PubMed:10074428 JSONTXT

{"project":"FSU-PRGE","denotations":[{"id":"T1","span":{"begin":38,"end":66},"obj":"protein"},{"id":"T2","span":{"begin":111,"end":115},"obj":"protein"},{"id":"T3","span":{"begin":121,"end":191},"obj":"protein"},{"id":"T4","span":{"begin":329,"end":332},"obj":"protein"},{"id":"T5","span":{"begin":366,"end":377},"obj":"protein"},{"id":"T6","span":{"begin":379,"end":385},"obj":"protein"},{"id":"T7","span":{"begin":412,"end":417},"obj":"protein"},{"id":"T8","span":{"begin":489,"end":493},"obj":"protein"},{"id":"T9","span":{"begin":503,"end":508},"obj":"protein"},{"id":"T10","span":{"begin":527,"end":533},"obj":"protein"},{"id":"T11","span":{"begin":588,"end":591},"obj":"protein"},{"id":"T12","span":{"begin":600,"end":615},"obj":"protein"},{"id":"T13","span":{"begin":625,"end":630},"obj":"protein"},{"id":"T14","span":{"begin":701,"end":705},"obj":"protein"},{"id":"T15","span":{"begin":733,"end":739},"obj":"protein"},{"id":"T16","span":{"begin":789,"end":795},"obj":"protein"},{"id":"T17","span":{"begin":858,"end":863},"obj":"protein"},{"id":"T18","span":{"begin":1001,"end":1006},"obj":"protein"},{"id":"T19","span":{"begin":1038,"end":1044},"obj":"protein"},{"id":"T20","span":{"begin":1049,"end":1054},"obj":"protein"},{"id":"T21","span":{"begin":1135,"end":1144},"obj":"protein"},{"id":"T22","span":{"begin":1185,"end":1209},"obj":"protein"},{"id":"T23","span":{"begin":1211,"end":1216},"obj":"protein"},{"id":"T24","span":{"begin":1226,"end":1251},"obj":"protein"},{"id":"T25","span":{"begin":1253,"end":1256},"obj":"protein"},{"id":"T26","span":{"begin":1281,"end":1287},"obj":"protein"},{"id":"T27","span":{"begin":1292,"end":1297},"obj":"protein"},{"id":"T28","span":{"begin":1378,"end":1384},"obj":"protein"},{"id":"T29","span":{"begin":1389,"end":1394},"obj":"protein"}],"text":"Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.\nThe tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate diverse biological functions, including cell proliferation, differentiation, and survival [1] [2] [3]. We have identified a new TNF-related ligand, designated human GITR ligand (hGITRL), and its human receptor (hGITR), an ortholog of the recently discovered murine glucocorticoid-induced TNFR-related (mGITR) protein [4]. The hGITRL gene mapped to chromosome 1q23, near the gene for the TNF homolog Fas/CD95 ligand [5]. The hGITR gene mapped to chromosome 1p36, near a cluster of five genes encoding TNFR homologs [1] [6]. We found hGITRL mRNA in several peripheral tissues, and detected hGITRL protein on cultured vascular endothelial cells. The levels of hGITR mRNA in tissues were generally low; in peripheral blood T cells, however, antigen-receptor stimulation led to a substantial induction of hGITR transcripts. Cotransfection of hGITRL and hGITR in embryonic kidney 293 cells activated the anti-apoptotic transcription factor NF-kappaB, via a pathway that appeared to involve TNFR-associated factor 2 (TRAF2) [7] and NF-kappaB-inducing kinase (NIK) [8]. Cotransfection of hGITRL and hGITR in Jurkat T leukemia cells inhibited antigen-receptor-induced cell death. Thus, hGITRL and hGITR may modulate T lymphocyte survival in peripheral tissues."}

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":366,"end":377},"obj":"protein"},{"id":"T2","span":{"begin":379,"end":385},"obj":"protein"},{"id":"T3","span":{"begin":412,"end":417},"obj":"protein"},{"id":"T4","span":{"begin":466,"end":517},"obj":"protein"},{"id":"T5","span":{"begin":527,"end":533},"obj":"protein"},{"id":"T6","span":{"begin":600,"end":603},"obj":"protein"},{"id":"T7","span":{"begin":604,"end":615},"obj":"protein"},{"id":"T8","span":{"begin":625,"end":630},"obj":"protein"},{"id":"T9","span":{"begin":733,"end":739},"obj":"protein"},{"id":"T10