Id |
Subject |
Object |
Predicate |
Lexical cue |
T283 |
773-783 |
NN |
denotes |
transcript |
T284 |
839-846 |
VBZ |
denotes |
encodes |
T285 |
784-788 |
WDT |
denotes |
that |
T140 |
30-32 |
CD |
denotes |
IV |
T141 |
33-34 |
-LRB- |
denotes |
( |
T142 |
34-38 |
NN |
denotes |
MLIV |
T143 |
38-39 |
-RRB- |
denotes |
) |
T144 |
43-45 |
DT |
denotes |
an |
T145 |
84-92 |
NN |
denotes |
disorder |
T146 |
46-55 |
JJ |
denotes |
autosomal |
T147 |
56-65 |
JJ |
denotes |
recessive |
T148 |
66-75 |
JJ |
denotes |
lysosomal |
T149 |
76-83 |
NN |
denotes |
storage |
T150 |
93-106 |
VBN |
denotes |
characterized |
T151 |
107-109 |
IN |
denotes |
by |
T152 |
110-116 |
JJ |
denotes |
severe |
T153 |
147-160 |
NNS |
denotes |
abnormalities |
T154 |
117-127 |
JJ |
denotes |
neurologic |
T155 |
128-131 |
CC |
denotes |
and |
T156 |
132-146 |
JJ |
denotes |
ophthalmologic |
T157 |
160-161 |
. |
denotes |
. |
T158 |
161-299 |
sentence |
denotes |
Recently the MLIV gene, MCOLN1, has been identified as a new member of the transient receptor potential (TRP) cation channel superfamily. |
T159 |
162-170 |
RB |
denotes |
Recently |
T160 |
203-213 |
VBN |
denotes |
identified |
T161 |
171-174 |
DT |
denotes |
the |
T162 |
180-184 |
NN |
denotes |
gene |
T163 |
175-179 |
NN |
denotes |
MLIV |
T164 |
184-186 |
, |
denotes |
, |
T165 |
186-192 |
NN |
denotes |
MCOLN1 |
T166 |
192-194 |
, |
denotes |
, |
T167 |
194-197 |
VBZ |
denotes |
has |
T168 |
198-202 |
VBN |
denotes |
been |
T169 |
214-216 |
IN |
denotes |
as |
T170 |
217-218 |
DT |
denotes |
a |
T171 |
223-229 |
NN |
denotes |
member |
T172 |
219-222 |
JJ |
denotes |
new |
T173 |
230-232 |
IN |
denotes |
of |
T134 |
0-10 |
sentence |
denotes |
Background |
T135 |
0-10 |
NN |
denotes |
Background |
T136 |
10-161 |
sentence |
denotes |
Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder characterized by severe neurologic and ophthalmologic abnormalities. |
T137 |
11-24 |
NN |
denotes |
Mucolipidosis |
T138 |
25-29 |
NN |
denotes |
type |
T139 |
40-42 |
VBZ |
denotes |
is |
T174 |
233-236 |
DT |
denotes |
the |
T175 |
287-298 |
NN |
denotes |
superfamily |
T176 |
237-246 |
JJ |
denotes |
transient |
T177 |
256-265 |
NN |
denotes |
potential |
T178 |
247-255 |
NN |
denotes |
receptor |
T179 |
266-267 |
-LRB- |
denotes |
( |
T180 |
267-270 |
NN |
denotes |
TRP |
T181 |
270-271 |
-RRB- |
denotes |
) |
T182 |
272-278 |
NN |
denotes |
cation |
T183 |
279-286 |
NN |
denotes |
channel |
T184 |
298-299 |
. |
denotes |
. |
T185 |
299-441 |
sentence |
denotes |
Here we report the cloning and characterization of the mouse homologue, Mcoln1, and report a novel splice variant that is not seen in humans. |
T186 |
300-304 |
RB |
denotes |
Here |
T187 |
308-314 |
VBP |
denotes |
report |
T188 |
305-307 |
PRP |
denotes |
we |
T189 |
315-318 |
DT |
denotes |
the |
T190 |
319-326 |
NN |
denotes |
cloning |
T191 |
327-330 |
CC |
denotes |
