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PubMed:10024664 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 13-24 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 354-365 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 514-525 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T4 661-672 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T5 976-987 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T6 1110-1121 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T7 1507-1518 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T8 1540-1551 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 13-24 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 354-365 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 514-525 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T4 661-672 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T5 976-987 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T6 1110-1121 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T7 1507-1518 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T8 1540-1551 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 13-24 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 354-365 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 514-525 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T4 661-672 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T5 976-987 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T6 1110-1121 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T7 1507-1518 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T8 1540-1551 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes Cell surface sialic acid and the regulation of immune cell interactions: the neuraminidase effect reconsidered.
TextSentencer_T2 112-334 Sentence denotes It has been known for over a decade that sialidase (neuraminidase) treatment could substantially enhance the capacity of resting B cells to stimulate the proliferation of allogeneic and antigen specific, syngeneic T cells.
TextSentencer_T3 335-433 Sentence denotes Thus, cell-surface sialic acid was implicated as a potential modulator of immune cell interaction.
TextSentencer_T4 434-839 Sentence denotes However, little progress has been made in either identifying explicit roles for sialic acid in this system or in hypothesizing mechanisms to explain the "neuraminidase effect." Here we show for the first time that cell surface sialic acid on medium incubated B cells blocks access to costimulatory molecules on the B cell surface, and that this is the most likely explanation for the neuraminidase effect.
TextSentencer_T5 840-1060 Sentence denotes Further, we show that it is likely to be upregulation of ICAM-1 and its subsequent engagement of LFA-1 rather than loss of cell surface sialic acid that in part regulates access to CD86 and other costimulatory molecules.
TextSentencer_T6 1061-1173 Sentence denotes However, we cannot exclude a role for CD86-bound sialic acid on the B cell in modulating binding to T cell CD28.
TextSentencer_T7 1174-1519 Sentence denotes Because sialidase treatment of resting B cells but not resting T cells enables T cell activation, we suggest that sialidase treatment may still be an analogue for an authentic step in B cell activation, and show that for highly activated B cells (activated with polyclonal anti-IgM plus INF-gamma) there is specific loss 2, 6-linked sialic acid.
TextSentencer_T8 1520-1608 Sentence denotes Potential roles for sialic acid in modulating B cell/T cell collaboration are discussed.
T1 0-111 Sentence denotes Cell surface sialic acid and the regulation of immune cell interactions: the neuraminidase effect reconsidered.
T2 112-334 Sentence denotes It has been known for over a decade that sialidase (neuraminidase) treatment could substantially enhance the capacity of resting B cells to stimulate the proliferation of allogeneic and antigen specific, syngeneic T cells.
T3 335-433 Sentence denotes Thus, cell-surface sialic acid was implicated as a potential modulator of immune cell interaction.
T4 434-839 Sentence denotes However, little progress has been made in either identifying explicit roles for sialic acid in this system or in hypothesizing mechanisms to explain the "neuraminidase effect." Here we show for the first time that cell surface sialic acid on medium incubated B cells blocks access to costimulatory molecules on the B cell surface, and that this is the most likely explanation for the neuraminidase effect.
T5 840-1060 Sentence denotes Further, we show that it is likely to be upregulation of ICAM-1 and its subsequent engagement of LFA-1 rather than loss of cell surface sialic acid that in part regulates access to CD86 and other costimulatory molecules.
T6 1061-1173 Sentence denotes However, we cannot exclude a role for CD86-bound sialic acid on the B cell in modulating binding to T cell CD28.
T7 1174-1519 Sentence denotes Because sialidase treatment of resting B cells but not resting T cells enables T cell activation, we suggest that sialidase treatment may still be an analogue for an authentic step in B cell activation, and show that for highly activated B cells (activated with polyclonal anti-IgM plus INF-gamma) there is specific loss 2, 6-linked sialic acid.
T8 1520-1608 Sentence denotes Potential roles for sialic acid in modulating B cell/T cell collaboration are discussed.
T1 0-111 Sentence denotes Cell surface sialic acid and the regulation of immune cell interactions: the neuraminidase effect reconsidered.
T2 112-334 Sentence denotes It has been known for over a decade that sialidase (neuraminidase) treatment could substantially enhance the capacity of resting B cells to stimulate the proliferation of allogeneic and antigen specific, syngeneic T cells.
T3 335-433 Sentence denotes Thus, cell-surface sialic acid was implicated as a potential modulator of immune cell interaction.
T4 434-839 Sentence denotes However, little progress has been made in either identifying explicit roles for sialic acid in this system or in hypothesizing mechanisms to explain the "neuraminidase effect." Here we show for the first time that cell surface sialic acid on medium incubated B cells blocks access to costimulatory molecules on the B cell surface, and that this is the most likely explanation for the neuraminidase effect.
T5 840-1060 Sentence denotes Further, we show that it is likely to be upregulation of ICAM-1 and its subsequent engagement of LFA-1 rather than loss of cell surface sialic acid that in part regulates access to CD86 and other costimulatory molecules.
T6 1061-1173 Sentence denotes However, we cannot exclude a role for CD86-bound sialic acid on the B cell in modulating binding to T cell CD28.
T7 1174-1519 Sentence denotes Because sialidase treatment of resting B cells but not resting T cells enables T cell activation, we suggest that sialidase treatment may still be an analogue for an authentic step in B cell activation, and show that for highly activated B cells (activated with polyclonal anti-IgM plus INF-gamma) there is specific loss 2, 6-linked sialic acid.
T8 1520-1608 Sentence denotes Potential roles for sialic acid in modulating B cell/T cell collaboration are discussed.