","span":{"begin":789,"end":795},"obj":"protein"},{"id":"T11","span":{"begin":858,"end":863},"obj":"protein"},{"id":"T12","span":{"begin":1001,"end":1006},"obj":"protein"},{"id":"T13","span":{"begin":1038,"end":1044},"obj":"protein"},{"id":"T14","span":{"begin":1049,"end":1054},"obj":"protein"},{"id":"T15","span":{"begin":1135,"end":1144},"obj":"protein"},{"id":"T16","span":{"begin":1185,"end":1209},"obj":"protein"},{"id":"T17","span":{"begin":1211,"end":1216},"obj":"protein"},{"id":"T18","span":{"begin":1226,"end":1251},"obj":"protein"},{"id":"T19","span":{"begin":1253,"end":1256},"obj":"protein"},{"id":"T20","span":{"begin":1281,"end":1287},"obj":"protein"},{"id":"T21","span":{"begin":1292,"end":1297},"obj":"protein"},{"id":"T22","span":{"begin":1378,"end":1384},"obj":"protein"},{"id":"T23","span":{"begin":1389,"end":1394},"obj":"protein"}],"text":"Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.\nThe tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate diverse biological functions, including cell proliferation, differentiation, and survival [1] [2] [3]. We have identified a new TNF-related ligand, designated human GITR ligand (hGITRL), and its human receptor (hGITR), an ortholog of the recently discovered murine glucocorticoid-induced TNFR-related (mGITR) protein [4]. The hGITRL gene mapped to chromosome 1q23, near the gene for the TNF homolog Fas/CD95 ligand [5]. The hGITR gene mapped to chromosome 1p36, near a cluster of five genes encoding TNFR homologs [1] [6]. We found hGITRL mRNA in several peripheral tissues, and detected hGITRL protein on cultured vascular endothelial cells. The levels of hGITR mRNA in tissues were generally low; in peripheral blood T cells, however, antigen-receptor stimulation led to a substantial induction of hGITR transcripts. Cotransfection of hGITRL and hGITR in embryonic kidney 293 cells activated the anti-apoptotic transcription factor NF-kappaB, via a pathway that appeared to involve TNFR-associated factor 2 (TRAF2) [7] and NF-kappaB-inducing kinase (NIK) [8]. Cotransfection of hGITRL and hGITR in Jurkat T leukemia cells inhibited antigen-receptor-induced cell death. Thus, hGITRL and hGITR may modulate T lymphocyte survival in peripheral tissues."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":121,"end":126},"obj":"HP_0002664"},{"id":"T2","span":{"begin":1310,"end":1318},"obj":"HP_0001909"}],"text":"Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.\nThe tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate diverse biological functions, including cell proliferation, differentiation, and survival [1] [2] [3]. We have identified a new TNF-related ligand, designated human GITR ligand (hGITRL), and its human receptor (hGITR), an ortholog of the recently discovered murine glucocorticoid-induced TNFR-related (mGITR) protein [4]. The hGITRL gene mapped to chromosome 1q23, near the gene for the TNF homolog Fas/CD95 ligand [5]. The hGITR gene mapped to chromosome 1p36, near a cluster of five genes encoding TNFR homologs [1] [6]. We found hGITRL mRNA in several peripheral tissues, and detected hGITRL protein on cultured vascular endothelial cells. The levels of hGITR mRNA in tissues were generally low; in peripheral blood T cells, however, antigen-receptor stimulation led to a substantial induction of hGITR transcripts. Cotransfection of hGITRL and hGITR in embryonic kidney 293 cells activated the anti-apoptotic transcription factor NF-kappaB, via a pathway that appeared to involve TNFR-associated factor 2 (TRAF2) [7] and NF-kappaB-inducing kinase (NIK) [8]. Cotransfection of hGITRL and hGITR in Jurkat T leukemia cells inhibited antigen-receptor-induced cell death. Thus, hGITRL and hGITR may modulate T lymphocyte survival in peripheral tissues."}