Id |
Subject |
Object |
Predicate |
Lexical cue |
T3016 |
12-22 |
NN |
denotes |
Comparison |
T3017 |
66-71 |
VBZ |
denotes |
shows |
T3018 |
23-25 |
IN |
denotes |
of |
T3019 |
26-32 |
NN |
denotes |
Mcoln1 |
T3020 |
33-40 |
NN |
denotes |
isoform |
T3021 |
41-42 |
CD |
denotes |
1 |
T3022 |
43-45 |
IN |
denotes |
to |
T3023 |
46-49 |
PRP$ |
denotes |
its |
T3024 |
56-65 |
NN |
denotes |
homologue |
T3025 |
50-55 |
JJ |
denotes |
human |
T3026 |
72-80 |
JJ |
denotes |
striking |
T3027 |
81-91 |
NN |
denotes |
similarity |
T3028 |
92-94 |
IN |
denotes |
at |
T3029 |
95-99 |
CC |
denotes |
both |
T3030 |
130-135 |
NN |
denotes |
level |
T3031 |
100-103 |
DT |
denotes |
the |
T3032 |
104-109 |
NN |
denotes |
amino |
T3033 |
110-114 |
NN |
denotes |
acid |
T3034 |
115-118 |
CC |
denotes |
and |
T3035 |
119-129 |
NN |
denotes |
nucleotide |
T3036 |
135-136 |
. |
denotes |
. |
T3037 |
136-235 |
sentence |
denotes |
All six of the transmembrane domains, as well as the putative cation channel are highly conserved. |
T3038 |
137-140 |
DT |
denotes |
All |
T3039 |
141-144 |
CD |
denotes |
six |
T3040 |
225-234 |
VBN |
denotes |
conserved |
T3041 |
145-147 |
IN |
denotes |
of |
T3042 |
148-151 |
DT |
denotes |
the |
T3043 |
166-173 |
NNS |
denotes |
domains |
T3044 |
152-165 |
NN |
denotes |
transmembrane |
T3045 |
173-175 |
, |
denotes |
, |
T3046 |
175-177 |
RB |
denotes |
as |
T3047 |
183-185 |
IN |
denotes |
as |
T3048 |
178-182 |
RB |
denotes |
well |
T3049 |
186-189 |
DT |
denotes |
the |
T3050 |
206-213 |
NN |
denotes |
channel |
T3051 |
190-198 |
JJ |
denotes |
putative |
T3052 |
199-205 |
NN |
denotes |
cation |
T3053 |
214-217 |
VBP |
denotes |
are |
T3054 |
218-224 |
RB |
denotes |
highly |
T3055 |
234-235 |
. |
denotes |
. |
T3056 |
235-379 |
sentence |
denotes |
The putative di-leucine (L-L-X-X) motif at the C-terminus, which may act as a late endosomal/lysosomal targeting signal, is also conserved [9]. |
T3057 |
236-239 |
DT |
denotes |
The |
T3058 |
270-275 |
NN |
denotes |
motif |
T3059 |
240-248 |
JJ |
denotes |
putative |
T3060 |
249-259 |
NN |
denotes |
di-leucine |
T3061 |
260-261 |
-LRB- |
denotes |
( |
T3062 |
267-268 |
NN |
denotes |
X |
T3063 |
261-262 |
NN |
denotes |
L |
T3064 |
262-263 |
HYPH |
denotes |
- |
T3065 |
263-264 |
NN |
denotes |
L |
T3066 |
264-265 |
HYPH |
denotes |
- |
T3067 |
265-266 |
NN |
denotes |
X |
T3068 |
266-267 |
HYPH |
denotes |
- |
T3069 |
268-269 |
-RRB- |
denotes |
) |
T3070 |
365-374 |
VBN |
denotes |
conserved |
T3071 |
276-278 |
IN |
denotes |
at |
T3072 |
279-282 |
DT |
denotes |
the |
T3073 |
285-293 |
NN |
denotes |
terminus |
T3074 |
283-284 |
NN |
denotes |
C |
T3075 |
284-285 |
HYPH |
denotes |
- |
T3076 |
293-295 |
, |
denotes |
, |
T3077 |
295-300 |
WDT |
denotes |
which |
T3078 |
305-308 |
VB |
denotes |
act |
T3079 |
301-304 |
MD |
denotes |
may |
T3080 |
309-311 |
IN |
denotes |
as |
T3081 |
312-313 |
DT |
denotes |
a |
T3082 |
349-355 |
NN |
denotes |
signal |
T3083 |
314-318 |
JJ |
denotes |
late |
T3084 |
319-328 |
JJ |
denotes |
endosomal |
T3085 |
329-338 |
JJ |
denotes |
lysosomal |
T3086 |
328-329 |
HYPH |
denotes |
/ |
T3087 |
339-348 |
NN |
denotes |
targeting |
T3088 |
355-357 |
, |
denotes |
, |
T3089 |
357-359 |
VBZ |
denotes |
is |
T3090 |
360-364 |
RB |
denotes |
also |
T3091 |
375-376 |
-LRB- |
denotes |
[ |
T3092 |
376-377 |
CD |
denotes |
9 |
T3093 |
377-378 |
-RRB- |
denotes |
] |
T3094 |
378-379 |
. |
denotes |
. |
T3095 |
379-579 |
sentence |
denotes |
This speculation is supported by work with cup-5[13], the c. elegans homologue of MCOLN1, since cellular localization studies suggest that the protein is found in the late endosomes and/or lysosomes. |
T3096 |
380-384 |
DT |
denotes |
This |
T3097 |
385-396 |
NN |
denotes |
speculation |
T3098 |
400-409 |
VBN |
denotes |
supported |
T3099 |
397-399 |
VBZ |
denotes |
is |
T3100 |
410-412 |
IN |
denotes |
by |
T3101 |
413-417 |
NN |
denotes |
work |
T3102 |
418-422 |
IN |
denotes |
with |
T3103 |
423-426 |
NN |
denotes |
cup |
T3104 |
427-428 |
NN |
denotes |
5 |
T3105 |
426-427 |
HYPH |
denotes |
- |
T3106 |
428-429 |
-LRB- |
denotes |
[ |
T3107 |
429-431 |
CD |
denotes |
13 |
T3108 |
431-432 |
-RRB- |
denotes |
] |
T3109 |
432-434 |
, |
denotes |
, |
T3110 |
434-437 |
DT |
denotes |
the |
T3111 |
449-458 |
NN |
denotes |
homologue |
T3112 |
438-440 |
NNP |
denotes |
c. |
T3113 |
441-448 |
NNP |
denotes |
elegans |
T3114 |
459-461 |
IN |
denotes |
of |
T3115 |
462-468 |
NN |
denotes |
MCOLN1 |
T3116 |
468-470 |
, |
denotes |
, |
T3117 |
470-475 |
IN |
denotes |
since |
T3118 |
506-513 |
VBP |
denotes |
suggest |
T3119 |
476-484 |
JJ |
denotes |
cellular |
T3120 |
485-497 |
NN |
denotes |
localization |
T3121 |
498-505 |
NNS |
denotes |
studies |
T3122 |
514-518 |
IN |
denotes |
that |
T3123 |
534-539 |
VBN |
denotes |
found |
T3124 |
519-522 |
DT |
denotes |
the |
T3125 |
523-530 |
NN |
denotes |
protein |
T3126 |
531-533 |
VBZ |
denotes |
is |
T3127 |
540-542 |
IN |
denotes |
in |
T3128 |
