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PMC:7799378 / 9930-11002 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
394 0-4 Gene denotes G6PD Gene:2539
395 207-211 Gene denotes IL-6 Gene:3569
396 217-222 Gene denotes IL-1β Gene:3552
397 427-431 Gene denotes G6PD Gene:2539
398 576-580 Gene denotes G6PD Gene:14380
399 694-698 Gene denotes IL-6 Gene:16193
400 700-705 Gene denotes IL-1β Gene:16175
401 711-716 Gene denotes MCP-1 Gene:20296
402 761-765 Gene denotes iNOS Gene:4843
403 816-820 Gene denotes G6PD Gene:14380
404 942-947 Gene denotes NF-κB Gene:4790
405 1006-1010 Gene denotes G6PD Gene:14380
406 613-617 Species denotes mice Tax:10090
407 309-320 Species denotes respiratory Tax:12814
408 492-508 Chemical denotes free fatty acids MESH:D005230
409 513-532 Chemical denotes lipopolysaccharides MESH:D008070
410 1046-1050 Chemical denotes 6-AN MESH:C050850
411 1052-1056 Chemical denotes DHEA MESH:D003687
412 124-138 Disease denotes G6PD-deficient MESH:D005955
413 263-277 Disease denotes G6PD-deficient MESH:D005955
414 408-417 Disease denotes infection MESH:D007239
415 607-612 Disease denotes obese MESH:D009765

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T84 0-89 Sentence denotes G6PD plays a role in the modulation of the inflammatory response in several immune cells.
T85 90-262 Sentence denotes Peripheral mononuclear cells from G6PD-deficient individuals produce lower levels of the pro-inflammatory cytokines, IL-6, and IL-1β, compared with normal individuals [40].
T86 263-426 Sentence denotes G6PD-deficient granulocytes display a reduced respiratory burst resulting in diminished bactericidal activity and an increased susceptibility to infection [41,42].
T87 427-544 Sentence denotes G6PD gene and protein expression are increased in macrophages by free fatty acids and lipopolysaccharides (LPS) [43].
T88 545-717 Sentence denotes Upregulation of the macrophage G6PD gene in adipose tissue of obese mice is associated with increased levels of proinflammatory cytokines, including IL-6, IL-1β, and MCP-1.
T89 718-849 Sentence denotes The prooxidative genes, including NOXs and iNOS, are also increased when accompanied by increased G6PD gene and protein expression.
T90 850-1072 Sentence denotes The increased pro-inflammatory cytokines and pro-oxidative genes are downregulated when the NF-κB and MAPK pathways are suppressed as well as if macrophage G6PD is reduced by chemical inhibitors (6-AN, DHEA) or siRNA [43].

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T19 390-417 Phenotype denotes susceptibility to infection http://purl.obolibrary.org/obo/HP_0002719