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PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity.
T2 132-280 Sentence denotes We previously reported that the role of reactive oxygen intermediates (ROIs) in NF-kappaB activation by proinflammatory cytokines was cell specific.
T3 281-417 Sentence denotes However, the sources for ROIs in various cell types are yet to be determined and might include 5-lipoxygenase (5-LOX) and NADPH oxidase.
T4 418-535 Sentence denotes 5-LOX and 5-LOX activating protein (FLAP) are coexpressed in lymphoid cells but not in monocytic or epithelial cells.
T5 536-814 Sentence denotes Stimulation of lymphoid cells with interleukin-1beta (IL-1beta) led to ROI production and NF-kappaB activation, which could both be blocked by antioxidants or FLAP inhibitors, confirming that 5-LOX was the source of ROIs and was required for NF-kappaB activation in these cells.
T6 815-945 Sentence denotes IL-1beta stimulation of epithelial cells did not generate any ROIs and NF-kappaB induction was not influenced by 5-LOX inhibitors.
T7 946-1078 Sentence denotes However, reintroduction of a functional 5-LOX system in these cells allowed ROI production and 5-LOX-dependent NF-kappaB activation.
T8 1079-1227 Sentence denotes In monocytic cells, IL-1beta treatment led to a production of ROIs which is independent of the 5-LOX enzyme but requires the NADPH oxidase activity.
T9 1228-1370 Sentence denotes This pathway involves the Rac1 and Cdc42 GTPases, two enzymes which are not required for NF-kappaB activation by IL-1beta in epithelial cells.
T10 1371-1667 Sentence denotes In conclusion, three different cell-specific pathways lead to NF-kappaB activation by IL-1beta: a pathway dependent on ROI production by 5-LOX in lymphoid cells, an ROI- and 5-LOX-independent pathway in epithelial cells, and a pathway requiring ROI production by NADPH oxidase in monocytic cells.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 39-48 protein denotes NF-kappaB
T2 63-80 protein denotes interleukin-1beta
T3 90-104 protein denotes 5-lipoxygenase
T4 212-221 protein denotes NF-kappaB
T5 236-261 protein denotes proinflammatory cytokines
T6 376-390 protein denotes 5-lipoxygenase
T7 392-397 protein denotes 5-LOX
T8 418-423 protein denotes 5-LOX
T9 428-452 protein denotes 5-LOX activating protein
T10 454-458 protein denotes FLAP
T11 479-493 cell_type denotes lymphoid cells
T12 505-534 cell_type denotes monocytic or epithelial cells
T13 551-565 cell_type denotes lymphoid cells
T14 571-588 protein denotes interleukin-1beta
T15 590-598 protein denotes IL-1beta
T16 626-635 protein denotes NF-kappaB
T17 695-699 protein denotes FLAP
T18 728-733 protein denotes 5-LOX
T19 778-787 protein denotes NF-kappaB
T20 815-823 protein denotes IL-1beta
T21 839-855 cell_type denotes epithelial cells
T22 886-895 protein denotes NF-kappaB
T23 928-933 protein denotes 5-LOX
T24 986-991 protein denotes 5-LOX
T25 1041-1046 protein denotes 5-LOX
T26 1057-1066 protein denotes NF-kappaB
T27 1082-1097 cell_type denotes monocytic cells
T28 1099-1107 protein denotes IL-1beta
T29 1174-1186 protein denotes 5-LOX enzyme
T30 1254-1258 protein denotes Rac1
T31 1263-1268 protein denotes Cdc42
T32 1269-1276 protein denotes GTPases
T33 1317-1326 protein denotes NF-kappaB
T34 1341-1349 protein denotes IL-1beta
T35 1353-1369 cell_type denotes epithelial cells
T36 1433-1442 protein denotes NF-kappaB
T37 1457-1465 protein denotes IL-1beta
T38 1508-1513 protein denotes 5-LOX
T39 1517-1531 cell_type denotes lymphoid cells
T40 1545-1550 protein denotes 5-LOX
T41 1574-1590 cell_type denotes epithelial cells
T42 1634-1647 protein denotes NADPH oxidase
T43 1651-1666 cell_type denotes monocytic cells

pubmed-enju-pas

Id Subject Object Predicate Lexical cue
EnjuParser_T0 0-8 JJ denotes Reactive
EnjuParser_T1 9-15 NN denotes oxygen
EnjuParser_T2 16-38 JJ denotes intermediate-dependent
EnjuParser_T3 39-48 NN denotes NF-kappaB
EnjuParser_T4 49-59 NN denotes activation
EnjuParser_T5 60-62 IN denotes by
EnjuParser_T6 63-80 NN denotes interleukin-1beta
EnjuParser_T7 81-89 VB denotes requires
EnjuParser_T8 90-104 NN denotes 5-lipoxygenase
EnjuParser_T9 105-107 CC denotes or
EnjuParser_T10 108-113 NN denotes NADPH
EnjuParser_T11 114-121 NN denotes oxidase
EnjuParser_T12 122-130 NN denotes activity
EnjuParser_T13 132-134 PRP denotes We
EnjuParser_T14 135-145 RB denotes previously
EnjuParser_T15 146-154 VB denotes reported
EnjuParser_T16 155-159 IN denotes that
EnjuParser_T17 160-163 DT denotes the
EnjuParser_T18 164-168 NN denotes role
EnjuParser_T19 169-171 IN denotes of
EnjuParser_T20 172-180 JJ denotes reactive
EnjuParser_T21 181-187 NN denotes oxygen
EnjuParser_T22 188-201 NN denotes intermediates
EnjuParser_T23 202-203 -LRB- denotes (
EnjuParser_T24 203-207 NN denotes ROIs
EnjuParser_T25 207-208 -RRB- denotes )
EnjuParser_T26 209-211 IN denotes in
EnjuParser_T27 212-221 NN denotes NF-kappaB
EnjuParser_T28 222-232 NN denotes activation
EnjuParser_T29 233-235 IN denotes by
EnjuParser_T30 236-251 JJ denotes proinflammatory
EnjuParser_T31 252-261 NN denotes cytokines
EnjuParser_T32 262-265 VB denotes was
EnjuParser_T33 266-270 NN denotes cell
EnjuParser_T34 271-279 JJ denotes specific
EnjuParser_T35 281-288 RB denotes However
EnjuParser_T36 288-289 -COMMA- denotes ,
EnjuParser_T37 290-293 DT denotes the
EnjuParser_T38 294-301 NN denotes sources
EnjuParser_T39 302-305 IN denotes for
EnjuParser_T40 306-310 NN denotes ROIs
EnjuParser_T41 311-313 IN denotes in
EnjuParser_T42 314-321 JJ denotes various
EnjuParser_T43 322-326 NN denotes cell
EnjuParser_T44 327-332 NN denotes types
EnjuParser_T45 333-336 VB denotes are
EnjuParser_T46 337-340 RB denotes yet
EnjuParser_T47 341-343 TO denotes to
EnjuParser_T48 344-346 VB denotes be
EnjuParser_T49 347-357 VB denotes determined
EnjuParser_T50 358-361 CC denotes and
EnjuParser_T51 362-367 MD denotes might
EnjuParser_T52 368-375 VB denotes include
EnjuParser_T53 376-390 NN denotes 5-lipoxygenase
EnjuParser_T54 391-392 -LRB- denotes (
EnjuParser_T55 392-397 NN denotes 5-LOX
EnjuParser_T56 397-398 -RRB- denotes )
EnjuParser_T57 399-402 CC denotes and
EnjuParser_T58 403-408 NN denotes NADPH
EnjuParser_T59 409-416 NN denotes oxidase
EnjuParser_T60 418-423 NN denotes 5-LOX