and |
T192 |
331-347 |
NN |
denotes |
characterization |
T193 |
348-350 |
IN |
denotes |
of |
T194 |
351-354 |
DT |
denotes |
the |
T195 |
361-370 |
NN |
denotes |
homologue |
T196 |
355-360 |
NN |
denotes |
mouse |
T197 |
370-372 |
, |
denotes |
, |
T198 |
372-378 |
NN |
denotes |
Mcoln1 |
T199 |
378-380 |
, |
denotes |
, |
T200 |
380-383 |
CC |
denotes |
and |
T201 |
384-390 |
VBP |
denotes |
report |
T202 |
391-392 |
DT |
denotes |
a |
T203 |
406-413 |
NN |
denotes |
variant |
T204 |
393-398 |
JJ |
denotes |
novel |
T205 |
399-405 |
NN |
denotes |
splice |
T206 |
414-418 |
WDT |
denotes |
that |
T207 |
426-430 |
VBN |
denotes |
seen |
T208 |
419-421 |
VBZ |
denotes |
is |
T209 |
422-425 |
RB |
denotes |
not |
T210 |
431-433 |
IN |
denotes |
in |
T211 |
434-440 |
NNS |
denotes |
humans |
T212 |
440-441 |
. |
denotes |
. |
T213 |
441-450 |
sentence |
denotes |
Results |
T214 |
443-450 |
NNS |
denotes |
Results |
T215 |
450-510 |
sentence |
denotes |
The human and mouse genes display a high degree of synteny. |
T216 |
451-454 |
DT |
denotes |
The |
T217 |
471-476 |
NNS |
denotes |
genes |
T218 |
455-460 |
JJ |
denotes |
human |
T219 |
465-470 |
NN |
denotes |
mouse |
T220 |
461-464 |
CC |
denotes |
and |
T221 |
477-484 |
VBP |
denotes |
display |
T222 |
485-486 |
DT |
denotes |
a |
T223 |
492-498 |
NN |
denotes |
degree |
T224 |
487-491 |
JJ |
denotes |
high |
T225 |
499-501 |
IN |
denotes |
of |
T226 |
502-509 |
NN |
denotes |
synteny |
T227 |
509-510 |
. |
denotes |
. |
T228 |
510-577 |
sentence |
denotes |
Mcoln1 shows 91% amino acid and 86% nucleotide identity to MCOLN1. |
T229 |
511-517 |
NN |
denotes |
Mcoln1 |
T230 |
518-523 |
VBZ |
denotes |
shows |
T231 |
524-526 |
CD |
denotes |
91 |
T232 |
526-527 |
NN |
denotes |
% |
T233 |
534-538 |
NN |
denotes |
acid |
T234 |
528-533 |
NN |
denotes |
amino |
T235 |
558-566 |
NN |
denotes |
identity |
T236 |
539-542 |
CC |
denotes |
and |
T237 |
543-545 |
CD |
denotes |
86 |
T238 |
545-546 |
NN |
denotes |
% |
T239 |
547-557 |
NN |
denotes |
nucleotide |
T240 |
567-569 |
IN |
denotes |
to |
T241 |
570-576 |
NN |
denotes |
MCOLN1 |
T242 |
576-577 |
. |
denotes |
. |
T243 |
577-768 |
sentence |
denotes |
Also, Mcoln1 maps to chromosome 8 and contains an open reading frame of 580 amino acids, with a transcript length of approximately 2 kb encoded by 14 exons, similar to its human counterpart. |
T244 |
578-582 |
RB |
denotes |
Also |
T245 |
591-595 |
VBZ |
denotes |
maps |
T246 |
582-584 |
, |
denotes |
, |
T247 |
584-590 |
NN |
denotes |
Mcoln1 |
T248 |
596-598 |
IN |
denotes |
to |
T249 |
599-609 |
NN |
denotes |
chromosome |
T250 |
610-611 |
CD |
denotes |
8 |
T251 |
612-615 |
CC |
denotes |
and |
T252 |
616-624 |
VBZ |
denotes |
contains |
T253 |
625-627 |
DT |
denotes |
an |
T254 |
641-646 |
NN |
denotes |
frame |
T255 |
628-632 |
JJ |
denotes |
open |
T256 |
633-640 |
NN |
denotes |
reading |
