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PubMed:1002701 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 90-93 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T3 243-246 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T5 552-555 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T7 691-694 Glycan_Motif denotes GM2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC
T9 764-767 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T11 946-949 Glycan_Motif denotes GM2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC
T13 1029-1032 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T15 1060-1069 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T18 1215-1218 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T20 1252-1255 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T22 1441-1444 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T24 1826-1829 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T26 1948-1951 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T28 2129-2132 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T30 2247-2250 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T32 2370-2373 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T34 2567-2570 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T36 2745-2748 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T38 2861-2864 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T40 2958-2961 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T42 3081-3084 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI

sentences

Id Subject Object Predicate Lexical cue
T1 0-47 Sentence denotes Lipolytic action of cholera toxin on fat cells.
T2 48-138 Sentence denotes Re-examination of the concept implicating GM1 ganglioside as the native membrane receptor.
T3 139-343 Sentence denotes The possible role of galactosyl-N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (GM1) ganglioside in the lipolytic activity of cholera toxin on isolated fat cells has been examined.
T4 344-756 Sentence denotes Analyses of the ganglioside content and composition of intact fat cells, their membranous ghosts, and the total particulate fraction of these cells indicate that N-acetylneuraminylgalactosylglucosylceramide (GM3) represents the major ganglioside, with substantial amounts of N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (GM2) and smaller amounts of other higher homologues also present.
T5 757-814 Sentence denotes Native GM1 was not detected in any of these preparations.
T6 815-1033 Sentence denotes Examination of the relative capacities of various exogenously added radiolabeled sphingolipids to bind to the cells indicated that GM2 and glucosylsphingosine were accumulated by the cells to extents comparable to GM1.
T7 1034-1148 Sentence denotes Galactosylsphingosine and sulfatide also exhibited significant, although lesser, binding affinities for the cells.
T8 1149-1398 Sentence denotes The adipocytes appeared to nonspecifically bind exogenously added GM1; saturation of binding sites for GM1 could not be observed up to the highest concentration tested (2 X 10(-4) M), wherein about 7 X 10(9) molecules were associated with the cells.
T9 1399-1501 Sentence denotes Essentially all of this exogenously added GM1 was found bound to the plasma membrane "ghost" fraction.
T10 1502-1709 Sentence denotes Investigation of the biological responses of the cells confirmed their sensitivities to both cholera toxin and epinephrine-stimulated lipolysis, as well as the lag period displayed during the toxin's action.
T11 1710-1928 Sentence denotes While we could confirm that the toxin's lipolytic activity can be enhanced by prior treatment of the fat cells with GM1, several of the observed characteristics of this phenomenon differ from earlier reported findings.
T12 1929-2082 Sentence denotes Accordingly, added GM1 was able to enhance only the subsequent rate, but not the extent, of toxin-stimulated glycerol release (lipolysis) from the cells.
T13 2083-2217 Sentence denotes We also were unable to confirm the ability of GM1 to enhance the toxin's activity at either saturating or at low toxin concentrations.
T14 2218-2337 Sentence denotes The limited ability of added GM1 to enhance the toxin's activity appeared in a unique bell-shaped dose-response manner.
T15 2338-2592 Sentence denotes The inability of high levels of GM1 to stimulate a dose of toxin that was ineffective on native cells suggests that the earlier reported ability of crude brain gangliosides to accomplish this was due to some component other than GM1 in the crude extract.
T16 2593-2865 Sentence denotes While several glycosphingolipids and some other carbohydrate-containing substances that were tested lacked the ability to mimic the enhancing effect of GM1, 4-methylumbelliferyl-beta-D-galactoside exhibited an effect similar to, although less pronounced than, that of GM1.
T17 2866-3208 Sentence denotes The findings in these studies are unable to lend support to the earlier hypothesis that (a) GM1 is cholera toxin's naturally occurring membrane receptor on native fat cells, and (b) the ability of exogenously added GM1 to enhance the toxin's lipolytic activity represents the specific creation of additional natural receptors on adipocytes...
T1 0-47 Sentence denotes Lipolytic action of cholera toxin on fat cells.
T2 48-138 Sentence denotes Re-examination of the concept implicating GM1 ganglioside as the native membrane receptor.
T3 139-343 Sentence denotes The possible role of galactosyl-N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (GM1) ganglioside in the lipolytic activity of cholera toxin on isolated fat cells has been examined.
T4 344-756 Sentence denotes Analyses of the ganglioside content and composition of intact fat cells, their membranous ghosts, and the total particulate fraction of these cells indicate that N-acetylneuraminylgalactosylglucosylceramide (GM3) represents the major ganglioside, with substantial amounts of N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (GM2) and smaller amounts of other higher homologues also present.
T5 757-814 Sentence denotes Native GM1 was not detected in any of these preparations.
T6 815-1033 Sentence denotes Examination of the relative capacities of various exogenously added radiolabeled sphingolipids to bind to the cells indicated that GM2 and glucosylsphingosine were accumulated by the cells to extents comparable to GM1.
T7 1034-1148 Sentence denotes Galactosylsphingosine and sulfatide also exhibited significant, although lesser, binding affinities for the cells.
T8 1149-1398 Sentence denotes The adipocytes appeared to nonspecifically bind exogenously added GM1; saturation of binding sites for GM1 could not be observed up to the highest concentration tested (2 X 10(-4) M), wherein about 7 X 10(9) molecules were associated with the cells.
T9 1399-1501 Sentence denotes Essentially all of this exogenously added GM1 was found bound to the plasma membrane "ghost" fraction.
T10 1502-1709 Sentence denotes Investigation of the biological responses of the cells confirmed their sensitivities to both cholera toxin and epinephrine-stimulated lipolysis, as well as the lag period displayed during the toxin's action.
T11 1710-1928 Sentence denotes While we could confirm that the toxin's lipolytic activity can be enhanced by prior treatment of the fat cells with GM1, several of the observed characteristics of this phenomenon differ from earlier reported findings.
T12 1929-2082 Sentence denotes Accordingly, added GM1 was able to enhance only the subsequent rate, but not the extent, of toxin-stimulated glycerol release (lipolysis) from the cells.
T13 2083-2217 Sentence denotes We also were unable to confirm the ability of GM1 to enhance the toxin's activity at either saturating or at low toxin concentrations.
T14 2218-2337 Sentence denotes The limited ability of added GM1 to enhance the toxin's activity appeared in a unique bell-shaped dose-response manner.
T15 2338-2592 Sentence denotes The inability of high levels of GM1 to stimulate a dose of toxin that was ineffective on native cells suggests that the earlier reported ability of crude brain gangliosides to accomplish this was due to some component other than GM1 in the crude extract.
T16 2593-2865 Sentence denotes While several glycosphingolipids and some other carbohydrate-containing substances that were tested lacked the ability to mimic the enhancing effect of GM1, 4-methylumbelliferyl-beta-D-galactoside exhibited an effect similar to, although less pronounced than, that of GM1.
T17 2866-3208 Sentence denotes The findings in these studies are unable to lend support to the earlier hypothesis that (a) GM1 is cholera toxin's naturally occurring membrane receptor on native fat cells, and (b) the ability of exogenously added GM1 to enhance the toxin's lipolytic activity represents the specific creation of additional natural receptors on adipocytes...