543-546 |
DT |
denotes |
the |
T3129 |
552-561 |
NNS |
denotes |
endosomes |
T3130 |
547-551 |
JJ |
denotes |
late |
T3131 |
562-565 |
CC |
denotes |
and |
T3132 |
565-566 |
HYPH |
denotes |
/ |
T3133 |
566-568 |
CC |
denotes |
or |
T3134 |
569-578 |
NNS |
denotes |
lysosomes |
T3135 |
578-579 |
. |
denotes |
. |
T3136 |
579-704 |
sentence |
denotes |
The mouse Mcoln1 gene has two alternatively spliced isoforms, with isoform 2 having a different c-terminal cytoplasmic tail. |
T3137 |
580-583 |
DT |
denotes |
The |
T3138 |
597-601 |
NN |
denotes |
gene |
T3139 |
584-589 |
NN |
denotes |
mouse |
T3140 |
590-596 |
NN |
denotes |
Mcoln1 |
T3141 |
602-605 |
VBZ |
denotes |
has |
T3142 |
606-609 |
CD |
denotes |
two |
T3143 |
632-640 |
NNS |
denotes |
isoforms |
T3144 |
610-623 |
RB |
denotes |
alternatively |
T3145 |
624-631 |
VBN |
denotes |
spliced |
T3146 |
640-642 |
, |
denotes |
, |
T3147 |
642-646 |
IN |
denotes |
with |
T3148 |
647-654 |
NN |
denotes |
isoform |
T3149 |
657-663 |
VBG |
denotes |
having |
T3150 |
655-656 |
CD |
denotes |
2 |
T3151 |
664-665 |
DT |
denotes |
a |
T3152 |
699-703 |
NN |
denotes |
tail |
T3153 |
666-675 |
JJ |
denotes |
different |
T3154 |
676-677 |
NN |
denotes |
c |
T3155 |
678-686 |
JJ |
denotes |
terminal |
T3156 |
677-678 |
HYPH |
denotes |
- |
T3157 |
687-698 |
JJ |
denotes |
cytoplasmic |
T3158 |
703-704 |
. |
denotes |
. |
T3159 |
704-878 |
sentence |
denotes |
The unique 86 amino acid c-terminal tail lacks the lysosomal targeting signal and does not contain any conserved domains when compared against the current profile databases. |
T3160 |
705-708 |
DT |
denotes |
The |
T3161 |
741-745 |
NN |
denotes |
tail |
T3162 |
709-715 |
JJ |
denotes |
unique |
T3163 |
716-718 |
CD |
denotes |
86 |
T3164 |
725-729 |
NN |
denotes |
acid |
T3165 |
719-724 |
NN |
denotes |
amino |
T3166 |
730-731 |
NN |
denotes |
c |
T3167 |
732-740 |
JJ |
denotes |
terminal |
T3168 |
731-732 |
HYPH |
denotes |
- |
T3169 |
746-751 |
VBZ |
denotes |
lacks |
T3170 |
752-755 |
DT |
denotes |
the |
T3171 |
776-782 |
NN |
denotes |
signal |
T3172 |
756-765 |
JJ |
denotes |
lysosomal |
T3173 |
766-775 |
NN |
denotes |
targeting |
T3174 |
783-786 |
CC |
denotes |
and |
T3175 |
787-791 |
VBZ |
denotes |
does |
T3176 |
796-803 |
VB |
denotes |
contain |
T3177 |
792-795 |
RB |
denotes |
not |
T3178 |
804-807 |
DT |
denotes |
any |
T3179 |
818-825 |
NNS |
denotes |
domains |
T3180 |
808-817 |
VBN |
denotes |
conserved |
T3181 |
826-830 |
WRB |
denotes |
when |
T3182 |
831-839 |
VBN |
denotes |
compared |
T3183 |
840-847 |
IN |
denotes |
against |
T3184 |
848-851 |
DT |
denotes |
the |
T3185 |
868-877 |
NNS |
denotes |
databases |
T3186 |
852-859 |
JJ |
denotes |
current |
T3187 |
860-867 |
NN |
denotes |
profile |
T3188 |
877-878 |
. |
denotes |
. |
T3189 |
878-1055 |
sentence |
denotes |
We speculate that this protein may have similar channel function but an alternate subcellular localization, but this must be proven once isoform-specific antibodies are raised. |
T3190 |
879-881 |
PRP |
denotes |
We |
T3191 |
882-891 |
VBP |
denotes |
speculate |
T3192 |
892-896 |
IN |
denotes |
that |
T3193 |
914-918 |
VB |
denotes |
have |
T3194 |
897-901 |
DT |
denotes |
this |
T3195 |
902-909 |
NN |
denotes |
protein |
T3196 |
910-913 |
MD |
denotes |
may |
T3197 |
919-926 |
JJ |
denotes |
similar |
T3198 |
935-943 |
NN |
denotes |
function |
T3199 |
927-934 |
NN |
denotes |
channel |
T3200 |
944-947 |
CC |
denotes |
but |
T3201 |
948-950 |
DT |
denotes |
an |
T3202 |
973-985 |
NN |
denotes |
localization |
T3203 |
951-960 |
JJ |
denotes |
alternate |
T3204 |
961-972 |
JJ |
denotes |
subcellular |
T3205 |
985-987 |
, |
denotes |
, |
T3206 |
987-990 |
CC |
denotes |
but |
T3207 |
991-995 |
DT |
denotes |
this |
T3208 |
1004-1010 |
VBN |
denotes |
proven |
T3209 |
996-1000 |
MD |
denotes |
must |
T3210 |
1001-1003 |
VB |
denotes |
be |
T3211 |
1011-1015 |
IN |
denotes |
once |
T3212 |
1048-1054 |
VBN |
denotes |
raised |
T3213 |
1016-1023 |
NN |
denotes |
isoform |
T3214 |
1024-1032 |
JJ |
denotes |
specific |
T3215 |
1023-1024 |
HYPH |
denotes |
- |
T3216 |
1033-1043 |
NNS |
denotes |
antibodies |
T3217 |
1044-1047 |
VBP |
denotes |
are |
T3218 |
1054-1055 |
. |
denotes |
. |
T3219 |
1055-1246 |
sentence |
denotes |
However, our results suggest that phenotypic assessment of Mcoln1 knock-out mice may be complicated and that care must be taken when interpreting data on mouse gene expression and phenotype. |
T3220 |
1056-1063 |
RB |
denotes |
However |
T3221 |
1077-1084 |
VBP |
denotes |
suggest |
T3222 |
1063-1065 |
, |
denotes |
, |
T3223 |
1065-1068 |
PRP$ |
denotes |
our |
T3224 |
1069-1076 |
NNS |
denotes |
results |
T3225 |
1085-1089 |
IN |
denotes |
that |
T3226 |
1141-1143 |
VB |
denotes |
be |
T3227 |
1090-1100 |
JJ |
denotes |
phenotypic |
T3228 |
1101-1111 |
NN |
denotes |
assessment |
T3229 |
1112-1114 |
IN |
denotes |
of |
T3230 |
1115-1121 |
NN |
denotes |
Mcoln1 |
T3231 |
1132-1136 |
NNS |
denotes |
mice |
T3232 |
