PubMed:10069428 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10069428","sourcedb":"PubMed","sourceid":"10069428","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10069428","text":"Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element P0 in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients.\nAllergen-specific T cells in atopic patients are polarized IL-4-producing Th2 cells, promoting IgE synthesis by B cells. The molecular basis for increased IL-4 gene expression in atopy is not fully understood. IL-4 gene regulation in general involves the nuclear factor of activated T cells (NFAT) family of transcription factors, of which NFAT1 and NFAT2 are most prominent in peripheral T cells. Recently, a unique inhibitory role of NFAT1 in IL-4 gene control was shown in the mouse. In a series of electrophoretic mobility shift assays with protein extracts of highly polarized Th2 clones from atopics and Th1 clones from controls we compared DNA-binding activities at the two NFAT-binding elements P0 and P1 of the crucial proximal human IL-4 promoter. At the most proximal P0 site, NFAT-containing complexes devoid of NFAT2 were readily inducible in the Th1 clones, but hardly or not in the Th2 clones. In contrast, both in Th1 and Th2 clones NFAT-containing complexes were strongly inducible at the P1 site, consisting of NFAT2 and a P0-compatible NFAT activity, without apparent differences between Th1 and Th2 clones. Like in Th2 clones, suppressed NFAT-P0 complex formation was observed also at the polyclonal level in peripheral blood mononuclear cells (PBMC) of three of five severe atopic dermatitis patients with strongly elevated serum IgE levels, but not in control PBMC. These findings suggest that high-level IL-4 production in atopic Th2 cells is associated with selective reduction of suppressive NFAT1 activity at the IL-4 P0 element and that some patients with this multifactorial disease may have a putative systemic disorder at this level.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":36,"end":66},"obj":"NP"},{"id":"C3","span":{"begin":70,"end":73},"obj":"NP"},{"id":"C2","span":{"begin":70,"end":122},"obj":"NP"},{"id":"C4","span":{"begin":186,"end":201},"obj":"NP"},{"id":"C5","span":{"begin":232,"end":247},"obj":"NP"},{"id":"C6","span":{"begin":382,"end":387},"obj":"NP"},{"id":"C7","span":{"begin":454,"end":532},"obj":"NP"},{"id":"C8","span":{"begin":537,"end":542},"obj":"NP"},{"id":"C9","span":{"begin":543,"end":548},"obj":"NP"},{"id":"C10","span":{"begin":553,"end":558},"obj":"NP"},{"id":"C11","span":{"begin":639,"end":644},"obj":"NP"},{"id":"C12","span":{"begin":801,"end":808},"obj":"NP"},{"id":"C13","span":{"begin":1027,"end":1032},"obj":"NP"},{"id":"C14","span":{"begin":1096,"end":1110},"obj":"NP"},{"id":"C15","span":{"begin":1133,"end":1151},"obj":"NP"},{"id":"C16","span":{"begin":1232,"end":1237},"obj":"NP"},{"id":"C17","span":{"begin":1310,"end":1328},"obj":"NP"},{"id":"C18","span":{"begin":1338,"end":1348},"obj":"NP"},{"id":"C19","span":{"begin":1738,"end":1757},"obj":"NP"},{"id":"C20","span":{"begin":1786,"end":1813},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-pron","subj":"C3","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C5","obj":"C4"},{"id":"R3","pred":"coref-relat","subj":"C8","obj":"C7"},{"id":"R4","pred":"coref-ident","subj":"C9","obj":"C1"},{"id":"R5","pred":"coref-ident","subj":"C11","obj":"C9"},{"id":"R6","pred":"coref-ident","subj":"C12","obj":"C5"},{"id":"R7","pred":"coref-ident","subj":"C13","obj":"C10"},{"id":"R8","pred":"coref-ident","subj":"C16","obj":"C13"},{"id":"R9","pred":"coref-ident","subj":"C17","obj":"C15"},{"id":"R10","pred":"coref-ident","subj":"C18","obj":"C14"},{"id":"R11","pred":"coref-ident","subj":"C19","obj":"C2"},{"id":"R12","pred":"coref-ident","subj":"C20","obj":"C6"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"}]},{"project":"metamap-sample","denotations":[{"id":"T1","span":{"begin":593,"end":600},"obj":"C0039194"},{"id":"T2","span":{"begin":222,"end":229},"obj":"C0039194"},{"id":"T3","span":{"begin":176,"end":183},"obj":"C0039194"},{"id":"T4","span":{"begin":1743,"end":1745},"obj":"C0021764"},{"id":"T5","span":{"begin":947,"end":949},"obj":"C0021764"},{"id":"T6","span":{"begin":263,"end":265},"obj":"C0021764"},{"id":"T7","span":{"begin":110,"end":112},"obj":"C0021764"},{"id":"T8","span":{"begin":512,"end":524},"obj":"C0040649"},{"id":"T9","span":{"begin":159,"end":172},"obj":"C0040649"},{"id":"T10","span":{"begin":41,"end":61},"obj":"C0040648"},{"id":"T11","span":{"begin":1773,"end":1781},"obj":"C0030705"},{"id":"T12","span":{"begin":1517,"end":1525},"obj":"C0030705"},{"id":"T13","span":{"begin":240,"end":248},"obj":"C0030705"},{"id":"T14","span":{"begin":194,"end":202},"obj":"C0030705"},{"id":"T15","span":{"begin":1751,"end":1758},"obj":"C0013879"},{"id":"T16","span":{"begin":898,"end":906},"obj":"C0013879"},{"id":"T17","span":{"begin":92,"end":99},"obj":"C0013879"},{"id":"T18","span":{"begin":1351,"end":1361},"obj":"C1260953"},{"id":"T19","span":{"begin":14,"end":24},"obj":"C1260953"},{"id":"T20","span":{"begin":1670,"end":1684},"obj":"C0332281"},{"id":"T21","span":{"begin":124,"end":139},"obj":"C0332281"},{"id":"T22","span":{"begin":140,"end":148},"obj":"C2349975"},{"id":"T23","span":{"begin":1721,"end":1726},"obj":"C1417695"},{"id":"T24","span":{"begin":640,"end":645},"obj":"C1417695"},{"id":"T25","span":{"begin":544,"end":549},"obj":"C1417695"},{"id":"T26","span":{"begin":62,"end":67},"obj":"C1417695"},{"id":"T27","span":{"begin":1650,"end":1656},"obj":"C0392707"},{"id":"T28","span":{"begin":802,"end":809},"obj":"C0392707"},{"id":"T29","span":{"begin":383,"end":388},"obj":"C0392707"},{"id":"T30","span":{"begin":233,"end":239},"obj":"C0392707"},{"id":"T31","span":{"begin":187,"end":193},"obj":"C0392707"},{"id":"T32","span":{"begin":649,"end":658},"obj":"C1708435"},{"id":"T33","span":{"begin":414,"end":423},"obj":"C1708435"},{"id":"T34","span":{"begin":952,"end":960},"obj":"C0086860"},{"id":"T35","span":{"begin":115,"end":123},"obj":"C0086860"},{"id":"T36","span":{"begin":1748,"end":1750},"obj":"C1419691"},{"id":"T37","span":{"begin":1367,"end":1368},"obj":"C1419691"},{"id":"T38","span":{"begin":1245,"end":1247},"obj":"C1419691"},{"id":"T39","span":{"begin":983,"end":985},"obj":"C1419691"},{"id":"T40","span":{"begin":907,"end":909},"obj":"C1419691"},{"id":"T41","span":{"begin":100,"end":102},"obj":"C1419691"},{"id":"T42","span":{"begin":1264,"end":1272},"obj":"C0441655"},{"id":"T43","span":{"begin":863,"end":873},"obj":"C0441655"},{"id":"T44","span":{"begin":25,"end":33},"obj":"C0441655"},{"id":"T45","span":{"begin":84,"end":91},"obj":"C1167622"},{"id":"T46","span":{"begin":932,"end":940},"obj":"C0205107"},{"id":"T47","span":{"begin":75,"end":83},"obj":"C0205107"},{"id":"T48","span":{"begin":1343,"end":1349},"obj":"C0009013"},{"id":"T49","span":{"begin":1146,"end":1152},"obj":"C0009013"},{"id":"T50","span":{"begin":1323,"end":1329},"obj":"C0009013"},{"id":"T51","span":{"begin":1657,"end":1666},"obj":"C0242633"},{"id":"T52","span":{"begin":684,"end":689},"obj":"C0026809"},{"id":"T53","span":{"begin":941,"end":946},"obj":"C0086418"},{"id":"T54","span":{"begin":1193,"end":1202},"obj":"C0669372"},{"id":"T55","span":{"begin":1047,"end":1056},"obj":"C0669372"},{"id":"T56","span":{"begin":1362,"end":1366},"obj":"C0288011"},{"id":"T57","span":{"begin":992,"end":996},"obj":"C0288011"},{"id":"T58","span":{"begin":885,"end":889},"obj":"C0288011"},{"id":"T59","span":{"begin":459,"end":494},"obj":"C0288011"},{"id":"T60","span":{"begin":1064,"end":1066},"obj":"C1423842"},{"id":"T61","span":{"begin":814,"end":817},"obj":"C1423842"},{"id":"T62","span":{"begin":1424,"end":1429},"obj":"C0441889"},{"id":"T63","span":{"begin":1559,"end":1565},"obj":"C0441889"},{"id":"T64","span":{"begin":402,"end":412},"obj":"C0162340"},{"id":"T65","span":{"begin":706,"end":743},"obj":"C0949632"},{"id":"T66","span":{"begin":621,"end":631},"obj":"C3463820"},{"id":"T67","span":{"begin":1233,"end":1238},"obj":"C1417694"},{"id":"T68","span":{"begin":1028,"end":1033},"obj":"C1417694"},{"id":"T69","span":{"begin":554,"end":559},"obj":"C1417694"},{"id":"T70","span":{"begin":1571,"end":1574},"obj":"C1518422"},{"id":"T71","span":{"begin":1090,"end":1093},"obj":"C1518422"},{"id":"T72","span":{"begin":392,"end":395},"obj":"C1518422"},{"id":"T73","span":{"begin":1578,"end":1585},"obj":"C1882979"},{"id":"T74","span":{"begin":830,"end":838},"obj":"C1882979"},{"id":"T75","span":{"begin":659,"end":666},"obj":"C1882979"},{"id":"T76","span":{"begin":1370,"end":1377},"obj":"C1704241"},{"id":"T77","span":{"begin":1169,"end":1178},"obj":"C1704241"},{"id":"T78","span":{"begin":1008,"end":1017},"obj":"C1704241"},{"id":"T79","span":{"begin":1807,"end":1814},"obj":"C0012634"},{"id":"T80","span":{"begin":204,"end":212},"obj":"C0002092"},{"id":"T81","span":{"begin":502,"end":508},"obj":"C0015576"},{"id":"T82","span":{"begin":749,"end":756},"obj":"C0033684"},{"id":"T83","span":{"begin":1586,"end":1590},"obj":"C1321301"},{"id":"T84","span":{"begin":969,"end":973},"obj":"C0205393"},{"id":"T85","span":{"begin":564,"end":568},"obj":"C0205393"},{"id":"T86","span":{"begin":1158,"end":1168},"obj":"C2700400"},{"id":"T87","span":{"begin":997,"end":1007},"obj":"C2700400"},{"id":"T88","span":{"begin":1378,"end":1387},"obj":"C0220781"},{"id":"T89","span":{"begin":842,"end":850},"obj":"C1707455"},{"id":"T90","span":{"begin":1116,"end":1124},"obj":"C1979874"},{"id":"T91","span":{"begin":1392,"end":1400},"obj":"C1441672"},{"id":"T92","span":{"begin":1598,"end":1605},"obj":"C2926606"},{"id":"T93","span":{"begin":289,"end":298},"obj":"C0033414"},{"id":"T94","span":{"begin":602,"end":610},"obj":"C0332185"},{"id":"T95","span":{"begin":696,"end":702},"obj":"C2348044"},{"id":"T96","span":{"begin":1478,"end":1483},"obj":"C0205449"},{"id":"T97","span":{"begin":1607,"end":1614},"obj":"C1705535"},{"id":"T98","span":{"begin":1540,"end":1558},"obj":"C1839165"},{"id":"T99","span":{"begin":1291,"end":1302},"obj":"C1705242"},{"id":"T100","span":{"begin":1126,"end":1130},"obj":"C0238767"},{"id":"T101","span":{"begin":881,"end":884},"obj":"C0205448"},{"id":"T102","span":{"begin":1631,"end":1646},"obj":"C1819457"},{"id":"T103","span":{"begin":329,"end":344},"obj":"C1853126"},{"id":"T104","span":{"begin":757,"end":764},"obj":"C2828366"},{"id":"T105","span":{"begin":769,"end":775},"obj":"C0205250"},{"id":"T106","span":{"begin":1219,"end":1229},"obj":"C0332529"},{"id":"T107","span":{"begin":632,"end":636},"obj":"C1705810"},{"id":"T108","span":{"begin":569,"end":578},"obj":"C0205402"},{"id":"T109","span":{"begin":424,"end":434},"obj":"C1327622"},{"id":"T110","span":{"begin":1709,"end":1720},"obj":"C0205367"},{"id":"T111","span":{"begin":671,"end":676},"obj":"C1547282"},{"id":"T112","span":{"begin":851,"end