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PubMed:10022897 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 312-323 DiseaseOrPhenotypicFeature denotes sensitivity 0000605

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 55-73 DNA denotes human Fas promoter
T2 83-100 protein denotes NF-kappaB p50-p65
T3 114-117 protein denotes Fas
T4 119-123 protein denotes CD95
T5 129-139 protein denotes Fas ligand
T6 141-146 protein denotes CD95L
T7 274-277 protein denotes Fas
T8 327-331 protein denotes FasL
T9 563-566 protein denotes Fas
T10 670-688 cell_line denotes Jurkat T-cell line
T11 775-790 protein denotes T-cell receptor
T12 812-832 cell_line denotes resting Jurkat cells
T13 841-844 protein denotes Fas
T14 846-854 RNA denotes Fas mRNA
T15 924-951 DNA denotes sequential deletion mutants
T16 959-977 DNA denotes human fas promoter
T17 1028-1042 DNA denotes 47-bp sequence
T18 1044-1066 DNA denotes positions -306 to -260
T19 1193-1228 DNA denotes unrecognized composite binding site
T20 1242-1245 protein denotes Sp1
T21 1250-1259 protein denotes NF-kappaB
T22 1260-1281 protein denotes transcription factors
T23 1285-1307 DNA denotes positions -295 to -286
T24 1427-1430 protein denotes Sp1
T25 1488-1518 protein denotes p50-p65 NF-kappaB heterodimers
T26 1541-1544 protein denotes Sp1
T27 1549-1558 protein denotes NF-kappaB
T28 1678-1681 protein denotes Sp1
T29 1698-1701 protein denotes p50
T30 1738-1763 DNA denotes kappaB-Sp1 composite site
T31 1767-1793 DNA denotes P/I-inducible fas promoter
T32 1834-1837 protein denotes Sp1
T33 1851-1863 DNA denotes -295 to -286
T34 1870-1921 DNA denotes thymidine kinase promoter-driven reporter construct
T35 1926-1952 DNA denotes native promoter constructs
T36 1956-1968 cell_line denotes Jurkat cells
T37 1984-1997 protein denotes IkappaB-alpha
T38 2068-2086 DNA denotes kappaB-Sp1 element

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 51-73 NP denotes the human Fas promoter
C2 114-124 NP denotes Fas (CD95)
C3 254-288 NP denotes the upregulation of Fas expression
C4 361-377 NP denotes Fas upregulation
C5 492-504 NP denotes this process
C6 544-579 NP denotes activation-induced Fas upregulation
C7 702-747 NP denotes phorbol myristate acetate and ionomycin (P/I)
C8 749-801 NP denotes pharmacological mimics of T-cell receptor activation
C9 841-844 NP denotes Fas
C10 955-977 NP denotes the human fas promoter
C11 1101-1135 NP denotes activation-driven fas upregulation
C12 1285-1307 NP denotes positions -295 to -286
C13 1309-1352 NP denotes Electrophoretic mobility shift assay (EMSA)
C14 1380-1391 NP denotes this region
C15 1626-1630 NP denotes EMSA
C16 1734-1763 NP denotes the kappaB-Sp1 composite site
C17 2120-2129 NP denotes this site
R1 C4 C3 coref-ident Fas upregulation,the upregulation of Fas expression
R2 C5 C4 coref-ident this process,Fas upregulation
R3 C6 C5 coref-ident activation-induced Fas upregulation,this process
R4 C8 C7 coref-appos pharmacological mimics of T-cell receptor activation,phorbol myristate acetate and ionomycin (P/I)
R5 C9 C2 coref-ident Fas,Fas (CD95)
R6 C10 C1 coref-ident the human fas promoter,the human Fas promoter
R7 C11 C6 coref-ident activation-driven fas upregulation,activation-induced Fas upregulation
R8 C14 C12 coref-ident this region,positions -295 to -286
R9 C15 C13 coref-ident EMSA,Electrophoretic mobility shift assay (EMSA)
R10 C17 C16 coref-ident this site,the kappaB-Sp1 composite site