1122-1127 |
NN |
denotes |
knock |
T3233 |
1128-1131 |
NN |
denotes |
out |
T3234 |
1127-1128 |
HYPH |
denotes |
- |
T3235 |
1137-1140 |
MD |
denotes |
may |
T3236 |
1144-1155 |
JJ |
denotes |
complicated |
T3237 |
1156-1159 |
CC |
denotes |
and |
T3238 |
1160-1164 |
IN |
denotes |
that |
T3239 |
1178-1183 |
VBN |
denotes |
taken |
T3240 |
1165-1169 |
NN |
denotes |
care |
T3241 |
1170-1174 |
MD |
denotes |
must |
T3242 |
1175-1177 |
VB |
denotes |
be |
T3243 |
1184-1188 |
WRB |
denotes |
when |
T3244 |
1189-1201 |
VBG |
denotes |
interpreting |
T3245 |
1202-1206 |
NNS |
denotes |
data |
T3246 |
1207-1209 |
IN |
denotes |
on |
T3247 |
1210-1215 |
NN |
denotes |
mouse |
T3248 |
1221-1231 |
NN |
denotes |
expression |
T3249 |
1216-1220 |
NN |
denotes |
gene |
T3250 |
1232-1235 |
CC |
denotes |
and |
T3251 |
1236-1245 |
NN |
denotes |
phenotype |
T3252 |
1245-1246 |
. |
denotes |
. |
T3253 |
1246-1402 |
sentence |
denotes |
Interestingly, the second Mcoln1 isoform is not seen in humans and the sequence of the alternatively spliced region is not conserved between man and mouse. |
T3254 |
1247-1260 |
RB |
denotes |
Interestingly |
T3255 |
1295-1299 |
VBN |
denotes |
seen |
T3256 |
1260-1262 |
, |
denotes |
, |
T3257 |
1262-1265 |
DT |
denotes |
the |
T3258 |
1280-1287 |
NN |
denotes |
isoform |
T3259 |
1266-1272 |
JJ |
denotes |
second |
T3260 |
1273-1279 |
NN |
denotes |
Mcoln1 |
T3261 |
1288-1290 |
VBZ |
denotes |
is |
T3262 |
1291-1294 |
RB |
denotes |
not |
T3263 |
1300-1302 |
IN |
denotes |
in |
T3264 |
1303-1309 |
NNS |
denotes |
humans |
T3265 |
1310-1313 |
CC |
denotes |
and |
T3266 |
1314-1317 |
DT |
denotes |
the |
T3267 |
1318-1326 |
NN |
denotes |
sequence |
T3268 |
1370-1379 |
VBN |
denotes |
conserved |
T3269 |
1327-1329 |
IN |
denotes |
of |
T3270 |
1330-1333 |
DT |
denotes |
the |
T3271 |
1356-1362 |
NN |
denotes |
region |
T3272 |
1334-1347 |
RB |
denotes |
alternatively |
T3273 |
1348-1355 |
VBN |
denotes |
spliced |
T3274 |
1363-1365 |
VBZ |
denotes |
is |
T3275 |
1366-1369 |
RB |
denotes |
not |
T3276 |
1380-1387 |
IN |
denotes |
between |
T3277 |
1388-1391 |
NN |
denotes |
man |
T3278 |
1392-1395 |
CC |
denotes |
and |
T3279 |
1396-1401 |
NN |
denotes |
mouse |
T3280 |
1401-1402 |
. |
denotes |
. |
T3281 |
1402-1501 |
sentence |
denotes |
To date, very few genes have been reported that show species specific alternative splice variants. |
T3282 |
1403-1405 |
IN |
denotes |
To |
T3283 |
1437-1445 |
VBN |
denotes |
reported |
T3284 |
1406-1410 |
NN |
denotes |
date |
T3285 |
1410-1412 |
, |
denotes |
, |
T3286 |
1412-1416 |
RB |
denotes |
very |
T3287 |
1417-1420 |
JJ |
denotes |
few |
T3288 |
1421-1426 |
NNS |
denotes |
genes |
T3289 |
1427-1431 |
VBP |
denotes |
have |
T3290 |
1432-1436 |
VBN |
denotes |
been |
T3291 |
1446-1450 |
WDT |
denotes |
that |
T3292 |
1451-1455 |
VBP |
denotes |
show |
T3293 |
1456-1463 |
NN |
denotes |
species |
T3294 |
1464-1472 |
JJ |
denotes |
specific |
T3295 |
1492-1500 |
NNS |
denotes |
variants |
T3296 |
1473-1484 |
JJ |
denotes |
alternative |
T3297 |
1485-1491 |
NN |
denotes |
splice |
T3298 |
1500-1501 |
. |
denotes |
. |
T3299 |
1501-1621 |
sentence |
denotes |
MOG, myelin/oligodendrocyte glycoprotein, has many different splice variants in humans that are not found in mice [17]. |
T3300 |
1502-1505 |
NN |
denotes |
MOG |
T3301 |
1544-1547 |
VBZ |
denotes |
has |
T3302 |
1505-1507 |
, |
denotes |
, |
T3303 |
1507-1513 |
NN |
denotes |
myelin |
T3304 |
1514-1529 |
NN |
denotes |
oligodendrocyte |
T3305 |
1513-1514 |
HYPH |
denotes |
/ |
T3306 |
1530-1542 |
NN |
denotes |
glycoprotein |
T3307 |
1542-1544 |
, |
denotes |
, |
T3308 |
1548-1552 |
JJ |
denotes |
many |
T3309 |
1570-1578 |
NNS |
denotes |
variants |
T3310 |
1553-1562 |
JJ |
denotes |
different |
T3311 |
1563-1569 |
NN |
denotes |
splice |
T3312 |
1579-1581 |
IN |
denotes |
in |
T3313 |
1582-1588 |
NNS |
denotes |
humans |
T3314 |
1589-1593 |
WDT |
denotes |
that |
T3315 |
1602-1607 |
VBN |
denotes |
found |
T3316 |
1594-1597 |
VBP |
denotes |
are |
T3317 |
1598-1601 |
RB |
denotes |
not |
T3318 |
1608-1610 |
IN |
denotes |
in |
T3319 |
1611-1615 |
NNS |
denotes |
mice |
T3320 |
1616-1617 |
-LRB- |
denotes |
[ |
T3321 |
1617-1619 |
CD |
denotes |
17 |
T3322 |
1619-1620 |
-RRB- |
denotes |
] |
T3323 |
1620-1621 |
. |
denotes |
. |
T3324 |
1621-1790 |
sentence |
denotes |
ATP11B, a P-type ATPase, has a rabbit-specific splice variant that deletes a transmembrane domain and therefore likely alters the putative function of the protein [18]. |
T3325 |
1622-1628 |
NN |
denotes |
ATP11B |
T3326 |
1647-1650 |
VBZ |
denotes |
has |
T3327 |
1628-1630 |
, |
denotes |
, |
T3328 |
1630-1631 |
DT |
denotes |
a |
T3329 |
1639-1645 |
NN |
denotes |
ATPase |
T3330 |
1632-1633 |
NN |
denotes |
P |
T3331 |
1634-1638 |
NN |
denotes |
type |
T3332 |
1633-1634 |
HYPH |
denotes |
- |
T3333 |
1645-1647 |
, |
denotes |
, |
T3334 |
1651-1652 |
DT |
denotes |
a |
T3335 |
1676-1683 |
NN |
denotes |
variant |
T3336 |
1653-1659 |
