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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 33-48 protein denotes adaptor protein
T2 49-54 protein denotes Cbl-b
T3 63-69 protein denotes kinase
T4 70-76 protein denotes zap-70
T5 106-113 cell_type denotes T cells
T6 133-166 protein denotes T-cell receptor (TCR)-CD3 complex
T7 213-223 protein denotes Src-family
T8 228-253 protein denotes Syk/Zap-70-family kinases
T9 269-286 protein denotes activated kinases
T10 331-362 protein denotes multiple intracellular proteins
T11 447-454 protein denotes kinases
T12 462-477 protein denotes adaptor protein
T13 518-521 protein denotes Cbl
T14 543-559 protein denotes upstream kinases
T15 568-571 protein denotes Syk
T16 576-582 protein denotes Zap-70
T17 592-597 protein denotes Cbl-b
T18 614-617 protein denotes Cbl
T19 675-694 cell_type denotes hematopoietic cells
T20 704-709 protein denotes Cbl-b
T21 775-778 protein denotes TCR
T22 823-828 protein denotes Cbl-b
T23 887-892 protein denotes Cbl-b
T24 896-903 cell_type denotes T cells
T25 947-1003 protein denotes transcription factor nuclear factor of activated T cells
T26 1005-1009 protein denotes NFAT
T27 1043-1048 protein denotes Cbl-b
T28 1083-1088 protein denotes Cbl-b
T29 1093-1099 protein denotes Zap-70
T30 1136-1141 protein denotes Cbl-b
T31 1165-1169 protein denotes NFAT
T32 1199-1202 protein denotes Cbl
T33 1257-1260 protein denotes Cbl
T34 1271-1276 protein denotes Cbl-b
T35 1364-1379 protein denotes upstream kinase
T36 1380-1386 protein denotes Zap-70

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 29-54 NP denotes the adaptor protein Cbl-b
C1 29-76 NP denotes the adaptor protein Cbl-b and the kinase zap-70
C3 106-113 NP denotes T cells
C4 213-261 NP denotes Src-family and Syk/Zap-70-family kinases [1] [2]
C5 263-286 NP denotes These activated kinases
C6 441-454 NP denotes these kinases
C7 518-521 NP denotes Cbl
C8 592-597 NP denotes Cbl-b
C10 614-617 NP denotes Cbl
C9 599-617 NP denotes a homologue of Cbl
C11 704-709 NP denotes Cbl-b
C12 823-828 NP denotes Cbl-b
C13 887-892 NP denotes Cbl-b
C14 896-903 NP denotes T cells
C15 943-1010 NP denotes the transcription factor nuclear factor of activated T cells (NFAT)
C16 1043-1048 NP denotes Cbl-b
C18 1083-1088 NP denotes Cbl-b
C17 1083-1099 NP denotes Cbl-b and Zap-70
C19 1165-1169 NP denotes NFAT
C20 1199-1202 NP denotes Cbl
C21 1257-1276 NP denotes Cbl homologue Cbl-b
R1 C5 C4 coref-ident These activated kinases,Src-family and Syk/Zap-70-family kinases [1] [2]
R2 C6 C5 coref-ident these kinases,These activated kinases
R3 C8 C2 coref-ident Cbl-b,the adaptor protein Cbl-b
R4 C10 C7 coref-ident Cbl,Cbl
R5 C9 C8 coref-appos a homologue of Cbl,Cbl-b
R6 C11 C8 coref-ident Cbl-b,Cbl-b
R7 C12 C11 coref-ident Cbl-b,Cbl-b
R8 C13 C12 coref-ident Cbl-b,Cbl-b
R9 C14 C3 coref-ident T cells,T cells
R10 C16 C13 coref-ident Cbl-b,Cbl-b
R11 C18 C16 coref-ident Cbl-b,Cbl-b
R12 C17 C1 coref-ident Cbl-b and Zap-70,the adaptor protein Cbl-b and the kinase zap-70
R13 C19 C15 coref-ident NFAT,the transcription factor nuclear factor of activated T cells (NFAT)
R14 C20 C18 coref-ident Cbl,Cbl-b
R15 C21 C20 coref-ident Cbl homologue Cbl-b,Cbl

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-114 Sentence denotes A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.