":862},"obj":"C1148673"},{"id":"T113","span":{"begin":1492,"end":1516},"obj":"C1861874"},{"id":"T114","span":{"begin":1282,"end":1289},"obj":"C0750489"},{"id":"T115","span":{"begin":1487,"end":1491},"obj":"C0205451"},{"id":"T116","span":{"begin":438,"end":444},"obj":"C1553889"},{"id":"T117","span":{"begin":1792,"end":1806},"obj":"C1837655"},{"id":"T118","span":{"begin":582,"end":592},"obj":"C0205100"},{"id":"T119","span":{"begin":1213,"end":1217},"obj":"C0205145"},{"id":"T120","span":{"begin":1768,"end":1772},"obj":"C0205392"},{"id":"T121","span":{"begin":614,"end":620},"obj":"C1710548"},{"id":"T122","span":{"begin":213,"end":221},"obj":"C0205369"},{"id":"T123","span":{"begin":369,"end":379},"obj":"C0185117"},{"id":"T124","span":{"begin":349,"end":358},"obj":"C0205217"},{"id":"T125","span":{"begin":1620,"end":1624},"obj":"C1299351"},{"id":"T126","span":{"begin":1248,"end":1258},"obj":"C1524057"}],"attributes":[{"subj":"T1","pred":"source","obj":"metamap-sample"},{"subj":"T2","pred":"source","obj":"metamap-sample"},{"subj":"T3","pred":"source","obj":"metamap-sample"},{"subj":"T4","pred":"source","obj":"metamap-sample"},{"subj":"T5","pred":"source","obj":"metamap-sample"},{"subj":"T6","pred":"source","obj":"metamap-sample"},{"subj":"T7","pred":"source","obj":"metamap-sample"},{"subj":"T8","pred":"source","obj":"metamap-sample"},{"subj":"T9","pred":"source","obj":"metamap-sample"},{"subj":"T10","pred":"source","obj":"metamap-sample"},{"subj":"T11","pred":"source","obj":"metamap-sample"},{"subj":"T12","pred":"source","obj":"metamap-sample"},{"subj":"T13","pred":"source","obj":"metamap-sample"},{"subj":"T14","pred":"source","obj":"metamap-sample"},{"subj":"T15","pred":"source","obj":"metamap-sample"},{"subj":"T16","pred":"source","obj":"metamap-sample"},{"subj":"T17","pred":"source","obj":"metamap-sample"},{"subj":"T18","pred":"source","obj":"metamap-sample"},{"subj":"T19","pred":"source","obj":"metamap-sample"},{"subj":"T20","pred":"source","obj":"metamap-sample"},{"subj":"T21","pred":"source","obj":"metamap-sample"},{"subj":"T22","pred":"source","obj":"metamap-sample"},{"subj":"T23","pred":"source","obj":"metamap-sample"},{"subj":"T24","pred":"source","obj":"metamap-sample"},{"subj":"T25","pred":"source","obj":"metamap-sample"},{"subj":"T26","pred":"source","obj":"metamap-sample"},{"subj":"T27","pred":"source","obj":"metamap-sample"},{"subj":"T28","pred":"source","obj":"metamap-sample"},{"subj":"T29","pred":"source","obj":"metamap-sample"},{"subj":"T30","pred":"source","obj":"metamap-sample"},{"subj":"T31","pred":"source","obj":"metamap-sample"},{"subj":"T32","pred":"source","obj":"metamap-sample"},{"subj":"T33","pred":"source","obj":"metamap-sample"},{"subj":"T34","pred":"source","obj":"metamap-sample"},{"subj":"T35","pred":"source","obj":"metamap-sample"},{"subj":"T36","pred":"source","obj":"metamap-sample"},{"subj":"T37","pred":"source","obj":"metamap-sample"},{"subj":"T38","pred":"source","obj":"metamap-sample"},{"subj":"T39","pred":"source","obj":"metamap-sample"},{"subj":"T40","pred":"source","obj":"metamap-sample"},{"subj":"T41","pred":"source","obj":"metamap-sample"},{"subj":"T42","pred":"source","obj":"metamap-sample"},{"subj":"T43","pred":"source","obj":"metamap-sample"},{"subj":"T44","pred":"source","obj":"metamap-sample"},{"subj":"T45","pred":"source","obj":"metamap-sample"},{"subj":"T46","pred":"source","obj":"metamap-sample"},{"subj":"T47","pred":"source","obj":"metamap-sample"},{"subj":"T48","pred":"source","obj":"metamap-sample"},{"subj":"T49","pred":"source","obj":"metamap-sample"},{"subj":"T50","pred":"source","obj":"metamap-sample"},{"subj":"T51","pred":"source","obj":"metamap-sample"},{"subj":"T52","pred":"source","obj":"metamap-sample"},{"subj":"T53","pred":"source","obj":"metamap-sample"},{"subj":"T54","pred":"source","obj":"metamap-sample"},{"subj":"T55","pred":"source","obj":"metamap-sample"},{"subj":"T56","pred":"source","obj":"metamap-sample"},{"subj":"T57","pred":"source","obj":"metamap-sample"},{"subj":"T58","pred":"source","obj":"metamap-sample"},{"subj":"T59","pred":"source","obj":"metamap-sample"},{"subj":"T60","pred":"source","obj":"metamap-sample"},{"subj":"T61","pred":"source","obj":"metamap-sample"},{"subj":"T62","pred":"source","obj":"metamap-sample"},{"subj":"T63","pred":"source","obj":"metamap-sample"},{"subj":"T64","pred":"source","obj":"metamap-sample"},{"subj":"T65","pred":"source","obj":"metamap-sample"},{"subj":"T66","pred":"source","obj":"metamap-sample"},{"subj":"T67","pred":"source","obj":"metamap-sample"},{"subj":"T68","pred":"source","obj":"metamap-sample"},{"subj":"T69","pred":"source","obj":"metamap-sample"},{"subj":"T70","pred":"source","obj":"metamap-sample"},{"subj":"T71","pred":"source","obj":"metamap-sample"},{"subj":"T72","pred":"source","obj":"metamap-sample"},{"subj":"T73","pred":"source","obj":"metamap-sample"},{"subj":"T74","pred":"source","obj":"metamap-sample"},{"subj":"T75","pred":"source","obj":"metamap-sample"},{"subj":"T76","pred":"source","obj":"metamap-sample"},{"subj":"T77","pred":"source","obj":"metamap-sample"},{"subj":"T78","pred":"source","obj":"metamap-sample"},{"subj":"T79","pred":"source","obj":"metamap-sample"},{"subj":"T80","pred":"source","obj":"metamap-sample"},{"subj":"T81","pred":"source","obj":"metamap-sample"},{"subj":"T82","pred":"source","obj":"metamap-sample"},{"subj":"T83","pred":"source","obj":"metamap-sample"},{"subj