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sentences

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins.
T2 103-254 Sentence denotes Integrin ligand binding induces a signaling complex formation via the direct association of the docking protein p130(Cas) (Cas) with diverse molecules.
T3 255-347 Sentence denotes We report here that the 14-3-3zeta protein interacts with Cas in the yeast two-hybrid assay.
T4 348-586 Sentence denotes We also found that the two proteins associate in mammalian cells and that this interaction takes place in a phosphoserine-dependent manner, because treatment of Cas with a serine phosphatase greatly reduced its ability to bind 14-3-3zeta.
T5 587-692 Sentence denotes Furthermore, the Cas-14-3-3zeta interaction was found to be regulated by integrin-mediated cell adhesion.
T6 693-887 Sentence denotes Thus, when cells are detached from the extracellular matrix, the binding of Cas to 14-3-3zeta is greatly diminished, whereas replating the cells onto fibronectin rapidly induces the association.
T7 888-1140 Sentence denotes Consistent with these results, we found that the subcellular localization of Cas and 14-3-3 is also regulated by integrin ligand binding and that the two proteins display a significant co-localization during cell attachment to the extracellular matrix.
T8 1141-1410 Sentence denotes In conclusion, our results demonstrate that 14-3-3 proteins participate in integrin-activated signaling pathways through their interaction with Cas, which, in turn, may contribute to important biological responses regulated by cell adhesion to the extracellular matrix.

bionlp-st-gro-2013-training

Id Subject Object Predicate Lexical cue
T6 86-101 Protein denotes 14-3-3 proteins
T7 103-111 Protein denotes Integrin
T8 112-118 Ligand denotes ligand
T14 226-229 Protein denotes Cas
T15 279-297 Protein denotes 14-3-3zeta protein
T17 313-316 Protein denotes Cas
T18 375-383 Protein denotes proteins
T19 397-406 Eukaryote denotes mammalian
T20 407-412 Cell denotes cells
T22 456-469 AminoAcid denotes phosphoserine
T23 496-505 ExperimentalMethod denotes treatment
T24 509-512 Protein denotes Cas
T25 520-538 Enzyme denotes serine phosphatase
T28 575-585 Protein denotes 14-3-3zeta
T29 604-618 Protein denotes Cas-14-3-3zeta
T32 660-668 Protein denotes integrin
T35 704-709 Cell denotes cells
T36 732-752 CellComponent denotes extracellular matrix
T38 769-772 Protein denotes Cas
T39 776-786 Protein denotes 14-3-3zeta
T43 965-968 Protein denotes Cas
T44 973-979 Protein denotes 14-3-3
T46 1001-1009 Protein denotes integrin
T47 1010-1016 Ligand denotes ligand
T49 1042-1050 Protein denotes proteins
T50 1119-1139 CellComponent denotes extracellular matrix
T51 1185-1200 Protein denotes 14-3-3 proteins
T52 1216-1224 Protein denotes integrin
T56 1285-1288 Protein denotes Cas
T59 1389-1409 CellComponent denotes extracellular matrix
T10 147-164 ProteinComplex denotes complex formation
T4 52-77 Protein denotes docking protein p130(Cas)
E1 0-13 CellAdhesion denotes Cell adhesion
E2 14-23 RegulatoryProcess denotes regulates
E3 28-39 BindingToProtein denotes interaction
E4 119-126 Binding denotes binding
E6 298-307 BindingToProtein denotes interacts
E7 427-438 BindingToProtein denotes interaction
E8 547-554 Decrease denotes reduced
E9 570-574 BindingToProtein denotes bind
E10 619-630 BindingToProtein denotes interaction
E11 647-656 RegulatoryProcess denotes regulated
E12 669-677 RegulatoryProcess denotes mediated
E13 678-691 CellAdhesion denotes cell adhesion
E14 758-765 BindingToProtein denotes binding
E15 798-808 NegativeRegulation denotes diminished
E16 863-870 Increase denotes induces
E17 937-961 Localization denotes subcellular localization
E18 988-997 RegulatoryProcess denotes regulated
E19 1017-1024 Binding denotes binding
E20 1225-1234 PositiveRegulation denotes activated
E21 1235-1253 SignalingPathway denotes signaling pathways
E22 1268-1279 BindingToProtein denotes interaction
E23 1355-1364 RegulatoryProcess denotes regulated
E24 1368-1381 CellAdhesion denotes cell adhesion
E5 137-146 SignalingPathway denotes signaling
E25 173-191 BindingToProtein denotes direct association
E26 384-393 BindingToProtein denotes associate
E27 1076-1088 Localization denotes localization
E28 1096-1111 CellAdhesion denotes cell attachment
E29 937-961 Localization denotes subcellular localization
E30 988-997 RegulatoryProcess denotes regulated
R20 T32 E12 hasAgent integrin,mediated
R21 E13 E12 hasPatient cell adhesion,mediated
R22 T39 E14 hasPatient 14-3-3zeta,binding
R23 T38 E14 hasPatient Cas,binding
R24 E14 E15 hasPatient binding,diminished
R25 T43 E17 hasPatient Cas,subcellular localization
R26 E19 E18 hasAgent binding,regulated
R27 E17 E18 hasPatient subcellular localization,regulated
R28 T47 E19 hasPatient ligand,binding
R29 T52 E20 hasAgent integrin,activated
R30 E21 E20 hasPatient signaling pathways,activated
R31 T56 E22 hasPatient Cas,interaction
R32 T51 E22 hasPatient 14-3-3 proteins,interaction
R33 E24 E23 hasAgent cell adhesion,regulated
R34 E4 E5 hasAgent binding,signaling
R35 T14 E25 hasPatient Cas,direct association
R36 T18 E26 hasPatient proteins,associate
R37 T49 E27 hasPatient proteins,localization
R38 T44 E29 hasPatient 14-3-3,subcellular localization
R39 E19 E30 hasAgent binding,regulated
R40 E29 E30 hasPatient subcellular localization,regulated
R3 T20 T19 fromSpecies cells,mammalian
R1 E26 T20 locatedIn associate,cells
R2 E24 T59 locatedIn cell adhesion,extracellular matrix
R4 E28 T50 locatedIn cell attachment,extracellular matrix
R6 E1 E2 hasAgent Cell adhesion,regulates
R7 E3 E2 hasPatient interaction,regulates
R8 T6 E3 hasPatient 14-3-3 proteins,interaction
R9 T4 E3 hasPatient docking protein p130(Cas),interaction
R10 T8 E4 hasPatient ligand,binding
R11 T17 E6 hasPatient Cas,interacts
R12 T15 E6 hasPatient 14-3-3zeta protein,interacts
R13 T23 E8 hasAgent treatment,reduced
R14 E9 E8 hasPatient bind,reduced
R15 T28 E9 hasPatient 14-3-3zeta,bind
R16 T24 E9 hasPatient Cas,bind
R17 T29 E10 hasPatient Cas-14-3-3zeta,interaction
R18 E13 E11 hasAgent cell adhesion,regulated
R19 E10 E11 hasPatient interaction,regulated

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 732-752 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T2 1119-1139 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T3 1389-1409 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012