T257 |
647-649 |
IN |
denotes |
of |
T258 |
650-653 |
CD |
denotes |
580 |
T259 |
660-665 |
NNS |
denotes |
acids |
T260 |
654-659 |
NN |
denotes |
amino |
T261 |
665-667 |
, |
denotes |
, |
T262 |
667-671 |
IN |
denotes |
with |
T263 |
672-673 |
DT |
denotes |
a |
T264 |
685-691 |
NN |
denotes |
length |
T265 |
674-684 |
NN |
denotes |
transcript |
T266 |
692-694 |
IN |
denotes |
of |
T267 |
695-708 |
RB |
denotes |
approximately |
T268 |
709-710 |
CD |
denotes |
2 |
T269 |
711-713 |
NNS |
denotes |
kb |
T270 |
714-721 |
VBN |
denotes |
encoded |
T271 |
722-724 |
IN |
denotes |
by |
T272 |
725-727 |
CD |
denotes |
14 |
T273 |
728-733 |
NNS |
denotes |
exons |
T274 |
733-735 |
, |
denotes |
, |
T275 |
735-742 |
JJ |
denotes |
similar |
T276 |
743-745 |
IN |
denotes |
to |
T277 |
746-749 |
PRP$ |
denotes |
its |
T278 |
756-767 |
NN |
denotes |
counterpart |
T279 |
750-755 |
JJ |
denotes |
human |
T280 |
767-768 |
. |
denotes |
. |
T281 |
768-903 |
sentence |
denotes |
The transcript that results from murine specific alternative splicing encodes a 611 amino acid protein that differs at the c-terminus. |
T282 |
769-772 |
DT |
denotes |
The |
T286 |
789-796 |
VBZ |
denotes |
results |
T287 |
797-801 |
IN |
denotes |
from |
T288 |
802-808 |
NN |
denotes |
murine |
T289 |
809-817 |
JJ |
denotes |
specific |
T290 |
830-838 |
NN |
denotes |
splicing |
T291 |
818-829 |
JJ |
denotes |
alternative |
T292 |
847-848 |
DT |
denotes |
a |
T293 |
864-871 |
NN |
denotes |
protein |
T294 |
849-852 |
CD |
denotes |
611 |
T295 |
859-863 |
NN |
denotes |
acid |
T296 |
853-858 |
NN |
denotes |
amino |
T297 |
872-876 |
WDT |
denotes |
that |
T298 |
877-884 |
VBZ |
denotes |
differs |
T299 |
885-887 |
IN |
denotes |
at |
T300 |
888-891 |
DT |
denotes |
the |
T301 |
894-902 |
NN |
denotes |
terminus |
T302 |
892-893 |
NN |
denotes |
c |
T303 |
893-894 |
HYPH |
denotes |
- |
T304 |
902-903 |
. |
denotes |
. |
T305 |
903-916 |
sentence |
denotes |
Conclusions |
T306 |
905-916 |
NNS |
denotes |
Conclusions |
T307 |
916-1013 |
sentence |
denotes |
Mcoln1 is highly similar to MCOLN1, especially in the transmembrane domains and ion pore region. |
T308 |
917-923 |
NN |
denotes |
Mcoln1 |
T309 |
924-926 |
VBZ |
denotes |
is |
T310 |
927-933 |
RB |
denotes |
highly |
T311 |
934-941 |
JJ |
denotes |
similar |
T312 |
942-944 |
IN |
denotes |
to |
T313 |
945-951 |
NN |
denotes |
MCOLN1 |
T314 |
951-953 |
, |
denotes |
, |
T315 |
953-963 |
RB |
denotes |
especially |
T316 |
964-966 |
IN |
denotes |
in |
T317 |
967-970 |
DT |
denotes |
the |
T318 |
985-992 |
NNS |
denotes |
domains |
T319 |
971-984 |
NN |
denotes |
transmembrane |
T320 |
993-996 |
CC |
denotes |
and |
T321 |
997-1000 |
NN |
denotes |
ion |
T322 |
1001-1005 |
NN |
denotes |
pore |
T323 |
1006-1012 |
NN |
denotes |
region |
T324 |
1012-1013 |
. |
denotes |
. |
T325 |
1013-1163 |
sentence |
denotes |