EnjuParser_T61 424-427 CC denotes and
EnjuParser_T62 428-433 NN denotes 5-LOX
EnjuParser_T63 434-444 VB denotes activating
EnjuParser_T64 445-452 NN denotes protein
EnjuParser_T65 453-454 -LRB- denotes (
EnjuParser_T66 454-458 NN denotes FLAP
EnjuParser_T67 458-459 -RRB- denotes )
EnjuParser_T68 460-463 VB denotes are
EnjuParser_T69 464-475 VB denotes coexpressed
EnjuParser_T70 476-478 IN denotes in
EnjuParser_T71 479-487 JJ denotes lymphoid
EnjuParser_T72 488-493 NN denotes cells
EnjuParser_T73 494-497 CC denotes but
EnjuParser_T74 498-501 RB denotes not
EnjuParser_T75 502-504 IN denotes in
EnjuParser_T76 505-514 JJ denotes monocytic
EnjuParser_T77 515-517 CC denotes or
EnjuParser_T78 518-528 JJ denotes epithelial
EnjuParser_T79 529-534 NN denotes cells
EnjuParser_T80 536-547 NN denotes Stimulation
EnjuParser_T81 548-550 IN denotes of
EnjuParser_T82 551-559 JJ denotes lymphoid
EnjuParser_T83 560-565 NN denotes cells
EnjuParser_T84 566-570 IN denotes with
EnjuParser_T85 571-588 NN denotes interleukin-1beta
EnjuParser_T86 589-590 -LRB- denotes (
EnjuParser_T87 590-598 NN denotes IL-1beta
EnjuParser_T88 598-599 -RRB- denotes )
EnjuParser_T89 600-603 VB denotes led
EnjuParser_T90 604-606 TO denotes to
EnjuParser_T91 607-610 NN denotes ROI
EnjuParser_T92 611-621 NN denotes production
EnjuParser_T93 622-625 CC denotes and
EnjuParser_T94 626-635 NN denotes NF-kappaB
EnjuParser_T95 636-646 NN denotes activation
EnjuParser_T96 646-647 -COMMA- denotes ,
EnjuParser_T97 648-653 WDT denotes which
EnjuParser_T98 654-659 MD denotes could
EnjuParser_T99 660-664 DT denotes both
EnjuParser_T100 665-667 VB denotes be
EnjuParser_T101 668-675 VB denotes blocked
EnjuParser_T102 676-678 IN denotes by
EnjuParser_T103 679-691 NN denotes antioxidants
EnjuParser_T104 692-694 CC denotes or
EnjuParser_T105 695-699 NN denotes FLAP
EnjuParser_T106 700-710 NN denotes inhibitors
EnjuParser_T107 710-711 -COMMA- denotes ,
EnjuParser_T108 712-722 VB denotes confirming
EnjuParser_T109 723-727 IN denotes that
EnjuParser_T110 728-733 NN denotes 5-LOX
EnjuParser_T111 734-737 VB denotes was
EnjuParser_T112 738-741 DT denotes the
EnjuParser_T113 742-748 NN denotes source
EnjuParser_T114 749-751 IN denotes of
EnjuParser_T115 752-756 NN denotes ROIs
EnjuParser_T116 757-760 CC denotes and
EnjuParser_T117 761-764 VB denotes was
EnjuParser_T118 765-773 VB denotes required
EnjuParser_T119 774-777 IN denotes for
EnjuParser_T120 778-787 NN denotes NF-kappaB
EnjuParser_T121 788-798 NN denotes activation
EnjuParser_T122 799-801 IN denotes in
EnjuParser_T123 802-807 DT denotes these
EnjuParser_T124 808-813 NN denotes cells
EnjuParser_T125 815-823 NN denotes IL-1beta
EnjuParser_T126 824-835 NN denotes stimulation
EnjuParser_T127 836-838 IN denotes of
EnjuParser_T128 839-849 JJ denotes epithelial
EnjuParser_T129 850-855 NN denotes cells
EnjuParser_T130 856-859 VB denotes did
EnjuParser_T131 860-863 RB denotes not
EnjuParser_T132 864-872 VB denotes generate
EnjuParser_T133 873-876 DT denotes any
EnjuParser_T134 877-881 NN denotes ROIs
EnjuParser_T135 882-885 CC denotes and
EnjuParser_T136 886-895 NN denotes NF-kappaB
EnjuParser_T137 896-905 NN denotes induction
EnjuParser_T138 906-909 VB denotes was
EnjuParser_T139 910-913 RB denotes not
EnjuParser_T140 914-924 VB denotes influenced
EnjuParser_T141 925-927 IN denotes by
EnjuParser_T142 928-933 NN denotes 5-LOX
EnjuParser_T143 934-944 NN denotes inhibitors
EnjuParser_T144 946-953 RB denotes However
EnjuParser_T145 953-954 -COMMA- denotes ,
EnjuParser_T146 955-969 NN denotes reintroduction
EnjuParser_T147 970-972 IN denotes of
EnjuParser_T148 973-974 DT denotes a
EnjuParser_T149 975-985 JJ denotes functional
EnjuParser_T150 986-991 NN denotes 5-LOX
EnjuParser_T151 992-998 NN denotes system
EnjuParser_T152 999-1001 IN denotes in
EnjuParser_T153 1002-1007 DT denotes these
EnjuParser_T154 1008-1013 NN denotes cells
EnjuParser_T155 1014-1021 VB denotes allowed
EnjuParser_T156 1022-1025 NN denotes ROI
EnjuParser_T157 1026-1036 NN denotes production
EnjuParser_T158 1037-1040 CC denotes and
EnjuParser_T159 1041-1056 JJ denotes 5-LOX-dependent
EnjuParser_T160 1057-1066 NN denotes NF-kappaB
EnjuParser_T161 1067-1077 NN denotes activation
EnjuParser_T162 1079-1081 IN denotes In
EnjuParser_T163 1082-1091 JJ denotes monocytic
EnjuParser_T164 1092-1097 NN denotes cells
EnjuParser_T165 1097-1098 -COMMA- denotes ,
EnjuParser_T166 1099-1107 NN denotes IL-1beta
EnjuParser_T167 1108-1117 NN denotes treatment
EnjuParser_T168 1118-1121 VB denotes led
EnjuParser_T169 1122-1124 TO denotes to
EnjuParser_T170 1125-1126 DT denotes a
EnjuParser_T171 1127-1137 NN denotes production
EnjuParser_T172 1138-1140 IN denotes of
EnjuParser_T173 1141-1145 NN denotes ROIs
EnjuParser_T174 1146-1151 WDT denotes which
EnjuParser_T175 1152-1154 VB denotes is
EnjuParser_T176 1155-1166 JJ denotes independent
EnjuParser_T177 1167-1169 IN denotes of
EnjuParser_T178 1170-1173 DT denotes the
EnjuParser_T179 1174-1179 NN denotes 5-LOX
EnjuParser_T180 1180-1186 NN denotes enzyme
EnjuParser_T181 1187-1190 CC denotes but
EnjuParser_T182 1191-1199 VB denotes requires
EnjuParser_T183 1200-1203 DT denotes the
EnjuParser_T184 1204-1209 NN denotes NADPH
EnjuParser_T185 1210-1217 NN denotes oxidase
EnjuParser_T186 1218-1226 NN denotes activity
EnjuParser_T187 1228-1232 DT denotes This
EnjuParser_T188 1233-1240 NN denotes pathway
EnjuParser_T189 1241-1249 VB denotes involves
EnjuParser_T190 1250-1253 DT denotes the
EnjuParser_T191 1254-1258 NN denotes Rac1
EnjuParser_T192 1259-1262 CC denotes and
EnjuParser_T193 1263-1268 NN denotes Cdc42
EnjuParser_T194 1269-1276 NN denotes GTPases
EnjuParser_T195 1276-1277 -COMMA- denotes ,
EnjuParser_T196 1278-1281 CD denotes two
EnjuParser_T197 1282-1289 NN denotes enzymes
EnjuParser_T198 1290-1295 WDT denotes which
EnjuParser_T199 1296-1299 VB denotes are
EnjuParser_T200 1300-1303 RB denotes not
EnjuParser_T201 1304-1312 VB denotes required
EnjuParser_T202 1313-1316 IN denotes for
EnjuParser_T203 1317-1326 NN denotes NF-kappaB
EnjuParser_T204 1327-1337 NN denotes activation
EnjuParser_T205 1338-1340 IN denotes by
EnjuParser_T206 1341-1349 NN denotes IL-1beta
EnjuParser_T207 1350-1352 IN denotes in
EnjuParser_T208 1353-1363 JJ denotes epithelial
EnjuParser_T209 1364-1369 NN denotes cells
