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PMC:7799378 / 3531-5289 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
127 13-17 Gene denotes G6PD Gene:2539
144 98-102 Gene denotes G6PD Gene:2539
145 369-373 Gene denotes G6PD Gene:2539
146 375-380 Gene denotes NADPH Gene:1666
147 463-468 Gene denotes NADPH Gene:1666
148 788-809 Gene denotes nitric oxide synthase Gene:4843
149 589-594 Gene denotes NADPH Gene:1666
150 212-217 Species denotes human Tax:9606
151 264-284 Chemical denotes hexose monophosphate
152 316-333 Chemical denotes pentose phosphate MESH:D010428
153 505-516 Chemical denotes glutathione MESH:D005978
154 518-521 Chemical denotes GSH
155 684-707 Chemical denotes reactive oxygen species MESH:D017382
156 709-712 Chemical denotes ROS MESH:D017382
157 727-735 Chemical denotes nitrogen MESH:D009584
158 745-748 Chemical denotes RNS MESH:D026361
159 292-295 Disease denotes HMS MESH:C537627
176 836-840 Gene denotes G6PD Gene:2539
177 920-924 Gene denotes G6PD Gene:2539
178 898-901 Chemical denotes ROS MESH:D017382
179 974-977 Chemical denotes ROS MESH:D017382
180 1018-1021 Chemical denotes ROS MESH:D017382
181 1064-1081 Chemical denotes hydrogen peroxide MESH:D006861
182 1083-1087 Chemical denotes H2O2 MESH:D006861
183 1224-1228 Chemical denotes H2O2 MESH:D006861
184 1360-1364 Chemical denotes H2O2 MESH:D006861
185 1475-1479 Chemical denotes H2O2 MESH:D006861
186 1529-1532 Chemical denotes ROS MESH:D017382
187 1606-1610 Chemical denotes H2O2 MESH:D006861
188 1660-1663 Chemical denotes ROS MESH:D017382
189 1108-1121 Disease denotes growth arrest MESH:D006323
190 1269-1282 Disease denotes growth arrest MESH:D006323
191 1405-1413 Disease denotes necrosis MESH:D009336

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T35 0-75 Sentence denotes Dual role of G6PD as an antioxidant and pro-oxidant enzyme in redox biology
T36 76-348 Sentence denotes The housekeeping gene G6PD or its ortholog, can be found in prokaryotic and eukaryotic organisms [15,16] as well as in all cells of the human body encoding the rate-limiting enzyme in the hexose monophosphate shunt (HMS), also known as the pentose phosphate pathway (PPP).
T37 349-462 Sentence denotes The main product of G6PD, NADPH, is required for reductive biosynthesis and the maintenance of redox homeostasis.
T38 463-588 Sentence denotes NADPH is critical for the regeneration of glutathione (GSH), which serves a significant role in cellular antioxidant defense.
T39 589-835 Sentence denotes NADPH also plays various roles in cytoregulation mediated by redox signaling, for instance, by reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced from NADPH oxidase (NOX) and nitric oxide synthase (NOS), respectively [17].
T40 836-902 Sentence denotes G6PD status is extremely important in modulating the level of ROS.
T41 903-1036 Sentence denotes On the one hand, G6PD maintains redox homeostasis by keeping cytotoxic ROS at proper levels because high levels of ROS are cytotoxic.
T42 1037-1315 Sentence denotes For example, 120-150 µM of hydrogen peroxide (H2O2) leads to temporary growth arrest, while repeated encounters of the treatment or an increase in concentration by 2-fold (250–450 µM) of H2O2 causes the cells to permanently undergo growth arrest or enter into a senescent state.
T43 1316-1390 Sentence denotes At even higher concentrations (0.5–1 mM) of H2O2, cells undergo apoptosis.
T44 1391-1485 Sentence denotes Cells exhibit necrosis when challenged with even higher concentrations (5-10 mM) of H2O2 [18].
T45 1486-1659 Sentence denotes On the other hand, different low levels of ROS can induce a wide spectrum of cellular responses such as with 3–15 µM of H2O2, which can stimulate mitogenic cell growth [19].
T46 1660-1758 Sentence denotes ROS at sub-micromolar ranges often serves as messengers for regulating cellular processes [20,21].