PMC:8275828 / 25976-27285 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/8275828","sourcedb":"PMC","sourceid":"8275828","source_url":"https://www.ncbi.nlm.nih.gov/pmc/8275828","text":"A subset analysis among non-demented subjects (GDS 1–3) was performed and Pearson's coefficients are illustrated in a heat map (Figure 2B, p-values provided in Supplementary Table 4B). In the models adjusted for covariates among the five NPs representing the highest variances, NP2 was consistently associated with higher scores on global cognition (r = 0.38, p = 0.070), memory (r = 0.38, p = 0.073), language (r = 0.42, p = 0.046), and lower depression score (r = −0.40, p = 0.090) (Figure 3). After additional adjustment for antidepressant use, the correlation with lower depression score remained borderline significant (r = −0.35, p = 0.100). Since NP2 is mainly described by carotenoids, significant correlations were also consistently observed between lutein, zeaxanthin, β-carotene and scores on global cognition, memory, language, and depression. Other notable associations included NP3 and NP5 and higher depression. Additional adjustment for antithrombotic use was performed for PK and MK-4 and their correlations with different cognitive domain composite scores remained statistically non-significant (p \u003e 0.05) for all six cognitive domains and activities of daily living, while the correlation between MK-4, but not PK, and depression remained statistically significant (Supplementary Table 4B).","tracks":[]}