PubMed:10026162
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 483-491 | Cell | denotes | neuronal | http://purl.obolibrary.org/obo/CL:0000540 |
| T2 | 905-923 | Cell | denotes | receptors and cell | http://purl.obolibrary.org/obo/CL:0000197 |
| T3 | 1335-1351 | Cell | denotes | chromaffin cells | http://purl.obolibrary.org/obo/CL:0000166 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-119 | Sentence | denotes | A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors. |
| T2 | 120-327 | Sentence | denotes | Poisoning with alpha-latrotoxin, a neurotoxic protein from black widow spider venom, results in a robust increase of spontaneous synaptic transmission and subsequent degeneration of affected nerve terminals. |
| T3 | 328-448 | Sentence | denotes | The neurotoxic action of alpha-latrotoxin involves extracellular binding to its high affinity receptors as a first step. |
| T4 | 449-561 | Sentence | denotes | One of these proteins, CIRL, is a neuronal G-protein-coupled receptor implicated in the regulation of secretion. |
| T5 | 562-682 | Sentence | denotes | We now demonstrate that CIRL has two close homologs with a similar domain structure and high degree of overall identity. |
| T6 | 683-942 | Sentence | denotes | These novel receptors, which we propose to name CIRL-2 and CIRL-3, together with CIRL (CIRL-1) belong to a recently identified subfamily of large orphan receptors with structural features typical of both G-protein-coupled receptors and cell adhesion proteins. |
| T7 | 943-1178 | Sentence | denotes | Northern blotting experiments indicate that CIRL-2 is expressed ubiquitously with highest concentrations found in placenta, kidney, spleen, ovary, heart, and lung, whereas CIRL-3 is expressed predominantly in brain similarly to CIRL-1. |
| T8 | 1179-1312 | Sentence | denotes | It appears that CIRL-2 can also bind alpha-latrotoxin, although its affinity to the toxin is about 14 times less than that of CIRL-1. |
| T9 | 1313-1463 | Sentence | denotes | When overexpressed in chromaffin cells, CIRL-2 increases their sensitivity to alpha-latrotoxin stimulation but also inhibits Ca2+-regulated secretion. |
| T10 | 1464-1534 | Sentence | denotes | Thus, CIRL-2 is a functionally competent receptor of alpha-latrotoxin. |
| T11 | 1535-1802 | Sentence | denotes | Our findings suggest that although the nervous system is the primary target of low doses of alpha-latrotoxin, cells of other tissues are also susceptible to the toxic effects of alpha-latrotoxin because of the presence of CIRL-2, a low affinity receptor of the toxin. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1057-1065 | http://purl.obolibrary.org/obo/MAT_0000279 | denotes | placenta |
| T2 | 1067-1073 | http://purl.obolibrary.org/obo/MAT_0000119 | denotes | kidney |
| T3 | 1075-1081 | http://purl.obolibrary.org/obo/MAT_0000085 | denotes | spleen |
| T4 | 1090-1095 | http://purl.obolibrary.org/obo/MAT_0000036 | denotes | heart |
| T5 | 1101-1105 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T6 | 1152-1157 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T7 | 1574-1588 | http://purl.obolibrary.org/obo/MAT_0000026 | denotes | nervous system |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 120-129 | Disease | denotes | Poisoning | http://purl.obolibrary.org/obo/MONDO_0029000 |
| T2 | 155-165 | Disease | denotes | neurotoxic | http://purl.obolibrary.org/obo/MONDO_0005527 |
| T3 | 332-342 | Disease | denotes | neurotoxic | http://purl.obolibrary.org/obo/MONDO_0005527 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1057-1065 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/MAT_0000279 |
| T2 | 1067-1073 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/MAT_0000119 |
| T3 | 1075-1081 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/MAT_0000085 |
| T4 | 1090-1095 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
| T5 | 1101-1105 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T6 | 1152-1157 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T7 | 1574-1588 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/MAT_0000026 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 179-197 | OrganismTaxon | denotes | black widow spider | 6924|6925 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 198-203 | Body_part | denotes | venom | http://purl.obolibrary.org/obo/UBERON_0007113 |
| T2 | 311-316 | Body_part | denotes | nerve | http://purl.obolibrary.org/obo/UBERON_0001021 |
| T3 | 379-392 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |
| T4 | 905-923 | Body_part | denotes | receptors and cell | http://purl.obolibrary.org/obo/CL_0000197 |
| T5 | 1057-1065 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T6 | 1067-1073 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T7 | 1075-1081 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/UBERON_0002106 |
| T8 | 1083-1088 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
| T9 | 1090-1095 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
| T13 | 1101-1105 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T14 | 1152-1157 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T16 | 1335-1351 | Body_part | denotes | chromaffin cells | http://purl.obolibrary.org/obo/UBERON_0001236 |
| T17 | 1574-1588 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |