PubMed:10025962 JSONTXT

{"project":"bionlp-st-gro-2013-training","denotations":[{"id":"T2","span":{"begin":79,"end":93},"obj":"Protein"},{"id":"T3","span":{"begin":138,"end":142},"obj":"DNA"},{"id":"T4","span":{"begin":172,"end":183},"obj":"AminoAcid"},{"id":"T5","span":{"begin":192,"end":204},"obj":"Protein"},{"id":"T6","span":{"begin":206,"end":209},"obj":"Protein"},{"id":"T7","span":{"begin":223,"end":228},"obj":"Eukaryote"},{"id":"T8","span":{"begin":235,"end":240},"obj":"Tissue"},{"id":"T9","span":{"begin":241,"end":245},"obj":"DNA"},{"id":"T11","span":{"begin":285,"end":289},"obj":"Protein"},{"id":"T12","span":{"begin":339,"end":344},"obj":"Protein"},{"id":"T13","span":{"begin":372,"end":390},"obj":"ProteinDomain"},{"id":"T14","span":{"begin":395,"end":417},"obj":"ProteinDomain"},{"id":"T15","span":{"begin":452,"end":456},"obj":"Protein"},{"id":"T16","span":{"begin":458,"end":462},"obj":"Protein"},{"id":"T18","span":{"begin":604,"end":608},"obj":"Protein"},{"id":"T19","span":{"begin":609,"end":613},"obj":"MessengerRNA"},{"id":"T20","span":{"begin":634,"end":647},"obj":"Tissue"},{"id":"T21","span":{"begin":649,"end":657},"obj":"Tissue"},{"id":"T22","span":{"begin":659,"end":672},"obj":"Tissue"},{"id":"T23","span":{"begin":674,"end":679},"obj":"Tissue"},{"id":"T24","span":{"begin":684,"end":699},"obj":"Tissue"},{"id":"T25","span":{"begin":703,"end":708},"obj":"Eukaryote"},{"id":"T26","span":{"begin":715,"end":722},"obj":"Tissue"},{"id":"T27","span":{"begin":738,"end":742},"obj":"Protein"},{"id":"T1","span":{"begin":50,"end":77},"obj":"Protein"},{"id":"T28","span":{"begin":748,"end":765},"obj":"Protein"},{"id":"T29","span":{"begin":780,"end":787},"obj":"Protein"},{"id":"T30","span":{"begin":791,"end":808},"obj":"Cell"},{"id":"T31","span":{"begin":565,"end":580},"obj":"Sequence"},{"id":"E1","span":{"begin":585,"end":602},"obj":"ProteinTransport"}],"relations":[{"id":"R1","pred":"encodes","subj":"T3","obj":"T5"},{"id":"R3","pred":"fromSpecies","subj":"T8","obj":"T7"},{"id":"R4","pred":"locatedIn","subj":"T9","obj":"T8"},{"id":"R5","pred":"hasPart","subj":"T12","obj":"T13"},{"id":"R6","pred":"hasPart","subj":"T12","obj":"T14"},{"id":"R7","pred":"encodes","subj":"T19","obj":"T18"},{"id":"R8","pred":"locatedIn","subj":"T19","obj":"T20"},{"id":"R9","pred":"locatedIn","subj":"T19","obj":"T21"},{"id":"R10","pred":"locatedIn","subj":"T19","obj":"T22"},{"id":"R11","pred":"locatedIn","subj":"T19","obj":"T23"},{"id":"R12","pred":"locatedIn","subj":"T19","obj":"T24"},{"id":"R13","pred":"locatedIn","subj":"T19","obj":"T26"},{"id":"R14","pred":"fromSpecies","subj":"T26","obj":"T25"},{"id":"R15","pred":"locatedIn","subj":"T29","obj":"T30"},{"id":"R17","pred":"hasAgent","subj":"T31","obj":"E1"}],"text":"Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3.\nUsing homology-based PCR, we have isolated cDNA encoding a novel member (491 amino acids) of the angiopoietin (Ang) family from human adult heart cDNA and have designated it angiopoietin-3 (Ang3). The NH2-terminal and COOH-terminal portions of Ang-3 contain the characteristic coiled-coil domain and fibrinogen-like domain that are conserved in other known Angs. Ang3 has a highly hydrophobic region at the N-terminus (approximately 21 amino acids) that is typical of a signal sequence for protein secretion. Ang3 mRNA is most abundant in adrenal gland, placenta, thyroid gland, heart and small intestine in human adult tissues. Additionally, Ang3 is a secretory protein, but is not a mitogen in endothelial cells."}