":"T84","pred":"source","obj":"metamap-sample"},{"subj":"T85","pred":"source","obj":"metamap-sample"},{"subj":"T86","pred":"source","obj":"metamap-sample"},{"subj":"T87","pred":"source","obj":"metamap-sample"},{"subj":"T88","pred":"source","obj":"metamap-sample"},{"subj":"T89","pred":"source","obj":"metamap-sample"},{"subj":"T90","pred":"source","obj":"metamap-sample"},{"subj":"T91","pred":"source","obj":"metamap-sample"},{"subj":"T92","pred":"source","obj":"metamap-sample"},{"subj":"T93","pred":"source","obj":"metamap-sample"},{"subj":"T94","pred":"source","obj":"metamap-sample"},{"subj":"T95","pred":"source","obj":"metamap-sample"},{"subj":"T96","pred":"source","obj":"metamap-sample"},{"subj":"T97","pred":"source","obj":"metamap-sample"},{"subj":"T98","pred":"source","obj":"metamap-sample"},{"subj":"T99","pred":"source","obj":"metamap-sample"},{"subj":"T100","pred":"source","obj":"metamap-sample"},{"subj":"T101","pred":"source","obj":"metamap-sample"},{"subj":"T102","pred":"source","obj":"metamap-sample"},{"subj":"T103","pred":"source","obj":"metamap-sample"},{"subj":"T104","pred":"source","obj":"metamap-sample"},{"subj":"T105","pred":"source","obj":"metamap-sample"},{"subj":"T106","pred":"source","obj":"metamap-sample"},{"subj":"T107","pred":"source","obj":"metamap-sample"},{"subj":"T108","pred":"source","obj":"metamap-sample"},{"subj":"T109","pred":"source","obj":"metamap-sample"},{"subj":"T110","pred":"source","obj":"metamap-sample"},{"subj":"T111","pred":"source","obj":"metamap-sample"},{"subj":"T112","pred":"source","obj":"metamap-sample"},{"subj":"T113","pred":"source","obj":"metamap-sample"},{"subj":"T114","pred":"source","obj":"metamap-sample"},{"subj":"T115","pred":"source","obj":"metamap-sample"},{"subj":"T116","pred":"source","obj":"metamap-sample"},{"subj":"T117","pred":"source","obj":"metamap-sample"},{"subj":"T118","pred":"source","obj":"metamap-sample"},{"subj":"T119","pred":"source","obj":"metamap-sample"},{"subj":"T120","pred":"source","obj":"metamap-sample"},{"subj":"T121","pred":"source","obj":"metamap-sample"},{"subj":"T122","pred":"source","obj":"metamap-sample"},{"subj":"T123","pred":"source","obj":"metamap-sample"},{"subj":"T124","pred":"source","obj":"metamap-sample"},{"subj":"T125","pred":"source","obj":"metamap-sample"},{"subj":"T126","pred":"source","obj":"metamap-sample"}]},{"project":"semrep-sample","denotations":[{"id":"E1-ti-1","span":{"begin":13,"end":23},"obj":"cui:C1260953"},{"id":"E2-ti-1","span":{"begin":24,"end":32},"obj":"cui:C0439167"},{"id":"E3-ti-1","span":{"begin":40,"end":60},"obj":"cui:C0040648"},{"id":"E4-ti-1","span":{"begin":61,"end":66},"obj":"entrez:4773"},{"id":"E5-ti-1","span":{"begin":74,"end":82},"obj":"cui:C0205107"},{"id":"E6-ti-1","span":{"begin":91,"end":98},"obj":"cui:C0013879"},{"id":"E7-ti-1","span":{"begin":109,"end":113},"obj":"cui:C0021758"},{"id":"E8-ti-1","span":{"begin":148,"end":157},"obj":"cui:C1334119"},{"id":"E9-ti-1","span":{"begin":158,"end":171},"obj":"cui:C0040649"},{"id":"E10-ti-1","span":{"begin":175,"end":182},"obj":"cui:C0039194"},{"id":"E11-ti-1","span":{"begin":186,"end":192},"obj":"cui:C0857523"},{"id":"E12-ti-1","span":{"begin":193,"end":201},"obj":"cui:C0030705"},{"id":"T1","span":{"begin":102,"end":104},"obj":"COEXISTS_WITH"},{"id":"T2","span":{"begin":123,"end":133},"obj":"COEXISTS_WITH"},{"id":"T3","span":{"begin":172,"end":174},"obj":"LOCATION_OF"},{"id":"T4","span":{"begin":186,"end":201},"obj":"PROCESS_OF"},{"id":"T5","span":{"begin":183,"end":185},"obj":"PART_OF"},{"id":"E1-ab-1","span":{"begin":203,"end":211},"obj":"cui:C0002092"},{"id":"E2-ab-1","span":{"begin":221,"end":228},"obj":"cui:C0039194"},{"id":"E3-ab-1","span":{"begin":232,"end":238},"obj":"cui:C0857523"},{"id":"E4-ab-1","span":{"begin":239,"end":247},"obj":"cui:C0030705"},{"id":"E5-ab-1","span":{"begin":262,"end":266},"obj":"cui:C0021758"},{"id":"E6-ab-1","span":{"begin":277,"end":286},"obj":"cui:C0242633"},{"id":"E7-ab-1","span":{"begin":298,"end":301},"obj":"entrez:3497"},{"id":"E8-ab-1","span":{"begin":302,"end":311},"obj":"cui:C0869032"},{"id":"E9-ab-1","span":{"begin":315,"end":322},"obj":"cui:C0004561"},{"id":"T6","span":{"begin":232,"end":247},"obj":"PROCESS_OF"},{"id":"E1-ab-2","span":{"begin":328,"end":337},"obj":"cui:C1521991"},{"id":"E2-ab-2","span":{"begin":338,"end":343},"obj":"cui:C1527178"},{"id":"E3-ab-2","span":{"begin":348,"end":357},"obj":"cui:C0205217"},{"id":"E4-ab-2","span":{"begin":358,"end":367},"obj":"cui:C1334119"},{"id":"E5-ab-2","span":{"begin":368,"end":378},"obj":"cui:C0185117"},{"id":"E6-ab-2","span":{"begin":382,"end":387},"obj":"cui:C0392707"},{"id":"E7-ab-2","span":{"begin":391,"end":394},"obj":"cui:C1518422"},{"id":"T7","span":{"begin":379,"end":381},"obj":"ASSOCIATED_WITH"},{"id":"E1-ab-3","span":{"begin":413,"end":422},"obj":"cui:C1334119"},{"id":"E2-ab-3","span":{"begin":423,"end":433},"obj":"cui:C0851285"},{"id":"E3-ab-3","span":{"begin":437,"end":444},"obj":"cui:C0205246"},{"id":"E4-ab-3","span":{"begin":458,"end":493},"obj":"cui:C0288011"},{"id":"E5-ab-3","span":{"begin":501,"end":507},"obj":"cui:C0015576"},{"id":"E6-ab-3","span":{"begin":511,"end":532},"obj":"cui:C0040648"},{"id":"E7-ab-3","span":{"begin":543,"end":548},"obj":"entrez:4773"},{"id":"E8-ab-3","span":{"begin":563,"end":567},"obj":"cui:C0205393"},{"id":"E9-ab-3","span":{"begin":568,"end":577},"obj":"cui:C0205402"},{"id":"E10-ab-3","span":{"begin