Also, the late endosomal/lysosomal targeting signal is conserved, supporting the hypothesis that the protein is localized to these vesicle membranes. |
T326 |
1014-1018 |
RB |
denotes |
Also |
T327 |
1069-1078 |
VBN |
denotes |
conserved |
T328 |
1018-1020 |
, |
denotes |
, |
T329 |
1020-1023 |
DT |
denotes |
the |
T330 |
1059-1065 |
NN |
denotes |
signal |
T331 |
1024-1028 |
JJ |
denotes |
late |
T332 |
1029-1038 |
JJ |
denotes |
endosomal |
T333 |
1039-1048 |
JJ |
denotes |
lysosomal |
T334 |
1038-1039 |
HYPH |
denotes |
/ |
T335 |
1049-1058 |
NN |
denotes |
targeting |
T336 |
1066-1068 |
VBZ |
denotes |
is |
T337 |
1078-1080 |
, |
denotes |
, |
T338 |
1080-1090 |
VBG |
denotes |
supporting |
T339 |
1091-1094 |
DT |
denotes |
the |
T340 |
1095-1105 |
NN |
denotes |
hypothesis |
T341 |
1106-1110 |
IN |
denotes |
that |
T342 |
1126-1135 |
VBN |
denotes |
localized |
T343 |
1111-1114 |
DT |
denotes |
the |
T344 |
1115-1122 |
NN |
denotes |
protein |
T345 |
1123-1125 |
VBZ |
denotes |
is |
T346 |
1136-1138 |
IN |
denotes |
to |
T347 |
1139-1144 |
DT |
denotes |
these |
T348 |
1153-1162 |
NNS |
denotes |
membranes |
T349 |
1145-1152 |
NN |
denotes |
vesicle |
T350 |
1162-1163 |
. |
denotes |
. |
T351 |
1163-1244 |
sentence |
denotes |
To date, there are very few reports describing species-specific splice variants. |
T352 |
1164-1166 |
IN |
denotes |
To |
T353 |
1179-1182 |
VBP |
denotes |
are |
T354 |
1167-1171 |
NN |
denotes |
date |
T355 |
1171-1173 |
, |
denotes |
, |
T356 |
1173-1178 |
EX |
denotes |
there |
T357 |
1183-1187 |
RB |
denotes |
very |
T358 |
1188-1191 |
JJ |
denotes |
few |
T359 |
1192-1199 |
NNS |
denotes |
reports |
T360 |
1200-1210 |
VBG |
denotes |
describing |
T361 |
1211-1218 |
NN |
denotes |
species |
T362 |
1219-1227 |
JJ |
denotes |
specific |
T363 |
1218-1219 |
HYPH |
denotes |
- |
T364 |
1235-1243 |
NNS |
denotes |
variants |
T365 |
1228-1234 |
NN |
denotes |
splice |
T366 |
1243-1244 |
. |
denotes |
. |
T367 |
1244-1479 |
sentence |
denotes |
While identification of Mcoln1 is crucial to the development of mouse models for MLIV, the fact that there are two transcripts in mice suggests an additional or alternate function of the gene that may complicate phenotypic assessment. |
T368 |
1245-1250 |
IN |
denotes |
While |
T369 |
1276-1278 |
VBZ |
denotes |
is |
T370 |
1251-1265 |
NN |
denotes |
identification |
T371 |
1266-1268 |
IN |
denotes |
of |
T372 |
1269-1275 |
NN |
denotes |
Mcoln1 |
T373 |
1380-1388 |
VBZ |
denotes |
suggests |
T374 |
1279-1286 |
JJ |
denotes |
crucial |
T375 |
1287-1289 |
IN |
denotes |
to |
T376 |
1290-1293 |
DT |
denotes |
the |
T377 |
1294-1305 |
NN |
denotes |
development |
T378 |
1306-1308 |
IN |
denotes |
of |
T379 |
1309-1314 |
NN |
denotes |
mouse |
T380 |
1315-1321 |
NNS |
denotes |
models |
T381 |
1322-1325 |
IN |
denotes |
for |
T382 |
1326-1330 |
NN |
denotes |
MLIV |
T383 |
1330-1332 |
, |
denotes |
, |
T384 |