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 0-12 FMAID:200942 denotes Cell surface
_T2 0-12 FMAID:212684 denotes Cell surface
_T3 5-12 FMAID:50594 denotes surface
_T4 5-12 FMAID:146300 denotes surface
_T5 195-208 FMAID:188924 denotes substantially
_T6 243-248 FMAID:68646 denotes cells
_T7 243-248 FMAID:169002 denotes cells
_T8 328-333 FMAID:68646 denotes cells
_T9 328-333 FMAID:169002 denotes cells
_T10 341-353 FMAID:200942 denotes cell-surface
_T11 341-353 FMAID:212684 denotes cell-surface
_T12 346-353 FMAID:50594 denotes surface
_T13 346-353 FMAID:146300 denotes surface
_T14 648-660 FMAID:212684 denotes cell surface
_T15 648-660 FMAID:200942 denotes cell surface
_T16 653-660 FMAID:50594 denotes surface
_T17 653-660 FMAID:146300 denotes surface
_T18 695-700 FMAID:169002 denotes cells
_T19 695-700 FMAID:68646 denotes cells
_T20 751-763 FMAID:212684 denotes cell surface
_T21 751-763 FMAID:200942 denotes cell surface
_T22 756-763 FMAID:50594 denotes surface
_T23 756-763 FMAID:146300 denotes surface
_T24 963-975 FMAID:200942 denotes cell surface
_T25 963-975 FMAID:212684 denotes cell surface
_T26 968-975 FMAID:146300 denotes surface
_T27 968-975 FMAID:50594 denotes surface
_T28 1215-1220 FMAID:169002 denotes cells
_T29 1215-1220 FMAID:68646 denotes cells
_T30 1239-1244 FMAID:68646 denotes cells
_T31 1239-1244 FMAID:169002 denotes cells
_T32 1414-1419 FMAID:169002 denotes cells
_T33 1414-1419 FMAID:68646 denotes cells
_T34 1452-1455 FMAID:167182 denotes IgM

uniprot-human

Id Subject Object Predicate Lexical cue
T1 718-741 http://www.uniprot.org/uniprot/Q5ZPR3 denotes costimulatory molecules
T2 1036-1059 http://www.uniprot.org/uniprot/Q5ZPR3 denotes costimulatory molecules
T3 897-903 http://www.uniprot.org/uniprot/P05362 denotes ICAM-1
T4 1021-1025 http://www.uniprot.org/uniprot/Q6GTS4 denotes CD86
T5 1099-1103 http://www.uniprot.org/uniprot/Q6GTS4 denotes CD86
T6 1168-1172 http://www.uniprot.org/uniprot/Q8WXJ2 denotes CD28
T7 1461-1464 http://www.uniprot.org/uniprot/P27352 denotes INF

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 718-741 http://www.uniprot.org/uniprot/Q8VE98 denotes costimulatory molecules
T2 1036-1059 http://www.uniprot.org/uniprot/Q8VE98 denotes costimulatory molecules
T3 897-903 http://www.uniprot.org/uniprot/P13597 denotes ICAM-1
T4 1021-1025 http://www.uniprot.org/uniprot/P42082 denotes CD86
T5 1099-1103 http://www.uniprot.org/uniprot/P42082 denotes CD86
T6 1168-1172 http://www.uniprot.org/uniprot/P31041 denotes CD28
T7 1461-1464 http://www.uniprot.org/uniprot/P52787 denotes INF

