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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/99044","sourcedb":"PMC","sourceid":"99044","source_url":"https://www.ncbi.nlm.nih.gov/pmc/99044","text":"Analysis\nThe two cohorts were followed up from date of first diagnosis of chronic AF (start date) and from a random date during 1996 in the general population cohort until the earliest of death, or end of follow-up (December 1999). Survival probability was computed in both cohorts and we estimated the relative risk of dying associated with AF using Cox proportional hazard regression to control for risk factors.\nA nested case-control analysis was performed in the AF cohort to assess risk factors of death. We used all deceased AF patients as cases (n = 234) and used their death date as index date. The remaining alive AF patients (n = 801) were considered controls and we sampled a random date during their follow-up period that was used as their index date. Estimates of mortality risk and 95% confidence interval (CI) were computed using logistic regression. We collected recorded information on the following risk factors: smoking status, BMI, alcohol consumption, as well as prior history of heart failure (HF), ischaemic heart disease (IHD), cerebrovascular disease (CVD), hypertension and diabetes. We used both the information in the questionnaire and computerized files to ascertain the cause of death.","divisions":[{"label":"title","span":{"begin":0,"end":8}},{"label":"p","span":{"begin":9,"end":414}}],"tracks":[]}