1332-1335 |
DT |
denotes |
the |
T385 |
1336-1340 |
NN |
denotes |
fact |
T386 |
1341-1345 |
IN |
denotes |
that |
T387 |
1352-1355 |
VBP |
denotes |
are |
T388 |
1346-1351 |
EX |
denotes |
there |
T389 |
1356-1359 |
CD |
denotes |
two |
T390 |
1360-1371 |
NNS |
denotes |
transcripts |
T391 |
1372-1374 |
IN |
denotes |
in |
T392 |
1375-1379 |
NNS |
denotes |
mice |
T393 |
1389-1391 |
DT |
denotes |
an |
T394 |
1416-1424 |
NN |
denotes |
function |
T395 |
1392-1402 |
JJ |
denotes |
additional |
T396 |
1403-1405 |
CC |
denotes |
or |
T397 |
1406-1415 |
JJ |
denotes |
alternate |
T398 |
1425-1427 |
IN |
denotes |
of |
T399 |
1428-1431 |
DT |
denotes |
the |
T400 |
1432-1436 |
NN |
denotes |
gene |
T401 |
1437-1441 |
WDT |
denotes |
that |
T402 |
1446-1456 |
VB |
denotes |
complicate |
T403 |
1442-1445 |
MD |
denotes |
may |
T404 |
1457-1467 |
JJ |
denotes |
phenotypic |
T405 |
1468-1478 |
NN |
denotes |
assessment |
T406 |
1478-1479 |
. |
denotes |
. |
R20 |
T137 |
T138 |
compound |
Mucolipidosis,type |
R21 |
T138 |
T139 |
nsubj |
type,is |
R22 |
T140 |
T138 |
nummod |
IV,type |
R23 |
T141 |
T138 |
punct |
(,type |
R24 |
T142 |
T138 |
appos |
MLIV,type |
R25 |
T143 |
T139 |
punct |
),is |
R26 |
T144 |
T145 |
det |
an,disorder |
R27 |
T145 |
T139 |
attr |
disorder,is |
R28 |
T146 |
T145 |
amod |
autosomal,disorder |
R29 |
T147 |
T145 |
amod |
recessive,disorder |
R30 |
T148 |
T145 |
amod |
lysosomal,disorder |
R31 |
T149 |
T145 |
compound |
storage,disorder |
R32 |
T150 |
T145 |
acl |
characterized,disorder |
R33 |
T151 |
T150 |
agent |
by,characterized |
R34 |
T152 |
T153 |
amod |
severe,abnormalities |
R36 |
T154 |
T153 |
amod |
neurologic,abnormalities |
R37 |
T155 |
T154 |
cc |
and,neurologic |
R38 |
T156 |
T154 |
conj |
ophthalmologic,neurologic |
R39 |
T157 |
T139 |
punct |
.,is |
R40 |
T159 |
T160 |
advmod |
Recently,identified |
R41 |
T161 |
T162 |
det |
the,gene |
R42 |
T162 |
T160 |
nsubjpass |
gene,identified |
R43 |
T163 |
T162 |
compound |
MLIV,gene |
R44 |
T164 |
T162 |
punct |
", ",gene |
R45 |
T165 |
T162 |
appos |
MCOLN1,gene |
R46 |
T166 |
T160 |
punct |
", ",identified |
R47 |
T167 |
T160 |
aux |
has,identified |
R48 |
T168 |
T160 |
auxpass |
been,identified |
R49 |
T169 |
T160 |
prep |
as,identified |
R50 |
T170 |
T171 |
det |
a,member |
R51 |
T171 |
T169 |
pobj |
member,as |
R52 |
T172 |
T171 |
amod |
new,member |
R53 |
T173 |
T171 |
prep |
of,member |
R54 |
T174 |
T175 |
det |
the,superfamily |
R55 |
T175 |
T173 |
pobj |
superfamily,of |
R56 |
T176 |
T177 |
amod |
transient,potential |
R57 |
T177 |
T175 |
nmod |
potential,superfamily |
R58 |
T178 |
T177 |
nmod |
receptor,potential |
R59 |
T179 |
T177 |
punct |
(,potential |
R60 |
T180 |
T177 |
appos |
TRP,potential |
R61 |
T181 |
T175 |
punct |
),superfamily |
R62 |
T182 |
T183 |
compound |
cation,channel |
R63 |
T183 |
T175 |
compound |
channel,superfamily |
R64 |
T184 |
T160 |
punct |
