> top > docs > PubMed:10026192 > annotations

PubMed:10026192 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells.
T2 124-316 Sentence denotes Phosphorylation of eukaryotic translation initiation factor-2alpha (eIF-2alpha) is one of the key steps where protein synthesis is regulated in response to changes in environmental conditions.
T3 317-529 Sentence denotes The phosphorylation is carried out in part by three distinct eIF-2alpha kinases including mammalian double-stranded RNA-dependent eIF-2alpha kinase (PKR) and heme-regulated inhibitor kinase (HRI), and yeast GCN2.
T4 530-714 Sentence denotes We report the identification and characterization of a related kinase, PEK, which shares common features with other eIF-2alpha kinases including phosphorylation of eIF-2alpha in vitro.
T5 715-791 Sentence denotes We show that human PEK is regulated by different mechanisms than PKR or HRI.
T6 792-1092 Sentence denotes In contrast to PKR or HRI, which are dependent on autophosphorylation for their kinase activity, a point mutation that replaced the conserved Lys-614 with an alanine completely abolished the eIF-2alpha kinase activity, whereas the mutant PEK was still autophosphorylated when expressed in Sf-9 cells.
T7 1093-1239 Sentence denotes Northern blot analysis indicates that PEK mRNA was predominantly expressed in pancreas, though low expression was also present in several tissues.
T8 1240-1443 Sentence denotes Consistent with the high levels of mRNA in pancreas, the PEK protein was only detected in human pancreatic islets, and the kinase co-localized with somatostatin, a pancreatic delta cell-specific hormone.
T9 1444-1580 Sentence denotes Thus PEK is believed to play an important role in regulating protein synthesis in the pancreatic islet, especially in islet delta cells.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1171-1179 http://purl.obolibrary.org/obo/MAT_0000075 denotes pancreas
T2 1283-1291 http://purl.obolibrary.org/obo/MAT_0000075 denotes pancreas
T3 1336-1353 http://purl.obolibrary.org/obo/MAT_0000076 denotes pancreatic islets
T4 1530-1546 http://purl.obolibrary.org/obo/MAT_0000076 denotes pancreatic islet

