PMC:8275828 / 33840-35083 JSONTXT

{"project":"TEST0","denotations":[{"id":"34268331-230-236-887408","span":{"begin":373,"end":375},"obj":"[\"28323829\"]"},{"id":"34268331-126-132-887409","span":{"begin":504,"end":506},"obj":"[\"19904605\", \"22466064\", \"1881238\"]"},{"id":"34268331-133-139-887410","span":{"begin":511,"end":513},"obj":"[\"15129301\", \"32864412\", \"33245132\", \"8785182\", \"25752849\"]"},{"id":"34268331-105-111-887411","span":{"begin":721,"end":723},"obj":"[\"28840052\"]"},{"id":"34268331-109-115-887412","span":{"begin":725,"end":727},"obj":"[\"27924168\"]"},{"id":"34268331-224-230-887413","span":{"begin":1149,"end":1151},"obj":"[\"19904605\", \"22466064\", \"1881238\"]"}],"text":"We acknowledge that this exploratory study is limited by a relatively small sample size (which is reflected by borderline significant p-values in Supplementary Table 4B) of mostly Caucasian women, and the inability to control for other covariates that may affect cognitive function such as alcohol and smoking history, physical activity, social interactions, and genetics (83). However, nutrient profiles and concentrations in this current analysis are similar to those of other cohorts of older adults (29–31, 84–88). NP1, described mostly by high fat content, was not associated with cognition in this population. Previous studies have reported benefits of diets high in n-3 PUFAs, especially DHA, on cognitive health (33, 89). While it is more appropriate to use absolute concentrations of FAs in the PCA, relative concentrations of FAs (i.e., FA composition) may be more relevant to the biological function of the brain. Additionally, it is unclear if the FA compositions in the brain of this cohort of the oldest old were in the normal range, since altered fatty acid compositions among cognitively impaired or demented subjects were reported (29–31), but no difference were observed between those with and without dementia in this study."}