PubMed:10022223 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/10022223","sourcedb":"PubMed","sourceid":"10022223","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10022223","text":"A case of leptomeningeal metastasis from lung adenocarcinoma diagnosed by reverse transcriptase-polymerase chain reaction for carcinoembryonic antigen.\nA case of leptomeningeal metastasis from lung adenocarcinoma is reported. In this case, we evaluated the feasibility of reverse transcriptased polymerase chain reaction (RT-PCR) methods to detect cancer cells in cerebrospinal fluids (CSF). Messenger RNA of carcinoembryonic antigen (CEA) was clearly demonstrated in CSF by reverse RT-PCR methods. An immunohistochemical study also demonstrated that tumor cells were stained positive with anti-CEA antibody. This case suggests that RT-PCR for CEA was a sensitive and useful method to diagnose leptomeningeal metastasis from lung adenocarcinoma.","tracks":[{"project":"DisGeNET5_gene_disease","denotations":[{"id":"10022223-0#126#150#gene1048","span":{"begin":126,"end":150},"obj":"gene1048"},{"id":"10022223-0#10#35#diseaseC1704231","span":{"begin":10,"end":35},"obj":"diseaseC1704231"},{"id":"10022223-5#35#38#gene1048","span":{"begin":644,"end":647},"obj":"gene1048"},{"id":"10022223-5#116#135#diseaseC0152013","span":{"begin":725,"end":744},"obj":"diseaseC0152013"}],"relations":[{"id":"126#150#gene104810#35#diseaseC1704231","pred":"associated_with","subj":"10022223-0#126#150#gene1048","obj":"10022223-0#10#35#diseaseC1704231"},{"id":"35#38#gene1048116#135#diseaseC0152013","pred":"associated_with","subj":"10022223-5#35#38#gene1048","obj":"10022223-5#116#135#diseaseC0152013"}],"attributes":[{"subj":"10022223-0#126#150#gene1048","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10022223-0#10#35#diseaseC1704231","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10022223-5#35#38#gene1048","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10022223-5#116#135#diseaseC0152013","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"PubCasesHPO","denotations":[{"id":"AB1","span":{"begin":193,"end":212},"obj":"HP:0030078"},{"id":"AB2","span":{"begin":725,"end":744},"obj":"HP:0030078"}],"attributes":[{"subj":"AB1","pred":"source","obj":"PubCasesHPO"},{"subj":"AB2","pred":"source","obj":"PubCasesHPO"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":193,"end":212},"obj":"HP_0030078"},{"id":"T2","span":{"begin":348,"end":354},"obj":"HP_0002664"},{"id":"T3","span":{"begin":551,"end":556},"obj":"HP_0002664"},{"id":"T4","span":{"begin":725,"end":744},"obj":"HP_0030078"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":644,"end":647},"obj":"gene:1048"},{"id":"T1","span":{"begin":694,"end":719},"obj":"disease:C1704231"},{"id":"T2","span":{"begin":644,"end":647},"obj":"gene:1048"},{"id":"T3","span":{"begin":725,"end":744},"obj":"disease:C0152013"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"DisGeNET5_gene_disease","color":"#93b1ec","default":true},{"id":"PubCasesHPO","color":"#cbec93"},{"id":"PubmedHPO","color":"#ec93e6"},{"id":"DisGeNET","color":"#93ecd8"}]}]}}