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 243-248 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T2 328-333 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 561-571 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanisms
T4 695-700 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 1215-1220 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T6 1239-1244 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T7 1414-1419 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 33-43 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T2 1001-1010 http://purl.obolibrary.org/obo/GO_0065007 denotes regulates
T3 33-58 http://purl.obolibrary.org/obo/GO_0002685 denotes regulation of immune cell
T4 33-58 http://purl.obolibrary.org/obo/GO_0002688 denotes regulation of immune cell
T5 33-58 http://purl.obolibrary.org/obo/GO_0002694 denotes regulation of immune cell
T6 33-58 http://purl.obolibrary.org/obo/GO_0043300 denotes regulation of immune cell
T7 33-58 http://purl.obolibrary.org/obo/GO_1902105 denotes regulation of immune cell
T8 233-240 http://purl.obolibrary.org/obo/GO_0043336 denotes resting
T9 1205-1212 http://purl.obolibrary.org/obo/GO_0043336 denotes resting
T10 1229-1236 http://purl.obolibrary.org/obo/GO_0043336 denotes resting
T11 241-279 http://purl.obolibrary.org/obo/GO_0030890 denotes B cells to stimulate the proliferation
T12 241-261 http://purl.obolibrary.org/obo/GO_0002672 denotes B cells to stimulate
T13 241-261 http://purl.obolibrary.org/obo/GO_0045579 denotes B cells to stimulate
T14 241-261 http://purl.obolibrary.org/obo/GO_0002869 denotes B cells to stimulate
T15 241-261 http://purl.obolibrary.org/obo/GO_0002904 denotes B cells to stimulate
T16 241-261 http://purl.obolibrary.org/obo/GO_0031296 denotes B cells to stimulate
T17 241-261 http://purl.obolibrary.org/obo/GO_0050871 denotes B cells to stimulate
T18 1358-1375 http://purl.obolibrary.org/obo/GO_0050871 denotes B cell activation
T19 1412-1430 http://purl.obolibrary.org/obo/GO_0050871 denotes B cells (activated
T20 243-279 http://purl.obolibrary.org/obo/GO_0001938 denotes cells to stimulate the proliferation
T21 243-279 http://purl.obolibrary.org/obo/GO_0008284 denotes cells to stimulate the proliferation
T22 243-279 http://purl.obolibrary.org/obo/GO_0032946 denotes cells to stimulate the proliferation
T23 243-279 http://purl.obolibrary.org/obo/GO_0050679 denotes cells to stimulate the proliferation
T24 243-279 http://purl.obolibrary.org/obo/GO_0002053 denotes cells to stimulate the proliferation
T25 243-279 http://purl.obolibrary.org/obo/GO_0042102 denotes cells to stimulate the proliferation
T26 243-279 http://purl.obolibrary.org/obo/GO_0070346 denotes cells to stimulate the proliferation
T27 243-279 http://purl.obolibrary.org/obo/GO_0050677 denotes cells to stimulate the proliferation
T28 243-279 http://purl.obolibrary.org/obo/GO_0070668 denotes cells to stimulate the proliferation
T29 1253-1270 http://purl.obolibrary.org/obo/GO_0032393 denotes T cell activation
T30 1253-1270 http://purl.obolibrary.org/obo/GO_0032394 denotes T cell activation
T31 1253-1270 http://purl.obolibrary.org/obo/GO_0032395 denotes T cell activation
T32 1253-1270 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T33 1253-1270 http://purl.obolibrary.org/obo/GO_0045582 denotes T cell activation
T34 1253-1270 http://purl.obolibrary.org/obo/GO_0050798 denotes T cell activation
T35 1253-1270 http://purl.obolibrary.org/obo/GO_0050863 denotes T cell activation
T36 1253-1270 http://purl.obolibrary.org/obo/GO_0051132 denotes T cell activation
T37 1253-1270 http://purl.obolibrary.org/obo/GO_1903905 denotes T cell activation
T38 1253-1270 http://purl.obolibrary.org/obo/GO_0042102 denotes T cell activation
T39 1255-1270 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T40 1360-1375 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T41 1414-1430 http://purl.obolibrary.org/obo/GO_0001775 denotes cells (activated
T42 1358-1375 http://purl.obolibrary.org/obo/GO_0002904 denotes B cell activation
T43 1412-1430 http://purl.obolibrary.org/obo/GO_0002904 denotes B cells (activated
T44 1358-1375 http://purl.obolibrary.org/obo/GO_0045579 denotes B cell activation
T45 1412-1430 http://purl.obolibrary.org/obo/GO_0045579 denotes B cells (activated
T46 1358-1375 http://purl.obolibrary.org/obo/GO_0002672 denotes B cell activation
T47 1412-1430 http://purl.obolibrary.org/obo/GO_0002672 denotes B cells (activated
T48 1358-1375 http://purl.obolibrary.org/obo/GO_0002869 denotes B cell activation
T49 1412-1430 http://purl.obolibrary.org/obo/GO_0002869 denotes B cells (activated
T50 1358-1375 http://purl.obolibrary.org/obo/GO_0030890 denotes B cell activation
T51 1412-1430 http://purl.obolibrary.org/obo/GO_0030890 denotes B cells (activated
T52 1358-1375 http://purl.obolibrary.org/obo/GO_0050864 denotes B cell activation
T53 1412-1430 http://purl.obolibrary.org/obo/GO_0050864 denotes B cells (activated
T54 1358-1375 http://purl.obolibrary.org/obo/GO_0050869 denotes B cell activation
T55 1412-1430 http://purl.obolibrary.org/obo/GO_0050869 denotes B cells (activated
T56 1402-1413 http://purl.obolibrary.org/obo/GO_0004066 denotes activated B