NN |
denotes |
rabbit |
T3337 |
1660-1668 |
JJ |
denotes |
specific |
T3338 |
1659-1660 |
HYPH |
denotes |
- |
T3339 |
1669-1675 |
NN |
denotes |
splice |
T3340 |
1684-1688 |
WDT |
denotes |
that |
T3341 |
1689-1696 |
VBZ |
denotes |
deletes |
T3342 |
1697-1698 |
DT |
denotes |
a |
T3343 |
1713-1719 |
NN |
denotes |
domain |
T3344 |
1699-1712 |
JJ |
denotes |
transmembrane |
T3345 |
1720-1723 |
CC |
denotes |
and |
T3346 |
1724-1733 |
RB |
denotes |
therefore |
T3347 |
1741-1747 |
VBZ |
denotes |
alters |
T3348 |
1734-1740 |
RB |
denotes |
likely |
T3349 |
1748-1751 |
DT |
denotes |
the |
T3350 |
1761-1769 |
NN |
denotes |
function |
T3351 |
1752-1760 |
JJ |
denotes |
putative |
T3352 |
1770-1772 |
IN |
denotes |
of |
T3353 |
1773-1776 |
DT |
denotes |
the |
T3354 |
1777-1784 |
NN |
denotes |
protein |
T3355 |
1785-1786 |
-LRB- |
denotes |
[ |
T3356 |
1786-1788 |
CD |
denotes |
18 |
T3357 |
1788-1789 |
-RRB- |
denotes |
] |
T3358 |
1789-1790 |
. |
denotes |
. |
T3359 |
1790-2029 |
sentence |
denotes |
Sequencing of the human genome has led to estimates of approximately 32,000 genes, a total surprise given the previous significantly higher estimates that were based on the number of expressed sequence tags (ESTs) in the public databases. |
T3360 |
1791-1801 |
NN |
denotes |
Sequencing |
T3361 |
1826-1829 |
VBN |
denotes |
led |
T3362 |
1802-1804 |
IN |
denotes |
of |
T3363 |
1805-1808 |
DT |
denotes |
the |
T3364 |
1815-1821 |
NN |
denotes |
genome |
T3365 |
1809-1814 |
JJ |
denotes |
human |
T3366 |
1822-1825 |
VBZ |
denotes |
has |
T3367 |
1830-1832 |
IN |
denotes |
to |
T3368 |
1833-1842 |
NNS |
denotes |
estimates |
T3369 |
1843-1845 |
IN |
denotes |
of |
T3370 |
1846-1859 |
RB |
denotes |
approximately |
T3371 |
1860-1866 |
CD |
denotes |
32,000 |
T3372 |
1867-1872 |
NNS |
denotes |
genes |
T3373 |
1872-1874 |
, |
denotes |
, |
T3374 |
1874-1875 |
DT |
denotes |
a |
T3375 |
1882-1890 |
NN |
denotes |
surprise |
T3376 |
1876-1881 |
JJ |
denotes |
total |
T3377 |
1891-1896 |
VBN |
denotes |
given |
T3378 |
1897-1900 |
DT |
denotes |
the |
T3379 |
1931-1940 |
NNS |
denotes |
estimates |
T3380 |
1901-1909 |
JJ |
denotes |
previous |
T3381 |
1910-1923 |
RB |
denotes |
significantly |
T3382 |
1924-1930 |
JJR |
denotes |
higher |
T3383 |
1941-1945 |
WDT |
denotes |
that |
T3384 |
1951-1956 |
VBN |
denotes |
based |
T3385 |
1946-1950 |
VBD |
denotes |
were |
T3386 |
1957-1959 |
IN |
denotes |
on |
T3387 |
1960-1963 |
DT |
denotes |
the |
T3388 |
1964-1970 |
NN |
denotes |
number |
T3389 |
1971-1973 |
IN |
denotes |
of |
T3390 |
1974-1983 |
VBN |
denotes |
expressed |
T3391 |
1993-1997 |
NNS |
denotes |
tags |
T3392 |
1984-1992 |
NN |
denotes |
sequence |
T3393 |
1998-1999 |
-LRB- |
denotes |
( |
T3394 |
1999-2003 |
NNS |
denotes |
ESTs |
T3395 |
2003-2004 |
-RRB- |
denotes |
) |
T3396 |
2005-2007 |
IN |
denotes |
in |
T3397 |
2008-2011 |
DT |
denotes |
the |
T3398 |
2019-2028 |
NNS |
denotes |
databases |
T3399 |
2012-2018 |
JJ |
denotes |
public |
T3400 |
2028-2029 |
. |
denotes |
. |
T3401 |
2029-2221 |
sentence |
denotes |
This apparent disparity suggests a major role for alternative splicing in creating genetic complexity, and has brought the study of splicing regulation to the forefront of molecular genetics. |
T3402 |
2030-2034 |
DT |
denotes |
This |
T3403 |
2044-2053 |
NN |
denotes |
disparity |
T3404 |
2035-2043 |
JJ |
denotes |
apparent |
T3405 |
2054-2062 |
VBZ |
denotes |
suggests |
T3406 |
2063-2064 |
DT |
denotes |
a |
T3407 |
2071-2075 |
NN |
denotes |
role |
T3408 |
2065-2070 |
JJ |
denotes |
major |
T3409 |
2076-2079 |
IN |
denotes |
for |
T3410 |
2080-2091 |
JJ |
denotes |
alternative |
T3411 |
2092-2100 |
NN |
denotes |
splicing |
T3412 |
2101-2103 |
IN |
denotes |
in |
T3413 |
2104-2112 |
VBG |
denotes |
creating |
T3414 |
2113-2120 |
JJ |
denotes |
genetic |
T3415 |
2121-2131 |
NN |
denotes |
complexity |
T3416 |
2131-2133 |
, |
denotes |
, |
T3417 |
2133-2136 |
CC |
denotes |
and |
T3418 |
2137-2140 |
VBZ |
denotes |
has |
T3419 |
2141-2148 |
VBN |
denotes |
brought |
T3420 |
2149-2152 |
DT |
denotes |
the |
T3421 |
2153-2158 |
NN |
denotes |
study |
T3422 |
2159-2161 |
IN |
denotes |
of |
T3423 |
2162-2170 |
NN |
denotes |
splicing |
T3424 |
2171-2181 |
NN |
denotes |
regulation |
T3425 |
2182-2184 |
IN |
denotes |
to |
T3426 |
2185-2188 |
DT |
denotes |
the |
T3427 |
2189-2198 |
NN |
denotes |
forefront |
T3428 |
2199-2201 |
IN |
denotes |
of |
T3429 |
2202-2211 |
JJ |
denotes |
molecular |
T3430 |
2212-2220 |
NN |
denotes |
genetics |
T3431 |
2220-2221 |
. |
denotes |
. |
T3432 |
2221-2380 |
sentence |
denotes |
It is likely that an abundance of species-specific splice variants will be identified as the characterization of alternatively spliced transcripts progresses. |
T3433 |
2222-2224 |
PRP |
denotes |
It |
T3434 |
2225-2227 |
VBZ |
denotes |
is |
T3435 |
2228-2234 |
JJ |
denotes |
likely |
T3436 |
2235-2239 |
IN |
denotes |
that |
T3437 |
2297-2307 |
VBN |
denotes |
identified |
T3438 |