EnjuParser_T210 1371-1373 IN denotes In
EnjuParser_T211 1374-1384 NN denotes conclusion
EnjuParser_T212 1384-1385 -COMMA- denotes ,
EnjuParser_T213 1386-1391 CD denotes three
EnjuParser_T214 1392-1401 JJ denotes different
EnjuParser_T215 1402-1415 JJ denotes cell-specific
EnjuParser_T216 1416-1424 NN denotes pathways
EnjuParser_T217 1425-1429 VB denotes lead
EnjuParser_T218 1430-1432 TO denotes to
EnjuParser_T219 1433-1442 NN denotes NF-kappaB
EnjuParser_T220 1443-1453 NN denotes activation
EnjuParser_T221 1454-1456 IN denotes by
EnjuParser_T222 1457-1465 NN denotes IL-1beta
EnjuParser_T223 1465-1466 -COLON- denotes :
EnjuParser_T224 1467-1468 DT denotes a
EnjuParser_T225 1469-1476 NN denotes pathway
EnjuParser_T226 1477-1486 JJ denotes dependent
EnjuParser_T227 1487-1489 IN denotes on
EnjuParser_T228 1490-1493 NN denotes ROI
EnjuParser_T229 1494-1504 NN denotes production
EnjuParser_T230 1505-1507 IN denotes by
EnjuParser_T231 1508-1513 NN denotes 5-LOX
EnjuParser_T232 1514-1516 IN denotes in
EnjuParser_T233 1517-1525 JJ denotes lymphoid
EnjuParser_T234 1526-1531 NN denotes cells
EnjuParser_T235 1531-1532 -COMMA- denotes ,
EnjuParser_T236 1533-1535 DT denotes an
EnjuParser_T237 1536-1540 NN denotes ROI-
EnjuParser_T238 1541-1544 CC denotes and
EnjuParser_T239 1545-1562 JJ denotes 5-LOX-independent
EnjuParser_T240 1563-1570 NN denotes pathway
EnjuParser_T241 1571-1573 IN denotes in
EnjuParser_T242 1574-1584 JJ denotes epithelial
EnjuParser_T243 1585-1590 NN denotes cells
EnjuParser_T244 1590-1591 -COMMA- denotes ,
EnjuParser_T245 1592-1595 CC denotes and
EnjuParser_T246 1596-1597 DT denotes a
EnjuParser_T247 1598-1605 NN denotes pathway
EnjuParser_T248 1606-1615 VB denotes requiring
EnjuParser_T249 1616-1619 NN denotes ROI
EnjuParser_T250 1620-1630 NN denotes production
EnjuParser_T251 1631-1633 IN denotes by
EnjuParser_T252 1634-1639 NN denotes NADPH
EnjuParser_T253 1640-1647 NN denotes oxidase
EnjuParser_T254 1648-1650 IN denotes in
EnjuParser_T255 1651-1660 JJ denotes monocytic
EnjuParser_T256 1661-1666 NN denotes cells
EnjuParser_R0 EnjuParser_T4 EnjuParser_T0 arg1Of activation,Reactive
EnjuParser_R1 EnjuParser_T2 EnjuParser_T1 arg1Of intermediate-dependent,oxygen
EnjuParser_R2 EnjuParser_T4 EnjuParser_T2 arg1Of activation,intermediate-dependent
EnjuParser_R3 EnjuParser_T4 EnjuParser_T3 arg1Of activation,NF-kappaB
EnjuParser_R4 EnjuParser_T4 EnjuParser_T5 arg1Of activation,by
EnjuParser_R5 EnjuParser_T6 EnjuParser_T5 arg2Of interleukin-1beta,by
EnjuParser_R6 EnjuParser_T4 EnjuParser_T7 arg1Of activation,requires
EnjuParser_R7 EnjuParser_T9 EnjuParser_T7 arg2Of or,requires
EnjuParser_R8 EnjuParser_T8 EnjuParser_T9 arg1Of 5-lipoxygenase,or
EnjuParser_R9 EnjuParser_T12 EnjuParser_T9 arg2Of activity,or
EnjuParser_R10 EnjuParser_T12 EnjuParser_T10 arg1Of activity,NADPH
EnjuParser_R11 EnjuParser_T12 EnjuParser_T11 arg1Of activity,oxidase
EnjuParser_R12 EnjuParser_T15 EnjuParser_T14 arg1Of reported,previously
EnjuParser_R13 EnjuParser_T13 EnjuParser_T15 arg1Of We,reported
EnjuParser_R14 EnjuParser_T32 EnjuParser_T15 arg2Of was,reported
EnjuParser_R15 EnjuParser_T32 EnjuParser_T16 arg1Of was,that
EnjuParser_R16 EnjuParser_T18 EnjuParser_T17 arg1Of role,the
EnjuParser_R17 EnjuParser_T18 EnjuParser_T19 arg1Of role,of
EnjuParser_R18 EnjuParser_T22 EnjuParser_T19 arg2Of intermediates,of
EnjuParser_R19 EnjuParser_T22 EnjuParser_T20 arg1Of intermediates,reactive
EnjuParser_R20 EnjuParser_T22 EnjuParser_T21 arg1Of intermediates,oxygen
EnjuParser_R21 EnjuParser_T22 EnjuParser_T23 arg1Of intermediates,(
EnjuParser_R22 EnjuParser_T24 EnjuParser_T23 arg2Of ROIs,(
EnjuParser_R23 EnjuParser_T25 EnjuParser_T23 arg3Of ),(
EnjuParser_R24 EnjuParser_T18 EnjuParser_T26 arg1Of role,in
EnjuParser_R25 EnjuParser_T28 EnjuParser_T26 arg2Of activation,in
EnjuParser_R26 EnjuParser_T28 EnjuParser_T27 arg1Of activation,NF-kappaB
EnjuParser_R27 EnjuParser_T28 EnjuParser_T29 arg1Of activation,by
EnjuParser_R28 EnjuParser_T31 EnjuParser_T29 arg2Of cytokines,by
EnjuParser_R29 EnjuParser_T31 EnjuParser_T30 arg1Of cytokines,proinflammatory
EnjuParser_R30 EnjuParser_T18 EnjuParser_T32 arg1Of role,was
EnjuParser_R31 EnjuParser_T34 EnjuParser_T32 arg2Of specific,was
EnjuParser_R32 EnjuParser_T34 EnjuParser_T33 arg1Of specific,cell
EnjuParser_R33 EnjuParser_T18 EnjuParser_T34 arg1Of role,specific
EnjuParser_R34 EnjuParser_T50 EnjuParser_T35 arg1Of and,However
EnjuParser_R35 EnjuParser_T50 EnjuParser_T36 arg1Of and,","
EnjuParser_R36 EnjuParser_T38 EnjuParser_T37 arg1Of sources,the
EnjuParser_R37 EnjuParser_T38 EnjuParser_T39 arg1Of sources,for
EnjuParser_R38 EnjuParser_T40 EnjuParser_T39 arg2Of ROIs,for
EnjuParser_R39 EnjuParser_T40 EnjuParser_T41 arg1Of ROIs,in
EnjuParser_R40 EnjuParser_T44 EnjuParser_T41 arg2Of types,in
EnjuParser_R41 EnjuParser_T44 EnjuParser_T42 arg1Of types,various
EnjuParser_R42 EnjuParser_T44 EnjuParser_T43 arg1Of types,cell
EnjuParser_R43 EnjuParser_T38 EnjuParser_T45 arg1Of sources,are
EnjuParser_R44 EnjuParser_T45 EnjuParser_T46 arg1Of are,yet
EnjuParser_R45 EnjuParser_T45 EnjuParser_T47 modOf are,to
EnjuParser_R46 EnjuParser_T49 EnjuParser_T47 arg1Of determined,to
EnjuParser_R47 EnjuParser_T38 EnjuParser_T48 arg1Of sources,be
EnjuParser_R48 EnjuParser_T49 EnjuParser_T48 arg2Of determined,be
EnjuParser_R49 EnjuParser_T38 EnjuParser_T49 arg2Of sources,determined
EnjuParser_R50 EnjuParser_T45 EnjuParser_T50 arg1Of are,and
EnjuParser_R51 EnjuParser_T52 EnjuParser_T50 arg2Of include,and
EnjuParser_R52 EnjuParser_T38 EnjuParser_T51 arg1Of sources,might
EnjuParser_R53 EnjuParser_T52 EnjuParser_T51 arg2Of include,might
EnjuParser_R54 EnjuParser_T38 EnjuParser_T52 arg1Of sources,include
EnjuParser_R55 EnjuParser_T57 EnjuParser_T52 arg2Of and,include
EnjuParser_R56 EnjuParser_T53 EnjuParser_T54 arg1Of 5-lipoxygenase,(
EnjuParser_R57 EnjuParser_T55 EnjuParser_T54 arg2Of 5-LOX,(
EnjuParser_R58 EnjuParser_T56 EnjuParser_T54 arg3Of ),(
EnjuParser_R59 EnjuParser_T53 EnjuParser_T57 arg1Of 5-lipoxygenase,and
EnjuParser_R60 EnjuParser_T59 EnjuParser_T57 arg2Of oxidase,and
EnjuParser_R61 EnjuParser_T59 EnjuParser_T58 arg1Of oxidase,NADPH
EnjuParser_R62 EnjuParser_T60 EnjuParser_T61 arg1Of 5-LOX,and
EnjuParser_R63 EnjuParser_T64 EnjuParser_T61 arg2Of protein,and