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 90-93 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T2 90-93 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T3 243-246 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T4 243-246 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T5 552-555 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 552-555 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 691-694 https://glytoucan.org/Structures/Glycans/G61168WC denotes GM2
T8 691-694 https://glytoucan.org/Structures/Glycans/G79389NT denotes GM2
T9 764-767 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T10 764-767 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T11 946-949 https://glytoucan.org/Structures/Glycans/G61168WC denotes GM2
T12 946-949 https://glytoucan.org/Structures/Glycans/G79389NT denotes GM2
T13 1029-1032 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T14 1029-1032 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T15 1060-1069 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T16 1060-1069 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T17 1060-1069 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T18 1215-1218 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T19 1215-1218 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T20 1252-1255 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T21 1252-1255 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T22 1441-1444 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T23 1441-1444 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T24 1826-1829 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T25 1826-1829 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T26 1948-1951 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T27 1948-1951 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T28 2129-2132 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T29 2129-2132 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T30 2247-2250 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T31 2247-2250 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T32 2370-2373 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T33 2370-2373 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T34 2567-2570 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T35 2567-2570 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T36 2745-2748 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T37 2745-2748 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T38 2861-2864 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T39 2861-2864 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T40 2958-2961 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T41 2958-2961 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T42 3081-3084 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T43 3081-3084 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 2492-2497 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 90-93 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T2 243-246 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T3 764-767 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T4 1029-1032 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T5 1215-1218 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T6 1252-1255 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T7 1441-1444 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T8 1826-1829 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T9 1948-1951 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T10 2129-2132 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T11 2247-2250 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T12 2370-2373 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T13 2567-2570 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T14 2745-2748 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T15 2861-2864 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T16 2958-2961 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T17 3081-3084 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 20-27 Disease denotes cholera http://purl.obolibrary.org/obo/MONDO_0015766
T2 289-296 Disease denotes cholera http://purl.obolibrary.org/obo/MONDO_0015766
T3 1595-1602 Disease denotes cholera http://purl.obolibrary.org/obo/MONDO_0015766
T4 2954-2961 Disease denotes (a) GM1 http://purl.obolibrary.org/obo/MONDO_0020729
T5 2965-2972 Disease denotes cholera http://purl.obolibrary.org/obo/MONDO_0015766

