PubMed:10070310 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/10070310","sourcedb":"PubMed","sourceid":"10070310","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10070310","text":"K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa.\nThe K-ras gene in codons 12 and 13 was investigated using allele-specific polymerase chain reaction in matched normal mucosa (n = 106), transitional mucosa (n = 69) and tumours (n = 149) from 149 patients with colorectal adenocarcinomas. K-ras mutations in codon 12 were detected in 41/149 (28%) of tumours and 4/69 (6%) of transitional mucosa samples, but not in the normal mucosa. Further, mutation rates were increased in younger patients (P = 0.001) and in mucinous carcinomas (50%) compared with well differentiated (17%), moderately differentiated (26%) or poorly differentiated (24%) tumours. Our findings indicate that mucinous carcinoma may represent a distinct genetic entity.","tracks":[{"project":"PennBioIE","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"protein"},{"id":"T2","span":{"begin":88,"end":93},"obj":"protein"},{"id":"T3","span":{"begin":102,"end":108},"obj":"protein"},{"id":"T4","span":{"begin":116,"end":118},"obj":"protein"},{"id":"T5","span":{"begin":158,"end":168},"obj":"protein"},{"id":"T6","span":{"begin":322,"end":327},"obj":"protein"},{"id":"T7","span":{"begin":328,"end":337},"obj":"protein"},{"id":"T8","span":{"begin":341,"end":349},"obj":"protein"},{"id":"T9","span":{"begin":476,"end":484},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"PennBioIE"},{"subj":"T2","pred":"source","obj":"PennBioIE"},{"subj":"T3","pred":"source","obj":"PennBioIE"},{"subj":"T4","pred":"source","obj":"PennBioIE"},{"subj":"T5","pred":"source","obj":"PennBioIE"},{"subj":"T6","pred":"source","obj":"PennBioIE"},{"subj":"T7","pred":"source","obj":"PennBioIE"},{"subj":"T8","pred":"source","obj":"PennBioIE"},{"subj":"T9","pred":"source","obj":"PennBioIE"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":253,"end":260},"obj":"HP_0002664"},{"id":"T2","span":{"begin":383,"end":390},"obj":"HP_0002664"},{"id":"T3","span":{"begin":675,"end":682},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PennBioIE","color":"#93ece0","default":true},{"id":"PubmedHPO","color":"#ecc693"}]}]}}