EnjuParser_R64 EnjuParser_T64 EnjuParser_T62 arg1Of protein,5-LOX
EnjuParser_R65 EnjuParser_T64 EnjuParser_T63 arg1Of protein,activating
EnjuParser_R66 EnjuParser_T64 EnjuParser_T65 arg1Of protein,(
EnjuParser_R67 EnjuParser_T66 EnjuParser_T65 arg2Of FLAP,(
EnjuParser_R68 EnjuParser_T67 EnjuParser_T65 arg3Of ),(
EnjuParser_R69 EnjuParser_T61 EnjuParser_T68 arg1Of and,are
EnjuParser_R70 EnjuParser_T69 EnjuParser_T68 arg2Of coexpressed,are
EnjuParser_R71 EnjuParser_T61 EnjuParser_T69 arg2Of and,coexpressed
EnjuParser_R72 EnjuParser_T69 EnjuParser_T70 arg1Of coexpressed,in
EnjuParser_R73 EnjuParser_T72 EnjuParser_T70 arg2Of cells,in
EnjuParser_R74 EnjuParser_T72 EnjuParser_T71 arg1Of cells,lymphoid
EnjuParser_R75 EnjuParser_T70 EnjuParser_T73 arg1Of in,but
EnjuParser_R76 EnjuParser_T75 EnjuParser_T73 arg2Of in,but
EnjuParser_R77 EnjuParser_T75 EnjuParser_T74 arg1Of in,not
EnjuParser_R78 EnjuParser_T69 EnjuParser_T75 arg1Of coexpressed,in
EnjuParser_R79 EnjuParser_T79 EnjuParser_T75 arg2Of cells,in
EnjuParser_R80 EnjuParser_T79 EnjuParser_T76 arg1Of cells,monocytic
EnjuParser_R81 EnjuParser_T76 EnjuParser_T77 arg1Of monocytic,or
EnjuParser_R82 EnjuParser_T78 EnjuParser_T77 arg2Of epithelial,or
EnjuParser_R83 EnjuParser_T79 EnjuParser_T78 arg1Of cells,epithelial
EnjuParser_R84 EnjuParser_T80 EnjuParser_T81 arg1Of Stimulation,of
EnjuParser_R85 EnjuParser_T83 EnjuParser_T81 arg2Of cells,of
EnjuParser_R86 EnjuParser_T83 EnjuParser_T82 arg1Of cells,lymphoid
EnjuParser_R87 EnjuParser_T83 EnjuParser_T84 arg1Of cells,with
EnjuParser_R88 EnjuParser_T85 EnjuParser_T84 arg2Of interleukin-1beta,with
EnjuParser_R89 EnjuParser_T83 EnjuParser_T86 arg1Of cells,(
EnjuParser_R90 EnjuParser_T87 EnjuParser_T86 arg2Of IL-1beta,(
EnjuParser_R91 EnjuParser_T88 EnjuParser_T86 arg3Of ),(
EnjuParser_R92 EnjuParser_T80 EnjuParser_T89 arg1Of Stimulation,led
EnjuParser_R93 EnjuParser_T89 EnjuParser_T90 arg1Of led,to
EnjuParser_R94 EnjuParser_T93 EnjuParser_T90 arg2Of and,to
EnjuParser_R95 EnjuParser_T92 EnjuParser_T91 arg1Of production,ROI
EnjuParser_R96 EnjuParser_T92 EnjuParser_T93 arg1Of production,and
EnjuParser_R97 EnjuParser_T95 EnjuParser_T93 arg2Of activation,and
EnjuParser_R98 EnjuParser_T95 EnjuParser_T94 arg1Of activation,NF-kappaB
EnjuParser_R99 EnjuParser_T93 EnjuParser_T96 arg1Of and,","
EnjuParser_R100 EnjuParser_T93 EnjuParser_T97 arg1Of and,which
EnjuParser_R101 EnjuParser_T93 EnjuParser_T98 arg1Of and,could
EnjuParser_R102 EnjuParser_T101 EnjuParser_T98 arg2Of blocked,could
EnjuParser_R103 EnjuParser_T101 EnjuParser_T99 arg1Of blocked,both
EnjuParser_R104 EnjuParser_T93 EnjuParser_T100 arg1Of and,be
EnjuParser_R105 EnjuParser_T101 EnjuParser_T100 arg2Of blocked,be
EnjuParser_R106 EnjuParser_T93 EnjuParser_T101 arg2Of and,blocked
EnjuParser_R107 EnjuParser_T93 EnjuParser_T102 arg1Of and,by
EnjuParser_R108 EnjuParser_T104 EnjuParser_T102 arg2Of or,by
EnjuParser_R109 EnjuParser_T103 EnjuParser_T104 arg1Of antioxidants,or
EnjuParser_R110 EnjuParser_T106 EnjuParser_T104 arg2Of inhibitors,or
EnjuParser_R111 EnjuParser_T106 EnjuParser_T105 arg1Of inhibitors,FLAP
EnjuParser_R112 EnjuParser_T89 EnjuParser_T107 arg1Of led,","
EnjuParser_R113 EnjuParser_T89 EnjuParser_T108 modOf led,confirming
EnjuParser_R114 EnjuParser_T116 EnjuParser_T108 arg2Of and,confirming
EnjuParser_R115 EnjuParser_T116 EnjuParser_T109 arg1Of and,that
EnjuParser_R116 EnjuParser_T110 EnjuParser_T111 arg1Of 5-LOX,was
EnjuParser_R117 EnjuParser_T113 EnjuParser_T111 arg2Of source,was
EnjuParser_R118 EnjuParser_T113 EnjuParser_T112 arg1Of source,the
EnjuParser_R119 EnjuParser_T113 EnjuParser_T114 arg1Of source,of
EnjuParser_R120 EnjuParser_T115 EnjuParser_T114 arg2Of ROIs,of
EnjuParser_R121 EnjuParser_T111 EnjuParser_T116 arg1Of was,and
EnjuParser_R122 EnjuParser_T118 EnjuParser_T116 arg2Of required,and
EnjuParser_R123 EnjuParser_T110 EnjuParser_T117 arg1Of 5-LOX,was
EnjuParser_R124 EnjuParser_T118 EnjuParser_T117 arg2Of required,was
EnjuParser_R125 EnjuParser_T110 EnjuParser_T118 arg2Of 5-LOX,required
EnjuParser_R126 EnjuParser_T122 EnjuParser_T118 arg3Of in,required
EnjuParser_R127 EnjuParser_T118 EnjuParser_T119 arg1Of required,for
EnjuParser_R128 EnjuParser_T121 EnjuParser_T119 arg2Of activation,for
EnjuParser_R129 EnjuParser_T121 EnjuParser_T120 arg1Of activation,NF-kappaB
EnjuParser_R130 EnjuParser_T124 EnjuParser_T122 arg2Of cells,in
EnjuParser_R131 EnjuParser_T124 EnjuParser_T123 arg1Of cells,these
EnjuParser_R132 EnjuParser_T126 EnjuParser_T125 arg1Of stimulation,IL-1beta
EnjuParser_R133 EnjuParser_T126 EnjuParser_T127 arg1Of stimulation,of
EnjuParser_R134 EnjuParser_T129 EnjuParser_T127 arg2Of cells,of
EnjuParser_R135 EnjuParser_T129 EnjuParser_T128 arg1Of cells,epithelial
EnjuParser_R136 EnjuParser_T126 EnjuParser_T130 arg1Of stimulation,did
EnjuParser_R137 EnjuParser_T132 EnjuParser_T130 arg2Of generate,did
EnjuParser_R138 EnjuParser_T132 EnjuParser_T131 arg1Of generate,not
EnjuParser_R139 EnjuParser_T126 EnjuParser_T132 arg1Of stimulation,generate
EnjuParser_R140 EnjuParser_T134 EnjuParser_T132 arg2Of ROIs,generate
EnjuParser_R141 EnjuParser_T134 EnjuParser_T133 arg1Of ROIs,any
EnjuParser_R142 EnjuParser_T132 EnjuParser_T135 arg1Of generate,and
EnjuParser_R143 EnjuParser_T140 EnjuParser_T135 arg2Of influenced,and
EnjuParser_R144 EnjuParser_T137 EnjuParser_T136 arg1Of induction,NF-kappaB
EnjuParser_R145 EnjuParser_T137 EnjuParser_T138 arg1Of induction,was
EnjuParser_R146 EnjuParser_T140 EnjuParser_T138 arg2Of influenced,was
EnjuParser_R147 EnjuParser_T140 EnjuParser_T139 arg1Of influenced,not
EnjuParser_R148 EnjuParser_T143 EnjuParser_T140 arg1Of inhibitors,influenced
EnjuParser_R149 EnjuParser_T137 EnjuParser_T140 arg2Of induction,influenced
EnjuParser_R150 EnjuParser_T143 EnjuParser_T141 arg2Of inhibitors,by
EnjuParser_R151 EnjuParser_T143 EnjuParser_T142 arg1Of inhibitors,5-LOX
EnjuParser_R152 EnjuParser_T155 EnjuParser_T144 arg1Of allowed,However
EnjuParser_R153 EnjuParser_T155 EnjuParser_T145 arg1Of allowed,","
EnjuParser_R154 EnjuParser_T146 EnjuParser_T147 arg1Of reintroduction,of
EnjuParser_R155 EnjuParser_T151 EnjuParser_T147 arg2Of system,of
EnjuParser_R156 EnjuParser_T151 EnjuParser_T148 arg1Of system,a
EnjuParser_R157 EnjuParser_T151 EnjuParser_T149 arg1Of system,functional