":581,"end":591},"obj":"cui:C0205100"},{"id":"E11-ab-3","span":{"begin":592,"end":599},"obj":"cui:C0039194"},{"id":"T8","span":{"begin":578,"end":580},"obj":"LOCATION_OF"},{"id":"E1-ab-4","span":{"begin":601,"end":609},"obj":"cui:C0332185"},{"id":"E2-ab-4","span":{"begin":620,"end":630},"obj":"cui:C0243077"},{"id":"E3-ab-4","span":{"begin":631,"end":635},"obj":"cui:C0035820"},{"id":"E4-ab-4","span":{"begin":639,"end":644},"obj":"entrez:4773"},{"id":"E5-ab-4","span":{"begin":648,"end":657},"obj":"cui:C1334119"},{"id":"E6-ab-4","span":{"begin":658,"end":665},"obj":"cui:C0243148"},{"id":"E7-ab-4","span":{"begin":683,"end":688},"obj":"cui:C0025914"},{"id":"T9","span":{"begin":658,"end":665},"obj":"INTERACTS_WITH"},{"id":"E1-ab-5","span":{"begin":695,"end":701},"obj":"cui:C0205549"},{"id":"E2-ab-5","span":{"begin":705,"end":742},"obj":"cui:C0949632"},{"id":"E3-ab-5","span":{"begin":748,"end":755},"obj":"cui:C0033684"},{"id":"E4-ab-5","span":{"begin":801,"end":808},"obj":"cui:C0857523"},{"id":"E5-ab-5","span":{"begin":813,"end":816},"obj":"entrez:51497"},{"id":"E6-ab-5","span":{"begin":829,"end":837},"obj":"cui:C0243148"},{"id":"E7-ab-5","span":{"begin":850,"end":861},"obj":"cui:C1148673"},{"id":"E8-ab-5","span":{"begin":862,"end":872},"obj":"cui:C0441655"},{"id":"E9-ab-5","span":{"begin":880,"end":883},"obj":"cui:C0205448"},{"id":"E10-ab-5","span":{"begin":884,"end":888},"obj":"cui:C0288011"},{"id":"E11-ab-5","span":{"begin":897,"end":905},"obj":"cui:C0013879"},{"id":"E12-ab-5","span":{"begin":931,"end":939},"obj":"cui:C0205107"},{"id":"E13-ab-5","span":{"begin":940,"end":945},"obj":"cui:C0020114"},{"id":"E14-ab-5","span":{"begin":946,"end":950},"obj":"cui:C0021758"},{"id":"T10","span":{"begin":940,"end":950},"obj":"PART_OF"},{"id":"E1-ab-6","span":{"begin":968,"end":972},"obj":"cui:C0205393"},{"id":"E2-ab-6","span":{"begin":973,"end":989},"obj":"cui:C0449638"},{"id":"E3-ab-6","span":{"begin":991,"end":995},"obj":"cui:C0288011"},{"id":"E4-ab-6","span":{"begin":996,"end":1006},"obj":"cui:C0332256"},{"id":"E5-ab-6","span":{"begin":1007,"end":1016},"obj":"cui:C0439855"},{"id":"E6-ab-6","span":{"begin":1063,"end":1066},"obj":"entrez:51497"},{"id":"E7-ab-6","span":{"begin":1067,"end":1073},"obj":"cui:C0009013"},{"id":"E8-ab-6","span":{"begin":1089,"end":1092},"obj":"cui:C1518422"},{"id":"E9-ab-6","span":{"begin":1104,"end":1110},"obj":"cui:C0009013"},{"id":"E1-ab-7","span":{"begin":1133,"end":1136},"obj":"entrez:51497"},{"id":"E2-ab-7","span":{"begin":1152,"end":1156},"obj":"cui:C0288011"},{"id":"E3-ab-7","span":{"begin":1157,"end":1167},"obj":"cui:C0332256"},{"id":"E4-ab-7","span":{"begin":1168,"end":1177},"obj":"cui:C0439855"},{"id":"E5-ab-7","span":{"begin":1212,"end":1216},"obj":"cui:C0205145"},{"id":"E6-ab-7","span":{"begin":1247,"end":1257},"obj":"cui:C1524057"},{"id":"E7-ab-7","span":{"begin":1258,"end":1262},"obj":"cui:C0288011"},{"id":"E8-ab-7","span":{"begin":1263,"end":1271},"obj":"cui:C0439167"},{"id":"E9-ab-7","span":{"begin":1281,"end":1289},"obj":"cui:C0750489"},{"id":"E10-ab-7","span":{"begin":1290,"end":1301},"obj":"cui:C1547020"},{"id":"E11-ab-7","span":{"begin":1310,"end":1313},"obj":"entrez:51497"},{"id":"E12-ab-7","span":{"begin":1322,"end":1328},"obj":"cui:C0009013"},{"id":"E1-ab-8","span":{"begin":1342,"end":1348},"obj":"cui:C0009013"},{"id":"E2-ab-8","span":{"begin":1361,"end":1365},"obj":"cui:C0288011"},{"id":"E3-ab-8","span":{"begin":1369,"end":1376},"obj":"cui:C0439855"},{"id":"E4-ab-8","span":{"begin":1377,"end":1386},"obj":"cui:C1522492"},{"id":"E5-ab-8","span":{"begin":1432,"end":1466},"obj":"cui:C1321301"},{"id":"E6-ab-8","span":{"begin":1477,"end":1482},"obj":"cui:C0205449"},{"id":"E7-ab-8","span":{"begin":1486,"end":1490},"obj":"cui:C0205451"},{"id":"E8-ab-8","span":{"begin":1491,"end":1497},"obj":"cui:C0205082"},{"id":"E9-ab-8","span":{"begin":1498,"end":1515},"obj":"cui:C0011615"},{"id":"E10-ab-8","span":{"begin":1516,"end":1524},"obj":"cui:C0030705"},{"id":"E11-ab-8","span":{"begin":1548,"end":1553},"obj":"cui:C0229671"},{"id":"E12-ab-8","span":{"begin":1539,"end":1557},"obj":"cui:C0236175"},{"id":"E13-ab-8","span":{"begin":1558,"end":1564},"obj":"cui:C0441889"},{"id":"E14-ab-8","span":{"begin":1570,"end":1573},"obj":"cui:C1518422"},{"id":"E15-ab-8","span":{"begin":1577,"end":1584},"obj":"cui:C0243148"},{"id":"E16-ab-8","span":{"begin":1585,"end":1589},"obj":"cui:C1321301"},{"id":"T11","span":{"begin":1498,"end":1524},"obj":"PROCESS_OF"},{"id":"T12","span":{"begin":1525,"end":1529},"obj":"PROCESS_OF"},{"id":"E1-ab-9","span":{"begin":1597,"end":1605},"obj":"cui:C0243095"},{"id":"E2-ab-9","span":{"begin":1619,"end":1624},"obj":"cui:C0205250"},{"id":"E3-ab-9","span":{"begin":1630,"end":1634},"obj":"cui:C0021758"},{"id":"E4-ab-9","span":{"begin":1635,"end":1645},"obj":"cui:C0033268"},{"id":"E5-ab-9","span":{"begin":1649,"end":1655},"obj":"cui:C0857523"},{"id":"E6-ab-9","span":{"begin":1656,"end":1665},"obj":"cui:C0242633"},{"id":"E7-ab-9","span":{"begin":1708,"end":1719},"obj":"cui:C0205367"},{"id":"E8-ab-9","span":{"begin":1720,"end":1725},"obj":"entrez:4773"},{"id":"E9-ab-9","span":{"begin":1726,"end":1734},"obj":"cui:C0439167"},{"id":"E10-ab-9","span":{"begin":1742,"end":1746},"obj":"cui:C0021758"},{"id":"E11-ab-9","span":{"begin":1750,"end":1757},"obj":"cui:C0013879"},{"id":"E12-ab-9","span":{"begin":1772,"end":1780},"obj":"cui:C0030705"},{"id":"E13-ab-9","span":{"begin":1806