PubMed:10022905 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/10022905","sourcedb":"PubMed","sourceid":"10022905","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10022905","text":"The Caenorhabditis elegans sex determination gene mog-1 encodes a member of the DEAH-Box protein family.\nIn the Caenorhabditis elegans hermaphrodite germ line, the sex-determining gene fem-3 is repressed posttranscriptionally to arrest spermatogenesis and permit oogenesis. This repression requires a cis-acting regulatory element in the fem-3 3' untranslated region; the FBF protein, which binds to this element; and at least six mog genes. In this paper, we report the molecular characterization of mog-1 as well as additional phenotypic characterization of this gene. The mog-1 gene encodes a member of the DEAH-box family. Three mog-1 alleles possess premature stop codons and are likely to be null alleles, and one is a missense mutation and is likely to retain residual activity. mog-1 mRNA is expressed in both germ line and somatic tissues and appears to be ubiquitous. The MOG-1 DEAH-box protein is most closely related to proteins essential for splicing in the yeast Saccharomyces cerevisiae, but splicing appears to occur normally in a mog-1-null mutant. In addition to its involvement in the sperm-oocyte switch and control of fem-3, zygotic mog-1 is required for robust germ line proliferation and for normal growth during development. We suggest that mog-1 plays a broader role in RNA regulation than previously considered.","tracks":[{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":229,"end":251},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0010052"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"}]},{"project":"FSU-PRGE","denotations":[{"id":"T1","span":{"begin":50,"end":55},"obj":"protein"},{"id":"T2","span":{"begin":185,"end":190},"obj":"protein"},{"id":"T3","span":{"begin":338,"end":343},"obj":"protein"},{"id":"T4","span":{"begin":372,"end":375},"obj":"protein"},{"id":"T5","span":{"begin":431,"end":434},"obj":"protein"},{"id":"T6","span":{"begin":501,"end":506},"obj":"protein"},{"id":"T7","span":{"begin":575,"end":580},"obj":"protein"},{"id":"T8","span":{"begin":633,"end":638},"obj":"protein"},{"id":"T9","span":{"begin":786,"end":791},"obj":"protein"},{"id":"T10","span":{"begin":882,"end":887},"obj":"protein"},{"id":"T11","span":{"begin":1047,"end":1052},"obj":"protein"},{"id":"T12","span":{"begin":1139,"end":1144},"obj":"protein"},{"id":"T13","span":{"begin":1154,"end":1159},"obj":"protein"},{"id":"T14","span":{"begin":1265,"end":1270},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"FSU-PRGE"},{"subj":"T2","pred":"source","obj":"FSU-PRGE"},{"subj":"T3","pred":"source","obj":"FSU-PRGE"},{"subj":"T4","pred":"source","obj":"FSU-PRGE"},{"subj":"T5","pred":"source","obj":"FSU-PRGE"},{"subj":"T6","pred":"source","obj":"FSU-PRGE"},{"subj":"T7","pred":"source","obj":"FSU-PRGE"},{"subj":"T8","pred":"source","obj":"FSU-PRGE"},{"subj":"T9","pred":"source","obj":"FSU-PRGE"},{"subj":"T10","pred":"source","obj":"FSU-PRGE"},{"subj":"T11","pred":"source","obj":"FSU-PRGE"},{"subj":"T12","pred":"source","obj":"FSU-PRGE"},{"subj":"T13","pred":"source","obj":"FSU-PRGE"},{"subj":"T14","pred":"source","obj":"FSU-PRGE"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":610,"end":614},"obj":"HP_0000365"},{"id":"T2","span":{"begin":888,"end":892},"obj":"HP_0000365"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PMID_GLOBAL","color":"#b693ec","default":true},{"id":"FSU-PRGE","color":"#93ec9c"},{"id":"PubmedHPO","color":"#ec93a3"}]}]}}