S2 115-262 Sentence denotes Engagement of the T-cell receptor (TCR)-CD3 complex induces a rapid increase in the activities of Src-family and Syk/Zap-70-family kinases [1] [2].
S3 263-404 Sentence denotes These activated kinases then induce the tyrosine phosphorylation of multiple intracellular proteins, eventually leading to T-cell activation.
S4 405-591 Sentence denotes One of the prominent substrates for these kinases is the adaptor protein Cbl [3] and recent studies suggest that Cbl negatively regulates upstream kinases such as Syk and Zap-70 [4] [5].
S5 592-703 Sentence denotes Cbl-b, a homologue of Cbl, is widely expressed in many tissues and cells including hematopoietic cells [6] [7].
S6 704-810 Sentence denotes Cbl-b undergoes rapid tyrosine phosphorylation upon stimulation of the TCR and cytokine receptors [8] [9].
S7 811-849 Sentence denotes The role of Cbl-b is unclear, however.
S8 850-1011 Sentence denotes Here, we show that overexpression of Cbl-b in T cells induced the constitutive activation of the transcription factor nuclear factor of activated T cells (NFAT).
S9 1012-1170 Sentence denotes A loss-of-function mutation in Cbl-b disrupted the interaction between Cbl-b and Zap-70 and nearly completely abrogated the Cbl-b-mediated activation of NFAT.
S10 1171-1387 Sentence denotes Unlike the proposed role of Cbl as a negative regulator, our results suggest that the Cbl homologue Cbl-b has a positive role in T-cell signaling, most likely via a direct interaction with the upstream kinase Zap-70.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 33-48 protein_family_or_group denotes adaptor protein
T2 49-54 protein_molecule denotes Cbl-b
T3 63-69 protein_family_or_group denotes kinase
T4 70-76 protein_molecule denotes zap-70
T5 106-113 cell_type denotes T cells
T6 133-148 protein_family_or_group denotes T-cell receptor
T7 150-153 protein_family_or_group denotes TCR
T8 213-223 protein_family_or_group denotes Src-family
T9 228-253 protein_family_or_group denotes Syk/Zap-70-family kinases
T10 269-286 protein_family_or_group denotes activated kinases
T11 303-311 amino_acid_monomer denotes tyrosine
T12 331-362 protein_family_or_group denotes multiple intracellular proteins
T13 386-403 other_name denotes T-cell activation
T14 447-454 protein_family_or_group denotes kinases
T15 462-477 protein_family_or_group denotes adaptor protein
T16 518-521 protein_molecule denotes Cbl
T17 543-559 protein_family_or_group denotes upstream kinases
T18 568-571 protein_molecule denotes Syk
T19 576-582 protein_molecule denotes Zap-70
T20 592-597 protein_molecule denotes Cbl-b
T21 614-617 protein_molecule denotes Cbl
T22 675-694 cell_type denotes hematopoietic cells
T23 704-709 protein_molecule denotes Cbl-b
T24 726-734 amino_acid_monomer denotes tyrosine
T25 775-778 protein_family_or_group denotes TCR
T26 823-828 protein_molecule denotes Cbl-b
T27 887-892 protein_molecule denotes Cbl-b
T28 896-903 cell_type denotes T cells
T29 947-1003 protein_family_or_group denotes transcription factor nuclear factor of activated T cells
T30 1005-1009 protein_family_or_group denotes NFAT
T31 1014-1039 other_name denotes loss-of-function mutation
T32 1043-1048 protein_molecule denotes Cbl-b
T33 1083-1088 protein_molecule denotes Cbl-b
T34 1093-1099 protein_molecule denotes Zap-70
T35 1136-1141 protein_molecule denotes Cbl-b
T36 1165-1169 protein_family_or_group denotes NFAT
T37 1199-1202 protein_molecule denotes Cbl
T38 1257-1260 protein_molecule denotes Cbl
T39 1271-1274 protein_molecule denotes Cbl
T40 1300-1316 other_name denotes T-cell signaling
T41 1364-1379 protein_family_or_group denotes upstream kinase
T42 1380-1386 protein_molecule denotes Zap-70