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 90-93 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T2 243-246 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T3 552-555 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 691-694 Glycan denotes GM2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T5 764-767 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T6 946-949 Glycan denotes GM2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T7 1029-1032 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T8 1215-1218 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T9 1252-1255 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T10 1441-1444 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T11 1826-1829 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T12 1948-1951 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T13 2129-2132 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T14 2247-2250 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T15 2370-2373 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T16 2567-2570 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T17 2745-2748 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T18 2861-2864 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T19 2958-2961 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T20 3081-3084 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 20-27 Disease denotes cholera http://purl.obolibrary.org/obo/MONDO_0015766
T2 289-296 Disease denotes cholera http://purl.obolibrary.org/obo/MONDO_0015766
T3 1595-1602 Disease denotes cholera http://purl.obolibrary.org/obo/MONDO_0015766
T4 2954-2961 Disease denotes (a) GM1 http://purl.obolibrary.org/obo/MONDO_0020729
T5 2965-2972 Disease denotes cholera http://purl.obolibrary.org/obo/MONDO_0015766

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 37-46 Cell denotes fat cells http://purl.obolibrary.org/obo/CL:0000136
T2 315-324 Cell denotes fat cells http://purl.obolibrary.org/obo/CL:0000136
T3 406-415 Cell denotes fat cells http://purl.obolibrary.org/obo/CL:0000136
T4 1153-1163 Cell denotes adipocytes http://purl.obolibrary.org/obo/CL:0000136
T5 1811-1820 Cell denotes fat cells http://purl.obolibrary.org/obo/CL:0000136
T6 3029-3038 Cell denotes fat cells http://purl.obolibrary.org/obo/CL:0000136
T7 3195-3205 Cell denotes adipocytes http://purl.obolibrary.org/obo/CL:0000136

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 37-46 Body_part denotes fat cells http://purl.obolibrary.org/obo/CL_0000136
T2 120-128 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T5 315-324 Body_part denotes fat cells http://purl.obolibrary.org/obo/CL_0000136
T6 406-415 Body_part denotes fat cells http://purl.obolibrary.org/obo/CL_0000136
T7 1153-1163 Body_part denotes adipocytes http://purl.obolibrary.org/obo/CL_0000136
T8 1468-1483 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T9 1811-1820 Body_part denotes fat cells http://purl.obolibrary.org/obo/CL_0000136
T10 2492-2497 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T12 3001-3009 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T15 3029-3038 Body_part denotes fat cells http://purl.obolibrary.org/obo/CL_0000136
T16 3195-3205 Body_part denotes adipocytes http://purl.obolibrary.org/obo/CL_0000136