bionlp-st-gro-2013-training

Id Subject Object Predicate Lexical cue
T18 466-469 Enzyme denotes PKR
T19 475-506 Enzyme denotes heme-regulated inhibitor kinase
T20 508-511 Enzyme denotes HRI
T14 378-396 Enzyme denotes eIF-2alpha kinases
T15 407-416 Eukaryote denotes mammalian
T16 417-436 RNA denotes double-stranded RNA
T17 447-464 Enzyme denotes eIF-2alpha kinase
T2 29-39 Tissue denotes pancreatic
T3 40-57 Enzyme denotes eIF-2alpha kinase
T4 59-62 Enzyme denotes PEK
T5 89-101 Protein denotes somatostatin
T6 105-122 Cell denotes islet delta cells
T8 143-153 Eukaryote denotes eukaryotic
T9 154-190 TranslationFactor denotes translation initiation factor-2alpha
T10 192-202 TranslationFactor denotes eIF-2alpha
T21 518-523 Eukaryote denotes yeast
T22 524-528 Enzyme denotes GCN2
T23 593-599 Enzyme denotes kinase
T24 601-604 Enzyme denotes PEK
T25 646-664 Enzyme denotes eIF-2alpha kinases
T27 694-704 TranslationFactor denotes eIF-2alpha
T28 728-733 Eukaryote denotes human
T29 734-737 Enzyme denotes PEK
T31 780-783 Enzyme denotes PKR
T32 787-790 Enzyme denotes HRI
T33 807-810 Enzyme denotes PKR
T34 814-817 Enzyme denotes HRI
T36 872-887 CatalyticActivity denotes kinase activity
T39 983-993 TranslationFactor denotes eIF-2alpha
T40 994-1009 CatalyticActivity denotes kinase activity
T41 1023-1033 MutantProtein denotes mutant PEK
T44 1081-1091 Cell denotes Sf-9 cells
T45 1131-1134 Enzyme denotes PEK
T46 1135-1139 MessengerRNA denotes mRNA
T48 1171-1179 Tissue denotes pancreas
T50 1231-1238 Tissue denotes tissues
T51 1275-1279 MessengerRNA denotes mRNA
T52 1283-1291 Tissue denotes pancreas
T53 1297-1308 Enzyme denotes PEK protein
T54 1330-1335 Eukaryote denotes human
T55 1336-1353 Tissue denotes pancreatic islets
T56 1363-1369 Enzyme denotes kinase
T57 1388-1400 Peptide denotes somatostatin
T58 1404-1414 Tissue denotes pancreatic
T59 1415-1425 Cell denotes delta cell
T60 1435-1442 Chemical denotes hormone
T61 1449-1452 Enzyme denotes PEK
T64 1530-1546 Tissue denotes pancreatic islet
T65 1562-1579 Cell denotes islet delta cells
T1 22-28 MutantProtein denotes mutant
E2 124-139 Phosphorylation denotes Phosphorylation
E3 234-251 ProteinBiosynthesis denotes protein synthesis
E4 255-264 RegulatoryProcess denotes regulated
E5 321-336 Phosphorylation denotes phosphorylation
E6 675-690 Phosphorylation denotes phosphorylation
E7 741-750 RegulatoryProcess denotes regulated
E8 842-861 Phosphorylation denotes autophosphorylation
E9 891-905 Mutation denotes point mutation
E10 969-978 NegativeRegulation denotes abolished
E11 1044-1062 Phosphorylation denotes autophosphorylated
E12 1068-1077 GeneExpression denotes expressed
E13 1158-1167 TranscriptionOfGene denotes expressed
E15 1494-1504 RegulatoryProcess denotes regulating
E16 1505-1522 ProteinBiosynthesis denotes protein synthesis
E1 268-276 ResponseProcess denotes response
E14 1188-1191 Decrease denotes low
E17 1192-1202 TranscriptionOfGene denotes expression
E18 1260-1271 Increase denotes high levels
E19 842-861 Phosphorylation denotes autophosphorylation
R30 E17 E14 hasPatient expression,low
R31 T51 E18 hasPatient mRNA,high levels
R32 T34 E19 hasPatient HRI,autophosphorylation
R1 T3 T2 locatedIn eIF-2alpha kinase,pancreatic
R2 T3 T6 locatedIn eIF-2alpha kinase,islet delta cells
R3 T5 T6 locatedIn somatostatin,islet delta cells
R4 T9 T8 fromSpecies translation initiation factor-2alpha,eukaryotic
R5 T17 T15 fromSpecies eIF-2alpha kinase,mammalian
R6 T22 T21 fromSpecies GCN2,yeast
R7 T29 T28 fromSpecies PEK,human
R8 T33 T36 hasFunction PKR,kinase activity
R9 T34 T36 hasFunction HRI,kinase activity
R10 T39 T40 hasFunction eIF-2alpha,kinase activity
R11 E12 T44 locatedIn expressed,Sf-9 cells
R12 T46 T45 encodes mRNA,PEK
R13 E13 T48 locatedIn expressed,pancreas
R15 T51 T52 locatedIn mRNA,pancreas
R16 T53 T55 locatedIn PEK protein,pancreatic islets
R17 T55 T54 fromSpecies pancreatic islets,human
R18 E16 T64 locatedIn protein synthesis,pancreatic islet
R20 E1 E4 precedes response,regulated
R14 E16 T65 locatedIn protein synthesis,islet delta cells
R16 T9 E2 hasPatient translation initiation factor-2alpha,Phosphorylation
R17 E3 E4 hasPatient protein synthesis,regulated
R18 T14 E5 hasAgent eIF-2alpha kinases,phosphorylation
R19 T24 E6 hasAgent PEK,phosphorylation
R20 T27 E6 hasPatient eIF-2alpha,phosphorylation
R21 T29 E7 hasPatient PEK,regulated
R22 T33 E8 hasPatient PKR,autophosphorylation
R23 E9 E10 hasAgent point mutation,abolished
R24 T40 E10 hasPatient kinase activity,abolished
R25 T41 E11 hasPatient mutant PEK,autophosphorylated
R26 T41 E12 hasPatient mutant PEK,expressed
R27 T46 E13 hasPatient mRNA,expressed
R28 T61 E15 hasAgent PEK,regulating
R29 E16 E15 hasPatient protein synthesis,regulating

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1171-1179 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040
T2 1283-1291 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 728-733 OrganismTaxon denotes human 9606
T2 1330-1335 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1171-1179 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264|http://purl.obolibrary.org/obo/UBERON_3011040
T3 1283-1291 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264|http://purl.obolibrary.org/obo/UBERON_3011040
T5 1336-1353 Body_part denotes pancreatic islets http://purl.obolibrary.org/obo/UBERON_0000006
T6 1404-1425 Body_part denotes pancreatic delta cell http://purl.obolibrary.org/obo/CL_0000173
T7 1530-1546 Body_part denotes pancreatic islet http://purl.obolibrary.org/obo/UBERON_0000006

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1171-1179 Body_part denotes pancreas http://purl.obolibrary.org/obo/MAT_0000075
T2 1283-1291 Body_part denotes pancreas http://purl.obolibrary.org/obo/MAT_0000075
T3 1336-1353 Body_part denotes pancreatic islets http://purl.obolibrary.org/obo/MAT_0000076
T4 1530-1546 Body_part denotes pancreatic islet http://purl.obolibrary.org/obo/MAT_0000076

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 111-116 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124
T2 1404-1425 Cell denotes pancreatic delta cell http://purl.obolibrary.org/obo/CL:0000173
T3 1415-1420 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124
T4 1568-1573 Cell denotes delta http://purl.obolibrary.org/obo/CL:0004124