EnjuParser_R158 EnjuParser_T151 EnjuParser_T150 arg1Of system,5-LOX
EnjuParser_R159 EnjuParser_T146 EnjuParser_T152 arg1Of reintroduction,in
EnjuParser_R160 EnjuParser_T154 EnjuParser_T152 arg2Of cells,in
EnjuParser_R161 EnjuParser_T154 EnjuParser_T153 arg1Of cells,these
EnjuParser_R162 EnjuParser_T146 EnjuParser_T155 arg1Of reintroduction,allowed
EnjuParser_R163 EnjuParser_T158 EnjuParser_T155 arg2Of and,allowed
EnjuParser_R164 EnjuParser_T157 EnjuParser_T156 arg1Of production,ROI
EnjuParser_R165 EnjuParser_T157 EnjuParser_T158 arg1Of production,and
EnjuParser_R166 EnjuParser_T161 EnjuParser_T158 arg2Of activation,and
EnjuParser_R167 EnjuParser_T161 EnjuParser_T159 arg1Of activation,5-LOX-dependent
EnjuParser_R168 EnjuParser_T161 EnjuParser_T160 arg1Of activation,NF-kappaB
EnjuParser_R169 EnjuParser_T181 EnjuParser_T162 arg1Of but,In
EnjuParser_R170 EnjuParser_T164 EnjuParser_T162 arg2Of cells,In
EnjuParser_R171 EnjuParser_T164 EnjuParser_T163 arg1Of cells,monocytic
EnjuParser_R172 EnjuParser_T181 EnjuParser_T165 arg1Of but,","
EnjuParser_R173 EnjuParser_T167 EnjuParser_T166 arg1Of treatment,IL-1beta
EnjuParser_R174 EnjuParser_T167 EnjuParser_T168 arg1Of treatment,led
EnjuParser_R175 EnjuParser_T168 EnjuParser_T169 arg1Of led,to
EnjuParser_R176 EnjuParser_T171 EnjuParser_T169 arg2Of production,to
EnjuParser_R177 EnjuParser_T174 EnjuParser_T169 arg3Of which,to
EnjuParser_R178 EnjuParser_T171 EnjuParser_T170 arg1Of production,a
EnjuParser_R179 EnjuParser_T171 EnjuParser_T172 arg1Of production,of
EnjuParser_R180 EnjuParser_T173 EnjuParser_T172 arg2Of ROIs,of
EnjuParser_R181 EnjuParser_T174 EnjuParser_T175 arg1Of which,is
EnjuParser_R182 EnjuParser_T176 EnjuParser_T175 arg2Of independent,is
EnjuParser_R183 EnjuParser_T174 EnjuParser_T176 arg1Of which,independent
EnjuParser_R184 EnjuParser_T176 EnjuParser_T177 arg1Of independent,of
EnjuParser_R185 EnjuParser_T180 EnjuParser_T177 arg2Of enzyme,of
EnjuParser_R186 EnjuParser_T180 EnjuParser_T178 arg1Of enzyme,the
EnjuParser_R187 EnjuParser_T180 EnjuParser_T179 arg1Of enzyme,5-LOX
EnjuParser_R188 EnjuParser_T175 EnjuParser_T181 arg1Of is,but
EnjuParser_R189 EnjuParser_T182 EnjuParser_T181 arg2Of requires,but
EnjuParser_R190 EnjuParser_T174 EnjuParser_T182 arg1Of which,requires
EnjuParser_R191 EnjuParser_T186 EnjuParser_T182 arg2Of activity,requires
EnjuParser_R192 EnjuParser_T184 EnjuParser_T183 arg1Of NADPH,the
EnjuParser_R193 EnjuParser_T186 EnjuParser_T184 arg1Of activity,NADPH
EnjuParser_R194 EnjuParser_T186 EnjuParser_T185 arg1Of activity,oxidase
EnjuParser_R195 EnjuParser_T188 EnjuParser_T187 arg1Of pathway,This
EnjuParser_R196 EnjuParser_T188 EnjuParser_T189 arg1Of pathway,involves
EnjuParser_R197 EnjuParser_T192 EnjuParser_T189 arg2Of and,involves
EnjuParser_R198 EnjuParser_T191 EnjuParser_T190 arg1Of Rac1,the
EnjuParser_R199 EnjuParser_T191 EnjuParser_T192 arg1Of Rac1,and
EnjuParser_R200 EnjuParser_T194 EnjuParser_T192 arg2Of GTPases,and
EnjuParser_R201 EnjuParser_T194 EnjuParser_T193 arg1Of GTPases,Cdc42
EnjuParser_R202 EnjuParser_T192 EnjuParser_T195 arg1Of and,","
EnjuParser_R203 EnjuParser_T197 EnjuParser_T195 arg2Of enzymes,","
EnjuParser_R204 EnjuParser_T197 EnjuParser_T196 arg1Of enzymes,two
EnjuParser_R205 EnjuParser_T197 EnjuParser_T198 arg1Of enzymes,which
EnjuParser_R206 EnjuParser_T197 EnjuParser_T199 arg1Of enzymes,are
EnjuParser_R207 EnjuParser_T201 EnjuParser_T199 arg2Of required,are
EnjuParser_R208 EnjuParser_T201 EnjuParser_T200 arg1Of required,not
EnjuParser_R209 EnjuParser_T197 EnjuParser_T201 arg2Of enzymes,required
EnjuParser_R210 EnjuParser_T201 EnjuParser_T202 arg1Of required,for
EnjuParser_R211 EnjuParser_T204 EnjuParser_T202 arg2Of activation,for
EnjuParser_R212 EnjuParser_T204 EnjuParser_T203 arg1Of activation,NF-kappaB
EnjuParser_R213 EnjuParser_T204 EnjuParser_T205 arg1Of activation,by
EnjuParser_R214 EnjuParser_T206 EnjuParser_T205 arg2Of IL-1beta,by
EnjuParser_R215 EnjuParser_T206 EnjuParser_T207 arg1Of IL-1beta,in
EnjuParser_R216 EnjuParser_T209 EnjuParser_T207 arg2Of cells,in
EnjuParser_R217 EnjuParser_T209 EnjuParser_T208 arg1Of cells,epithelial
EnjuParser_R218 EnjuParser_T217 EnjuParser_T210 arg1Of lead,In
EnjuParser_R219 EnjuParser_T211 EnjuParser_T210 arg2Of conclusion,In
EnjuParser_R220 EnjuParser_T217 EnjuParser_T212 arg1Of lead,","
EnjuParser_R221 EnjuParser_T216 EnjuParser_T213 arg1Of pathways,three
EnjuParser_R222 EnjuParser_T216 EnjuParser_T214 arg1Of pathways,different
EnjuParser_R223 EnjuParser_T216 EnjuParser_T215 arg1Of pathways,cell-specific
EnjuParser_R224 EnjuParser_T216 EnjuParser_T217 arg1Of pathways,lead
EnjuParser_R225 EnjuParser_T217 EnjuParser_T218 arg1Of lead,to
EnjuParser_R226 EnjuParser_T220 EnjuParser_T218 arg2Of activation,to
EnjuParser_R227 EnjuParser_T220 EnjuParser_T219 arg1Of activation,NF-kappaB
EnjuParser_R228 EnjuParser_T220 EnjuParser_T221 arg1Of activation,by
EnjuParser_R229 EnjuParser_T222 EnjuParser_T221 arg2Of IL-1beta,by
EnjuParser_R230 EnjuParser_T220 EnjuParser_T223 arg1Of activation,:
EnjuParser_R231 EnjuParser_T225 EnjuParser_T223 arg2Of pathway,:
EnjuParser_R232 EnjuParser_T225 EnjuParser_T224 arg1Of pathway,a
EnjuParser_R233 EnjuParser_T225 EnjuParser_T226 arg1Of pathway,dependent
EnjuParser_R234 EnjuParser_T226 EnjuParser_T227 arg1Of dependent,on
EnjuParser_R235 EnjuParser_T229 EnjuParser_T227 arg2Of production,on
EnjuParser_R236 EnjuParser_T229 EnjuParser_T228 arg1Of production,ROI
EnjuParser_R237 EnjuParser_T229 EnjuParser_T230 arg1Of production,by
EnjuParser_R238 EnjuParser_T245 EnjuParser_T230 arg2Of and,by
EnjuParser_R239 EnjuParser_T231 EnjuParser_T232 arg1Of 5-LOX,in
EnjuParser_R240 EnjuParser_T234 EnjuParser_T232 arg2Of cells,in
EnjuParser_R241 EnjuParser_T234 EnjuParser_T233 arg1Of cells,lymphoid
EnjuParser_R242 EnjuParser_T234 EnjuParser_T235 arg1Of cells,","
EnjuParser_R243 EnjuParser_T237 EnjuParser_T235 arg2Of ROI-,","
EnjuParser_R244 EnjuParser_T237 EnjuParser_T236 arg1Of ROI-,an
EnjuParser_R245 EnjuParser_T231 EnjuParser_T238 arg1Of 5-LOX,and
EnjuParser_R246 EnjuParser_T240 EnjuParser_T238 arg2Of pathway,and
EnjuParser_R247 EnjuParser_T240 EnjuParser_T239 arg1Of pathway,5-LOX-independent
EnjuParser_R248 EnjuParser_T238 EnjuParser_T241 arg1Of and,in
EnjuParser_R249 EnjuParser_T243 EnjuParser_T241 arg2Of cells,in
