> top > docs > PubMed:10026181 > annotations

PubMed:10026181 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repair.
T2 116-213 Sentence denotes The human XPG endonuclease cuts on the 3' side of a DNA lesion during nucleotide excision repair.
T3 214-306 Sentence denotes Mutations in XPG can lead to the disorders xeroderma pigmentosum (XP) and Cockayne syndrome.
T4 307-418 Sentence denotes XPG shares sequence similarities in two regions with a family of structure-specific nucleases and exonucleases.
T5 419-726 Sentence denotes To begin defining its catalytic mechanism, we changed highly conserved residues and determined the effects on the endonuclease activity of isolated XPG, its function in open complex formation and dual incision reconstituted with purified proteins, and its ability to restore cellular resistance to UV light.
T6 727-903 Sentence denotes The substitution A792V present in two XP complementation group G (XP-G) individuals reduced but did not abolish endonuclease activity, explaining their mild clinical phenotype.
T7 904-982 Sentence denotes Isolated XPG proteins with Asp-77 or Glu-791 substitutions did not cleave DNA.
T8 983-1191 Sentence denotes In the reconstituted repair system, alanine substitutions at these positions permitted open complex formation but were inactive for 3' cleavage, whereas D77E and E791D proteins retained considerable activity.
T9 1192-1328 Sentence denotes The function of each mutant protein in the reconstituted system was mirrored by its ability to restore UV resistance to XP-G cell lines.
T10 1329-1593 Sentence denotes Hydrodynamic measurements indicated that XPG exists as a monomer in high salt conditions, but immunoprecipitation of intact and truncated XPG proteins showed that XPG polypeptides can interact with each other, suggesting dimerization as an element of XPG function.
T11 1594-1814 Sentence denotes The mutation results define critical residues in the catalytic center of XPG and strongly suggest that key features of the strand cleavage mechanism and active site structure are shared by members of the nuclease family.

bionlp-st-gro-2013-training

Id Subject Object Predicate Lexical cue
T1 22-27 Eukaryote denotes human
T2 28-39 Enzyme denotes XPG protein
T3 54-71 CatalyticActivity denotes nuclease activity
T5 120-125 Eukaryote denotes human
T6 126-142 Enzyme denotes XPG endonuclease
T7 168-171 DNA denotes DNA
T10 227-230 Enzyme denotes XPG
T13 307-310 Enzyme denotes XPG
T14 391-400 Enzyme denotes nucleases
T15 405-417 Enzyme denotes exonucleases
T16 533-554 CatalyticActivity denotes endonuclease activity
T17 558-570 Enzyme denotes isolated XPG
T18 657-665 Protein denotes proteins
T19 839-860 CatalyticActivity denotes endonuclease activity
T20 904-925 Enzyme denotes Isolated XPG proteins
T23 1213-1227 MutantProtein denotes mutant protein
T24 1370-1373 Enzyme denotes XPG
T25 1467-1479 Enzyme denotes XPG proteins
T26 1492-1495 Enzyme denotes XPG
T27 1496-1508 Peptide denotes polypeptides
T29 1580-1583 Enzyme denotes XPG
T31 1667-1670 Enzyme denotes XPG
T33 1798-1806 Enzyme denotes nuclease
T36 441-460 CatalyticActivity denotes catalytic mechanism
T39 793-797 Enzyme denotes XP-G
T42 893-902 Phenotype denotes phenotype
T46 1312-1327 Cell denotes XP-G cell lines
T48 1717-1723 DNA denotes strand
E1 88-114 CellularMetabolicProcess denotes nucleotide excision repair
E2 186-212 CellularMetabolicProcess denotes nucleotide excision repair
E3 214-223 Mutation denotes Mutations
E5 288-305 Disease denotes Cockayne syndrome
E6 1070-1092 FormationOfProteinDNAComplex denotes open complex formation
E7 1118-1126 Cleavage denotes cleavage
E8 1513-1521 BindingToProtein denotes interact
E9 1598-1606 Mutation denotes mutation
E10 1724-1732 Cleavage denotes cleavage
E11 143-147 Cleavage denotes cuts
E12 280-282 Disease denotes XP
E13 694-725 ResponseProcess denotes cellular resistance to UV light
E14 686-693 ActivationOfProcess denotes restore
E15 811-818 Decrease denotes reduced
E16 731-749 Mutation denotes substitution A792V
E17 1004-1017 CellularMetabolicProcess denotes repair system
E18 1287-1294 ActivationOfProcess denotes restore
E19 1295-1308 ResponseProcess denotes UV resistance
E20 1550-1562 Dimerization denotes dimerization
R1 T2 T1 fromSpecies XPG protein,human
R2 T6 T5 fromSpecies XPG endonuclease,human
R5 T17 T16 hasFunction isolated XPG,endonuclease activity
R6 T26 T27 hasPart XPG,polypeptides
R3 E19 T46 locatedIn UV resistance,XP-G cell lines
R5 T10 E3 hasPatient XPG,Mutations
R6 E3 E5 hasAgent Mutations,Cockayne syndrome
R7 T27 E8 hasPatient polypeptides,interact
R8 T31 E9 hasPatient XPG,mutation
R9 T48 E10 hasPatient strand,cleavage
R10 T6 E11 hasAgent XPG endonuclease,cuts
R11 T7 E11 hasPatient DNA,cuts
R12 E13 E14 hasPatient cellular resistance to UV light,restore
R13 E16 E15 hasAgent substitution A792V,reduced
R14 T19 E15 hasPatient endonuclease activity,reduced
R15 T39 E16 hasPatient XP-G,substitution A792V
R16 E19 E18 hasPatient UV resistance,restore
R17 T29 E20 hasPatient XPG,dimerization

