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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-44 DNA denotes Megakaryocyte/Platelet-specific enhancer
T2 52-77 DNA denotes alpha2beta1 integrin gene
T3 90-99 DNA denotes AP1 sites
T4 108-140 protein denotes mitogen-activated protein kinase
T5 164-184 protein denotes alpha2beta1 integrin
T6 209-218 cell_type denotes platelets
T7 223-237 cell_type denotes megakaryocytes
T8 315-335 DNA denotes alpha2 integrin gene
T9 398-411 DNA denotes core promoter
T10 438-446 DNA denotes silencer
T11 476-500 DNA denotes megakaryocytic enhancers
T12 508-523 DNA denotes distal 5' flank
T13 550-563 DNA denotes 229-bp region
T14 571-586 DNA denotes distal 5' flank
T15 594-614 DNA denotes alpha2 integrin gene
T16 628-665 cell_type denotes high-level enhancer activity in cells
T17 707-724 DNA denotes AP1 binding sites
T18 787-806 protein denotes DNA-protein complex
T19 837-855 protein denotes c-fos/c-jun family
T20 877-880 protein denotes AP1
T21 917-949 protein denotes mitogen-activated protein kinase
T22 951-955 protein denotes MAPK
T23 989-1009 DNA denotes alpha2 integrin gene
T24 1040-1050 protein denotes MAP kinase
T25 1097-1110 protein denotes MAPK kinase 1
T26 1144-1167 protein denotes alpha2 integrin subunit
T27 1291-1311 DNA denotes alpha2 integrin gene
T28 1339-1349 protein denotes MAP kinase
T29 1381-1398 DNA denotes AP1 binding sites
T30 1406-1430 DNA denotes alpha2 integrin enhancer

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 48-77 NP denotes the alpha2beta1 integrin gene
C2 160-184 NP denotes The alpha2beta1 integrin
C3 186-237 NP denotes a collagen receptor on platelets and megakaryocytes
C4 311-335 NP denotes the alpha2 integrin gene
C5 356-386 NP denotes megakaryocytic differentiation
C6 590-614 NP denotes the alpha2 integrin gene
C7 989-1020 NP denotes alpha2 integrin gene expression
C8 1064-1071 NP denotes PD98059
C9 1073-1110 NP denotes a specific inhibitor of MAPK kinase 1
C11 1233-1263 NP denotes megakaryocytic differentiation
C10 1222-1263 NP denotes a model of megakaryocytic differentiation
C12 1267-1272 NP denotes which
C14 1287-1311 NP denotes the alpha2 integrin gene
C13 1273-1311 NP denotes expression of the alpha2 integrin gene
R1 C3 C2 coref-appos a collagen receptor on platelets and megakaryocytes,The alpha2beta1 integrin
R2 C4 C1 coref-ident the alpha2 integrin gene,the alpha2beta1 integrin gene
R3 C6 C4 coref-ident the alpha2 integrin gene,the alpha2 integrin gene
R4 C9 C8 coref-appos a specific inhibitor of MAPK kinase 1,PD98059
R5 C11 C5 coref-ident megakaryocytic differentiation,megakaryocytic differentiation
R6 C12 C10 coref-relat which,a model of megakaryocytic differentiation
R7 C14 C6 coref-ident the alpha2 integrin gene,the alpha2 integrin gene
R8 C13 C7 coref-ident expression of the alpha2 integrin gene,alpha2 integrin gene expression

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-159 Sentence denotes The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade.
S2 160-280 Sentence denotes The alpha2beta1 integrin, a collagen receptor on platelets and megakaryocytes, is required for normal platelet function.
S3 281-524 Sentence denotes Transcriptional regulation of the alpha2 integrin gene in cells undergoing megakaryocytic differentiation requires a core promoter between bp -30 and -92, a silencer between bp -92 and -351, and megakaryocytic enhancers in the distal 5' flank.
S4 525-695 Sentence denotes We have now identified a 229-bp region of the distal 5' flank of the alpha2 integrin gene required for high-level enhancer activity in cells with megakaryocytic features.
S5 696-856 Sentence denotes Two tandem AP1 binding sites with dyad symmetry are required for enhancer activity and for DNA-protein complex formation with members of the c-fos/c-jun family.
S6 857-1021 Sentence denotes The requirement for AP1 activation suggested a role for the mitogen-activated protein kinase (MAPK) signaling pathway in regulating alpha2 integrin gene expression.
S7 1022-1210 Sentence denotes Inhibition of the MAP kinase cascade with PD98059, a specific inhibitor of MAPK kinase 1, prevented the expression of the alpha2 integrin subunit in cells induced to become megakaryocytic.
S8 1211-1431 Sentence denotes We provide a model of megakaryocytic differentiation in which expression of the alpha2 integrin gene requires signaling via the MAP kinase pathway to activate two tandem AP1 binding sites in the alpha2 integrin enhancer.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-44 DNA_domain_or_region denotes Megakaryocyte/Platelet-specific enhancer
T2 52-77 DNA_domain_or_region denotes alpha2beta1 integrin gene
T3 90-99 DNA_domain_or_region denotes AP1 sites
T4 108-140 protein_family_or_group denotes mitogen-activated protein kinase
T5 164-184 protein_family_or_group denotes alpha2beta1 integrin
T6 209-218 cell_type denotes platelets
T7 223-237 cell_type denotes megakaryocytes
T8 255-279 other_name denotes normal platelet function
T9 315-335 DNA_domain_or_region denotes alpha2 integrin gene
T10 356-386 other_name denotes megakaryocytic differentiation
T11 398-411 DNA_domain_or_region denotes core promoter
T12 438-446 DNA_family_or_group denotes silencer
T13 476-500 DNA_domain_or_region denotes megakaryocytic enhancers
T14 508-523 DNA_domain_or_region denotes distal 5' flank
T15 550-563 DNA_domain_or_region denotes 229-bp region
T16 571-586 DNA_domain_or_region denotes distal 5' flank
T17 594-614 DNA_domain_or_region denotes alpha2 integrin gene
T18 628-665 cell_type denotes high-level enhancer activity in cells
T19 671-694 other_name denotes megakaryocytic features
T20 707-724 DNA_domain_or_region denotes AP1 binding sites
T21 761-778 other_name denotes enhancer activity
T22 787-806 protein_complex denotes DNA-protein complex
T23 837-855 protein_domain_or_region denotes c-fos/c-jun family
T24 877-880 protein_molecule denotes AP1
T25 917-949 protein_family_or_group denotes mitogen-activated protein kinase
T26 951-955 protein_family_or_group denotes MAPK
T27 989-1009 DNA_domain_or_region denotes alpha2 integrin gene
T28 1040-1050 protein_family_or_group denotes MAP kinase
T29 1064-1071 other_organic_compound denotes PD98059
T30 1097-1110 protein_molecule denotes MAPK kinase 1
T31 1144-1167 protein_subunit denotes alpha2 integrin subunit
T32 1233-1263 other_name denotes megakaryocytic differentiation
T33 1291-1311 DNA_domain_or_region denotes alpha2 integrin gene
T34 1339-1349 protein_family_or_group denotes MAP kinase
T35 1381-1398 DNA_domain_or_region denotes AP1 binding sites
T36 1406-1430 DNA_domain_or_region denotes alpha2 integrin enhancer