EnjuParser_R250 EnjuParser_T243 EnjuParser_T242 arg1Of cells,epithelial
EnjuParser_R251 EnjuParser_T245 EnjuParser_T244 arg1Of and,","
EnjuParser_R252 EnjuParser_T238 EnjuParser_T245 arg1Of and,and
EnjuParser_R253 EnjuParser_T250 EnjuParser_T245 arg2Of production,and
EnjuParser_R254 EnjuParser_T250 EnjuParser_T246 arg1Of production,a
EnjuParser_R255 EnjuParser_T250 EnjuParser_T247 arg1Of production,pathway
EnjuParser_R256 EnjuParser_T250 EnjuParser_T248 arg1Of production,requiring
EnjuParser_R257 EnjuParser_T250 EnjuParser_T249 arg1Of production,ROI
EnjuParser_R258 EnjuParser_T250 EnjuParser_T251 arg1Of production,by
EnjuParser_R259 EnjuParser_T253 EnjuParser_T251 arg2Of oxidase,by
EnjuParser_R260 EnjuParser_T253 EnjuParser_T252 arg1Of oxidase,NADPH
EnjuParser_R261 EnjuParser_T253 EnjuParser_T254 arg1Of oxidase,in
EnjuParser_R262 EnjuParser_T256 EnjuParser_T254 arg2Of cells,in
EnjuParser_R263 EnjuParser_T256 EnjuParser_T255 arg1Of cells,monocytic

genia-medco-coref

Id Subject Object Predicate Lexical cue
C7 403-416 NP denotes NADPH oxidase
C8 418-423 NP denotes 5-LOX
C9 479-493 NP denotes lymphoid cells
C10 551-565 NP denotes lymphoid cells
C11 571-599 NP denotes interleukin-1beta (IL-1beta)
C13 607-621 NP denotes ROI production
C12 607-646 NP denotes ROI production and NF-kappaB activation
C14 648-653 NP denotes which
C15 660-664 NP denotes both
C16 728-733 NP denotes 5-LOX
C17 752-756 NP denotes ROIs
C18 802-813 NP denotes these cells
C19 839-855 NP denotes epithelial cells
C20 1002-1013 NP denotes these cells
C21 1022-1036 NP denotes ROI production
C22 1082-1097 NP denotes monocytic cells
C24 1141-1145 NP denotes ROIs
C23 1125-1145 NP denotes a production of ROIs
C25 1146-1151 NP denotes which
C26 1200-1226 NP denotes the NADPH oxidase activity
C27 1250-1276 NP denotes the Rac1 and Cdc42 GTPases
C29 1278-1289 NP denotes two enzymes
C30 1290-1295 NP denotes which
C31 1341-1349 NP denotes IL-1beta
C32 1353-1369 NP denotes epithelial cells
C28 1278-1369 NP denotes two enzymes which are not required for NF-kappaB activation by IL-1beta in epithelial cells
C33 1457-1465 NP denotes IL-1beta
C34 1508-1513 NP denotes 5-LOX
C35 1517-1531 NP denotes lymphoid cells
C36 1574-1590 NP denotes epithelial cells
C37 1634-1647 NP denotes NADPH oxidase
C38 1651-1666 NP denotes monocytic cells
C1 63-80 NP denotes interleukin-1beta
C2 90-104 NP denotes 5-lipoxygenase
C3 108-130 NP denotes NADPH oxidase activity
C4 172-208 NP denotes reactive oxygen intermediates (ROIs)
C5 306-310 NP denotes ROIs
C6 376-398 NP denotes 5-lipoxygenase (5-LOX)
R1 C5 C4 coref-ident ROIs,reactive oxygen intermediates (ROIs)
R2 C6 C2 coref-ident 5-lipoxygenase (5-LOX),5-lipoxygenase
R3 C8 C6 coref-ident 5-LOX,5-lipoxygenase (5-LOX)
R4 C10 C9 coref-ident lymphoid cells,lymphoid cells
R5 C11 C1 coref-ident interleukin-1beta (IL-1beta),interleukin-1beta
R6 C14 C12 coref-relat which,ROI production and NF-kappaB activation
R7 C15 C12 coref-pron both,ROI production and NF-kappaB activation
R8 C16 C8 coref-ident 5-LOX,5-LOX
R9 C17 C5 coref-ident ROIs,ROIs
R10 C18 C10 coref-ident these cells,lymphoid cells
R11 C20 C19 coref-ident these cells,epithelial cells
R12 C21 C13 coref-ident ROI production,ROI production
R13 C24 C17 coref-ident ROIs,ROIs
R14 C25 C23 coref-relat which,a production of ROIs
R15 C26 C3 coref-ident the NADPH oxidase activity,NADPH oxidase activity
R16 C30 C29 coref-relat which,two enzymes
R17 C31 C11 coref-ident IL-1beta,interleukin-1beta (IL-1beta)
R18 C32 C19 coref-ident epithelial cells,epithelial cells
R19 C28 C27 coref-appos two enzymes which are not required for NF-kappaB activation by IL-1beta in epithelial cells,the Rac1 and Cdc42 GTPases
R20 C33 C31 coref-ident IL-1beta,IL-1beta
R21 C34 C16 coref-ident 5-LOX,5-LOX
R22 C35 C18 coref-ident lymphoid cells,these cells
R23 C36 C32 coref-ident epithelial cells,epithelial cells
R24 C37 C7 coref-ident NADPH oxidase,NADPH oxidase
R25 C38 C22 coref-ident monocytic cells,monocytic cells

semrep-sample

Id Subject Object Predicate Lexical cue
E1-ti-1 0-28 cui:C0920643 denotes Reactive oxygen intermediate
E2-ti-1 39-48 cui:C0214222 denotes NF-kappaB
E3-ti-1 63-80 cui:C0021753 denotes interleukin-1beta
E4-ti-1 92-104 cui:C0023837 denotes lipoxygenase
E5-ti-1 108-130 cui:C1151146 denotes NADPH oxidase activity
T1 49-59 STIMULATES denotes activation
E1-ab-1 164-168 cui:C0035820 denotes role
E2-ab-1 172-201 cui:C0920643 denotes reactive oxygen intermediates
E3-ab-1 212-221 cui:C0079904 denotes NF-kappaB
E4-ab-1 252-261 cui:C0079189 denotes cytokines
E5-ab-1 266-270 cui:C0007634 denotes cell
T2 222-232 STIMULATES denotes activation
E1-ab-2 306-310 cui:C0035820 denotes ROIs
E2-ab-2 306-310 cui:C0920643 denotes ROIs
E3-ab-2 322-332 cui:C0007634 denotes cell types
E4-ab-2 378-390 cui:C0023837 denotes lipoxygenase
E5-ab-2 403-416 cui:C0068355 denotes NADPH oxidase
T3 306-310 AFFECTS denotes ROIs
T4 306-310 AFFECTS denotes ROIs
E1-ab-3 418-423 cui:C0023837 denotes 5-LOX
E2-ab-3 428-452 cui:C0049275 denotes 5-LOX activating protein
E3-ab-3 454-458 cui:C0038925 denotes FLAP
E4-ab-3 479-493 cui:C0086574 denotes lymphoid cells
E5-ab-3 498-501 cui:C1518422 denotes not
E6-ab-3 505-514 cui:C0026473 denotes monocytic
E7-ab-3 518-534 cui:C0014597 denotes epithelial cells
T5 476-478 LOCATION_OF denotes in
T6 476-478 LOCATION_OF denotes in
T7 476-478 LOCATION_OF denotes in
T8 476-478 LOCATION_OF denotes in
E1-ab-4 536-547 cui:C1292856 denotes Stimulation
E2-ab-4 551-565 cui:C0086574 denotes lymphoid cells
E3-ab-4 571-588 cui:C0021753 denotes interleukin-1beta
E4-ab-4 611-621 cui:C0033268 denotes production
E5-ab-4 626-635 cui:C0214222 denotes NF-kappaB
E6-ab-4 679-691 cui:C0003402 denotes antioxidants
E7-ab-4 695-699 cui:C0038925 denotes FLAP
E8-ab-4 700-710 cui:C0243077 denotes inhibitors
E9-ab-4 728-733 cui:C0023837 denotes 5-LOX
E10-ab-4 752-756 cui:C0035820 denotes ROIs
E11-ab-4 752-756 cui:C0920643 denotes ROIs
E12-ab-4 778-787 cui:C0214222 denotes NF-kappaB
E13-ab-4 808-813 cui:C0007634 denotes cells
T9 536-547 AUGMENTS denotes Stimulation
T10 636-646 STIMULATES denotes activation
T11 700-710 DISRUPTS denotes inhibitors
T12 788-798 STIMULATES denotes activation
E1-ab-5 815-823 cui:C0021753 denotes IL-1beta
E2-ab-5 824-835 cui:C1292856 denotes stimulation