.,identified |
R65 |
T186 |
T187 |
advmod |
Here,report |
R66 |
T188 |
T187 |
nsubj |
we,report |
R67 |
T189 |
T190 |
det |
the,cloning |
R68 |
T190 |
T187 |
dobj |
cloning,report |
R69 |
T191 |
T190 |
cc |
and,cloning |
R70 |
T192 |
T190 |
conj |
characterization,cloning |
R71 |
T193 |
T190 |
prep |
of,cloning |
R72 |
T194 |
T195 |
det |
the,homologue |
R73 |
T195 |
T193 |
pobj |
homologue,of |
R74 |
T196 |
T195 |
compound |
mouse,homologue |
R75 |
T197 |
T195 |
punct |
", ",homologue |
R76 |
T198 |
T195 |
appos |
Mcoln1,homologue |
R77 |
T199 |
T187 |
punct |
", ",report |
R78 |
T200 |
T187 |
cc |
and,report |
R79 |
T201 |
T187 |
conj |
report,report |
R80 |
T202 |
T203 |
det |
a,variant |
R81 |
T203 |
T201 |
dobj |
variant,report |
R82 |
T204 |
T203 |
amod |
novel,variant |
R83 |
T205 |
T203 |
compound |
splice,variant |
R84 |
T206 |
T207 |
dep |
that,seen |
R85 |
T207 |
T203 |
relcl |
seen,variant |
R86 |
T208 |
T207 |
auxpass |
is,seen |
R87 |
T209 |
T207 |
neg |
not,seen |
R88 |
T210 |
T207 |
prep |
in,seen |
R89 |
T211 |
T210 |
pobj |
humans,in |
R90 |
T212 |
T187 |
punct |
.,report |
R91 |
T216 |
T217 |
det |
The,genes |
R93 |
T218 |
T219 |
amod |
human,mouse |
R94 |
T219 |
T217 |
compound |
mouse,genes |
R95 |
T220 |
T219 |
cc |
and,mouse |
R96 |
T222 |
T223 |
det |
a,degree |
R97 |
T223 |
T221 |
dobj |
degree,display |
R98 |
T224 |
T223 |
amod |
high,degree |
R99 |
T225 |
T223 |
prep |
of,degree |
R100 |
T226 |
T225 |
pobj |
synteny,of |
R101 |
T227 |
T221 |
punct |
.,display |
R102 |
T229 |
T230 |
nsubj |
Mcoln1,shows |
R103 |
T231 |
T232 |
nummod |
91,% |
R104 |
T232 |
T233 |
nmod |
%,acid |
R105 |
T233 |
T235 |
nmod |
acid,identity |
R106 |
T234 |
T233 |
nmod |
amino,acid |
R107 |
T235 |
T230 |
dobj |
identity,shows |
R108 |
T236 |
T233 |
cc |
and,acid |
R109 |
T237 |
T238 |
nummod |
86,% |
R110 |
T238 |
T239 |
compound |
%,nucleotide |
R111 |
T239 |
T233 |
conj |
nucleotide,acid |
R112 |
T240 |
T235 |
prep |
to,identity |
R113 |
T241 |
T240 |
pobj |
MCOLN1,to |
R114 |
T242 |
T230 |
punct |
.,shows |
R115 |
T244 |
T245 |
advmod |
Also,maps |
R116 |
T246 |
T245 |
punct |
", ",maps |
R117 |
T247 |
T245 |
nsubj |
Mcoln1,maps |
R118 |
T248 |
T245 |
prep |
to,maps |
R119 |
T249 |
T248 |
pobj |
chromosome,to |
R120 |
T250 |
T249 |
nummod |
8,chromosome |
R121 |
T251 |
T245 |
cc |
and,maps |
R122 |
T252 |
T245 |
conj |
contains,maps |
R123 |
T253 |
T254 |
det |
an,frame |
R124 |
T254 |
T252 |
dobj |
frame,contains |
R125 |
T255 |
T254 |
amod |
open,frame |
R126 |
T256 |
T254 |
compound |
reading,frame |
R127 |
T257 |
T254 |
prep |
of,frame |
R128 |
T258 |
T259 |
nummod |
580,acids |
R129 |
T259 |
T257 |
pobj |
acids,of |
R130 |
T260 |
T259 |
compound |
amino,acids |
R131 |
T261 |
T254 |
punct |
", ",frame |
R132 |
T262 |
T254 |
prep |
with,frame |
R133 |
T263 |
T264 |
det |
a,length |
R134 |
T264 |
T262 |
pobj |
length,with |
R135 |
T265 |
