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PMC:7799378 / 3607-4366 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
144 22-26 Gene denotes G6PD Gene:2539
145 293-297 Gene denotes G6PD Gene:2539
146 299-304 Gene denotes NADPH Gene:1666
147 387-392 Gene denotes NADPH Gene:1666
148 712-733 Gene denotes nitric oxide synthase Gene:4843
149 513-518 Gene denotes NADPH Gene:1666
150 136-141 Species denotes human Tax:9606
151 188-208 Chemical denotes hexose monophosphate
152 240-257 Chemical denotes pentose phosphate MESH:D010428
153 429-440 Chemical denotes glutathione MESH:D005978
154 442-445 Chemical denotes GSH
155 608-631 Chemical denotes reactive oxygen species MESH:D017382
156 633-636 Chemical denotes ROS MESH:D017382
157 651-659 Chemical denotes nitrogen MESH:D009584
158 669-672 Chemical denotes RNS MESH:D026361
159 216-219 Disease denotes HMS MESH:C537627

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T36 0-272 Sentence denotes The housekeeping gene G6PD or its ortholog, can be found in prokaryotic and eukaryotic organisms [15,16] as well as in all cells of the human body encoding the rate-limiting enzyme in the hexose monophosphate shunt (HMS), also known as the pentose phosphate pathway (PPP).
T37 273-386 Sentence denotes The main product of G6PD, NADPH, is required for reductive biosynthesis and the maintenance of redox homeostasis.
T38 387-512 Sentence denotes NADPH is critical for the regeneration of glutathione (GSH), which serves a significant role in cellular antioxidant defense.
T39 513-759 Sentence denotes NADPH also plays various roles in cytoregulation mediated by redox signaling, for instance, by reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced from NADPH oxidase (NOX) and nitric oxide synthase (NOS), respectively [17].