2240-2242 |
DT |
denotes |
an |
T3439 |
2243-2252 |
NN |
denotes |
abundance |
T3440 |
2253-2255 |
IN |
denotes |
of |
T3441 |
2256-2263 |
NN |
denotes |
species |
T3442 |
2264-2272 |
JJ |
denotes |
specific |
T3443 |
2263-2264 |
HYPH |
denotes |
- |
T3444 |
2280-2288 |
NNS |
denotes |
variants |
T3445 |
2273-2279 |
NN |
denotes |
splice |
T3446 |
2289-2293 |
MD |
denotes |
will |
T3447 |
2294-2296 |
VB |
denotes |
be |
T3448 |
2308-2310 |
IN |
denotes |
as |
T3449 |
2369-2379 |
VBZ |
denotes |
progresses |
T3450 |
2311-2314 |
DT |
denotes |
the |
T3451 |
2315-2331 |
NN |
denotes |
characterization |
T3452 |
2332-2334 |
IN |
denotes |
of |
T3453 |
2335-2348 |
RB |
denotes |
alternatively |
T3454 |
2349-2356 |
VBN |
denotes |
spliced |
T3455 |
2357-2368 |
NNS |
denotes |
transcripts |
T3456 |
2379-2380 |
. |
denotes |
. |
R1777 |
T3016 |
T3017 |
nsubj |
Comparison,shows |
R1778 |
T3018 |
T3016 |
prep |
of,Comparison |
R1779 |
T3019 |
T3020 |
compound |
Mcoln1,isoform |
R1780 |
T3020 |
T3018 |
pobj |
isoform,of |
R1781 |
T3021 |
T3020 |
nummod |
1,isoform |
R1782 |
T3022 |
T3016 |
prep |
to,Comparison |
R1783 |
T3023 |
T3024 |
poss |
its,homologue |
R1784 |
T3024 |
T3022 |
pobj |
homologue,to |
R1785 |
T3025 |
T3024 |
amod |
human,homologue |
R1786 |
T3026 |
T3027 |
amod |
striking,similarity |
R1787 |
T3027 |
T3017 |
dobj |
similarity,shows |
R1788 |
T3028 |
T3017 |
prep |
at,shows |
R1789 |
T3029 |
T3030 |
preconj |
both,level |
R1790 |
T3030 |
T3028 |
pobj |
level,at |
R1791 |
T3031 |
T3030 |
det |
the,level |
R1792 |
T3032 |
T3033 |
nmod |
amino,acid |
R1793 |
T3033 |
T3030 |
nmod |
acid,level |
R1794 |
T3034 |
T3033 |
cc |
and,acid |
R1795 |
T3035 |
T3033 |
conj |
nucleotide,acid |
R1796 |
T3036 |
T3017 |
punct |
.,shows |
R1797 |
T3038 |
T3039 |
det |
All,six |
R1798 |
T3039 |
T3040 |
nsubjpass |
six,conserved |
R1799 |
T3041 |
T3039 |
prep |
of,six |
R1800 |
T3042 |
T3043 |
det |
the,domains |
R1801 |
T3043 |
T3041 |
pobj |
domains,of |
R1802 |
T3044 |
T3043 |
compound |
transmembrane,domains |
R1803 |
T3045 |
T3039 |
punct |
", ",six |
R1804 |
T3046 |
T3047 |
advmod |
as,as |
R1805 |
T3047 |
T3039 |
cc |
as,six |
R1806 |
T3048 |
T3047 |
advmod |
well,as |
R1807 |
T3049 |
T3050 |
det |
the,channel |
R1808 |
T3050 |
T3039 |
conj |
channel,six |
R1809 |
T3051 |
T3050 |
amod |
putative,channel |
R1810 |
T3052 |
T3050 |
compound |
cation,channel |
R1811 |
T3053 |
T3040 |
auxpass |
are,conserved |
R1812 |
T3054 |
T3040 |
advmod |
highly,conserved |
R1813 |
T3055 |
T3040 |
punct |
.,conserved |
R1814 |
T3057 |
T3058 |
det |
The,motif |
R1815 |
T3058 |
T3070 |
nsubjpass |
motif,conserved |
R1816 |
T3059 |
T3058 |
amod |
putative,motif |
R1817 |
T3060 |
T3058 |
nmod |
di-leucine,motif |
R1818 |
T3061 |
T3062 |
punct |
(,X |
R1819 |
T3062 |
T3060 |
parataxis |
X,di-leucine |
R1820 |
T3063 |
T3062 |
compound |
L,X |
R1821 |
T3064 |
T3062 |
punct |
-,X |
R1822 |
T3065 |
T3062 |
compound |
L,X |
R1823 |
T3066 |
T3062 |
punct |
-,X |
R1824 |
T3067 |
T3062 |
compound |
X,X |
R1825 |
T3068 |
T3062 |
punct |
-,X |
R1826 |
T3069 |
T3062 |
punct |
),X |
R1827 |
T3071 |
T3058 |
prep |
at,motif |
R1828 |
T3072 |
T3073 |
det |
the,terminus |
R1829 |
T3073 |
T3071 |
pobj |
terminus,at |
R1830 |
T3074 |
T3073 |
compound |
C,terminus |
R1831 |
T3075 |
T3073 |
punct |
-,terminus |
R1832 |
T3076 |
T3058 |
punct |
", ",motif |
R1833 |
T3077 |
T3078 |
dep |
which,act |
R1834 |
T3078 |
T3058 |
relcl |
act,motif |
R1835 |
T3079 |
T3078 |
aux |
may,act |
R1836 |
T3080 |
T3078 |
prep |
as,act |
R1837 |
T3081 |
T3082 |
det |
a,signal |
R1838 |
T3082 |
T3080 |
pobj |
signal,as |
R1839 |
T3083 |
T3082 |
amod |
late,signal |
R1840 |
T3084 |
T3085 |
amod |
endosomal,lysosomal |
R1841 |
T3085 |
T3082 |
amod |
lysosomal,signal |
R1842 |
T3086 |
T3085 |
punct |
/,lysosomal |
R1843 |
T3087 |
T3082 |
compound |
targeting,signal |
R1844 |
T3088 |
T3070 |
punct |
", ",conserved |
R1845 |
T3089 |
T3070 |
auxpass |
is,conserved |
R1846 |
T3090 |
T3070 |
advmod |
also,conserved |
R1847 |
T3091 |
T3092 |
punct |
[,9 |
R1848 |
T3092 |
T3070 |
parataxis |
9,conserved |
R1849 |
T3093 |
T3092 |
punct |
],9 |
R1850 |
T3094 |
T3070 |
punct |
.,conserved |
R1851 |
T3096 |
T3097 |
det |
This,speculation |
R1852 |
T3097 |
T3098 |
nsubjpass |
speculation,supported |
R1853 |
T3099 |
T3098 |
auxpass |
is,supported |
R1854 |
T3100 |
T3098 |
agent |
by,supported |
R1855 |
T3101 |
T3100 |
pobj |
work,by |
R1856 |
T3102 |
T3101 |
prep |
with,work |
R1857 |
T3103 |
T3104 |
compound |
cup,5 |
R1858 |
T3104 |
T3102 |
pobj |
5,with |
R1859 |
T3105 |
T3104 |
punct |
-,5 |
R1860 |
T3106 |
T3107 |
punct |
[,13 |
R1861 |
T3107 |
T3101 |
parataxis |
13,work |
R1862 |
T3108 |
T3107 |
punct |
],13 |
R1863 |
T3109 |
T3101 |
punct |
", ",work |
R1864 |
T3110 |
T3111 |
det |
the,homologue |
R1865 |
T3111 |
T3101 |
appos |
homologue,work |
R1866 |
T3112 |
T3113 |
compound |
c.,elegans |
R1867 |
T3113 |
T3111 |
compound |
elegans,homologue |
R1868 |
T3114 |
T3111 |
prep |
of,homologue |
