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PubMed:10026184 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-40 Sentence denotes Mapping the functional domains of BRCA1.
T2 41-99 Sentence denotes Interaction of the ring finger domains of BRCA1 and BARD1.
T3 100-261 Sentence denotes Breast cancer 1 (BRCA1) and BRCA1-associated RING domain 1 (BARD1) are multidomain proteins that interact in vivo via their N-terminal RING finger motif regions.
T4 262-501 Sentence denotes To characterize functional aspects of the BRCA1/BARD1 interaction, we have defined the structural domains required for the interaction, as well as their oligomerization state, relative stability, and possible nucleic acid binding activity.
T5 502-702 Sentence denotes We have found that the RING finger motifs do not themselves constitute stable structural domains but are instead part of larger domains comprising residues 1-109 of BRCA1 and residues 26-119 of BARD1.
T6 703-782 Sentence denotes These domains exist as homodimers and preferentially form a stable heterodimer.
T7 783-1005 Sentence denotes Shorter BRCA1 RING finger constructs do not interact with BARD1 or with longer BRCA1 constructs, indicating that the heterodimeric and homodimer interactions are mediated by regions outside the canonical RING finger motif.
T8 1006-1083 Sentence denotes Nucleic acid binding is a generally proposed function of RING finger domains.
T9 1084-1363 Sentence denotes We show that neither the homodimers nor the heterodimer displays affinity for nucleic acids, indicating that the proposed roles of BRCA1 and BARD1 in DNA repair and/or transcriptional activation must be mediated either by other regions of the proteins or by additional cofactors.

bionlp-st-gro-2013-training

Id Subject Object Predicate Lexical cue
T1 23-30 ProteinDomain denotes domains
T2 34-39 Protein denotes BRCA1
T4 60-79 ProteinDomain denotes ring finger domains
T5 83-88 Protein denotes BRCA1
T6 93-98 Protein denotes BARD1
T8 117-122 Protein denotes BRCA1
T10 160-165 Protein denotes BARD1
T11 171-191 Protein denotes multidomain proteins
T13 235-260 ProteinDomain denotes RING finger motif regions
T14 304-315 Protein denotes BRCA1/BARD1
T16 349-367 ProteinDomain denotes structural domains
T18 471-483 NucleicAcid denotes nucleic acid
T20 525-543 ProteinDomain denotes RING finger motifs
T21 580-598 ProteinDomain denotes structural domains
T22 623-637 ProteinDomain denotes larger domains
T23 667-672 Protein denotes BRCA1
T24 696-701 Protein denotes BARD1
T25 709-716 ProteinDomain denotes domains
T26 791-796 Protein denotes BRCA1
T27 797-819 ProteinDomain denotes RING finger constructs
T29 841-846 Protein denotes BARD1
T30 862-878 Protein denotes BRCA1 constructs
T33 977-1004 ProteinDomain denotes canonical RING finger motif
T34 1006-1018 NucleicAcid denotes Nucleic acid
T36 1063-1082 ProteinDomain denotes RING finger domains
T37 1162-1175 NucleicAcid denotes nucleic acids
T38 1215-1220 Protein denotes BRCA1
T39 1225-1230 Protein denotes BARD1
T40 1234-1237 DNA denotes DNA
T44 1312-1319 ProteinDomain denotes regions
T45 1327-1335 Protein denotes proteins
T46 1353-1362 TranscriptionCofactor denotes cofactors
E1 41-52 BindingToProtein denotes Interaction
E2 197-205 BindingToProtein denotes interact
E3 316-327 BindingToProtein denotes interaction
E4 385-396 BindingToProtein denotes interaction
E5 484-500 Binding denotes binding activity
E6 827-835 BindingToProtein denotes interact
E9 1019-1026 Binding denotes binding
E10 1252-1267 Transcription denotes transcriptional
E11 1268-1278 PositiveRegulation denotes activation
E13 726-736 Homodimerization denotes homodimers
E14 770-781 Heterodimerization denotes heterodimer
E15 900-913 Heterodimerization denotes heterodimeric
E7 918-940 Homodimerization denotes homodimer interactions
E8 1109-1119 Homodimerization denotes homodimers
E16 1128-1139 Heterodimerization denotes heterodimer
E17 1238-1244 CellularMetabolicProcess denotes repair
E12 1268-1278 PositiveRegulation denotes activation
E18 1238-1244 CellularMetabolicProcess denotes repair
R7 T6 T4 hasPart BARD1,ring finger domains
R8 T23 T22 hasPart BRCA1,larger domains
R9 T24 T22 hasPart BARD1,larger domains
R3 T8 T13 hasPart BRCA1,RING finger motif regions
R4 T10 T13 hasPart BARD1,RING finger motif regions
R7 T4 E1 hasPatient ring finger domains,Interaction
R9 T13 E2 hasPatient RING finger motif regions,interact
R10 T14 E3 hasPatient BRCA1/BARD1,interaction
R11 T16 E4 hasPatient structural domains,interaction
R12 T18 E5 hasPatient nucleic acid,binding activity
R13 T36 E9 hasAgent RING finger domains,binding
R14 T34 E9 hasPatient Nucleic acid,binding
R15 T38 E11 hasAgent BRCA1,activation
R16 E10 E11 hasPatient transcriptional,activation
R17 T25 E13 hasAgent domains,homodimers
R18 T25 E14 hasAgent domains,heterodimer
R19 T38 E17 hasAgent BRCA1,repair
R20 T40 E17 hasPatient DNA,repair
R21 T39 E12 hasAgent BARD1,activation
R22 E10 E12 hasPatient transcriptional,activation
R23 T39 E18 hasAgent BARD1,repair
R24 T40 E18 hasPatient DNA,repair
R1 T2 T1 hasPart BRCA1,domains
R2 T5 T4 hasPart BRCA1,ring finger domains
R5 T26 T27 hasPart BRCA1,RING finger constructs
R6 T45 T44 hasPart proteins,regions

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 100-113 HP_0003002 denotes Breast cancer
T2 100-113 HP_0100013 denotes Breast cancer
T3 107-113 HP_0002664 denotes cancer

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 100-113 Phenotype denotes Breast cancer HP:0003002

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 100-113 Disease denotes Breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 60-71 Body_part denotes ring finger http://purl.obolibrary.org/obo/UBERON_0003624
T2 100-106 Body_part denotes Breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 235-246 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T4 525-536 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T5 797-808 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T6 987-998 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T7 1063-1074 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624