PubMed:10025961 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/10025961","sourcedb":"PubMed","sourceid":"10025961","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10025961","text":"The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution.\nLatrophilin is a brain-specific Ca2+-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin. We now report the finding of two novel latrophilin homologues. All three latrophilins are unusual G protein-coupled receptors. They exhibit strong similarities within their lectin, olfactomedin and transmembrane domains but possess variable C-termini. Latrophilins have up to seven sites of alternative splicing; some splice variants contain an altered third cytoplasmic loop or a truncated cytoplasmic tail. Only latrophilin-1 binds alpha-latrotoxin; it is abundant in brain and is present in endocrine cells. Latrophilin-3 is also brain-specific, whereas latrophilin-2 is ubiquitous. Together, latrophilins form a novel family of heterogeneous G protein-coupled receptors with distinct tissue distribution and functions.","tracks":[]}