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-113 Sentence denotes Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment.
S2 114-220 Sentence denotes Fas (CD95) and Fas ligand (CD95L) are an interacting receptor-ligand pair required for immune homeostasis.
S3 221-351 Sentence denotes Lymphocyte activation results in the upregulation of Fas expression and the acquisition of sensitivity to FasL-mediated apoptosis.
S4 352-505 Sentence denotes Although Fas upregulation is central to the preservation of immunologic tolerance, little is known about the molecular machinery underlying this process.
S5 506-802 Sentence denotes To investigate the events involved in activation-induced Fas upregulation, we have examined mRNA accumulation, fas promoter activity, and protein expression in the Jurkat T-cell line treated with phorbol myristate acetate and ionomycin (P/I), pharmacological mimics of T-cell receptor activation.
S6 803-917 Sentence denotes Although resting Jurkat cells express Fas, Fas mRNA was induced approximately 10-fold in 2 h upon P/I stimulation.
S7 918-1136 Sentence denotes Using sequential deletion mutants of the human fas promoter in transient transfection assays, we identified a 47-bp sequence (positions -306 to -260 relative to the ATG) required for activation-driven fas upregulation.
S8 1137-1308 Sentence denotes Sequence analysis revealed the presence of a previously unrecognized composite binding site for both the Sp1 and NF-kappaB transcription factors at positions -295 to -286.
S9 1309-1540 Sentence denotes Electrophoretic mobility shift assay (EMSA) and supershift analyses of this region documented constitutive binding of Sp1 in unactivated nuclear extracts and inducible binding of p50-p65 NF-kappaB heterodimers after P/I activation.
S10 1541-1702 Sentence denotes Sp1 and NF-kappaB transcription factor binding was shown to be mutually exclusive by EMSA displacement studies with purified recombinant Sp1 and recombinant p50.
S11 1703-1998 Sentence denotes The functional contribution of the kappaB-Sp1 composite site in P/I-inducible fas promoter activation was verified by using kappaB-Sp1 concatamers (-295 to -286) in a thymidine kinase promoter-driven reporter construct and native promoter constructs in Jurkat cells overexpressing IkappaB-alpha.
S12 1999-2177 Sentence denotes Site-directed mutagenesis of the critical guanine nucleotides in the kappaB-Sp1 element documented the essential role of this site in activation-dependent fas promoter induction.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-47 other_name denotes Activation-dependent transcriptional regulation
T2 55-73 DNA_domain_or_region denotes human Fas promoter
T3 83-100 protein_complex denotes NF-kappaB p50-p65
T4 114-117 protein_molecule denotes Fas
T5 119-123 protein_molecule denotes CD95
T6 129-139 protein_molecule denotes Fas ligand
T7 141-146 protein_molecule denotes CD95L
T8 201-219 other_name denotes immune homeostasis
T9 221-242 other_name denotes Lymphocyte activation
T10 274-277 protein_molecule denotes Fas
T11 327-331 protein_molecule denotes FasL
T12 461-480 other_name denotes molecular machinery
T13 563-566 protein_molecule denotes Fas
T14 598-615 other_name denotes mRNA accumulation
T15 617-638 other_name denotes fas promoter activity
T16 644-662 other_name denotes protein expression
T17 670-688 cell_line denotes Jurkat T-cell line
T18 702-727 other_organic_compound denotes phorbol myristate acetate
T19 732-741 other_organic_compound denotes ionomycin
T20 743-746 other_organic_compound denotes P/I
T21 775-790 protein_family_or_group denotes T-cell receptor
T22 812-832 cell_line denotes resting Jurkat cells
T23 841-844 protein_molecule denotes Fas
T24 846-849 protein_molecule denotes Fas
T25 901-904 other_organic_compound denotes P/I
T26 924-951 DNA_family_or_group denotes sequential deletion mutants
T27 959-977 DNA_domain_or_region denotes human fas promoter
T28 1028-1042 DNA_domain_or_region denotes 47-bp sequence
T29 1044-1066 DNA_domain_or_region denotes positions -306 to -260
T30 1083-1086 polynucleotide denotes ATG
T31 1101-1135 other_name denotes activation-driven fas upregulation
T32 1137-1154 other_name denotes Sequence analysis
T33 1193-1228 DNA_domain_or_region denotes unrecognized composite binding site
T34 1242-1245 protein_molecule denotes Sp1
T35 1250-1259 protein_complex denotes NF-kappaB
T36 1260-1281 protein_family_or_group denotes transcription factors
T37 1285-1307 DNA_domain_or_region denotes positions -295 to -286
T38 1309-1345 other_name denotes Electrophoretic mobility shift assay
T39 1347-1351 other_name denotes EMSA
T40 1427-1430 protein_molecule denotes Sp1
T41 1488-1495 protein_complex denotes p50-p65
T42 1496-1505 protein_complex denotes NF-kappaB
T43 1525-1528 other_organic_compound denotes P/I
T44 1541-1544 protein_molecule denotes Sp1
T45 1549-1558 protein_complex denotes NF-kappaB
T46 1559-1587 other_name denotes transcription factor binding
T47 1626-1630 other_name denotes EMSA
T48 1678-1681 protein_molecule denotes Sp1
T49 1698-1701 protein_subunit denotes p50
T50 1738-1745 DNA_domain_or_region denotes kappaB-
T51 1745-1748 protein_molecule denotes Sp1
T52 1767-1770 other_organic_compound denotes P/I
T53 1834-1837 protein_molecule denotes Sp1
T54 1851-1863 DNA_domain_or_region denotes -295 to -286
T55 1870-1921 DNA_molecule denotes thymidine kinase promoter-driven reporter construct
T56 1926-1952 DNA_family_or_group denotes native promoter constructs
T57 1956-1968 cell_line denotes Jurkat cells
T58 1984-1997 protein_molecule denotes IkappaB-alpha
T59 2041-2060 nucleotide denotes guanine nucleotides
T60 2068-2075 DNA_domain_or_region denotes kappaB-
T61 2075-2078 protein_molecule denotes Sp1
T62 2133-2176 other_name denotes activation-dependent fas promoter induction