T264 |
compound |
transcript,length |
R136 |
T266 |
T264 |
prep |
of,length |
R137 |
T267 |
T268 |
advmod |
approximately,2 |
R138 |
T268 |
T269 |
nummod |
2,kb |
R139 |
T269 |
T266 |
pobj |
kb,of |
R140 |
T270 |
T264 |
acl |
encoded,length |
R141 |
T271 |
T270 |
agent |
by,encoded |
R142 |
T272 |
T273 |
nummod |
14,exons |
R143 |
T273 |
T271 |
pobj |
exons,by |
R144 |
T274 |
T254 |
punct |
", ",frame |
R145 |
T275 |
T254 |
amod |
similar,frame |
R146 |
T276 |
T275 |
prep |
to,similar |
R147 |
T277 |
T278 |
poss |
its,counterpart |
R148 |
T278 |
T276 |
pobj |
counterpart,to |
R149 |
T279 |
T278 |
amod |
human,counterpart |
R150 |
T280 |
T245 |
punct |
.,maps |
R151 |
T282 |
T283 |
det |
The,transcript |
R152 |
T283 |
T284 |
nsubj |
transcript,encodes |
R153 |
T285 |
T286 |
dep |
that,results |
R154 |
T286 |
T283 |
relcl |
results,transcript |
R155 |
T287 |
T286 |
prep |
from,results |
R156 |
T288 |
T289 |
npadvmod |
murine,specific |
R157 |
T289 |
T290 |
amod |
specific,splicing |
R158 |
T290 |
T287 |
pobj |
splicing,from |
R159 |
T291 |
T290 |
amod |
alternative,splicing |
R160 |
T292 |
T293 |
det |
a,protein |
R162 |
T294 |
T295 |
nummod |
611,acid |
R163 |
T295 |
T293 |
compound |
acid,protein |
R164 |
T296 |
T295 |
compound |
amino,acid |
R165 |
T297 |
T298 |
dep |
that,differs |
R166 |
T298 |
T293 |
relcl |
differs,protein |
R167 |
T299 |
T298 |
prep |
at,differs |
R168 |
T300 |
T301 |
det |
the,terminus |
R169 |
T301 |
T299 |
pobj |
terminus,at |
R170 |
T302 |
T301 |
compound |
c,terminus |
R171 |
T303 |
T301 |
punct |
-,terminus |
R172 |
T304 |
T284 |
punct |
.,encodes |
R173 |
T308 |
T309 |
nsubj |
Mcoln1,is |
R174 |
T310 |
T311 |
advmod |
highly,similar |
R175 |
T311 |
T309 |
acomp |
similar,is |
R176 |
T312 |
T311 |
prep |
to,similar |
R177 |
T313 |
T312 |
pobj |
MCOLN1,to |
R178 |
T314 |
T309 |
punct |
", ",is |
R179 |
T315 |
T316 |
advmod |
especially,in |
R180 |
T316 |
T309 |
prep |
in,is |
R181 |
T317 |
T318 |
det |
the,domains |
R182 |
T318 |
T316 |
pobj |
domains,in |
R183 |
T319 |
T318 |
compound |
transmembrane,domains |
R184 |
T320 |
T318 |
cc |
and,domains |
R185 |
T321 |
T322 |
compound |
ion,pore |
R186 |
T322 |
T323 |
compound |
pore,region |
R187 |
T323 |
T318 |
conj |
region,domains |
R188 |
T324 |
T309 |
punct |
.,is |
R189 |
T326 |
T327 |
advmod |
Also,conserved |
R190 |
T328 |
T327 |
punct |
", ",conserved |
R191 |
T329 |
T330 |
det |
the,signal |
R192 |
T330 |
T327 |
nsubjpass |
signal,conserved |
R193 |
T331 |
T330 |
amod |
late,signal |
R194 |
T332 |
T333 |
amod |
endosomal,lysosomal |
R195 |
T333 |
T330 |
amod |
lysosomal,signal |
R196 |
T334 |
T333 |
punct |
/,lysosomal |
R197 |
T335 |
T330 |
compound |
targeting,signal |
R198 |
T336 |
T327 |
auxpass |
is,conserved |
R199 |
T337 |
T327 |
punct |
", ",conserved |
R200 |
T338 |
T327 |
advcl |
supporting,conserved |
R201 |
T339 |
T340 |
det |
the,hypothesis |
R202 |
T340 |