E3-ab-5 839-855 cui:C0014597 denotes epithelial cells
E4-ab-5 860-863 cui:C1518422 denotes not
E5-ab-5 873-876 cui:C1552551 denotes any
E6-ab-5 877-881 cui:C0035820 denotes ROIs
E7-ab-5 877-881 cui:C0920643 denotes ROIs
E8-ab-5 886-895 cui:C0079904 denotes NF-kappaB
E9-ab-5 896-905 cui:C0857127 denotes induction
E10-ab-5 910-913 cui:C1518422 denotes not
E11-ab-5 928-944 cui:C1289971 denotes 5-LOX inhibitors
T13 824-835 AUGMENTS denotes stimulation
T14 914-924 INTERACTS_WITH denotes influenced
E1-ab-6 986-991 cui:C0023837 denotes 5-LOX
E2-ab-6 975-998 cui:C1180473 denotes functional 5-LOX system
E3-ab-6 1008-1013 cui:C0007634 denotes cells
E4-ab-6 1026-1036 cui:C0033268 denotes production
E5-ab-6 1041-1046 cui:C0023837 denotes 5-LOX
E6-ab-6 1057-1066 cui:C0214222 denotes NF-kappaB
E1-ab-7 1082-1091 cui:C0026473 denotes monocytic
E2-ab-7 1092-1097 cui:C0007634 denotes cells
E3-ab-7 1099-1107 cui:C0021753 denotes IL-1beta
E4-ab-7 1127-1137 cui:C0033268 denotes production
E5-ab-7 1141-1145 cui:C0035820 denotes ROIs
E6-ab-7 1141-1145 cui:C0920643 denotes ROIs
E7-ab-7 1174-1179 cui:C0023837 denotes 5-LOX
E8-ab-7 1180-1186 cui:C0014442 denotes enzyme
E9-ab-7 1204-1226 cui:C1151146 denotes NADPH oxidase activity
T15 1127-1137 PRODUCES denotes production
E1-ab-8 1233-1240 cui:C0243123 denotes pathway
E2-ab-8 1254-1258 entrez:5879 denotes Rac1
E3-ab-8 1263-1268 cui:C1366537 denotes Cdc42
E4-ab-8 1269-1276 cui:C0018296 denotes GTPases
E5-ab-8 1278-1281 cui:C0205448 denotes two
E6-ab-8 1282-1289 cui:C0014442 denotes enzymes
E7-ab-8 1300-1303 cui:C1518422 denotes not
E8-ab-8 1317-1326 cui:C0079904 denotes NF-kappaB
E9-ab-8 1341-1349 cui:C0021753 denotes IL-1beta
E10-ab-8 1353-1369 cui:C0014597 denotes epithelial cells
T16 1327-1337 STIMULATES denotes activation
T17 1350-1352 LOCATION_OF denotes in
E1-ab-9 1386-1391 cui:C0205449 denotes three
E2-ab-9 1392-1401 cui:C1547020 denotes different
E3-ab-9 1402-1406 cui:C0007634 denotes cell
E4-ab-9 1433-1442 cui:C0079904 denotes NF-kappaB
E5-ab-9 1457-1465 cui:C0021753 denotes IL-1beta
E6-ab-9 1469-1476 cui:C0243123 denotes pathway
E7-ab-9 1494-1504 cui:C0033268 denotes production
E8-ab-9 1508-1513 cui:C0023837 denotes 5-LOX
E9-ab-9 1517-1531 cui:C0086574 denotes lymphoid cells
E10-ab-9 1545-1570 cui:C1157322 denotes 5-LOX-independent pathway
E11-ab-9 1574-1590 cui:C0014597 denotes epithelial cells
E12-ab-9 1598-1605 cui:C0243123 denotes pathway
E13-ab-9 1606-1615 cui:C1514872 denotes requiring
E14-ab-9 1620-1630 cui:C0033268 denotes production
E15-ab-9 1634-1647 cui:C0068355 denotes NADPH oxidase
E16-ab-9 1651-1660 cui:C0026473 denotes monocytic
E17-ab-9 1661-1666 cui:C0007634 denotes cells
T18 1443-1453 STIMULATES denotes activation
T19 1514-1516 LOCATION_OF denotes in
T20 1571-1573 LOCATION_OF denotes in
T21 1648-1650 LOCATION_OF denotes in
R1 E3-ti-1 T1 subjectOf interleukin-1beta,activation
R2 E2-ti-1 T1 objectOf NF-kappaB,activation
R3 E4-ab-1 T2 subjectOf cytokines,activation
R4 E3-ab-1 T2 objectOf NF-kappaB,activation
R5 E4-ab-2 T3 subjectOf lipoxygenase,ROIs
R6 E3-ab-2 T3 objectOf cell types,ROIs
R7 E5-ab-2 T4 subjectOf NADPH oxidase,ROIs
R8 E3-ab-2 T4 objectOf cell types,ROIs
R9 E4-ab-3 T5 subjectOf lymphoid cells,in
R10 E2-ab-3 T5 objectOf 5-LOX activating protein,in
R11 E4-ab-3 T6 subjectOf lymphoid cells,in
R12 E1-ab-3 T6 objectOf 5-LOX,in
R13 E7-ab-3 T7 subjectOf epithelial cells,in
R14 E2-ab-3 T7 objectOf 5-LOX activating protein,in
R15 E7-ab-3 T8 subjectOf epithelial cells,in
R16 E1-ab-3 T8 objectOf 5-LOX,in
R17 E3-ab-4 T9 subjectOf interleukin-1beta,Stimulation
R18 E2-ab-4 T9 objectOf lymphoid cells,Stimulation
R19 E9-ab-4 T10 subjectOf 5-LOX,activation
R20 E5-ab-4 T10 objectOf NF-kappaB,activation
R21 E6-ab-4 T11 subjectOf antioxidants,inhibitors
R22 E7-ab-4 T11 objectOf FLAP,inhibitors
R23 E11-ab-4 T12 subjectOf ROIs,activation
R24 E12-ab-4 T12 objectOf NF-kappaB,activation
R25 E1-ab-5 T13 subjectOf IL-1beta,stimulation
R26 E3-ab-5 T13 objectOf epithelial cells,stimulation
R27 E11-ab-5 T14 subjectOf 5-LOX inhibitors,influenced
R28 E7-ab-5 T14 objectOf ROIs,influenced
R29 E2-ab-7 T15 subjectOf cells,production
R30 E6-ab-7 T15 objectOf ROIs,production
R31 E9-ab-8 T16 subjectOf IL-1beta,activation
R32 E8-ab-8 T16 objectOf NF-kappaB,activation
R33 E10-ab-8 T17 subjectOf epithelial cells,in
R34 E9-ab-8 T17 objectOf IL-1beta,in
R35 E5-ab-9 T18 subjectOf IL-1beta,activation
R36 E4-ab-9 T18 objectOf NF-kappaB,activation
R37 E9-ab-9 T19 subjectOf lymphoid cells,in
R38 E8-ab-9 T19 objectOf 5-LOX,in
R39 E11-ab-9 T20 subjectOf epithelial cells,in
R40 E8-ab-9 T20 objectOf 5-LOX,in
R41 E17-ab-9 T21 subjectOf cells,in
R42 E15-ab-9 T21 objectOf NADPH oxidase,in

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-131 Sentence denotes Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity.
S2 132-280 Sentence denotes We previously reported that the role of reactive oxygen intermediates (ROIs) in NF-kappaB activation by proinflammatory cytokines was cell specific.
S3 281-417 Sentence denotes However, the sources for ROIs in various cell types are yet to be determined and might include 5-lipoxygenase (5-LOX) and NADPH oxidase.
S4 418-535 Sentence denotes 5-LOX and 5-LOX activating protein (FLAP) are coexpressed in lymphoid cells but not in monocytic or epithelial cells.
S5 536-814 Sentence denotes Stimulation of lymphoid cells with interleukin-1beta (IL-1beta) led to ROI production and NF-kappaB activation, which could both be blocked by antioxidants or FLAP inhibitors, confirming that 5-LOX was the source of ROIs and was required for NF-kappaB activation in these cells.
S6 815-945 Sentence denotes IL-1beta stimulation of epithelial cells did not generate any ROIs and NF-kappaB induction was not influenced by 5-LOX inhibitors.
S7 946-1078 Sentence denotes However, reintroduction of a functional 5-LOX system in these cells allowed ROI production and 5-LOX-dependent NF-kappaB activation.
S8 1079-1227 Sentence denotes In monocytic cells, IL-1beta treatment led to a production of ROIs which is independent of the 5-LOX enzyme but requires the NADPH oxidase activity.
S9 1228-1370 Sentence denotes This pathway involves the Rac1 and Cdc42 GTPases, two enzymes which are not required for NF-kappaB activation by IL-1beta in epithelial cells.
