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PubMed:10029594 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 13-33 cell_type denotes isolated eosinophils
T2 396-408 DNA denotes X-chromosome
T3 525-546 DNA denotes HpaII and Hha I sites
T4 556-588 DNA denotes polymorphic trinucleotide repeat
T5 596-624 DNA denotes human androgen receptor gene
T6 626-632 DNA denotes HUMARA
T7 809-820 DNA denotes HUMARA loci
T8 824-844 cell_type denotes purified eosinophils
T9 885-913 cell_type denotes Peripheral blood eosinophils
T10 984-995 cell_type denotes Eosinophils
T11 1103-1133 cell_type denotes Eosinophil-depleted leukocytes
T12 1171-1177 DNA denotes HUMARA
T13 1323-1334 cell_type denotes eosinophils
T14 1366-1386 cell_type denotes purified eosinophils
T15 1401-1412 cell_type denotes eosinophils
T16 1625-1631 DNA denotes HUMARA
T17 1847-1853 DNA denotes HUMARA

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10029594-5#126#132#gene367 809-815 gene367 denotes HUMARA
10029594-5#188#200#diseaseC0014457 871-883 diseaseC0014457 denotes eosinophilia
10029594-5#188#200#diseaseC1306759 871-883 diseaseC1306759 denotes eosinophilia
126#132#gene367188#200#diseaseC0014457 10029594-5#126#132#gene367 10029594-5#188#200#diseaseC0014457 associated_with HUMARA,eosinophilia
126#132#gene367188#200#diseaseC1306759 10029594-5#126#132#gene367 10029594-5#188#200#diseaseC1306759 associated_with HUMARA,eosinophilia

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 37-67 NP denotes the hypereosinophilic syndrome
C2 69-117 NP denotes The idiopathic hypereosinophilic syndrome (IHES)
C3 378-382 NP denotes IHES
C4 667-681 NP denotes X-inactivation
C5 885-913 NP denotes Peripheral blood eosinophils
C6 931-936 NP denotes their
C8 1043-1047 NP denotes IHES
C7 1010-1047 NP denotes a female patient presenting with IHES
C9 1087-1101 NP denotes X-inactivation
C10 1139-1151 NP denotes this patient
C11 1171-1186 NP denotes HUMARA analysis
C12 1276-1279 NP denotes her
C13 1492-1514 NP denotes reactive eosinophilias
C14 1607-1621 NP denotes X-inactivation
C15 1625-1640 NP denotes HUMARA analysis
C17 1706-1710 NP denotes IHES
C16 1680-1710 NP denotes a patient presenting with IHES
C18 1762-1789 NP denotes a low-grade clonal disorder
C19 1790-1794 NP denotes that
C20 1821-1843 NP denotes reactive eosinophilias
C21 1847-1862 NP denotes HUMARA analysis
R1 C2 C1 coref-ident The idiopathic hypereosinophilic syndrome (IHES),the hypereosinophilic syndrome
R2 C3 C2 coref-ident IHES,The idiopathic hypereosinophilic syndrome (IHES)
R3 C6 C5 coref-pron their,Peripheral blood eosinophils
R4 C8 C3 coref-ident IHES,IHES
R5 C9 C4 coref-ident X-inactivation,X-inactivation
R6 C10 C7 coref-ident this patient,a female patient presenting with IHES
R7 C12 C10 coref-pron her,this patient
R8 C14 C9 coref-ident X-inactivation,X-inactivation
R9 C15 C11 coref-ident HUMARA analysis,HUMARA analysis
R10 C17 C8 coref-ident IHES,IHES
R11 C16 C10 coref-ident a patient presenting with IHES,this patient
R12 C19 C18 coref-relat that,a low-grade clonal disorder
R13 C20 C13 coref-ident reactive eosinophilias,reactive eosinophilias
R14 C21 C15 coref-ident HUMARA analysis,HUMARA analysis