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 2492-2497 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

sentences

Id Subject Object Predicate Lexical cue
T1 0-47 Sentence denotes Lipolytic action of cholera toxin on fat cells.
T2 48-138 Sentence denotes Re-examination of the concept implicating GM1 ganglioside as the native membrane receptor.
T3 139-343 Sentence denotes The possible role of galactosyl-N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (GM1) ganglioside in the lipolytic activity of cholera toxin on isolated fat cells has been examined.
T4 344-756 Sentence denotes Analyses of the ganglioside content and composition of intact fat cells, their membranous ghosts, and the total particulate fraction of these cells indicate that N-acetylneuraminylgalactosylglucosylceramide (GM3) represents the major ganglioside, with substantial amounts of N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (GM2) and smaller amounts of other higher homologues also present.
T5 757-814 Sentence denotes Native GM1 was not detected in any of these preparations.
T6 815-1033 Sentence denotes Examination of the relative capacities of various exogenously added radiolabeled sphingolipids to bind to the cells indicated that GM2 and glucosylsphingosine were accumulated by the cells to extents comparable to GM1.
T7 1034-1148 Sentence denotes Galactosylsphingosine and sulfatide also exhibited significant, although lesser, binding affinities for the cells.
T8 1149-1398 Sentence denotes The adipocytes appeared to nonspecifically bind exogenously added GM1; saturation of binding sites for GM1 could not be observed up to the highest concentration tested (2 X 10(-4) M), wherein about 7 X 10(9) molecules were associated with the cells.
T9 1399-1501 Sentence denotes Essentially all of this exogenously added GM1 was found bound to the plasma membrane "ghost" fraction.
T10 1502-1709 Sentence denotes Investigation of the biological responses of the cells confirmed their sensitivities to both cholera toxin and epinephrine-stimulated lipolysis, as well as the lag period displayed during the toxin's action.
T11 1710-1928 Sentence denotes While we could confirm that the toxin's lipolytic activity can be enhanced by prior treatment of the fat cells with GM1, several of the observed characteristics of this phenomenon differ from earlier reported findings.
T12 1929-2082 Sentence denotes Accordingly, added GM1 was able to enhance only the subsequent rate, but not the extent, of toxin-stimulated glycerol release (lipolysis) from the cells.
T13 2083-2217 Sentence denotes We also were unable to confirm the ability of GM1 to enhance the toxin's activity at either saturating or at low toxin concentrations.
T14 2218-2337 Sentence denotes The limited ability of added GM1 to enhance the toxin's activity appeared in a unique bell-shaped dose-response manner.
T15 2338-2592 Sentence denotes The inability of high levels of GM1 to stimulate a dose of toxin that was ineffective on native cells suggests that the earlier reported ability of crude brain gangliosides to accomplish this was due to some component other than GM1 in the crude extract.
T16 2593-2865 Sentence denotes While several glycosphingolipids and some other carbohydrate-containing substances that were tested lacked the ability to mimic the enhancing effect of GM1, 4-methylumbelliferyl-beta-D-galactoside exhibited an effect similar to, although less pronounced than, that of GM1.
T17 2866-3208 Sentence denotes The findings in these studies are unable to lend support to the earlier hypothesis that (a) GM1 is cholera toxin's naturally occurring membrane receptor on native fat cells, and (b) the ability of exogenously added GM1 to enhance the toxin's lipolytic activity represents the specific creation of additional natural receptors on adipocytes...
T1 0-47 Sentence denotes Lipolytic action of cholera toxin on fat cells.
T2 48-138 Sentence denotes Re-examination of the concept implicating GM1 ganglioside as the native membrane receptor.
T3 139-343 Sentence denotes The possible role of galactosyl-N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (GM1) ganglioside in the lipolytic activity of cholera toxin on isolated fat cells has been examined.
T4 344-756 Sentence denotes Analyses of the ganglioside content and composition of intact fat cells, their membranous ghosts, and the total particulate fraction of these cells indicate that N-acetylneuraminylgalactosylglucosylceramide (GM3) represents the major ganglioside, with substantial amounts of N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (GM2) and smaller amounts of other higher homologues also present.
T5 757-814 Sentence denotes Native GM1 was not detected in any of these preparations.
T6 815-1033 Sentence denotes Examination of the relative capacities of various exogenously added radiolabeled sphingolipids to bind to the cells indicated that GM2 and glucosylsphingosine were accumulated by the cells to extents comparable to GM1.
T7 1034-1148 Sentence denotes Galactosylsphingosine and sulfatide also exhibited significant, although lesser, binding affinities for the cells.
T8 1149-1398 Sentence denotes The adipocytes appeared to nonspecifically bind exogenously added GM1; saturation of binding sites for GM1 could not be observed up to the highest concentration tested (2 X 10(-4) M), wherein about 7 X 10(9) molecules were associated with the cells.
T9 1399-1501 Sentence denotes Essentially all of this exogenously added GM1 was found bound to the plasma membrane "ghost" fraction.
T10 1502-1709 Sentence denotes Investigation of the biological responses of the cells confirmed their sensitivities to both cholera toxin and epinephrine-stimulated lipolysis, as well as the lag period displayed during the toxin's action.
T11 1710-1928 Sentence denotes While we could confirm that the toxin's lipolytic activity can be enhanced by prior treatment of the fat cells with GM1, several of the observed characteristics of this phenomenon differ from earlier reported findings.
T12 1929-2082 Sentence denotes Accordingly, added GM1 was able to enhance only the subsequent rate, but not the extent, of toxin-stimulated glycerol release (lipolysis) from the cells.
T13 2083-2217 Sentence denotes We also were unable to confirm the ability of GM1 to enhance the toxin's activity at either saturating or at low toxin concentrations.
T14 2218-2337 Sentence denotes The limited ability of added GM1 to enhance the toxin's activity appeared in a unique bell-shaped dose-response manner.
T15 2338-2592 Sentence denotes The inability of high levels of GM1 to stimulate a dose of toxin that was ineffective on native cells suggests that the earlier reported ability of crude brain gangliosides to accomplish this was due to some component other than GM1 in the crude extract.
T16 2593-2865 Sentence denotes While several glycosphingolipids and some other carbohydrate-containing substances that were tested lacked the ability to mimic the enhancing effect of GM1, 4-methylumbelliferyl-beta-D-galactoside exhibited an effect similar to, although less pronounced than, that of GM1.
T17 2866-3208 Sentence denotes The findings in these studies are unable to lend support to the earlier hypothesis that (a) GM1 is cholera toxin's naturally occurring membrane receptor on native fat cells, and (b) the ability of exogenously added GM1 to enhance the toxin's lipolytic activity represents the specific creation of additional natural receptors on adipocytes...