T338 |
dobj |
hypothesis,supporting |
R203 |
T341 |
T342 |
mark |
that,localized |
R205 |
T343 |
T344 |
det |
the,protein |
R206 |
T344 |
T342 |
nsubjpass |
protein,localized |
R207 |
T345 |
T342 |
auxpass |
is,localized |
R208 |
T346 |
T342 |
prep |
to,localized |
R209 |
T347 |
T348 |
det |
these,membranes |
R210 |
T348 |
T346 |
pobj |
membranes,to |
R211 |
T349 |
T348 |
compound |
vesicle,membranes |
R212 |
T350 |
T327 |
punct |
.,conserved |
R213 |
T352 |
T353 |
prep |
To,are |
R214 |
T354 |
T352 |
pobj |
date,To |
R215 |
T355 |
T353 |
punct |
", ",are |
R216 |
T356 |
T353 |
expl |
there,are |
R217 |
T357 |
T358 |
advmod |
very,few |
R218 |
T358 |
T359 |
amod |
few,reports |
R219 |
T359 |
T353 |
attr |
reports,are |
R220 |
T360 |
T359 |
acl |
describing,reports |
R221 |
T361 |
T362 |
npadvmod |
species,specific |
R222 |
T362 |
T364 |
amod |
specific,variants |
R223 |
T363 |
T362 |
punct |
-,specific |
R224 |
T364 |
T360 |
dobj |
variants,describing |
R225 |
T365 |
T364 |
compound |
splice,variants |
R226 |
T366 |
T353 |
punct |
.,are |
R227 |
T368 |
T369 |
mark |
While,is |
R229 |
T370 |
T369 |
nsubj |
identification,is |
R230 |
T371 |
T370 |
prep |
of,identification |
R231 |
T372 |
T371 |
pobj |
Mcoln1,of |
R232 |
T374 |
T369 |
acomp |
crucial,is |
R233 |
T375 |
T374 |
prep |
to,crucial |
R234 |
T376 |
T377 |
det |
the,development |
R235 |
T377 |
T375 |
pobj |
development,to |
R236 |
T378 |
T377 |
prep |
of,development |
R237 |
T379 |
T380 |
compound |
mouse,models |
R238 |
T380 |
T378 |
pobj |
models,of |
R239 |
T381 |
T377 |
prep |
for,development |
R240 |
T382 |
T381 |
pobj |
MLIV,for |
R241 |
T383 |
T373 |
punct |
", ",suggests |
R242 |
T384 |
T385 |
det |
the,fact |
R243 |
T385 |
T373 |
nsubj |
fact,suggests |
R244 |
T386 |
T387 |
mark |
that,are |
R245 |
T387 |
T385 |
acl |
are,fact |
R246 |
T388 |
T387 |
expl |
there,are |
R247 |
T389 |
T390 |
nummod |
two,transcripts |
R248 |
T390 |
T387 |
attr |
transcripts,are |
R249 |
T391 |
T387 |
prep |
in,are |
R250 |
T392 |
T391 |
pobj |
mice,in |
R251 |
T393 |
T394 |
det |
an,function |
R253 |
T395 |
T394 |
amod |
additional,function |
R254 |
T396 |
T395 |
cc |
or,additional |
R255 |
T397 |
T395 |
conj |
alternate,additional |
R256 |
T398 |
T394 |
prep |
of,function |
R257 |
T399 |
T400 |
det |
the,gene |
R258 |
T400 |
T398 |
pobj |
gene,of |
R259 |
T401 |
T402 |
dep |
that,complicate |
R260 |
T402 |
T394 |
relcl |
complicate,function |
R261 |
T403 |
T402 |
aux |
may,complicate |
R262 |
T404 |
T405 |
amod |
phenotypic,assessment |
R263 |
T405 |
T402 |
dobj |
assessment,complicate |
R264 |
T406 |
T373 |
punct |
.,suggests |
R35 |
T153 |
T151 |
pobj |
abnormalities,by |
R92 |
T217 |
T221 |
nsubj |
genes,display |
R161 |
T293 |
T284 |
dobj |
protein,encodes |
R204 |
T342 |
T340 |
acl |
localized,hypothesis |
R228 |
T369 |
T373 |
advcl |
is,suggests |
R252 |
T394 |
T373 |
dobj |
function,suggests |