,"end":1813},"obj":"cui:C0012634"},{"id":"E14-ab-9","span":{"begin":1834,"end":1842},"obj":"cui:C0205373"},{"id":"E15-ab-9","span":{"begin":1843,"end":1851},"obj":"cui:C0012634"},{"id":"T13","span":{"begin":1646,"end":1648},"obj":"LOCATION_OF"},{"id":"T14","span":{"begin":1781,"end":1785},"obj":"PROCESS_OF"},{"id":"T15","span":{"begin":1818,"end":1822},"obj":"PROCESS_OF"}],"relations":[{"id":"R1","pred":"subjectOf","subj":"E4-ti-1","obj":"T1"},{"id":"R2","pred":"objectOf","subj":"E7-ti-1","obj":"T1"},{"id":"R3","pred":"subjectOf","subj":"E8-ti-1","obj":"T2"},{"id":"R4","pred":"objectOf","subj":"E7-ti-1","obj":"T2"},{"id":"R5","pred":"subjectOf","subj":"E10-ti-1","obj":"T3"},{"id":"R6","pred":"objectOf","subj":"E8-ti-1","obj":"T3"},{"id":"R7","pred":"subjectOf","subj":"E11-ti-1","obj":"T4"},{"id":"R8","pred":"objectOf","subj":"E12-ti-1","obj":"T4"},{"id":"R9","pred":"subjectOf","subj":"E10-ti-1","obj":"T5"},{"id":"R10","pred":"objectOf","subj":"E12-ti-1","obj":"T5"},{"id":"R11","pred":"subjectOf","subj":"E3-ab-1","obj":"T6"},{"id":"R12","pred":"objectOf","subj":"E4-ab-1","obj":"T6"},{"id":"R13","pred":"subjectOf","subj":"E4-ab-2","obj":"T7"},{"id":"R14","pred":"objectOf","subj":"E6-ab-2","obj":"T7"},{"id":"R15","pred":"subjectOf","subj":"E11-ab-3","obj":"T8"},{"id":"R16","pred":"objectOf","subj":"E7-ab-3","obj":"T8"},{"id":"R17","pred":"subjectOf","subj":"E4-ab-4","obj":"T9"},{"id":"R18","pred":"objectOf","subj":"E5-ab-4","obj":"T9"},{"id":"R19","pred":"subjectOf","subj":"E14-ab-5","obj":"T10"},{"id":"R20","pred":"objectOf","subj":"E13-ab-5","obj":"T10"},{"id":"R21","pred":"subjectOf","subj":"E9-ab-8","obj":"T11"},{"id":"R22","pred":"objectOf","subj":"E10-ab-8","obj":"T11"},{"id":"R23","pred":"subjectOf","subj":"E12-ab-8","obj":"T12"},{"id":"R24","pred":"objectOf","subj":"E10-ab-8","obj":"T12"},{"id":"R25","pred":"subjectOf","subj":"E6-ab-9","obj":"T13"},{"id":"R26","pred":"objectOf","subj":"E3-ab-9","obj":"T13"},{"id":"R27","pred":"subjectOf","subj":"E13-ab-9","obj":"T14"},{"id":"R28","pred":"objectOf","subj":"E12-ab-9","obj":"T14"},{"id":"R29","pred":"subjectOf","subj":"E15-ab-9","obj":"T15"},{"id":"R30","pred":"objectOf","subj":"E12-ab-9","obj":"T15"}],"attributes":[{"subj":"E1-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E2-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E3-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E4-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E5-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E6-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E7-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E8-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E9-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E10-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E11-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E12-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"T1","pred":"source","obj":"semrep-sample"},{"subj":"T2","pred":"source","obj":"semrep-sample"},{"subj":"T3","pred":"source","obj":"semrep-sample"},{"subj":"T4","pred":"source","obj":"semrep-sample"},{"subj":"T5","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"T6","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"T7","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E10-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E11-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"T8","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"T9","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E10-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E11-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E12-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E13-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E14-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"T10","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E10-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E11-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E12-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E10-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E11-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E12-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E13-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E14-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E15-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E16-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"T11","pred":"source","obj":"semrep-sample"},{"subj":"T12","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E10-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E11-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E12-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E13-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E14-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E15-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"T13","pred":"source","obj":"semrep-sample"},{"subj":"T14","pred":"source","obj":"semrep-sample"},{"subj":"T15","pred":"source","obj":"semrep-sample"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":1539,"end":1557},"obj":"HP_0003212"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":1630,"end":1634},"obj":"gene:3565"},{"id":"T1","span":{"begin":1834,"end":1851},"obj":"disease:C0442893"},{"id":"T2","span":{"begin":1720,"end":1725},"obj":"gene:4773"},{"id":"T3","span":{"begin":1834,"end":1851},"obj":"disease:C0442