R1869 |
T3115 |
T3114 |
pobj |
MCOLN1,of |
R1870 |
T3116 |
T3098 |
punct |
", ",supported |
R1871 |
T3117 |
T3118 |
mark |
since,suggest |
R1872 |
T3118 |
T3098 |
advcl |
suggest,supported |
R1873 |
T3119 |
T3120 |
amod |
cellular,localization |
R1874 |
T3120 |
T3121 |
compound |
localization,studies |
R1875 |
T3121 |
T3118 |
nsubj |
studies,suggest |
R1876 |
T3122 |
T3123 |
mark |
that,found |
R1877 |
T3123 |
T3118 |
ccomp |
found,suggest |
R1878 |
T3124 |
T3125 |
det |
the,protein |
R1879 |
T3125 |
T3123 |
nsubjpass |
protein,found |
R1880 |
T3126 |
T3123 |
auxpass |
is,found |
R1881 |
T3127 |
T3123 |
prep |
in,found |
R1882 |
T3128 |
T3129 |
det |
the,endosomes |
R1883 |
T3129 |
T3127 |
pobj |
endosomes,in |
R1884 |
T3130 |
T3129 |
amod |
late,endosomes |
R1885 |
T3131 |
T3129 |
cc |
and,endosomes |
R1886 |
T3132 |
T3131 |
punct |
/,and |
R1887 |
T3133 |
T3131 |
cc |
or,and |
R1888 |
T3134 |
T3129 |
conj |
lysosomes,endosomes |
R1889 |
T3135 |
T3098 |
punct |
.,supported |
R1890 |
T3137 |
T3138 |
det |
The,gene |
R1891 |
T3138 |
T3141 |
nsubj |
gene,has |
R1892 |
T3139 |
T3138 |
compound |
mouse,gene |
R1893 |
T3140 |
T3138 |
compound |
Mcoln1,gene |
R1894 |
T3142 |
T3143 |
nummod |
two,isoforms |
R1895 |
T3143 |
T3141 |
dobj |
isoforms,has |
R1896 |
T3144 |
T3145 |
advmod |
alternatively,spliced |
R1897 |
T3145 |
T3143 |
amod |
spliced,isoforms |
R1898 |
T3146 |
T3141 |
punct |
", ",has |
R1899 |
T3147 |
T3141 |
prep |
with,has |
R1900 |
T3148 |
T3149 |
nsubj |
isoform,having |
R1901 |
T3149 |
T3147 |
pcomp |
having,with |
R1902 |
T3150 |
T3148 |
nummod |
2,isoform |
R1903 |
T3151 |
T3152 |
det |
a,tail |
R1904 |
T3152 |
T3149 |
dobj |
tail,having |
R1905 |
T3153 |
T3152 |
amod |
different,tail |
R1906 |
T3154 |
T3155 |
npadvmod |
c,terminal |
R1907 |
T3155 |
T3152 |
amod |
terminal,tail |
R1908 |
T3156 |
T3155 |
punct |
-,terminal |
R1909 |
T3157 |
T3152 |
amod |
cytoplasmic,tail |
R1910 |
T3158 |
T3141 |
punct |
.,has |
R1911 |
T3160 |
T3161 |
det |
The,tail |
R1912 |
T3161 |
T3169 |
nsubj |
tail,lacks |
R1913 |
T3162 |
T3161 |
amod |
unique,tail |
R1914 |
T3163 |
T3164 |
nummod |
86,acid |
R1915 |
T3164 |
T3161 |
nmod |
acid,tail |
R1916 |
T3165 |
T3164 |
nmod |
amino,acid |
R1917 |
T3166 |
T3167 |
npadvmod |
c,terminal |
R1918 |
T3167 |
T3161 |
amod |
terminal,tail |
R1919 |
T3168 |
T3167 |
punct |
-,terminal |
R1920 |
T3170 |
T3171 |
det |
the,signal |
R1921 |
T3171 |
T3169 |
dobj |
signal,lacks |
R1922 |
T3172 |
T3171 |
amod |
lysosomal,signal |
R1923 |
T3173 |
T3171 |
compound |
targeting,signal |
R1924 |
T3174 |
T3169 |
cc |
and,lacks |
R1925 |
T3175 |
T3176 |
aux |
does,contain |
R1926 |
T3176 |
T3169 |
conj |
contain,lacks |
R1927 |
T3177 |
T3176 |
neg |
not,contain |
R1928 |
T3178 |
T3179 |
det |
any,domains |
R1929 |
T3179 |
T3176 |
dobj |
domains,contain |
R1930 |
T3180 |
T3179 |
amod |
conserved,domains |
R1931 |
T3181 |
T3182 |
advmod |
when,compared |
R1932 |
T3182 |
T3176 |
advcl |
compared,contain |
R1933 |
T3183 |
T3182 |
prep |
against,compared |
R1934 |
T3184 |
T3185 |
det |
the,databases |
R1935 |
T3185 |
T3183 |
pobj |
databases,against |
R1936 |
T3186 |
T3185 |
amod |
current,databases |
R1937 |
T3187 |
T3185 |
compound |
profile,databases |
R1938 |
T3188 |
T3169 |
punct |
.,lacks |
R1939 |
T3190 |
T3191 |
nsubj |
We,speculate |
R1940 |
T3192 |
T3193 |
mark |
that,have |
R1941 |
T3193 |
T3191 |
ccomp |
have,speculate |
R1942 |
T3194 |
T3195 |
det |
this,protein |
R1943 |
T3195 |
T3193 |
nsubj |
protein,have |
R1944 |
T3196 |
T3193 |
aux |
may,have |
R1945 |
T3197 |
T3198 |
amod |
similar,function |
R1946 |
T3198 |
T3193 |
dobj |
function,have |
R1947 |
T3199 |
T3198 |
compound |
channel,function |
R1948 |
T3200 |
T3198 |
cc |
but,function |
R1949 |
T3201 |
T3202 |
det |
an,localization |
R1950 |
T3202 |
T3198 |
conj |
localization,function |
R1951 |
T3203 |
T3202 |
amod |
alternate,localization |
R1952 |
T3204 |
T3202 |
amod |
subcellular,localization |
R1953 |
T3205 |
T3191 |
punct |
", ",speculate |
R1954 |
T3206 |
T3191 |
cc |
but,speculate |
R1955 |
T3207 |
T3208 |
nsubjpass |
this,proven |
R1956 |
T3208 |
T3191 |
conj |
proven,speculate |
R1957 |
T3209 |
T3208 |
aux |
must,proven |
R1958 |
T3210 |
T3208 |
auxpass |
be,proven |
R1959 |
T3211 |
T3212 |
mark |
once,raised |
R1960 |
T3212 |
T3208 |
advcl |
raised,proven |
R1961 |
T3213 |
T3214 |
npadvmod |
isoform,specific |
R1962 |
T3214 |
T3216 |
amod |
specific,antibodies |
R1963 |
T3215 |
T3214 |
punct |
-,specific |
R1964 |
T3216 |
T3212 |
nsubjpass |
antibodies,raised |
R1965 |
T3217 |
T3212 |
auxpass |
are,raised |
R1966 |
T3218 |
T3208 |
punct |
.,proven |
R1967 |
T3220 |
T3221 |
advmod |
However,suggest |
R1968 |
T3222 |
T3221 |
punct |
", ",suggest |
R1969 |
T3223 |
T3224 |
poss |
our,results |
R1970 |
T3224 |
T3221 |
nsubj |
results,suggest |
R1971 |
T3225 |
T3226 |
mark |
that,be |
R1972 |
T3226 |
T3221 |
advcl |
be,suggest |
R1973 |
T3227 |
T3228 |
amod |
phenotypic,assessment |
R1974 |
T3228 |
T3226 |
nsubj |
assessment,be |
