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PubMed:10026134 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-160 Sentence denotes Cadmium-mediated activation of the metal response element in human neuroblastoma cells lacking functional metal response element-binding transcription factor-1.
T2 161-364 Sentence denotes Metal response element-binding transcription factor-1 (MTF-1) binds specifically to metal response elements (MREs) and transactivates metallothionein (MT) gene expression in response to zinc and cadmium.
T3 365-599 Sentence denotes This investigation contrasts the mechanism of mouse MT gene (mMT-I) promoter activation by cadmium and zinc in IMR-32 human neuroblastoma cells to determine whether MTF-1 binding to the MRE is necessary for activation by these metals.
T4 600-718 Sentence denotes Cadmium activated a mMT-1 promoter (-150 base pairs) luciferase reporter 20-25-fold through a MRE-dependent mechanism.
T5 719-788 Sentence denotes In contrast, zinc had little effect on the mMT-1 luciferase reporter.
T6 789-900 Sentence denotes IMR-32 cells lacked MRE binding activity, and treatment with zinc in vitro or in vivo did not generate a MTF-1.
T7 901-965 Sentence denotes MRE complex, suggesting that IMR-32 cells lack functional MTF-1.
T8 966-1077 Sentence denotes Overexpression of mMTF-1 regenerated a zinc-mediated induction of the MRE without affecting cadmium activation.
T9 1078-1183 Sentence denotes Because no other transition metals tested activated the MRE, this effect appeared to be cadmium-specific.
T10 1184-1403 Sentence denotes These data demonstrate that in IMR-32 human neuroblastoma cells, zinc and cadmium can use independent mechanisms for activation of the mMT-I promoter and cadmium-mediated MRE activation is independent of MTF-1 and zinc.

PennBioIE

Id Subject Object Predicate Lexical cue
T1 67-80 protein denotes neuroblastoma
T2 106-159 protein denotes metal response element-binding transcription factor-1
T3 170-214 protein denotes ponse element-binding transcription factor-1
T4 216-221 protein denotes MTF-1
T5 295-310 protein denotes metallothionein
T6 312-314 protein denotes MT
T7 417-419 protein denotes MT
T8 426-431 protein denotes mMT-I
T9 489-502 protein denotes neuroblastoma
T10 530-535 protein denotes MTF-1
T11 620-625 protein denotes mMT-1
T12 653-663 protein denotes luciferase
T13 762-767 protein denotes mMT-1
T14 768-778 protein denotes luciferase
T15 894-899 protein denotes MTF-1
T16 959-964 protein denotes MTF-1
T17 984-990 protein denotes mMTF-1
T18 1228-1241 protein denotes neuroblastoma
T19 1319-1324 protein denotes mMT-I
T20 1388-1393 protein denotes MTF-1

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 489-502 HP_0003006 denotes neuroblastoma
T2 1228-1241 HP_0003006 denotes neuroblastoma

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 67-80 Phenotype denotes neuroblastoma HP:0003006
T2 489-502 Phenotype denotes neuroblastoma HP:0003006
T3 1228-1241 Phenotype denotes neuroblastoma HP:0003006

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 67-80 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T2 489-502 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T3 1228-1241 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 61-66 OrganismTaxon denotes human 9606
T2 411-416 OrganismTaxon denotes mouse 10088|10090
T4 483-488 OrganismTaxon denotes human 9606
T5 1222-1227 OrganismTaxon denotes human 9606