893"},{"id":"T4","span":{"begin":1742,"end":1746},"obj":"gene:3565"},{"id":"T5","span":{"begin":1834,"end":1851},"obj":"disease:C0442893"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":40,"end":60},"obj":"protein"},{"id":"T2","span":{"begin":61,"end":66},"obj":"protein"},{"id":"T3","span":{"begin":74,"end":98},"obj":"DNA"},{"id":"T4","span":{"begin":99,"end":101},"obj":"DNA"},{"id":"T5","span":{"begin":109,"end":122},"obj":"DNA"},{"id":"T6","span":{"begin":148,"end":157},"obj":"DNA"},{"id":"T7","span":{"begin":175,"end":182},"obj":"cell_type"},{"id":"T8","span":{"begin":221,"end":228},"obj":"cell_type"},{"id":"T9","span":{"begin":262,"end":286},"obj":"cell_line"},{"id":"T10","span":{"begin":298,"end":301},"obj":"protein"},{"id":"T11","span":{"begin":315,"end":322},"obj":"cell_type"},{"id":"T12","span":{"begin":358,"end":367},"obj":"DNA"},{"id":"T13","span":{"begin":413,"end":422},"obj":"DNA"},{"id":"T14","span":{"begin":458,"end":507},"obj":"protein"},{"id":"T15","span":{"begin":511,"end":532},"obj":"protein"},{"id":"T16","span":{"begin":543,"end":548},"obj":"protein"},{"id":"T17","span":{"begin":553,"end":558},"obj":"protein"},{"id":"T18","span":{"begin":581,"end":599},"obj":"cell_type"},{"id":"T19","span":{"begin":639,"end":644},"obj":"protein"},{"id":"T20","span":{"begin":648,"end":657},"obj":"DNA"},{"id":"T21","span":{"begin":768,"end":795},"obj":"cell_line"},{"id":"T22","span":{"begin":813,"end":823},"obj":"cell_line"},{"id":"T23","span":{"begin":884,"end":905},"obj":"DNA"},{"id":"T24","span":{"begin":906,"end":908},"obj":"DNA"},{"id":"T25","span":{"begin":913,"end":915},"obj":"DNA"},{"id":"T26","span":{"begin":946,"end":959},"obj":"DNA"},{"id":"T27","span":{"begin":982,"end":984},"obj":"DNA"},{"id":"T28","span":{"begin":1027,"end":1032},"obj":"protein"},{"id":"T29","span":{"begin":1063,"end":1073},"obj":"cell_line"},{"id":"T30","span":{"begin":1100,"end":1110},"obj":"cell_line"},{"id":"T31","span":{"begin":1133,"end":1151},"obj":"cell_line"},{"id":"T32","span":{"begin":1209,"end":1216},"obj":"DNA"},{"id":"T33","span":{"begin":1232,"end":1237},"obj":"protein"},{"id":"T34","span":{"begin":1244,"end":1246},"obj":"DNA"},{"id":"T35","span":{"begin":1258,"end":1262},"obj":"protein"},{"id":"T36","span":{"begin":1310,"end":1328},"obj":"cell_line"},{"id":"T37","span":{"begin":1338,"end":1348},"obj":"cell_line"},{"id":"T38","span":{"begin":1366,"end":1368},"obj":"DNA"},{"id":"T39","span":{"begin":1432,"end":1466},"obj":"cell_type"},{"id":"T40","span":{"begin":1468,"end":1472},"obj":"cell_type"},{"id":"T41","span":{"begin":1554,"end":1557},"obj":"protein"},{"id":"T42","span":{"begin":1585,"end":1589},"obj":"cell_type"},{"id":"T43","span":{"begin":1630,"end":1634},"obj":"protein"},{"id":"T44","span":{"begin":1649,"end":1665},"obj":"cell_type"},{"id":"T45","span":{"begin":1720,"end":1725},"obj":"protein"},{"id":"T46","span":{"begin":1742,"end":1757},"obj":"DNA"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"},{"subj":"T24","pred":"source","obj":"jnlpba-st-training"},{"subj":"T25","pred":"source","obj":"jnlpba-st-training"},{"subj":"T26","pred":"source","obj":"jnlpba-st-training"},{"subj":"T27","pred":"source","obj":"jnlpba-st-training"},{"subj":"T28","pred":"source","obj":"jnlpba-st-training"},{"subj":"T29","pred":"source","obj":"jnlpba-st-training"},{"subj":"T30","pred":"source","obj":"jnlpba-st-training"},{"subj":"T31","pred":"source","obj":"jnlpba-st-training"},{"subj":"T32","pred":"source","obj":"jnlpba-st-training"},{"subj":"T33","pred":"source","obj":"jnlpba-st-training"},{"subj":"T34","pred":"source","obj":"jnlpba-st-training"},{"subj":"T35","pred":"source","obj":"jnlpba-st-training"},{"subj":"T36","pred":"source","obj":"jnlpba-st-training"},{"subj":"T37","pred":"source","obj":"jnlpba-st-training"},{"subj":"T38","pred":"source","obj":"jnlpba-st-training"},{"subj":"T39","pred":"source","obj":"jnlpba-st-training"},{"subj":"T40","pred":"source","obj":"jnlpba-st-training"},{"subj":"T41","pred":"source","obj":"jnlpba-st-training"},{"subj":"T42","pred":"source","obj":"jnlpba-st-training"},{"subj":"T43","pred":"source","obj":"jnlpba-st-training"},{"subj":"T44","pred":"source","obj":"jnlpba-st-training"},{"subj":"T45","pred":"source","obj":"jnlpba-st-training"},{"subj":"T46","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":202},"obj":"Sentence"},{"id":"S2","span":{"begin":203,"end":323},"obj":"Sentence"},{"id":"S3","span":{"begin":324,"end":412},"obj":"Sentence"},{"id":"S4","span":{"begin":413,"end":600},"obj":"Sentence"},{"id":"S5","span":{"begin":601,"end":689},"obj":"Sentence"},{"id":"S6","span":{"begin":690,"end":960},"obj":"Sentence"},{"id":"S7","span":{"begin":961,"end":1111},"obj":"Sentence"},{"id":"S8","span":{"begin":1112,"end":1329},"obj":"Sentence"},{"id":"S9","span":{"begin":1330,"end":1590},"obj":"Sentence"},{"id":"S10","span":{"begin":1591,"end":1866},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S9","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S10","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":40,"end":60},"obj":"protein_family_or_group"},{"id":"T2","span":{"begin":61,"end":66},"obj":"protein_molecule"},{"id":"T3","span":{"begin":74,"end":98},"obj":"DNA_domain_or_region"},{"id":"T4","span":{"begin":99,"end":101},"obj":"DNA_domain_or_region"},{"id":"T5","span":{"begin":109,"end":122},"obj":"DNA_domain_or_region"},{"id":"T6","span":{"begin":148,"end":