R1975 |
T3229 |
T3228 |
prep |
of,assessment |
R1976 |
T3230 |
T3231 |
compound |
Mcoln1,mice |
R1977 |
T3231 |
T3229 |
pobj |
mice,of |
R1978 |
T3232 |
T3233 |
compound |
knock,out |
R1979 |
T3233 |
T3231 |
compound |
out,mice |
R1980 |
T3234 |
T3233 |
punct |
-,out |
R1981 |
T3235 |
T3226 |
aux |
may,be |
R1982 |
T3236 |
T3226 |
acomp |
complicated,be |
R1983 |
T3237 |
T3226 |
cc |
and,be |
R1984 |
T3238 |
T3239 |
mark |
that,taken |
R1985 |
T3239 |
T3226 |
conj |
taken,be |
R1986 |
T3240 |
T3239 |
nsubjpass |
care,taken |
R1987 |
T3241 |
T3239 |
aux |
must,taken |
R1988 |
T3242 |
T3239 |
auxpass |
be,taken |
R1989 |
T3243 |
T3244 |
advmod |
when,interpreting |
R1990 |
T3244 |
T3239 |
advcl |
interpreting,taken |
R1991 |
T3245 |
T3244 |
dobj |
data,interpreting |
R1992 |
T3246 |
T3245 |
prep |
on,data |
R1993 |
T3247 |
T3248 |
compound |
mouse,expression |
R1994 |
T3248 |
T3246 |
pobj |
expression,on |
R1995 |
T3249 |
T3248 |
compound |
gene,expression |
R1996 |
T3250 |
T3248 |
cc |
and,expression |
R1997 |
T3251 |
T3248 |
conj |
phenotype,expression |
R1998 |
T3252 |
T3221 |
punct |
.,suggest |
R1999 |
T3254 |
T3255 |
advmod |
Interestingly,seen |
R2000 |
T3256 |
T3255 |
punct |
", ",seen |
R2001 |
T3257 |
T3258 |
det |
the,isoform |
R2002 |
T3258 |
T3255 |
nsubjpass |
isoform,seen |
R2003 |
T3259 |
T3258 |
amod |
second,isoform |
R2004 |
T3260 |
T3258 |
compound |
Mcoln1,isoform |
R2005 |
T3261 |
T3255 |
auxpass |
is,seen |
R2006 |
T3262 |
T3255 |
neg |
not,seen |
R2007 |
T3263 |
T3255 |
prep |
in,seen |
R2008 |
T3264 |
T3263 |
pobj |
humans,in |
R2009 |
T3265 |
T3255 |
cc |
and,seen |
R2010 |
T3266 |
T3267 |
det |
the,sequence |
R2011 |
T3267 |
T3268 |
nsubjpass |
sequence,conserved |
R2012 |
T3268 |
T3255 |
conj |
conserved,seen |
R2013 |
T3269 |
T3267 |
prep |
of,sequence |
R2014 |
T3270 |
T3271 |
det |
the,region |
R2015 |
T3271 |
T3269 |
pobj |
region,of |
R2016 |
T3272 |
T3273 |
advmod |
alternatively,spliced |
R2017 |
T3273 |
T3271 |
amod |
spliced,region |
R2018 |
T3274 |
T3268 |
auxpass |
is,conserved |
R2019 |
T3275 |
T3268 |
neg |
not,conserved |
R2020 |
T3276 |
T3268 |
prep |
between,conserved |
R2021 |
T3277 |
T3276 |
pobj |
man,between |
R2022 |
T3278 |
T3277 |
cc |
and,man |
R2023 |
T3279 |
T3277 |
conj |
mouse,man |
R2024 |
T3280 |
T3255 |
punct |
.,seen |
R2025 |
T3282 |
T3283 |
prep |
To,reported |
R2026 |
T3284 |
T3282 |
pobj |
date,To |
R2027 |
T3285 |
T3283 |
punct |
", ",reported |
R2028 |
T3286 |
T3287 |
advmod |
very,few |
R2029 |
T3287 |
T3288 |
amod |
few,genes |
R2030 |
T3288 |
T3283 |
nsubjpass |
genes,reported |
R2031 |
T3289 |
T3283 |
aux |
have,reported |
R2032 |
T3290 |
T3283 |
auxpass |
been,reported |
R2033 |
T3291 |
T3292 |
dep |
that,show |
R2034 |
T3292 |
T3283 |
ccomp |
show,reported |
R2035 |
T3293 |
T3294 |
npadvmod |
species,specific |
R2036 |
T3294 |
T3295 |
amod |
specific,variants |
R2037 |
T3295 |
T3292 |
dobj |
variants,show |
R2038 |
T3296 |
T3295 |
amod |
alternative,variants |
R2039 |
T3297 |
T3295 |
compound |
splice,variants |
R2040 |
T3298 |
T3283 |
punct |
.,reported |
R2041 |
T3300 |
T3301 |
nsubj |
MOG,has |
R2042 |
T3302 |
T3300 |
punct |
", ",MOG |
R2043 |
T3303 |
T3304 |
compound |
myelin,oligodendrocyte |
R2044 |
T3304 |
T3306 |
compound |
oligodendrocyte,glycoprotein |
R2045 |
T3305 |
T3304 |
punct |
/,oligodendrocyte |
R2046 |
T3306 |
T3300 |
appos |
glycoprotein,MOG |
R2047 |
T3307 |
T3301 |
punct |
", ",has |
R2048 |
T3308 |
T3309 |
amod |
many,variants |
R2049 |
T3309 |
T3301 |
dobj |
variants,has |
R2050 |
T3310 |
T3309 |
amod |
different,variants |
R2051 |
T3311 |
T3309 |
compound |
splice,variants |
R2052 |
T3312 |
T3301 |
prep |
in,has |
R2053 |
T3313 |
T3312 |
pobj |
humans,in |
R2054 |
T3314 |
T3315 |
dep |
that,found |
R2055 |
T3315 |
T3301 |
ccomp |
found,has |
R2056 |
T3316 |
T3315 |
auxpass |
are,found |
R2057 |
T3317 |
T3315 |
neg |
not,found |
R2058 |
T3318 |
T3315 |
prep |
in,found |
R2059 |
T3319 |
T3318 |
pobj |
mice,in |
R2060 |
T3320 |
T3321 |
punct |
[,17 |
R2061 |
T3321 |
T3301 |
parataxis |
17,has |
R2062 |
T3322 |
T3321 |
punct |
],17 |
R2063 |
T3323 |
T3301 |
punct |
.,has |
R2064 |
T3325 |
T3326 |
nsubj |
ATP11B,has |
R2065 |
T3327 |
T3325 |
punct |
", ",ATP11B |
R2066 |
T3328 |
T3329 |
det |
a,ATPase |
R2067 |
T3329 |
T3325 |
appos |
ATPase,ATP11B |
R2068 |
T3330 |
T3331 |
compound |
P,type |
R2069 |
T3331 |
T3329 |
compound |
type,ATPase |
R2070 |
T3332 |
T3331 |
punct |
-,type |
R2071 |
T3333 |
T3326 |
punct |
", ",has |
R2072 |
T3334 |
T3335 |
det |
a,variant |
R2073 |
T3335 |
T3326 |
dobj |
variant,has |
R2074 |
T3336 |
T3337 |
npadvmod |
rabbit,specific |
R2075 |
T3337 |
T3335 |
amod |
specific,variant |
R2076 |
T3338 |
T3337 |
punct |
-,specific |
R2077 |
T3339 |
T3335 |
compound |
splice,variant |
R2078 |
T3340 |
T3341 |
dep |
that,deletes |
R2079 |
T3341 |
T3335 |
relcl |
deletes,variant |
R2080 |
T3342 |
T3343 |
det |
a,domain |
R2081 |
T3343 |
T3341 |
dobj |
domain,deletes |
R2082 |
T3344 |
T3343 |
amod |