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20043624 0-1020 p(HGNC:JUN) increases r(HGNC:ITGA2) denotes The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade. The alpha2beta1 integrin, a collagen receptor on platelets and megakaryocytes, is required for normal platelet function. Transcriptional regulation of the alpha2 integrin gene in cells undergoing megakaryocytic differentiation requires a core promoter between bp -30 and -92, a silencer between bp -92 and -351, and megakaryocytic enhancers in the distal 5' flank. We have now identified a 229-bp region of the distal 5' flank of the alpha2 integrin gene required for high-level enhancer activity in cells with megakaryocytic features. Two tandem AP1 binding sites with dyad symmetry are required for enhancer activity and for DNA-protein complex formation with members of the c-fos/c-jun family. The requirement for AP1 activation suggested a role for the mitogen-activated protein kinase (MAPK) signaling pathway in regulating alpha2 integrin gene expression
BEL:20043794 0-1422 p(HGNC:MAP2K1) increases r(HGNC:ITGA2B) denotes The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade. The alpha2beta1 integrin, a collagen receptor on platelets and megakaryocytes, is required for normal platelet function. Transcriptional regulation of the alpha2 integrin gene in cells undergoing megakaryocytic differentiation requires a core promoter between bp -30 and -92, a silencer between bp -92 and -351, and megakaryocytic enhancers in the distal 5' flank. We have now identified a 229-bp region of the distal 5' flank of the alpha2 integrin gene required for high-level enhancer activity in cells with megakaryocytic features. Two tandem AP1 binding sites with dyad symmetry are required for enhancer activity and for DNA-protein complex formation with members of the c-fos/c-jun family. The requirement for AP1 activation suggested a role for the mitogen-activated protein kinase (MAPK) signaling pathway in regulating alpha2 integrin gene expression. Inhibition of the MAP kinase cascade with PD98059, a specific inhibitor of MAPK kinase 1, prevented the expression of the alpha2 integrin subunit in cells induced to become megakaryocytic. We provide a model of megakaryocytic differentiation in which expression of the alpha2 integrin gene requires signaling via the MAP kinase pathway to activate two tandem AP1 binding sites in the alpha2 integrin
BEL:20043800 0-1422 p(HGNC:MAP2K2) increases r(HGNC:ITGA2B) denotes The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade. The alpha2beta1 integrin, a collagen receptor on platelets and megakaryocytes, is required for normal platelet function. Transcriptional regulation of the alpha2 integrin gene in cells undergoing megakaryocytic differentiation requires a core promoter between bp -30 and -92, a silencer between bp -92 and -351, and megakaryocytic enhancers in the distal 5' flank. We have now identified a 229-bp region of the distal 5' flank of the alpha2 integrin gene required for high-level enhancer activity in cells with megakaryocytic features. Two tandem AP1 binding sites with dyad symmetry are required for enhancer activity and for DNA-protein complex formation with members of the c-fos/c-jun family. The requirement for AP1 activation suggested a role for the mitogen-activated protein kinase (MAPK) signaling pathway in regulating alpha2 integrin gene expression. Inhibition of the MAP kinase cascade with PD98059, a specific inhibitor of MAPK kinase 1, prevented the expression of the alpha2 integrin subunit in cells induced to become megakaryocytic. We provide a model of megakaryocytic differentiation in which expression of the alpha2 integrin gene requires signaling via the MAP kinase pathway to activate two tandem AP1 binding sites in the alpha2 integrin