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-68 Sentence denotes Clonality of isolated eosinophils in the hypereosinophilic syndrome.
S2 69-274 Sentence denotes The idiopathic hypereosinophilic syndrome (IHES) is a rare disorder characterized by unexplained, persistent eosinophilia associated with multiple organ dysfunction due to eosinophilic tissue infiltration.
S3 275-383 Sentence denotes In the absence of karyotypic abnormalities, there is no specific test to detect clonal eosinophilia in IHES.
S4 384-509 Sentence denotes Analysis of X-chromosome inactivation patterns can be used to determine whether proliferative disorders are clonal in origin.
S5 510-682 Sentence denotes Methylation of HpaII and Hha I sites near the polymorphic trinucleotide repeat of the human androgen receptor gene (HUMARA) has been shown to correlate with X-inactivation.
S6 683-884 Sentence denotes In this study, we have used the polymerase chain reaction (PCR) with nested primers to analyze X-inactivation patterns of the HUMARA loci in purified eosinophils from female patients with eosinophilia.
S7 885-983 Sentence denotes Peripheral blood eosinophils were isolated by their autofluoresence using flow cytometric sorting.
S8 984-1102 Sentence denotes Eosinophils purified from a female patient presenting with IHES were found to show a clonal pattern of X-inactivation.
S9 1103-1239 Sentence denotes Eosinophil-depleted leukocytes from this patient were polyclonal by HUMARA analysis, thus excluding skewedness of random X-inactivation.
S10 1240-1387 Sentence denotes After corticosteroid suppression of her blood eosinophilia, a clonal population of eosinophils could no longer be detected in purified eosinophils.
S11 1388-1641 Sentence denotes In contrast, eosinophils purified from a patient with Churg-Strauss syndrome and from six patients with reactive eosinophilias attributed to allergy, parasitic infection, or drug reaction showed a polyclonal pattern of X-inactivation by HUMARA analysis.
S12 1642-1863 Sentence denotes The finding of clonal eosinophilia in a patient presenting with IHES indicates that such patients may have, in reality, a low-grade clonal disorder that can be distinguished from reactive eosinophilias by HUMARA analysis.
S13 1864-1937 Sentence denotes Further, the method described can be used to monitor disease progression.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 13-33 cell_type denotes isolated eosinophils
T2 41-67 other_name denotes hypereosinophilic syndrome
T3 84-110 other_name denotes hypereosinophilic syndrome
T4 112-116 other_name denotes IHES
T5 167-190 other_name denotes persistent eosinophilia
T6 207-233 other_name denotes multiple organ dysfunction
T7 241-273 other_name denotes eosinophilic tissue infiltration
T8 293-317 other_name denotes karyotypic abnormalities
T9 355-374 other_name denotes clonal eosinophilia
T10 378-382 other_name denotes IHES
T11 396-408 DNA_molecule denotes X-chromosome
T12 556-588 DNA_domain_or_region denotes polymorphic trinucleotide repeat
T13 596-624 DNA_domain_or_region denotes human androgen receptor gene
T14 626-632 DNA_domain_or_region denotes HUMARA
T15 667-681 other_name denotes X-inactivation
T16 715-740 other_name denotes polymerase chain reaction
T17 742-745 other_name denotes PCR
T18 778-792 other_name denotes X-inactivation
T19 809-815 DNA_domain_or_region denotes HUMARA
T20 824-844 cell_type denotes purified eosinophils
T21 857-865 multi_cell denotes patients
T22 871-883 other_name denotes eosinophilia
T23 885-913 cell_type denotes Peripheral blood eosinophils
T24 937-952 other_name denotes autofluoresence
T25 984-995 cell_type denotes Eosinophils
T26 1012-1026 multi_cell denotes female patient
T27 1043-1047 other_name denotes IHES
T28 1087-1101 other_name denotes X-inactivation
T29 1103-1133 cell_type denotes Eosinophil-depleted leukocytes
T30 1171-1177 DNA_domain_or_region denotes HUMARA
T31 1217-1223 other_name denotes random
T32 1224-1238 other_name denotes X-inactivation
T33 1246-1260 lipid denotes corticosteroid
T34 1286-1298 other_name denotes eosinophilia
T35 1323-1334 cell_type denotes eosinophils
T36 1366-1374 cell_type denotes purified
T37 1375-1386 cell_type denotes eosinophils
T38 1401-1412 cell_type denotes eosinophils
T39 1442-1464 other_name denotes Churg-Strauss syndrome
T40 1478-1486 multi_cell denotes patients
T41 1501-1514 other_name denotes eosinophilias
T42 1538-1557 other_name denotes parasitic infection
T43 1607-1621 other_name denotes X-inactivation
T44 1625-1631 DNA_domain_or_region denotes HUMARA
T45 1657-1676 other_name denotes clonal eosinophilia
T46 1706-1710 other_name denotes IHES
T47 1731-1739 multi_cell denotes patients
T48 1830-1843 other_name denotes eosinophilias
T49 1847-1853 DNA_domain_or_region denotes HUMARA
T50 1909-1936 other_name denotes monitor disease progression

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 178-190 HP_0001880 denotes eosinophilia
T2 362-374 HP_0001880 denotes eosinophilia
T3 871-883 HP_0001880 denotes eosinophilia
T4 1286-1298 HP_0001880 denotes eosinophilia
T5 1501-1514 HP_0001880 denotes eosinophilias
T6 1529-1536 HP_0012393 denotes allergy
T7 1664-1676 HP_0001880 denotes eosinophilia
T8 1830-1843 HP_0001880 denotes eosinophilias

DisGeNET

Id Subject Object Predicate Lexical cue
T0 809-815 gene:367 denotes HUMARA
T1 871-883 disease:C0014457 denotes eosinophilia
T2 809-815 gene:367 denotes HUMARA
T3 871-883 disease:C1306759 denotes eosinophilia
T4 809-815 gene:367 denotes HUMARA
T5 871-883 disease:C1636667 denotes eosinophilia
R1 T0 T1 associated_with HUMARA,eosinophilia
R2 T2 T3 associated_with HUMARA,eosinophilia
R3 T4 T5 associated_with HUMARA,eosinophilia