157},"obj":"DNA_domain_or_region"},{"id":"T7","span":{"begin":175,"end":182},"obj":"cell_type"},{"id":"T8","span":{"begin":186,"end":201},"obj":"multi_cell"},{"id":"T9","span":{"begin":221,"end":228},"obj":"cell_type"},{"id":"T10","span":{"begin":232,"end":247},"obj":"multi_cell"},{"id":"T11","span":{"begin":262,"end":286},"obj":"cell_line"},{"id":"T12","span":{"begin":298,"end":301},"obj":"protein_family_or_group"},{"id":"T13","span":{"begin":315,"end":322},"obj":"cell_type"},{"id":"T14","span":{"begin":358,"end":367},"obj":"DNA_domain_or_region"},{"id":"T15","span":{"begin":382,"end":387},"obj":"other_name"},{"id":"T16","span":{"begin":413,"end":422},"obj":"DNA_domain_or_region"},{"id":"T17","span":{"begin":458,"end":485},"obj":"protein_family_or_group"},{"id":"T18","span":{"begin":486,"end":493},"obj":"cell_type"},{"id":"T19","span":{"begin":495,"end":499},"obj":"protein_family_or_group"},{"id":"T20","span":{"begin":511,"end":532},"obj":"protein_family_or_group"},{"id":"T21","span":{"begin":543,"end":548},"obj":"protein_molecule"},{"id":"T22","span":{"begin":553,"end":558},"obj":"protein_molecule"},{"id":"T23","span":{"begin":581,"end":599},"obj":"cell_type"},{"id":"T24","span":{"begin":639,"end":644},"obj":"protein_molecule"},{"id":"T25","span":{"begin":648,"end":657},"obj":"DNA_domain_or_region"},{"id":"T26","span":{"begin":683,"end":688},"obj":"multi_cell"},{"id":"T27","span":{"begin":705,"end":742},"obj":"other_name"},{"id":"T28","span":{"begin":748,"end":764},"obj":"other_name"},{"id":"T29","span":{"begin":768,"end":795},"obj":"cell_line"},{"id":"T30","span":{"begin":801,"end":808},"obj":"multi_cell"},{"id":"T31","span":{"begin":813,"end":823},"obj":"cell_line"},{"id":"T32","span":{"begin":850,"end":872},"obj":"other_name"},{"id":"T33","span":{"begin":884,"end":905},"obj":"DNA_domain_or_region"},{"id":"T34","span":{"begin":906,"end":908},"obj":"DNA_domain_or_region"},{"id":"T35","span":{"begin":913,"end":915},"obj":"DNA_domain_or_region"},{"id":"T36","span":{"begin":946,"end":959},"obj":"DNA_domain_or_region"},{"id":"T37","span":{"begin":982,"end":984},"obj":"DNA_domain_or_region"},{"id":"T38","span":{"begin":1027,"end":1032},"obj":"protein_molecule"},{"id":"T39","span":{"begin":1063,"end":1073},"obj":"cell_line"},{"id":"T40","span":{"begin":1100,"end":1110},"obj":"cell_line"},{"id":"T41","span":{"begin":1209,"end":1216},"obj":"DNA_domain_or_region"},{"id":"T42","span":{"begin":1232,"end":1237},"obj":"protein_molecule"},{"id":"T43","span":{"begin":1244,"end":1246},"obj":"DNA_domain_or_region"},{"id":"T44","span":{"begin":1258,"end":1262},"obj":"protein_family_or_group"},{"id":"T45","span":{"begin":1338,"end":1348},"obj":"cell_line"},{"id":"T46","span":{"begin":1361,"end":1366},"obj":"other_name"},{"id":"T47","span":{"begin":1366,"end":1368},"obj":"DNA_domain_or_region"},{"id":"T48","span":{"begin":1412,"end":1428},"obj":"other_name"},{"id":"T49","span":{"begin":1432,"end":1466},"obj":"cell_type"},{"id":"T50","span":{"begin":1468,"end":1472},"obj":"cell_type"},{"id":"T51","span":{"begin":1548,"end":1553},"obj":"other_name"},{"id":"T52","span":{"begin":1554,"end":1557},"obj":"protein_family_or_group"},{"id":"T53","span":{"begin":1585,"end":1589},"obj":"cell_type"},{"id":"T54","span":{"begin":1619,"end":1629},"obj":"other_name"},{"id":"T55","span":{"begin":1630,"end":1634},"obj":"protein_molecule"},{"id":"T56","span":{"begin":1649,"end":1665},"obj":"cell_type"},{"id":"T57","span":{"begin":1720,"end":1725},"obj":"protein_molecule"},{"id":"T58","span":{"begin":1742,"end":1746},"obj":"protein_molecule"},{"id":"T59","span":{"begin":1791,"end":1813},"obj":"other_name"},{"id":"T60","span":{"begin":1825,"end":1851},"obj":"other_name"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"},{"subj":"T36","pred":"source","obj":"GENIAcorpus"},{"subj":"T37","pred":"source","obj":"GENIAcorpus"},{"subj":"T38","pred":"source","obj":"GENIAcorpus"},{"subj":"T39","pred":"source","obj":"GENIAcorpus"},{"subj":"T40","pred":"source","obj":"GENIAcorpus"},{"subj":"T41","pred":"source","obj":"GENIAcorpus"},{"subj":"T42","pred":"source","obj":"GENIAcorpus"},{"subj":"T43","pred":"source","obj":"GENIAcorpus"},{"subj":"T44","pred":"source","obj":"GENIAcorpus"},{"subj":"T45","pred":"source","obj":"GENIAcorpus"},{"subj":"T46","pred":"source","obj":"GENIAcorpus"},{"subj":"T47","pred":"source","obj":"GENIAcorpus"},{"subj":"T48","pred":"source","obj":"GENIAcorpus"},{"subj":"T49","pred":"source","obj":"GENIAcorpus"},{"subj":"T50","pred":"source","obj":"GENIAcorpus"},{"subj":"T51","pred":"source","obj":"GENIAcorpus"},{"subj":"T52","pred":"source","obj":"GENIAcorpus"},{"subj":"T53","pred":"source","obj":"GENIAcorpus"},{"subj":"T54","pred":"source","obj":"GENIAcorpus"},{"subj":"T55","pred":"source","obj":"GENIAcorpus"},{"subj":"T56","pred":"source","obj":"GENIAcorpus"},{"subj":"T57","pred":"source","obj":"GENIAcorpus"},{"subj":"T58","pred":"source","obj":"GENIAcorpus"},{"subj":"T59","pred":"source","obj":"GENIAcorpus"},{"subj":"T60","pred":"source","obj":"GENIAcorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#93ece2","default":true},{"id":"metamap-sample","color":"#ecc793"},{"id":"semrep-sample","color":"#ad93ec"},{"id":"PubmedHPO","color":"#93ec93"},{"id":"DisGeNET","color":"#ec93ac"},{"id":"jnlpba-st-training","color":"#93c6ec"},{"id":"pubmed-sentences-benchmark","color":"#e0ec93"},{"id":"GENIAcorpus","color":"#de93ec"}]}]}}