancer DU145 cells further demonstrates that ARA55 can enhance AR transcriptional activity in the presence of 1 nM dihydrotestosterone or its antagonists such as 100 nM 17beta-estradiol or 1 microM hydroxyflutamide.
T7 953-1072 Sentence denotes Our data also suggest the C-terminal half of ARA55, which includes three LIM motifs, is sufficient to interact with AR.
T8 1073-1216 Sentence denotes Northern blot and polymerase chain reaction quantitation showed ARA55 can be expressed differently in normal prostate and prostate tumor cells.
T9 1217-1364 Sentence denotes Together, our data suggests that ARA55 may play very important roles in the progression of prostate cancer by the modulation of AR transactivation.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 79-87 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate
T2 728-736 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate
T3 1182-1190 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate
T4 1195-1203 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate
T5 1308-1316 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate

relna

Id Subject Object Predicate Lexical cue
T1 32-49 DNA denotes androgen receptor
T2 63-68 Protein denotes ARA55
T3 89-106 DNA denotes Androgen receptor
T4 108-110 DNA denotes AR
T5 345-347 DNA denotes AR
T6 360-365 Protein denotes ARA55
T7 399-404 Protein denotes ARA55
T8 528-532 Protein denotes hic5
T9 536-545 Protein denotes TGF-beta1
T10 645-650 Protein denotes ARA55
T11 663-665 DNA denotes AR
T12 782-787 Protein denotes ARA55
T13 800-802 DNA denotes AR
T14 998-1003 Protein denotes ARA55
T15 1069-1071 DNA denotes AR
T16 1137-1142 Protein denotes ARA55
T17 1250-1255 Protein denotes ARA55
T18 1345-1347 DNA denotes AR
R0 T10 T11 linked ARA55,AR

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10075738-7#64#69#gene7041 1137-1142 gene7041 denotes ARA55
10075738-7#122#136#diseaseC0033578 1195-1209 diseaseC0033578 denotes prostate tumor
10075738-8#33#38#gene7041 1250-1255 gene7041 denotes ARA55
10075738-8#128#130#gene367 1345-1347 gene367 denotes AR
10075738-8#91#106#diseaseC0376358 1308-1323 diseaseC0376358 denotes prostate cancer
10075738-8#91#106#diseaseC0600139 1308-1323 diseaseC0600139 denotes prostate cancer
10075738-8#91#106#diseaseC0376358 1308-1323 diseaseC0376358 denotes prostate cancer
10075738-8#91#106#diseaseC0600139 1308-1323 diseaseC0600139 denotes prostate cancer
64#69#gene7041122#136#diseaseC0033578 10075738-7#64#69#gene7041 10075738-7#122#136#diseaseC0033578 associated_with ARA55,prostate tumor
33#38#gene704191#106#diseaseC0376358 10075738-8#33#38#gene7041 10075738-8#91#106#diseaseC0376358 associated_with ARA55,prostate cancer
33#38#gene704191#106#diseaseC0600139 10075738-8#33#38#gene7041 10075738-8#91#106#diseaseC0600139 associated_with ARA55,prostate cancer
33#38#gene704191#106#diseaseC0376358 10075738-8#33#38#gene7041 10075738-8#91#106#diseaseC0376358 associated_with ARA55,prostate cancer
33#38#gene704191#106#diseaseC0600139 10075738-8#33#38#gene7041 10075738-8#91#106#diseaseC0600139 associated_with ARA55,prostate cancer
128#130#gene36791#106#diseaseC0376358 10075738-8#128#130#gene367 10075738-8#91#106#diseaseC0376358 associated_with AR,prostate cancer
128#130#gene36791#106#diseaseC0600139 10075738-8#128#130#gene367 10075738-8#91#106#diseaseC0600139 associated_with AR,prostate cancer
128#130#gene36791#106#diseaseC0376358 10075738-8#128#130#gene367 10075738-8#91#106#diseaseC0376358 associated_with AR,prostate cancer
128#130#gene36791#106#diseaseC0600139 10075738-8#128#130#gene367 10075738-8#91#106#diseaseC0600139 associated_with AR,prostate cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T0 782-787 gene:7041 denotes ARA55
T1 728-743 disease:C0376358 denotes prostate cancer
T2 782-787 gene:7041 denotes ARA55
T3 728-743 disease:C0600139 denotes prostate cancer
T4 800-802 gene:367 denotes AR
T5 728-743 disease:C0376358 denotes prostate cancer
T6 800-802 gene:367 denotes AR
T7 728-743 disease:C0600139 denotes prostate cancer
R1 T0 T1 associated_with ARA55,prostate cancer
R2 T2 T3 associated_with ARA55,prostate cancer
R3 T4 T5 associated_with AR,prostate cancer
R4 T6 T7 associated_with AR,prostate cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 728-743 HP_0012125 denotes prostate cancer
T2 737-743 HP_0002664 denotes cancer
T3 1182-1209 HP_0012125 denotes prostate and prostate tumor
T4 1195-1209 HP_0012125 denotes prostate tumor
T5 1204-1209 HP_0002664 denotes tumor
T6 1308-1323 HP_0012125 denotes prostate cancer
T7 1317-1323 HP_0002664 denotes cancer

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 728-743 Disease denotes prostate cancer http://purl.obolibrary.org/obo/MONDO_0008315
T2 1195-1209 Disease denotes prostate tumor http://purl.obolibrary.org/obo/MONDO_0021259
T3 1308-1323 Disease denotes prostate cancer http://purl.obolibrary.org/obo/MONDO_0008315

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 728-743 Phenotype denotes prostate cancer HP:0012125
T2 1204-1209 Phenotype denotes tumor HP:0002664
T3 1308-1323 Phenotype denotes prostate cancer HP:0012125

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 73-78 OrganismTaxon denotes human 9606
T2 522-527 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 79-87 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T2 728-736 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T3 1182-1190 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T4 1195-1203 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T5 1308-1316 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 79-87 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T2 728-736 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T3 1182-1190 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T4 1195-1203 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T5 1308-1316 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078