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-47 Sentence denotes Lipolytic action of cholera toxin on fat cells.
T2 48-138 Sentence denotes Re-examination of the concept implicating GM1 ganglioside as the native membrane receptor.
T3 139-343 Sentence denotes The possible role of galactosyl-N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (GM1) ganglioside in the lipolytic activity of cholera toxin on isolated fat cells has been examined.
T4 344-756 Sentence denotes Analyses of the ganglioside content and composition of intact fat cells, their membranous ghosts, and the total particulate fraction of these cells indicate that N-acetylneuraminylgalactosylglucosylceramide (GM3) represents the major ganglioside, with substantial amounts of N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (GM2) and smaller amounts of other higher homologues also present.
T5 757-814 Sentence denotes Native GM1 was not detected in any of these preparations.
T6 815-1033 Sentence denotes Examination of the relative capacities of various exogenously added radiolabeled sphingolipids to bind to the cells indicated that GM2 and glucosylsphingosine were accumulated by the cells to extents comparable to GM1.
T7 1034-1148 Sentence denotes Galactosylsphingosine and sulfatide also exhibited significant, although lesser, binding affinities for the cells.
T8 1149-1398 Sentence denotes The adipocytes appeared to nonspecifically bind exogenously added GM1; saturation of binding sites for GM1 could not be observed up to the highest concentration tested (2 X 10(-4) M), wherein about 7 X 10(9) molecules were associated with the cells.
T9 1399-1501 Sentence denotes Essentially all of this exogenously added GM1 was found bound to the plasma membrane "ghost" fraction.
T10 1502-1709 Sentence denotes Investigation of the biological responses of the cells confirmed their sensitivities to both cholera toxin and epinephrine-stimulated lipolysis, as well as the lag period displayed during the toxin's action.
T11 1710-1928 Sentence denotes While we could confirm that the toxin's lipolytic activity can be enhanced by prior treatment of the fat cells with GM1, several of the observed characteristics of this phenomenon differ from earlier reported findings.
T12 1929-2082 Sentence denotes Accordingly, added GM1 was able to enhance only the subsequent rate, but not the extent, of toxin-stimulated glycerol release (lipolysis) from the cells.
T13 2083-2217 Sentence denotes We also were unable to confirm the ability of GM1 to enhance the toxin's activity at either saturating or at low toxin concentrations.
T14 2218-2337 Sentence denotes The limited ability of added GM1 to enhance the toxin's activity appeared in a unique bell-shaped dose-response manner.
T15 2338-2592 Sentence denotes The inability of high levels of GM1 to stimulate a dose of toxin that was ineffective on native cells suggests that the earlier reported ability of crude brain gangliosides to accomplish this was due to some component other than GM1 in the crude extract.
T16 2593-2865 Sentence denotes While several glycosphingolipids and some other carbohydrate-containing substances that were tested lacked the ability to mimic the enhancing effect of GM1, 4-methylumbelliferyl-beta-D-galactoside exhibited an effect similar to, although less pronounced than, that of GM1.
T17 2866-3208 Sentence denotes The findings in these studies are unable to lend support to the earlier hypothesis that (a) GM1 is cholera toxin's naturally occurring membrane receptor on native fat cells, and (b) the ability of exogenously added GM1 to enhance the toxin's lipolytic activity represents the specific creation of additional natural receptors on adipocytes...