S10 1371-1667 Sentence denotes In conclusion, three different cell-specific pathways lead to NF-kappaB activation by IL-1beta: a pathway dependent on ROI production by 5-LOX in lymphoid cells, an ROI- and 5-LOX-independent pathway in epithelial cells, and a pathway requiring ROI production by NADPH oxidase in monocytic cells.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 39-48 protein_complex denotes NF-kappaB
T2 63-80 protein_molecule denotes interleukin-1beta
T3 90-104 protein_molecule denotes 5-lipoxygenase
T4 108-113 other_organic_compound denotes NADPH
T5 172-201 inorganic denotes reactive oxygen intermediates
T6 203-207 inorganic denotes ROIs
T7 212-221 protein_complex denotes NF-kappaB
T8 236-261 protein_family_or_group denotes proinflammatory cytokines
T9 306-310 inorganic denotes ROIs
T10 376-390 protein_molecule denotes 5-lipoxygenase
T11 392-397 protein_molecule denotes 5-LOX
T12 403-408 other_organic_compound denotes NADPH
T13 418-423 protein_molecule denotes 5-LOX
T14 428-433 protein_molecule denotes 5-LOX
T15 454-458 protein_molecule denotes FLAP
T16 479-493 cell_type denotes lymphoid cells
T17 551-565 cell_type denotes lymphoid cells
T18 571-588 protein_molecule denotes interleukin-1beta
T19 590-598 protein_molecule denotes IL-1beta
T20 626-635 protein_complex denotes NF-kappaB
T21 695-699 protein_molecule denotes FLAP
T22 728-733 protein_molecule denotes 5-LOX
T23 752-756 inorganic denotes ROIs
T24 778-787 protein_complex denotes NF-kappaB
T25 815-823 protein_molecule denotes IL-1beta
T26 839-855 cell_type denotes epithelial cells
T27 877-881 inorganic denotes ROIs
T28 886-895 protein_complex denotes NF-kappaB
T29 928-933 protein_molecule denotes 5-LOX
T30 986-991 protein_molecule denotes 5-LOX
T31 1022-1036 other_name denotes ROI production
T32 1041-1046 protein_molecule denotes 5-LOX
T33 1057-1066 protein_complex denotes NF-kappaB
T34 1082-1097 cell_type denotes monocytic cells
T35 1099-1107 protein_molecule denotes IL-1beta
T36 1141-1145 inorganic denotes ROIs
T37 1174-1179 protein_molecule denotes 5-LOX
T38 1204-1209 other_organic_compound denotes NADPH
T39 1254-1258 protein_molecule denotes Rac1
T40 1263-1268 protein_molecule denotes Cdc42
T41 1269-1276 protein_family_or_group denotes GTPases
T42 1317-1326 protein_complex denotes NF-kappaB
T43 1341-1349 protein_molecule denotes IL-1beta
T44 1353-1369 cell_type denotes epithelial cells
T45 1402-1424 other_name denotes cell-specific pathways
T46 1433-1442 protein_complex denotes NF-kappaB
T47 1457-1465 protein_molecule denotes IL-1beta
T48 1490-1504 other_name denotes ROI production
T49 1508-1513 protein_molecule denotes 5-LOX
T50 1517-1531 cell_type denotes lymphoid cells
T51 1536-1544 other_name denotes ROI- and
T52 1545-1550 protein_molecule denotes 5-LOX
T53 1574-1590 cell_type denotes epithelial cells
T54 1634-1639 other_organic_compound denotes NADPH
T55 1651-1666 cell_type denotes monocytic cells

metamap-sample

Id Subject Object Predicate Lexical cue
T1 1457-1465 C0021753 denotes IL-1beta
T2 1341-1349 C0021753 denotes IL-1beta
T3 1099-1107 C0021753 denotes IL-1beta
T4 815-823 C0021753 denotes IL-1beta
T5 571-588 C0021753 denotes interleukin-1beta
T6 63-80 C0021753 denotes interleukin-1beta
T7 1634-1647 C1151146 denotes NADPH oxidase
T8 1204-1226 C1151146 denotes NADPH oxidase activity
T9 403-416 C1151146 denotes NADPH oxidase
T10 108-130 C1151146 denotes NADPH oxidase activity
T11 1041-1046 C1412361 denotes 5-LOX
T12 728-733 C1412361 denotes 5-LOX
T13 418-423 C1412361 denotes 5-LOX
T14 376-390 C1412361 denotes 5-lipoxygenase
T15 90-104 C1412361 denotes 5-lipoxygenase
T16 1433-1453 C1523116 denotes NF-kappaB activation
T17 1057-1077 C1523116 denotes NF-kappaB activation
T18 212-232 C1523116 denotes NF-kappaB activation
T19 39-59 C1523116 denotes NF-kappaB activation
T20 1477-1486 C0851827 denotes dependent
T21 1047-1056 C0851827 denotes dependent
T22 29-38 C0851827 denotes dependent
T23 1141-1145 C0920643 denotes ROIs
T24 877-881 C0920643 denotes ROIs
T25 752-756 C0920643 denotes ROIs
T26 306-310 C0920643 denotes ROIs
T27 172-201 C0920643 denotes reactive oxygen intermediates
T28 0-28 C0920643 denotes Reactive oxygen intermediate
T29 1517-1531 C0086574 denotes lymphoid cells
T30 551-565 C0086574 denotes lymphoid cells
T31 479-493 C0086574 denotes lymphoid cells
T32 1651-1660 C0026473 denotes monocytic
T33 1082-1091 C0026473 denotes monocytic
T34 505-514 C0026473 denotes monocytic
T35 1174-1179 C0023837 denotes 5-LOX
T36 986-991 C0023837 denotes 5-LOX
T37 1108-1117 C0039798 denotes treatment
T38 1416-1424 C1704259 denotes pathways
T39 1233-1240 C1704259 denotes pathway
T40 1127-1137 C0033268 denotes production
T41 1026-1036 C0033268 denotes production
T42 611-621 C0033268 denotes production
T43 1022-1025 C0803113 denotes ROI
T44 607-610 C0803113 denotes ROI
T45 695-710 C2936593 denotes FLAP inhibitors
T46 1269-1276 C0018296 denotes GTPases
T47 679-691 C0003402 denotes antioxidants
T48 1300-1303 C1518422 denotes not
T49 498-501 C1518422 denotes not
T50 1661-1666 C0007634 denotes cells
T51 1092-1097 C0007634 denotes cells
T52 1008-1013 C0007634 denotes cells
T53 808-813 C0007634 denotes cells
T54 1574-1590 C1273342 denotes epithelial cells
T55 1353-1369 C1273342 denotes epithelial cells
T56 839-855 C1273342 denotes epithelial cells
T57 252-261 C0079189 denotes cytokines
T58 886-895 C0079904 denotes NF-kappaB
T59 1141-1145 C1705810 denotes ROIs
T60 877-881 C1705810 denotes ROIs
T61 164-168 C1705810 denotes role
T62 428-452 C1412362 denotes 5-LOX activating protein
T63 454-458 C1412362 denotes FLAP
T64 1282-1289 C0014445 denotes enzymes
T65 1640-1647 C0242417 denotes oxidase
T66 1402-1406 C1269647 denotes cell
T67 266-270 C1269647 denotes cell
T68 1407-1415 C0205369 denotes specific
T69 271-279 C0205369 denotes specific
T70 824-835 C1292856 denotes stimulation
T71 536-547 C1292856 denotes Stimulation
T72 1304-1312 C1514873 denotes required
T73 765-773 C1514873 denotes required
T74 1118-1121 C1708698 denotes led
T75 600-603 C1708698 denotes led
T76 1180-1186 C0014442 denotes enzyme
T77 955-969 C0376495 denotes reintroduction
T78 1374-1384 C1707478 denotes conclusion
T79 712-722 C0521093 denotes confirming
T80 368-375 C2700399 denotes include
T81 1254-1258 C1419227 denotes Rac1
T82 146-154 C0684224 denotes reported
T83 1014-1021 C0683607 denotes allowed
T84 322-332 C0449475 denotes cell types
T85 896-905 C0205263 denotes induction
T86 668-675 C0332206 denotes blocked
T87 1155-1169 C0332291 denotes independent of
T88 1425-1429 C2348269 denotes lead
T89 1278-1281 C0205448 denotes two
T90 314-321 C0440102 denotes various
T91 1392-1401 C1705242 denotes different
T92 1386-1391 C0205449 denotes three
T93 873-876 C1552551 denotes any
T94 1545-1550 C0439084 denotes 5-LOX
T95 1551-1562 C1299583 denotes independent

pubtator-sample

Id Subject Object Predicate Lexical cue
T1 9-15 Chemical_D010100 denotes oxygen
T2 39-48 Gene_4790 denotes NF-kappaB
T3 63-80 Gene_3553 denotes interleukin-1beta
T4 90-104 Gene_240 denotes 5-lipoxygenase
T5 108-113 Chemical_D009249 denotes NADPH
T6 181-187 Chemical_D010100 denotes oxygen
T7 212-221 Gene_4790 denotes NF-kappaB
T8 403-452 Gene_4015 denotes NADPH oxidase. 5-LOX and 5-LOX activating protein
T9 454-458 Gene_241 denotes FLAP
T10 571-588 Gene_3553 denotes interleukin-1beta
T11 590-598 Gene_3553 denotes IL-1beta
T12 626-635 Gene_4790 denotes NF-kappaB
T13 695-699 Gene_241 denotes FLAP
T14 729-733 Gene_4015 denotes -LOX
T15 778-787 Gene_4790 denotes NF-kappaB
T16 815-823 Gene_3553 denotes IL-1beta
T17 886-895 Gene_4790 denotes NF-kappaB
T18 1057-1066 Gene_4790 denotes NF-kappaB
T19 1099-1107 Gene_3553 denotes IL-1beta
T20 1204-1209 Chemical_D009249 denotes NADPH
T21 1254-1258 Gene_5879 denotes Rac1
T22 1317-1326 Gene_4790 denotes NF-kappaB
T23 1341-1349 Gene_3553 denotes IL-1beta
T24 1433-1442 Gene_4790 denotes NF-kappaB
T25 1457-1465 Gene_3553 denotes IL-1beta
T26 1509-1513 Gene_4015 denotes -LOX
T27 1546-1550 Gene_4015 denotes -LOX
T28 1634-1639 Chemical_D009249 denotes NADPH