GO-MF

Id Subject Object Predicate Lexical cue
T1 1150-1157 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 1150-1157 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T3 1150-1157 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T4 1150-1157 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T5 1150-1167 http://purl.obolibrary.org/obo/GO_0042608 denotes binding to T cell
T6 1358-1375 http://purl.obolibrary.org/obo/GO_0003823 denotes B cell activation
T7 1412-1430 http://purl.obolibrary.org/obo/GO_0003823 denotes B cells (activated

GO-CC

Id Subject Object Predicate Lexical cue
T1 0-4 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T2 54-58 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 341-345 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 416-420 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 648-652 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 751-755 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T7 963-967 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8 1131-1135 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9 1163-1167 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10 1255-1259 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T11 1360-1364 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T12 1568-1572 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13 243-248 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14 328-333 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15 695-700 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16 1215-1220 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17 1239-1244 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18 1414-1419 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19 0-12 http://purl.obolibrary.org/obo/GO_0009986 denotes Cell surface
T20 341-353 http://purl.obolibrary.org/obo/GO_0009986 denotes cell-surface
T21 648-660 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T22 751-763 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T23 963-975 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 59-71 http://edamontology.org/topic_0602 denotes interactions
T2 298-305 http://edamontology.org/topic_2830 denotes antigen
T3 421-432 http://edamontology.org/topic_0602 denotes interaction
T4 732-741 http://edamontology.org/topic_2839 denotes molecules
T5 1050-1059 http://edamontology.org/topic_2839 denotes molecules

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 483-494 http://edamontology.org/data_2611 denotes identifying
T2 483-494 http://edamontology.org/data_0842 denotes identifying

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 937-940 https://acgg.asia/db/lfdb/LfDB0086 denotes LFA

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 47-58 Body_part denotes immune cell http://purl.obolibrary.org/obo/CL_0000738
T2 409-420 Body_part denotes immune cell http://purl.obolibrary.org/obo/CL_0000738
T3 749-755 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T4 1129-1135 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T5 1161-1167 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T6 1253-1259 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T7 1358-1364 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T8 1566-1572 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T9 1573-1579 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 47-58 Cell denotes immune cell http://purl.obolibrary.org/obo/CL:0000738
T2 241-248 Cell denotes B cells http://purl.obolibrary.org/obo/CL:0000236
T3 326-333 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T4 409-420 Cell denotes immune cell http://purl.obolibrary.org/obo/CL:0000738
T5 693-700 Cell denotes B cells http://purl.obolibrary.org/obo/CL:0000236
T6 749-755 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T7 1129-1135 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T8 1161-1167 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T9 1213-1220 Cell denotes B cells http://purl.obolibrary.org/obo/CL:0000236
T10 1237-1244 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T11 1253-1259 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T12 1358-1364 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T13 1412-1419 Cell denotes B cells http://purl.obolibrary.org/obo/CL:0000236
T14 1566-1572 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T15 1573-1579 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084