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 90-93 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T2 243-246 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T3 552-555 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 691-694 Glycan denotes GM2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T5 764-767 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T6 946-949 Glycan denotes GM2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T7 1029-1032 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T8 1215-1218 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T9 1252-1255 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T10 1441-1444 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T11 1826-1829 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T12 1948-1951 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T13 2129-2132 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T14 2247-2250 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T15 2370-2373 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T16 2567-2570 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T17 2745-2748 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T18 2861-2864 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T19 2958-2961 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T20 3081-3084 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 90-93 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T2 243-246 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T3 764-767 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T4 1029-1032 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T5 1215-1218 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T6 1252-1255 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T7 1441-1444 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T8 1826-1829 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T9 1948-1951 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T10 2129-2132 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T11 2247-2250 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T12 2370-2373 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T13 2567-2570 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T14 2745-2748 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T15 2861-2864 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T16 2958-2961 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T17 3081-3084 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 90-93 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T2 243-246 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T3 764-767 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T4 1029-1032 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T5 1215-1218 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T6 1252-1255 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T7 1441-1444 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T8 1826-1829 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T9 1948-1951 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T10 2129-2132 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T11 2247-2250 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T12 2370-2373 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T13 2567-2570 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T14 2745-2748 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T15 2861-2864 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T16 2958-2961 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T17 3081-3084 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 2492-2497 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 37-46 Body_part denotes fat cells http://purl.obolibrary.org/obo/CL_0000136
T2 120-128 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T5 315-324 Body_part denotes fat cells http://purl.obolibrary.org/obo/CL_0000136
T6 406-415 Body_part denotes fat cells http://purl.obolibrary.org/obo/CL_0000136
T7 1153-1163 Body_part denotes adipocytes http://purl.obolibrary.org/obo/CL_0000136
T8 1468-1483 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T9 1811-1820 Body_part denotes fat cells http://purl.obolibrary.org/obo/CL_0000136
T10 2492-2497 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T12 3001-3009 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T15 3029-3038 Body_part denotes fat cells http://purl.obolibrary.org/obo/CL_0000136
T16 3195-3205 Body_part denotes adipocytes http://purl.obolibrary.org/obo/CL_0000136

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 37-46 Cell denotes fat cells http://purl.obolibrary.org/obo/CL:0000136
T2 315-324 Cell denotes fat cells http://purl.obolibrary.org/obo/CL:0000136
T3 406-415 Cell denotes fat cells http://purl.obolibrary.org/obo/CL:0000136
T4 1153-1163 Cell denotes adipocytes http://purl.obolibrary.org/obo/CL:0000136
T5 1811-1820 Cell denotes fat cells http://purl.obolibrary.org/obo/CL:0000136
T6 3029-3038 Cell denotes fat cells http://purl.obolibrary.org/obo/CL:0000136
T7 3195-3205 Cell denotes adipocytes http://purl.obolibrary.org/obo/CL:0000136