PubMed:1000087 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/1000087","sourcedb":"PubMed","sourceid":"1000087","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/1000087","text":"[Longtime therapy of congenital factor XIII deficiency using factor XIII concentrate].\nErfahrungen bei der Langzeitbehandlung des angeborenen Faktor XIII-mangels mit Faktor XIII-Konzentrat\nFactor XIII was determined by enzymatic and immunochemical methods in 3 patients with congenital factor XIII deficiency. Factor XIII activity measured by trans-glutaminase assay was below 1% of normal value in each of these cases. Immunelectrophoresis determination revealed the absence of the functionally active subunit A, whereas subunit S was only slightly diminished (30 to 50% of the normal value). Substitution with factor XIII concentrate caused a parallel increase of factor XIII activity and subunit A concentration. No uptake of factor XIII activity or of subunit. A by platelets could be demonstrated. Despite discontinuous substitution over a period of six years no antibody against factor XIII activity could be demonstrated in one patient with congenital factor XIII deficiency.","tracks":[{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":86},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":87,"end":188},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":189,"end":309},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":310,"end":419},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":420,"end":593},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":594,"end":715},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":716,"end":764},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":765,"end":802},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":803,"end":982},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":86},"obj":"Sentence"},{"id":"T2","span":{"begin":87,"end":188},"obj":"Sentence"},{"id":"T3","span":{"begin":189,"end":309},"obj":"Sentence"},{"id":"T4","span":{"begin":310,"end":419},"obj":"Sentence"},{"id":"T5","span":{"begin":420,"end":593},"obj":"Sentence"},{"id":"T6","span":{"begin":594,"end":715},"obj":"Sentence"},{"id":"T7","span":{"begin":716,"end":764},"obj":"Sentence"},{"id":"T8","span":{"begin":765,"end":802},"obj":"Sentence"},{"id":"T9","span":{"begin":803,"end":982},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"}]},{"project":"PubCasesORDO","denotations":[{"id":"TI1","span":{"begin":21,"end":54},"obj":"ORDO:331"},{"id":"AB1","span":{"begin":275,"end":308},"obj":"ORDO:331"},{"id":"AB2","span":{"begin":948,"end":981},"obj":"ORDO:331"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"attributes":[{"subj":"TI1","pred":"source","obj":"PubCasesORDO"},{"subj":"AB1","pred":"source","obj":"PubCasesORDO"},{"subj":"AB2","pred":"source","obj":"PubCasesORDO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#ece793","default":true},{"id":"PubCasesORDO","color":"#cd93ec"}]}]}}