PubMed:10037712
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-86 | Sentence | denotes | Tissue-selective expression of alpha-dystrobrevin is determined by multiple promoters. |
| T2 | 87-234 | Sentence | denotes | alpha-Dystrobrevin, the mammalian orthologue of the Torpedo 87-kDa postsynaptic protein, is a dystrophin-associated and dystrophin-related protein. |
| T3 | 235-299 | Sentence | denotes | Knockout of the gene in the mouse results in muscular dystrophy. |
| T4 | 300-391 | Sentence | denotes | The control of the alpha-dystrobrevin gene in the various tissues is therefore of interest. |
| T5 | 392-512 | Sentence | denotes | Multiple dystrobrevin isoforms differing in their domain content are generated by alternative splicing of a single gene. |
| T6 | 513-725 | Sentence | denotes | The data presented here demonstrate that expression of alpha-dystrobrevin from three promoters, that are active in a tissue-selective manner, also plays a role in the function of the protein in different tissues. |
| T7 | 726-908 | Sentence | denotes | The most proximal promoter A is active in brain and to a lesser extent in lung, whereas the most distal promoter B, which possesses several Sp1 binding sites, is restricted to brain. |
| T8 | 909-1036 | Sentence | denotes | Promoter C, which contains multiple consensus myogenic binding sites, is up-regulated during in vitro myoblast differentiation. |
| T9 | 1037-1169 | Sentence | denotes | Interestingly, the organization and the activity of the alpha-dystrobrevin promoters is reminiscent of those in the dystrophin gene. |
| T10 | 1170-1434 | Sentence | denotes | Taken together we suggest that the multipromoter system, distributed over a region of 270 kilobases at the 5'-end of the alpha-dystrobrevin gene, has been developed to allow the regulation of this gene in different cell types and/or different developmental stages. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 735-743 | http://purl.obolibrary.org/obo/MAT_0000491 | denotes | proximal |
| T2 | 768-773 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T3 | 800-804 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T4 | 902-907 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 280-298 | HP_0003560 | denotes | muscular dystrophy |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 280-298 | Disease | denotes | muscular dystrophy | http://purl.obolibrary.org/obo/MONDO_0020121 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 735-743 | Body_part | denotes | proximal | http://purl.obolibrary.org/obo/MAT_0000491 |
| T2 | 768-773 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T3 | 800-804 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T4 | 902-907 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 280-298 | Phenotype | denotes | muscular dystrophy | HP:0003560 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 139-146 | OrganismTaxon | denotes | Torpedo | 7786 |
| T2 | 263-268 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 0-6 | Body_part | denotes | Tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T2 | 630-636 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T3 | 768-773 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T5 | 800-804 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T6 | 902-907 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T8 | 1011-1019 | Body_part | denotes | myoblast | http://purl.obolibrary.org/obo/CL_0000056 |
Glycosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1011-1019 | Cell | denotes | myoblast | http://purl.obolibrary.org/obo/CL:0000056 |