transmembrane,domain |
R2083 |
T3345 |
T3341 |
cc |
and,deletes |
R2084 |
T3346 |
T3347 |
advmod |
therefore,alters |
R2085 |
T3347 |
T3341 |
conj |
alters,deletes |
R2086 |
T3348 |
T3347 |
advmod |
likely,alters |
R2087 |
T3349 |
T3350 |
det |
the,function |
R2088 |
T3350 |
T3347 |
dobj |
function,alters |
R2089 |
T3351 |
T3350 |
amod |
putative,function |
R2090 |
T3352 |
T3350 |
prep |
of,function |
R2091 |
T3353 |
T3354 |
det |
the,protein |
R2092 |
T3354 |
T3352 |
pobj |
protein,of |
R2093 |
T3355 |
T3356 |
punct |
[,18 |
R2094 |
T3356 |
T3326 |
parataxis |
18,has |
R2095 |
T3357 |
T3356 |
punct |
],18 |
R2096 |
T3358 |
T3326 |
punct |
.,has |
R2097 |
T3360 |
T3361 |
nsubj |
Sequencing,led |
R2098 |
T3362 |
T3360 |
prep |
of,Sequencing |
R2099 |
T3363 |
T3364 |
det |
the,genome |
R2100 |
T3364 |
T3362 |
pobj |
genome,of |
R2101 |
T3365 |
T3364 |
amod |
human,genome |
R2102 |
T3366 |
T3361 |
aux |
has,led |
R2103 |
T3367 |
T3361 |
prep |
to,led |
R2104 |
T3368 |
T3367 |
pobj |
estimates,to |
R2105 |
T3369 |
T3368 |
prep |
of,estimates |
R2106 |
T3370 |
T3371 |
advmod |
approximately,"32,000" |
R2107 |
T3371 |
T3372 |
nummod |
"32,000",genes |
R2108 |
T3372 |
T3369 |
pobj |
genes,of |
R2109 |
T3373 |
T3361 |
punct |
", ",led |
R2110 |
T3374 |
T3375 |
det |
a,surprise |
R2111 |
T3375 |
T3361 |
npadvmod |
surprise,led |
R2112 |
T3376 |
T3375 |
amod |
total,surprise |
R2113 |
T3377 |
T3375 |
prep |
given,surprise |
R2114 |
T3378 |
T3379 |
det |
the,estimates |
R2115 |
T3379 |
T3377 |
pobj |
estimates,given |
R2116 |
T3380 |
T3379 |
amod |
previous,estimates |
R2117 |
T3381 |
T3382 |
advmod |
significantly,higher |
R2118 |
T3382 |
T3379 |
amod |
higher,estimates |
R2119 |
T3383 |
T3384 |
dep |
that,based |
R2120 |
T3384 |
T3379 |
relcl |
based,estimates |
R2121 |
T3385 |
T3384 |
auxpass |
were,based |
R2122 |
T3386 |
T3384 |
prep |
on,based |
R2123 |
T3387 |
T3388 |
det |
the,number |
R2124 |
T3388 |
T3386 |
pobj |
number,on |
R2125 |
T3389 |
T3388 |
prep |
of,number |
R2126 |
T3390 |
T3391 |
amod |
expressed,tags |
R2127 |
T3391 |
T3389 |
pobj |
tags,of |
R2128 |
T3392 |
T3391 |
compound |
sequence,tags |
R2129 |
T3393 |
T3391 |
punct |
(,tags |
R2130 |
T3394 |
T3391 |
appos |
ESTs,tags |
R2131 |
T3395 |
T3388 |
punct |
),number |
R2132 |
T3396 |
T3388 |
prep |
in,number |
R2133 |
T3397 |
T3398 |
det |
the,databases |
R2134 |
T3398 |
T3396 |
pobj |
databases,in |
R2135 |
T3399 |
T3398 |
amod |
public,databases |
R2136 |
T3400 |
T3361 |
punct |
.,led |
R2137 |
T3402 |
T3403 |
det |
This,disparity |
R2138 |
T3403 |
T3405 |
nsubj |
disparity,suggests |
R2139 |
T3404 |
T3403 |
amod |
apparent,disparity |
R2140 |
T3406 |
T3407 |
det |
a,role |
R2141 |
T3407 |
T3405 |
dobj |
role,suggests |
R2142 |
T3408 |
T3407 |
amod |
major,role |
R2143 |
T3409 |
T3405 |
prep |
for,suggests |
R2144 |
T3410 |
T3411 |
amod |
alternative,splicing |
R2145 |
T3411 |
T3409 |
pobj |
splicing,for |
R2146 |
T3412 |
T3405 |
prep |
in,suggests |
R2147 |
T3413 |
T3412 |
pcomp |
creating,in |
R2148 |
T3414 |
T3415 |
amod |
genetic,complexity |
R2149 |
T3415 |
T3413 |
dobj |
complexity,creating |
R2150 |
T3416 |
T3405 |
punct |
", ",suggests |
R2151 |
T3417 |
T3405 |
cc |
and,suggests |
R2152 |
T3418 |
T3419 |
aux |
has,brought |
R2153 |
T3419 |
T3405 |
conj |
brought,suggests |
R2154 |
T3420 |
T3421 |
det |
the,study |
R2155 |
T3421 |
T3419 |
dobj |
study,brought |
R2156 |
T3422 |
T3421 |
prep |
of,study |
R2157 |
T3423 |
T3424 |
compound |
splicing,regulation |
R2158 |
T3424 |
T3422 |
pobj |
regulation,of |
R2159 |
T3425 |
T3419 |
prep |
to,brought |
R2160 |
T3426 |
T3427 |
det |
the,forefront |
R2161 |
T3427 |
T3425 |
pobj |
forefront,to |
R2162 |
T3428 |
T3427 |
prep |
of,forefront |
R2163 |
T3429 |
T3430 |
amod |
molecular,genetics |
R2164 |
T3430 |
T3428 |
pobj |
genetics,of |
R2165 |
T3431 |
T3405 |
punct |
.,suggests |
R2166 |
T3433 |
T3434 |
nsubj |
It,is |
R2167 |
T3435 |
T3434 |
acomp |
likely,is |
R2168 |
T3436 |
T3437 |
mark |
that,identified |
R2169 |
T3437 |
T3434 |
ccomp |
identified,is |
R2170 |
T3438 |
T3439 |
det |
an,abundance |
R2171 |
T3439 |
T3437 |
nsubjpass |
abundance,identified |
R2172 |
T3440 |
T3439 |
prep |
of,abundance |
R2173 |
T3441 |
T3442 |
npadvmod |
species,specific |
R2174 |
T3442 |
T3444 |
amod |
specific,variants |
R2175 |
T3443 |
T3442 |
punct |
-,specific |
R2176 |
T3444 |
T3440 |
pobj |
variants,of |
R2177 |
T3445 |
T3444 |
compound |
splice,variants |
R2178 |
T3446 |
T3437 |
aux |
will,identified |
R2179 |
T3447 |
T3437 |
auxpass |
be,identified |
R2180 |
T3448 |
T3449 |
mark |
as,progresses |
R2181 |
T3449 |
T3437 |
advcl |
progresses,identified |
R2182 |
T3450 |
T3451 |
det |
the,characterization |
R2183 |
T3451 |
T3449 |
nsubj |
characterization,progresses |
R2184 |
T3452 |
T3451 |
prep |
of,characterization |
R2185 |
T3453 |
T3454 |
advmod |
alternatively,spliced |
R2186 |
T3454 |
T3455 |
amod |
spliced,transcripts |
R2187 |
T3455 |
T3452 |
pobj |
transcripts,of |
R2188 |
T3456 |
T3434 |
punct |
.,is |