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 28-31 Disease denotes XPG http://purl.obolibrary.org/obo/MONDO_0010216
T2 126-129 Disease denotes XPG http://purl.obolibrary.org/obo/MONDO_0010216
T3 227-230 Disease denotes XPG http://purl.obolibrary.org/obo/MONDO_0010216
T4 257-278 Disease denotes xeroderma pigmentosum http://purl.obolibrary.org/obo/MONDO_0019600
T5 280-282 Disease denotes XP http://purl.obolibrary.org/obo/MONDO_0019600
T6 288-305 Disease denotes Cockayne syndrome http://purl.obolibrary.org/obo/MONDO_0016006
T7 307-310 Disease denotes XPG http://purl.obolibrary.org/obo/MONDO_0010216
T8 567-570 Disease denotes XPG http://purl.obolibrary.org/obo/MONDO_0010216
T9 765-767 Disease denotes XP http://purl.obolibrary.org/obo/MONDO_0019600
T10 793-797 Disease denotes XP-G http://purl.obolibrary.org/obo/MONDO_0010216
T11 793-795 Disease denotes XP http://purl.obolibrary.org/obo/MONDO_0019600
T12 913-916 Disease denotes XPG http://purl.obolibrary.org/obo/MONDO_0010216
T13 1312-1316 Disease denotes XP-G http://purl.obolibrary.org/obo/MONDO_0010216
T14 1312-1314 Disease denotes XP http://purl.obolibrary.org/obo/MONDO_0019600
T15 1370-1373 Disease denotes XPG http://purl.obolibrary.org/obo/MONDO_0010216
T16 1467-1470 Disease denotes XPG http://purl.obolibrary.org/obo/MONDO_0010216
T17 1492-1495 Disease denotes XPG http://purl.obolibrary.org/obo/MONDO_0010216
T18 1580-1583 Disease denotes XPG http://purl.obolibrary.org/obo/MONDO_0010216
T19 1667-1670 Disease denotes XPG http://purl.obolibrary.org/obo/MONDO_0010216

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 22-27 OrganismTaxon denotes human 9606
T2 120-125 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1315-1321 Body_part denotes G cell http://purl.obolibrary.org/obo/CL_0000508

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1315-1321 Cell denotes G cell http://purl.obolibrary.org/obo/CL:0000508